10 completed, 8 recruiting, 5 unknown, 3 active not recruiting. 9 Phase 4, 8 Phase 3, 5 Phase 2, 3 Not applicable, 3 Phase 1.
Follow Penicillin G: new trials by email Literature Review of Penicillin G trials Research Report on Penicillin G
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis Linezolid (LZD), Amoxicillin, Benzathine Penicillin G - Syphilis, Congenital | Phase 2 | Recruiting | London School of Hygiene and Tropical Medicine | 90 | 2026-05-04 | 2026-10-22 |
| Continuous Antibiotic Infusion In Children Benzylpenicillin - Infection | Phase 3 | Recruiting | Tampere University Hospital | 150 | 2026-04-21 | 2026-05-08 |
| Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy Ceftriaxon, Benzathine penicillin G - Pregnancy | Recruiting | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 110 | 2026-02-16 | 2026-08-06 | |
| Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing, Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge, Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge - Drug Allergy, Cephalosporin Allergy | Phase 2 | Recruiting | Massachusetts General Hospital | 300 | 2025-05-05 | 2026-09-04 |
| Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia Penicillin G_1200mg, cloxacillin - Staphylococcus Aureus Bacteraemia, Staphylococcal Bacteraemia | Phase 4 | Recruiting | Region Skane | 420 | 2025-03-10 | 2026-04-30 |
| Oral Amoxicillin Compared to Penicillin G Benzathine for the Treatment of Acquired Syphilis. Amoxicillin, Penicillin G, Benzathine - Syphilis Acquired | Phase 3 | Active not recruiting | Hospital de Niños R. Gutierrez de Buenos Aires | 120 | 2024-08-14 | 2026-10-21 |
| Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline Benzathine Penicillin G, Doxycycline Capsule - Early Syphilis, Latent, Serological Relapse After Treatment | Not applicable | Recruiting | National Taiwan University Hospital | 688 | 2024-01-01 | 2026-08-06 |
| Urogenital Infections in Women of Reproductive Age and the Activity of 4-Thiazolidinone Derivatives Against Pathogens Microbiological identification kits (ANAEROtest, STAPHYtest, ENTEROtest, NEFERMtest), Antibiotic therapy after the results of antibiotic sensitivity test (Mostly Oxacillin, Benzylpenicillin, Ceftriaxone, Doxycycline, Clindamycin), Suppositoria for vaginal microflora recovery (Giynoflor) - Bacterial Vaginosis | Phase 1 | Active not recruiting | Danylo Halytsky Lviv National Medical University | 200 | 2023-09-01 | 2024-09-27 |
| GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial phenoxymethyl penicillin, intramuscular benzathine penicillin G (BPG) prophylaxis - Rheumatic Heart Disease | Phase 2 | Active not recruiting | Children's Hospital Medical Center, Cincinnati | 1004 | 2023-09-01 | 2026-10-19 |
| Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline Doxycycline, Ceftriaxone, benzathine penicillin G - Early Syphilis | Phase 4 | Terminated | National Taiwan University Hospital | 109 | 2023-03-10 | 2026-02-25 |
| Single Dose Intravenous Antibiotics for Complicated Urinary Tract Infections in Children Benzylpenicillin - single dose, Benzylpenicillin - three days, Gentamicin - single dose - Complicated Urinary Tract Infection, Infection | Phase 4 | Recruiting | Murdoch Childrens Research Institute | 396 | 2022-05-30 | 2026-10-09 |
| Staphylococcus Aureus Network Adaptive Platform Trial Cefazolin, Penicillin, Clindamycin - Staphylococcus Aureus Bacteremia | Phase 4 | Recruiting | University of Melbourne | 8000 | 2022-02-16 | 2026-05-06 |
| Closed-loop Control of Penicillin Delivery Microneedle array, Microneedle array and closed-loop control of penicillin delivery, Penicillin G_1200mg - Healthy Volunteers | Phase 1 | Completed | Imperial College London | 6 | 2019-11-05 | 2024-07-10 |
| A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia Benzyl penicillin, Gentamicin Sulfate, Ceftriaxone - Pneumonia | Phase 3 | Completed | University of Oxford | 4392 | 2019-08-19 | 2024-07-08 |
| Penicillin Against Flucloxacillin Treatment Evaluation Benzylpenicillin, Flucloxacillin - Staphylococcus Aureus | Phase 4 | Withdrawn | The University of Queensland | 2019-07-01 | 2022-11-16 | |
| Cefixime for Alternative Syphilis Treatment Cefixime 400 milligram Oral Capsule [Suprax], Benzathine Penicillin G - Syphilis, Early Syphilis | Phase 2 | Completed | University of California, Los Angeles | 58 | 2018-09-03 | 2022-07-26 |
| A Study of Benzathine Benzylpenicillin Intramuscular Injection in Japanese Healthy Subjects penicillin G benzathine - Healthy | Phase 1 | Completed | Pfizer | 8 | 2018-08-20 | 2018-10-10 |
| Determining the Impact of Penicillin in Latent RHD: The GOAL Trial intramuscular benzathine penicillin G (BPG) prophylaxis - Rheumatic Heart Disease in Children, Latent Rheumatic Heart Disease | Phase 2 | Unknown | Children's National Research Institute | 807 | 2018-06-26 | 2019-10-01 |
| Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia Continuous infusion of beta-lactam antibiotics ., Therapeutic drug monitoring of beta-lactam antibiotics. - Bacteremia | Phase 4 | Withdrawn | Sara Thønnings | 2017-10-01 | 2023-03-29 | |
| First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition Ceftriaxone, Benzyl penicillin, Metronidazole - Malnutrition Severe, Antibiotic Resistance | Phase 3 | Unknown | University of Oxford | 2000 | 2017-09-04 | 2020-05-19 |
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Syphilis (6) · Pneumonia (3) · Treponemal Infections (3) · Bacteremia (2) · Infections (2) · Osteomyelitis (2) · Rheumatic Heart Disease (2) · Staphylococcal Infections (2) · AIDS-Related Complex (1) · Acquired Immunodeficiency Syndrome (1) · Anaphylaxis (1) · Chlamydia Infections (1) · Drug Hypersensitivity (1) · Endocarditis (1) · Gonorrhea (1)
National Taiwan University Hospital (2) · University of Oxford (2) · AllerQuest LLC (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's National Research Institute (1) · Danylo Halytsky Lviv National Medical University (1) · Holbaek Sygehus (1) · Hospital de Niños R. Gutierrez de Buenos Aires (1) · Imperial College London (1) · International Maternal Pediatric Adolescent AIDS Clinical Trials Group (1) · Johns Hopkins University (1) · Julio Ramirez (1) · Jun Li (1) · KEMRI-Wellcome Trust Collaborative Research Program (1) · Lihir Medical Centre (1)
United States (7) · Australia (3) · Kenya (3) · Uganda (3) · China (2) · France (2) · Japan (2) · New Zealand (2) · South Africa (2) · Sweden (2) · Taiwan (2) · United Kingdom (2) · Argentina (1) · Brazil (1) · Canada (1)
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