410 completed, 58 unknown, 49 recruiting, 26 active not recruiting. 161 Phase 3, 94 Phase 2, 89 Not applicable, 83 Phase 1, 60 Phase 4.
Follow Streptococcal Infections: new trials by email Literature Review of Streptococcal Infections trials Research Report on Streptococcal Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of the Prevalence of Rheumatic Heart Disease in School Settings in Mayotte and the Acquisition of Ultrasound Sequences Guided by Artificial Intelligence Ultrasound performed bycardiologis for diagnosis of rheumatic heart disease - Rheumatic Heart Diseases, Scabies | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de la Réunion | 900 | 2027-10-01 | 2026-10-29 |
| Multi-country Evaluation of Early RHD in Children Across Africa for Vaccine Trial Readiness Rheumatic Heart Disease in Children | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 7500 | 2027-02-01 | 2026-08-27 | |
| Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children Oral Penicillin V - Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 9622 | 2027-02-01 | 2026-09-03 |
| Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases | Not applicable | Not yet recruiting | Ladoke Akintola University of Technology, Ogbomoso, Nigeria | 474 | 2027-01-05 | 2026-06-04 |
| Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda The ACT+ Strategy - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 16 | 2026-12-01 | 2026-10-13 |
| ACT4RHD is an Open-label, Randomised, Adaptive Platform Trial to Evaluate Novel and Repurposed Clinical Interventions for Patients With Acute Rheumatic Fever and Carditis. ACT4RHD Seeks to Determine Whether These Interventions Reduce RHD Severity at 6 Months. Hydroxychloroquine (HCQ), No Hydroxychloroquine (HCQ), Prednisone or Prednisolone - Rheumatic Fever, Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Starship Child Health, Te Toka Tumai Auckland | 600 | 2026-12-01 | 2026-10-07 |
| Artificial Intelligence to Scale Early Rheumatic Heart Disease Detection AI assisted echocardiography - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 62 | 2026-11-01 | 2026-10-16 |
| Effects of Paraffin Wax Therapy and Dry Cupping on Pain and Wrist Function in Patients With Rheumatoid Arthritis Paraffin Wax Therapy, Dry cupping - Rheumatic Arthritis | Not applicable | Not yet recruiting | University of Baghdad | 100 | 2026-10-25 | 2026-10-29 |
| MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT) Antiphospholipid (aPL)-Positive, Rheumatic Arthritis | Not yet recruiting | Axiom Bioregistry | 5000 | 2026-10-18 | 2026-10-23 | |
| A Multicenter Evaluation of SalivIQ™ Strep A for Detecting Group A Streptococcus From Saliva and Throat Swabs in Patients With Acute Pharyngitis qPCR - Streptococcal Pharyngitis, Group A Streptococcal Infection | Not yet recruiting | SalivIQ Diagnostics, Inc. | 668 | 2026-10-09 | 2026-10-28 | |
| Secondary Bacterial Infections and Nasal Colonization in Scabies and Atopic Dermatitis Atopic Dermatitis (AD), Scabies | Not yet recruiting | Istanbul Medeniyet University | 51 | 2026-10-01 | 2026-09-15 | |
| Randomized Controlled Trial Of Text Messages To Increase Pneumococcal Vaccination In Adults In Chile. WhatsApp text message reminder for pneumococcal vaccination - Pneumococcal Infections, Immunization Programs | Not applicable | Enrolling by invitation | Pablo Tomás Valenzuela García | 40753 | 2026-10-01 | 2026-10-22 |
| A Study to Assess the Safety, Tolerability, and Immunogenicity of 3 Lots of a Multivalent Pneumococcal Conjugate Vaccine Administered to Adults PG4 Multivalent Vaccine, 20 Valent Pneumococcal Conjugate Vaccine (20vPnC) - Pneumococcal Disease | Phase 3 | Recruiting | Pfizer | 4670 | 2026-09-08 | 2026-10-14 |
| Comparative Study of Adherence to Antibiotic Therapy Among Pediatric Patients: Hospital Emergency Department vs. Primary Care Center Tonsillitis Acute, Pneumonia - Bacterial | Not yet recruiting | University Hospital, Montpellier | 191 | 2026-09-01 | 2026-07-17 | |
| A Clinical Trial of the 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/Tetanus Toxoid) Previously vaccinated with PCV13 (CanSino), Previously vaccinated with PCV13 (Pfizer) - Pneumococcal Infections, Streptococcal Infections | Not yet recruiting | CanSino Biologics Inc. | 100 | 2026-09-01 | 2026-08-05 | |
| A Study to Evaluate 20vPnC in Healthy Chinese Infants 20vPnC, 13vPnC - Pneumococcal Diseases | Phase 3 | Recruiting | Pfizer | 1250 | 2026-07-25 | 2026-08-10 |
| Induction of Cross-protective Antibodies for Serogroup 33 by Pneumococcal Conjugate Vaccines Pneumococcal Vaccine - Vaccine, Pneumococcal Disease | Phase 4 | Recruiting | University of Alabama at Birmingham | 70 | 2026-07-01 | 2026-08-21 |
| Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica (JADORE) biobank sample collection - Polymyalgia Rheumatica, Inflammatory Rheumatism | Not yet recruiting | University Hospital, Brest | 400 | 2026-07-01 | 2026-06-08 | |
| Study to Learn About Safety, Tolerability, and Immune Response of a Catch-up Pneumococcal Vaccine in Children and Adolescents PG4, 20-valent pneumococcal conjugate vaccine (20vPnC) - Pneumococcal Disease | Phase 3 | Recruiting | Pfizer | 1200 | 2026-06-15 | 2026-10-26 |
| A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-A1 in Healthy Young Adults Placebo, VAX-A1 Low, VAX-A1 Mid - Group A Streptococcal Infection | Phase 1 | Recruiting | Vaxcyte, Inc. | 80 | 2026-06-01 | 2026-06-16 |
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Pneumococcal Infections (298) · Rheumatic Heart Disease (56) · Rheumatic Fever (53) · Pneumonia, Pneumococcal (44) · Pneumonia (36) · Impetigo (30) · Cellulitis (15) · Otitis Media (14) · Haemophilus Infections (13) · HIV Infections (12) · Erysipelas (11) · Arthritis, Rheumatoid (10) · Endocarditis, Subacute Bacterial (10) · Influenza, Human (10)
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GlaxoSmithKline (75) · Pfizer (64) · Merck Sharp & Dohme LLC (46) · Wyeth is now a wholly owned subsidiary of Pfizer (16) · Assistance Publique - Hôpitaux de Paris (13) · Children's Hospital Medical Center, Cincinnati (12) · National Institute of Allergy and Infectious Diseases (NIAID) (10) · Sinovac Life Sciences Co., Ltd. (7) · Assiut University (6) · Minervax ApS (6) · St George's, University of London (6) · Vaxcyte, Inc. (6) · Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd (5) · CanSino Biologics Inc. (5) · PATH (5)
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PMID 11115712, PMID 1347058, PMID 24086113, PMID 25008901, PMID 25278086, PMID 2572650, PMID 25785969, PMID 30365584, PMID 30689507, PMID 3183430, PMID 34986178, PMID 36211411, PMID 36368038, PMID 3652522, PMID 37846456, PMID 41187484, PMID 10212363, PMID 1053919, PMID 10709851, PMID 10717828, PMID 10762563, PMID 10895619, PMID 11139785, PMID 11172176, PMID 11199555, PMID 11321382, PMID 11409642, PMID 1157366, PMID 1170757, PMID 11723015, PMID 11875603, PMID 12436828, PMID 12685620, PMID 12723166, PMID 12767443, PMID 12873775, PMID 13263433, PMID 14446037, PMID 1452871, PMID 14557958, PMID 14722149, PMID 14894244, PMID 14998500, PMID 15188713, PMID 15190533, PMID 15356783, PMID 15851928, PMID 15882530, PMID 15917682, PMID 15995950
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