2148 completed, 441 unknown, 273 recruiting, 161 terminated. 652 Not applicable, 616 Phase 2, 589 Phase 3, 450 Phase 1, 305 Phase 4.
Follow Gram-Positive Bacterial Infections: new trials by email Literature Review of Gram-Positive Bacterial Infections trials Research Report on Gram-Positive Bacterial Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Clinical Benefit and Safety Following CYFENDUS Administration for Post-Exposure Prophylaxis of Anthrax Disease. CYFENDUS - Anthrax | Not yet recruiting | Emergent BioSolutions | 250 | 2035-11-01 | 2025-12-08 | |
| Assessment of the Prevalence of Rheumatic Heart Disease in School Settings in Mayotte and the Acquisition of Ultrasound Sequences Guided by Artificial Intelligence Ultrasound performed bycardiologis for diagnosis of rheumatic heart disease - Rheumatic Heart Diseases, Scabies | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de la Réunion | 900 | 2027-10-01 | 2026-10-29 |
| A Field Study Evaluating Clinical Benefit and Safety of AIGIV (ANTHRASIL®) in Inhalational Anthrax Patients AIGIV - Inhalational Anthrax | Not yet recruiting | Emergent BioSolutions | 100 | 2027-05-30 | 2026-02-06 | |
| Observational Study of Raxibacumab in Sporadic Cases of Systemic Anthrax Collection of samples - Infections, Bacterial | Not yet recruiting | Emergent BioSolutions | 10 | 2027-05-01 | 2026-03-17 | |
| Advanced HIV Re-engagement in Care ARC - Advanced HIV Disease | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 724 | 2027-05-01 | 2026-07-23 |
| Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin - Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection | Phase 2 | Not yet recruiting | The University of Queensland | 300 | 2027-04-01 | 2026-03-20 |
| Multi-country Evaluation of Early RHD in Children Across Africa for Vaccine Trial Readiness Rheumatic Heart Disease in Children | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 7500 | 2027-02-01 | 2026-08-27 | |
| Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children Oral Penicillin V - Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 9622 | 2027-02-01 | 2026-09-03 |
| Re-evaluating the Duration in Children of TB Treatment Rifampicin, Isoniazid, Pyrazinamide - Tuberculosis | Phase 2 | Not yet recruiting | University of Wisconsin, Madison | 230 | 2027-02-01 | 2026-11-02 |
| Therapeutic ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB ID93 + GLA-SE vaccine, Placebo vaccine - Tuberculosis, Pulmonary | Phase 2 | Not yet recruiting | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 1500 | 2027-01-31 | 2026-08-24 |
| Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases | Not applicable | Not yet recruiting | Ladoke Akintola University of Technology, Ogbomoso, Nigeria | 474 | 2027-01-05 | 2026-06-04 |
| A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization Resistant Potato Starch, Maltodextrin - Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA) | Phase 2 | Not yet recruiting | VA Office of Research and Development | 120 | 2027-01-01 | 2026-08-28 |
| Clinical Benefit and Safety of Raxibacumab in Patients With Symptomatic Inhalational Anthrax in a Mass Exposure Scenario Sample Collection - Infections, Bacterial | Phase 4 | Not yet recruiting | Emergent BioSolutions | 100 | 2027-01-01 | 2026-02-06 |
| Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin Vancomycin (POC) - Clostridioides Difficile, Vancomycin Resistance Enterococcus Faecium | Phase 2 / Phase 3 | Withdrawn | University of Maryland, Baltimore | 2027-01-01 | 2026-07-29 | |
| Bacterial Decolonization to Prevent Severe Radiation Dermatitis in Head and Neck Squamous Cell Carcinoma Bacterial decolonization, Standard Hygiene Measures - HNSCC | Not applicable | Not yet recruiting | Institut Cancerologie de l'Ouest | 144 | 2027-01-01 | 2026-10-22 |
| Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa VPM1002 Vaccine, BCG Vaccine, Placebo - Tuberculosis, HIV Infections | Phase 1 / Phase 2 | Withdrawn | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 2026-12-31 | 2026-08-17 | |
| Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda The ACT+ Strategy - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 16 | 2026-12-01 | 2026-10-13 |
| Shaping a Community-based Pathway to Improve TB Surveillance Among African and Hindustan Immigrants Experiencing Vulnerabilities Tuberculosis, Tuberculosis (TB) | Not yet recruiting | Universidade Nova de Lisboa | 200 | 2026-12-01 | 2026-07-07 | |
| ACT4RHD is an Open-label, Randomised, Adaptive Platform Trial to Evaluate Novel and Repurposed Clinical Interventions for Patients With Acute Rheumatic Fever and Carditis. ACT4RHD Seeks to Determine Whether These Interventions Reduce RHD Severity at 6 Months. Hydroxychloroquine (HCQ), No Hydroxychloroquine (HCQ), Prednisone or Prednisolone - Rheumatic Fever, Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Starship Child Health, Te Toka Tumai Auckland | 600 | 2026-12-01 | 2026-10-07 |
| Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children Cryopreserved aorta - Trachea Diseases, Tracheal Stenosis | Not applicable | Enrolling by invitation | National Taiwan University Hospital | 5 | 2026-12-01 | 2026-08-17 |
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Isoniazid (166) · Rifampin (147) · Pyrazinamide (92) · Vancomycin (88) · Ethambutol (87) · 13-valent pneumococcal vaccine (73) · bedaquiline (69) · Linezolid (65) · Tetanus Toxoid (65) · Moxifloxacin (56) · rifapentine (53) · Heptavalent Pneumococcal Conjugate Vaccine (46) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (46) · Pneumococcal Vaccines (44) · Fecal Microbiota Transplantation (38)
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