Bacterial Infections: Clinical Trials

4027 completed, 814 unknown, 550 recruiting, 321 terminated. 1216 Not applicable, 1122 Phase 2, 1059 Phase 3, 794 Phase 1, 626 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	1216	Completed 713, Unknown 191, Recruiting 131, Not yet recruiting 65, Terminated 55, Active not recruiting 28, Withdrawn 24, Suspended 5, Enrolling by invitation 4
Phase 2	1122	Completed 760, Recruiting 90, Unknown 87, Terminated 76, Active not recruiting 39, Withdrawn 35, Not yet recruiting 27, Enrolling by invitation 5, Suspended 3
Phase 3	1059	Completed 776, Unknown 86, Recruiting 64, Terminated 55, Active not recruiting 37, Not yet recruiting 22, Withdrawn 16, Suspended 2, Enrolling by invitation 1
Phase 1	794	Completed 585, Unknown 52, Recruiting 50, Terminated 37, Not yet recruiting 22, Active not recruiting 21, Withdrawn 21, Enrolling by invitation 4, Suspended 2
Phase 4	626	Completed 375, Unknown 88, Terminated 54, Recruiting 43, Withdrawn 26, Not yet recruiting 23, Active not recruiting 14, Suspended 2, Enrolling by invitation 1
Early Phase 1	60	Completed 30, Recruiting 8, Unknown 7, Not yet recruiting 6, Withdrawn 4, Terminated 3, Active not recruiting 2

Follow Bacterial Infections: new trials by email Literature Review of Bacterial Infections trials Research Report on Bacterial Infections

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Evaluation of Clinical Benefit and Safety Following CYFENDUS Administration for Post-Exposure Prophylaxis of Anthrax Disease. CYFENDUS - Anthrax		Not yet recruiting	Emergent BioSolutions	250	2035-11-01	2025-12-08
Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans Integrated care - Opioid Use Disorder, HIV	Not applicable	Not yet recruiting	VA Office of Research and Development	60	2028-04-03	2026-04-24
Improving Clinic Delivery of HIV-related Anal Health Services PEACHES 2.0 Implementation Strategies - HIV, Gonorrhea	Not applicable	Not yet recruiting	Albert Einstein College of Medicine	8	2028-02-01	2026-10-13
A Field Study Evaluating Clinical Benefit and Safety of AIGIV (ANTHRASIL®) in Inhalational Anthrax Patients AIGIV - Inhalational Anthrax		Not yet recruiting	Emergent BioSolutions	100	2027-05-30	2026-02-06
Observational Study of Raxibacumab in Sporadic Cases of Systemic Anthrax Collection of samples - Infections, Bacterial		Not yet recruiting	Emergent BioSolutions	10	2027-05-01	2026-03-17
Advanced HIV Re-engagement in Care ARC - Advanced HIV Disease	Not applicable	Not yet recruiting	University of Alabama at Birmingham	724	2027-05-01	2026-07-23
Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin - Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection	Phase 2	Not yet recruiting	The University of Queensland	300	2027-04-01	2026-03-20
Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System	Phase 4	Not yet recruiting	Radboud University Medical Center	50	2027-03-01	2026-08-27
A Study to Test New Investigational Drugs (LCFA-01and LC103) for Bacterial Vaginosis (BV) Treatment metronidazole (MTZ)+ LCFA-01 placebo + LC103 placebo, metronidazole (MTZ)+ LCFA-01 + LC103 placebo, metronidazole (MTZ)+ LC103 + LCFA-01 placebo - Bacterial Vaginosis	Phase 1	Not yet recruiting	Massachusetts General Hospital	280	2027-02-03	2026-10-15
Multi-country Evaluation of Early RHD in Children Across Africa for Vaccine Trial Readiness Rheumatic Heart Disease in Children		Not yet recruiting	Children's Hospital Medical Center, Cincinnati	7500	2027-02-01	2026-08-27
Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children Oral Penicillin V - Rheumatic Heart Disease in Children	Phase 3	Not yet recruiting	Children's Hospital Medical Center, Cincinnati	9622	2027-02-01	2026-09-03
Therapeutic ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB ID93 + GLA-SE vaccine, Placebo vaccine - Tuberculosis, Pulmonary	Phase 2	Not yet recruiting	Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections	1500	2027-01-31	2026-08-24
A Trial to Evaluate the Safety and Reactogenicity of an Investigational Pneumococcal Vaccine in Infants Receiving 3-dose Primary Dosing Series Followed by a Booster Dose at 12 to 15 Months of Age Pn-MAPS30plus, PCV20 - Pneumonia, Bacterial	Phase 1	Not yet recruiting	GlaxoSmithKline	60	2027-01-25	2026-07-16
Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases	Not applicable	Not yet recruiting	Ladoke Akintola University of Technology, Ogbomoso, Nigeria	474	2027-01-05	2026-06-04
A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization Resistant Potato Starch, Maltodextrin - Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA)	Phase 2	Not yet recruiting	VA Office of Research and Development	120	2027-01-01	2026-08-28
Clinical Benefit and Safety of Raxibacumab in Patients With Symptomatic Inhalational Anthrax in a Mass Exposure Scenario Sample Collection - Infections, Bacterial	Phase 4	Not yet recruiting	Emergent BioSolutions	100	2027-01-01	2026-02-06
Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin Vancomycin (POC) - Clostridioides Difficile, Vancomycin Resistance Enterococcus Faecium	Phase 2 / Phase 3	Withdrawn	University of Maryland, Baltimore		2027-01-01	2026-07-29
Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa VPM1002 Vaccine, BCG Vaccine, Placebo - Tuberculosis, HIV Infections	Phase 1 / Phase 2	Withdrawn	International Maternal Pediatric Adolescent AIDS Clinical Trials Group		2026-12-31	2026-08-17
Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda The ACT+ Strategy - Rheumatic Heart Disease	Not applicable	Not yet recruiting	Children's Hospital Medical Center, Cincinnati	16	2026-12-01	2026-10-13
Shaping a Community-based Pathway to Improve TB Surveillance Among African and Hindustan Immigrants Experiencing Vulnerabilities Tuberculosis, Tuberculosis (TB)		Not yet recruiting	Universidade Nova de Lisboa	200	2026-12-01	2026-07-07

Showing 20 of 6334. Sign in to see all of them.

Narrower conditions

Tuberculosis (1142)  ·  Tuberculosis, Pulmonary (309)  ·  Tetanus (302)  ·  Pneumococcal Infections (298)  ·  Staphylococcal Infections (292)  ·  Hidradenitis Suppurativa (280)  ·  Whooping Cough (269)  ·  Bacteremia (259)  ·  Diphtheria (254)  ·  Clostridium Infections (244)  ·  Vaginosis, Bacterial (232)  ·  Meningococcal Infections (229)  ·  HIV Infections (220)  ·  Latent Tuberculosis (198)

Broader conditions

Bacterial Infections and Mycoses (6328)  ·  Infections (6151)  ·  Gram-Positive Bacterial Infections (3291)  ·  Actinomycetales Infections (1975)  ·  Gram-Negative Bacterial Infections (1801)  ·  Mycobacterium Infections (1655)  ·  Pathological Conditions, Signs and Symptoms (1189)  ·  Respiratory Tract Diseases (1153)  ·  Pathologic Processes (1015)  ·  Urogenital Diseases (960)  ·  Respiratory Tract Infections (952)  ·  Genital Diseases (822)  ·  Lung Diseases (783)  ·  Communicable Diseases (688)

Interventions

Isoniazid (166)  ·  Rifampin (157)  ·  Azithromycin (119)  ·  Vancomycin (110)  ·  Pyrazinamide (92)  ·  13-valent pneumococcal vaccine (90)  ·  Ethambutol (87)  ·  Linezolid (87)  ·  Moxifloxacin (84)  ·  Tetanus Toxoid (83)  ·  Meningococcal Vaccines (81)  ·  Blood Specimen Collection (77)  ·  Metronidazole (72)  ·  Doxycycline (71)  ·  bedaquiline (69)

Sponsors

GlaxoSmithKline (352)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (234)  ·  Pfizer (135)  ·  Sanofi Pasteur, a Sanofi Company (127)  ·  Merck Sharp & Dohme LLC (80)  ·  Assistance Publique - Hôpitaux de Paris (76)  ·  University of Oxford (71)  ·  Novartis Vaccines (63)  ·  Johns Hopkins University (59)  ·  Centers for Disease Control and Prevention (47)  ·  University of California, San Francisco (46)  ·  National Taiwan University Hospital (40)  ·  London School of Hygiene and Tropical Medicine (39)  ·  Sanofi (39)  ·  Wyeth is now a wholly owned subsidiary of Pfizer (39)

Countries

United States (1798)  ·  France (465)  ·  China (383)  ·  South Africa (355)  ·  Canada (312)  ·  United Kingdom (280)  ·  Germany (269)  ·  Spain (253)  ·  South Korea (188)  ·  Australia (186)  ·  Italy (185)  ·  India (165)  ·  Brazil (146)  ·  Poland (146)  ·  Uganda (143)

Top investigators

Helen McShane (20)  ·  Nicholas Paton (10)

Results publications

PMID 33616229, PMID 30597021, PMID 34922058, PMID 35164991, PMID 40122135, PMID 42286373, PMID 25466778, PMID 31110098, PMID 35257644, PMID 36808186, PMID 41245385, PMID 19819004, PMID 22461716, PMID 27518661, PMID 27568215, PMID 28043488, PMID 28063795, PMID 29380251, PMID 30075748, PMID 30716446, PMID 31411386, PMID 31589610, PMID 31604104, PMID 33020485, PMID 33326848, PMID 33542052, PMID 34741280, PMID 35776862, PMID 36746171, PMID 39230271, PMID 40277027, PMID 41248770, PMID 42525209, PMID 11115712, PMID 1347058, PMID 16531428, PMID 16640454, PMID 17287313, PMID 17301105, PMID 17716936, PMID 17957238, PMID 18444791, PMID 18444848, PMID 18508226, PMID 18532873, PMID 19095213, PMID 19095679, PMID 19220138, PMID 19237886, PMID 19321868

NIH funding

2023 (33), 2019 (32), 2018 (30), 2016 (21), 2014 (20), 2025 (20), 2017 (19), 2015 (18), 2008 (15), 2009 (15), 2005 (8), R01HD071779 (6), U01AI068636 (4), UM1AI068636 (4), UM1AI104681 (4)