39 completed, 18 unknown, 17 recruiting, 13 not yet recruiting. 38 Not applicable, 12 Phase 3, 6 Phase 2, 4 Phase 1, 2 Phase 4.
Follow Rheumatic Fever: new trials by email Literature Review of Rheumatic Fever trials Research Report on Rheumatic Fever
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multi-country Evaluation of Early RHD in Children Across Africa for Vaccine Trial Readiness Rheumatic Heart Disease in Children | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 7500 | 2027-02-01 | 2026-08-27 | |
| Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children Oral Penicillin V - Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 9622 | 2027-02-01 | 2026-09-03 |
| Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases | Not applicable | Not yet recruiting | Ladoke Akintola University of Technology, Ogbomoso, Nigeria | 474 | 2027-01-05 | 2026-06-04 |
| Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda The ACT+ Strategy - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 16 | 2026-12-01 | 2026-10-13 |
| ACT4RHD is an Open-label, Randomised, Adaptive Platform Trial to Evaluate Novel and Repurposed Clinical Interventions for Patients With Acute Rheumatic Fever and Carditis. ACT4RHD Seeks to Determine Whether These Interventions Reduce RHD Severity at 6 Months. Hydroxychloroquine (HCQ), No Hydroxychloroquine (HCQ), Prednisone or Prednisolone - Rheumatic Fever, Rheumatic Heart Disease in Children | Phase 3 | Not yet recruiting | Starship Child Health, Te Toka Tumai Auckland | 600 | 2026-12-01 | 2026-10-07 |
| Artificial Intelligence to Scale Early Rheumatic Heart Disease Detection AI assisted echocardiography - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 62 | 2026-11-01 | 2026-10-16 |
| MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT) Antiphospholipid (aPL)-Positive, Rheumatic Arthritis | Not yet recruiting | Axiom Bioregistry | 5000 | 2026-10-18 | 2026-10-23 | |
| Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica (JADORE) biobank sample collection - Polymyalgia Rheumatica, Inflammatory Rheumatism | Not yet recruiting | University Hospital, Brest | 400 | 2026-07-01 | 2026-06-08 | |
| A Non-Inferiority Trial of Stopping Penicillin in Early Rheumatic Heart Disease: GOAL-Stop Secondary Prophylaxis - Rheumatic Heart Disease | Phase 3 | Recruiting | Children's Hospital Medical Center, Cincinnati | 922 | 2026-03-23 | 2026-06-22 |
| Intervention to Support Partners and Informal Caregivers of Frail RA-patients Caregiver support - Rheumatic Arthritis | Not applicable | Recruiting | Glostrup University Hospital, Copenhagen | 25 | 2026-03-15 | 2026-03-17 |
| Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor StrepIncor, Placebo - Rheumatic Heart Disease, Rheumatic Heart Disease in Children | Phase 1 / Phase 2 | Not yet recruiting | University of Sao Paulo General Hospital | 60 | 2025-10-01 | 2025-07-22 |
| Vitamin K Antagonist in Rheumatic Heart Disease Patients With Mechanical Heart Valves: Our Current Status Rheumatic Heart Disease | Not yet recruiting | Ahmed Hassan Rostom Ibrahim | 165 | 2025-09-01 | 2025-08-28 | |
| Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice Heart Valve Diseases, Aortic Valve Stenosis | Not yet recruiting | Yonsei University | 30000 | 2025-08-01 | 2025-07-16 | |
| Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis. Resveratrol 1 gm., Methotrexate - Rheumatic Arthritis, Rheumatoid Arthritis (RA) Prevention | Not applicable | Recruiting | Ain Shams University | 118 | 2025-08-01 | 2025-07-28 |
| Effectiveness of Edutainment-Based Interventions in Increasing Knowledge of Rheumatic Fever and Rheumatic Heart Disease Among School-Going Children in Nepal: Study Protocol for Colors to Save Hearts Quasi-Experimental Pretest-Posttest Study education material - Rheumatic Heart Disease | Not applicable | Not yet recruiting | Kathmandu Institute of Child Health | 2400 | 2025-07-28 | 2025-07-15 |
| Effects of Task-Oriented Training and Mulligan Mobilization on Hand Function, Pain and Quality of Life in Patients With Rheumatoid Arthritis Task-oriented trainig, Mulligan mobilization, Conventional treatment - Rheumatic Arthritis | Not applicable | Completed | Kirsehir Ahi Evran Universitesi | 54 | 2025-07-01 | 2025-12-10 |
| Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVE SmartWave Lithotripsy balloon - Mitral Annulus Calcification, Rheumatic Heart Disease | Not applicable | Recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 10 | 2025-03-08 | 2026-09-16 |
| Dynamics in Bone Turnover Markers During and After Short-term Glucocorticoid Treatment in Patients With an Inflammatory Joint Disease Glucocorticoid Effect - Osteoporosis, Osteoporosis, Steroid Induced | Recruiting | Diakonhjemmet Hospital | 160 | 2025-01-01 | 2026-08-19 | |
| School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions School nurse program - Rheumatic Heart Disease in Children | Not applicable | Recruiting | Thomas Pilgrim | 6000 | 2024-12-15 | 2026-01-20 |
| Manual Diaphragmatic Release on Ventilatory Functions in Women With Rheumatoid Arthritis Aerobic training, Manual Diaphragm Release - Rheumatic Arthritis, Lung Function | Not applicable | Not yet recruiting | Middle East University | 60 | 2024-12-03 | 2024-12-09 |
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Rheumatic Heart Disease (55) · Arthritis, Rheumatoid (8) · Heart Valve Diseases (7) · Mitral Valve Stenosis (7) · Atrial Fibrillation (5) · Arthritis, Psoriatic (4) · Rheumatic Diseases (4) · Spondylarthritis (4) · COVID-19 (3) · Heart Diseases (3) · Heart Failure (3) · Joint Diseases (3) · Lupus Erythematosus, Systemic (3) · Polymyalgia Rheumatica (3)
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Echocardiography (3) · Rivaroxaban (3) · Surveys and Questionnaires (3) · Blood Specimen Collection (2) · Penicillin G (2) · Penicillin G Benzathine (2) · Penicillin V (2) · Warfarin (2) · 5-(tetradecyloxy)-2-furancarboxylic acid (1) · Aspirin (1) · Atorvastatin (1) · Azithromycin (1) · Bronchoalveolar Lavage (1) · Cardiac Surgical Procedures (1) · Case Managers (1)
Children's Hospital Medical Center, Cincinnati (12) · Assiut University (4) · Insel Gruppe AG, University Hospital Bern (3) · University Hospital, Brest (3) · Aesculap AG (2) · Assistance Publique - Hôpitaux de Paris (2) · Diakonhjemmet Hospital (2) · Molde University College (2) · Population Health Research Institute (2) · Starship Child Health, Te Toka Tumai Auckland (2) · Sun Yat-sen University (2) · Thomas Pilgrim (2) · University of Washington (2) · AO GENERIUM (1) · Ahmed Hassan Rostom Ibrahim (1)
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