105 completed, 29 recruiting, 10 unknown, 8 active not recruiting. 54 Not applicable, 52 Phase 3, 26 Phase 4, 9 Phase 2, 2 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stellate Ganglion Neuromodulation for the Treatment of Electrical Storm Stellate Ganglion Block Injection with Bupivicaine, Sham procedure control - Ventricular Tachycardia (V-Tach) Storm | Not applicable | Not yet recruiting | Population Health Research Institute | 300 | 2027-01-01 | 2026-10-08 |
| Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy Semaglutide - Ischemic Stroke | Phase 2 | Not yet recruiting | Population Health Research Institute | 100 | 2026-10-31 | 2026-09-24 |
| Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe (CATIS- ICAS) Rivaroxaban, ASA - Ischemic Stroke, Intracranial Atherosclerosis | Phase 3 | Not yet recruiting | Population Health Research Institute | 1172 | 2026-09-30 | 2026-09-01 |
| Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage Colchicine 0.5 MG, Placebo - Colchicine, ICH - Intracerebral Hemorrhage | Phase 3 | Not yet recruiting | Population Health Research Institute | 1125 | 2026-09-30 | 2026-09-01 |
| Head of Bed After Ischemic Stroke Thrombectomy (HoBIT) Head of bed position of 0-degrees, Head of bed position of 30-degrees or greater - Large Vessel Occlusion, Stroke | Not applicable | Recruiting | Population Health Research Institute | 2240 | 2026-09-03 | 2026-09-18 |
| Comparative Outcomes of Mammary Artery Harvesting: Infection, Occlusion Rates and Thoracic Pain Assessment Skeletonized LIMA Harvesting, Non-Skeletonized LIMA Harvesting - Coronary Artery Disease, Coronary Artery Bypass Grafting | Not applicable | Withdrawn | Hamilton Health Sciences Corporation | 2026-09-01 | 2026-07-28 | |
| Study of Feasibility for Surgical Patients Undergoing Heart Surgery With the Mammary Arteries: Reviewing Infection, Occlusion Rates and Pain Assessments. Skeletonized vs non-skeletonized harvesting of the left internal mammary artery - Graft Patency | Not applicable | Recruiting | Ottawa Heart Institute Research Corporation | 35 | 2026-08-31 | 2026-09-08 |
| Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2 Continuous vital signs measurement device - Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS) | Not yet recruiting | Hamilton Health Sciences Corporation | 20000 | 2026-06-01 | 2026-04-14 | |
| DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial VKA, Direct Oral Anticoagulant (DOAC) - Atrial Fibrillation (AF), Stroke (in Patients With Atrial Fibrillation) | Early Phase 1 | Not yet recruiting | Population Health Research Institute | 100 | 2025-09-03 | 2025-06-08 |
| Non-invasive Ventilation and Dexmedetomidine in Critically Ill Adults Dexmedetomidine, Placebo Control - Non-Invasive Ventilation | Phase 3 | Recruiting | St. Joseph's Healthcare Hamilton | 846 | 2025-07-29 | 2025-09-10 |
| Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial Desmopressin Injectable Solution, Tranexamic Acid Injectable Product, Placebo - Chronic Kidney Diseases, Acute Kidney Injury | Phase 3 | Recruiting | Hamilton Health Sciences Corporation | 100 | 2025-06-09 | 2026-05-22 |
| Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy Tideglusib, Placebo - Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy | Phase 2 | Recruiting | Hamilton Health Sciences Corporation | 120 | 2025-03-21 | 2026-03-12 |
| CCTA to Optimize Diagnostic Yield of Invasive Angiography With AI Usual Care, Centralized triage with risk score-based screening for obstructive CAD - Coronary Artery Disease | Not applicable | Completed | Hamilton Health Sciences Corporation | 251 | 2025-01-09 | 2026-05-11 |
| The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery retrograde autologous priming (RAP), Crystalloid priming - Red Blood Cell Transfusion | Not applicable | Recruiting | Population Health Research Institute | 4500 | 2024-12-04 | 2025-03-04 |
| International CRDS Registry Calcium Release Deficiency Syndrome | Recruiting | Population Health Research Institute | 500 | 2024-11-21 | 2026-09-28 | |
| Pericardiotomy in Cardiac Surgery Left Posterior Pericardiotomy - Atrial Fibrillation, Atrial Flutter | Not applicable | Recruiting | Population Health Research Institute | 1400 | 2024-10-21 | 2026-10-21 |
| DETECTion of PeriOperative Atrial Fibrillation After Noncardiac Surgery Cardiac monitoring device - Atrial Fibrillation, Atrial Flutter | Recruiting | Population Health Research Institute | 750 | 2024-10-15 | 2024-11-07 | |
| Post Discharge After Surgery Virtual Care with Remote Automated Monitoring Technology-2 (PVC-RAM-2) Trial Virtual care with remote automated monitoring - Surgery, Perioperative Complication | Not applicable | Recruiting | Population Health Research Institute | 2000 | 2024-10-04 | 2024-11-15 |
| Single Dose Flecainide for Early Sinus Rhythm Conversion of Perioperative Atrial Fibrillation After Noncardiac Surgery Flecainide - Atrial Fibrillation, Surgery | Phase 4 | Withdrawn | Population Health Research Institute | 2024-07-01 | 2024-08-29 | |
| Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial Amiodarone Hydrochloride 200 MG - Atrial Fibrillation New Onset | Phase 3 | Recruiting | Population Health Research Institute | 400 | 2024-06-13 | 2026-09-04 |
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Atrial Fibrillation (33) · Stroke (22) · Myocardial Infarction (16) · Cardiovascular Diseases (14) · Heart Failure (12) · Ischemic Stroke (10) · Diabetes Mellitus, Type 2 (8) · Coronary Artery Disease (7) · Hemorrhage (7) · ST Elevation Myocardial Infarction (7) · Acute Coronary Syndrome (6) · Arrhythmias, Cardiac (6) · Hypertension (6) · Insulin Resistance (6) · Diabetes Mellitus (5)
Aspirin (11) · Colchicine (11) · Rivaroxaban (10) · Insulin Glargine (6) · Exercise (5) · Metformin (5) · Tranexamic Acid (5) · apixaban (5) · Cefazolin (4) · Dabigatran (4) · Diet (4) · Warfarin (4) · Amiodarone (3) · Bacitracin (3) · Cephalexin (3)
Canada (145) · United States (34) · United Kingdom (28) · Spain (23) · Germany (22) · India (22) · China (21) · Australia (20) · Brazil (20) · Italy (20) · Belgium (18) · Netherlands (18) · South Africa (18) · Denmark (17) · France (16)
PJ Devereaux, MD, PhD (6) · Stuart Connolly, MD (6) · Andre Lamy, MD (4) · Aristeidis Katsanos, MD (4) · Michael McGillion, PhD (4) · Sanjit S Jolly, MD (4) · Ashkan Shoamanesh, MD (3) · Carlos Morillo, MD (3) · Darryl Leong, PhD. MBBSm (3) · David Conen, MD, MPH (3) · Hertzel Gerstein, MD (3) · Jason D Roberts, MD MAS (3) · Jeff Healey, M.D. (3) · John Eikelboom, MD (3)
PMID 18940900, PMID 36700520, PMID 40490702, PMID 16531613, PMID 17470822, PMID 17954810, PMID 18003666, PMID 18325134, PMID 18364343, PMID 18480196, PMID 19104516, PMID 19228852, PMID 19261658, PMID 19376304, PMID 19376733, PMID 19458363, PMID 19540385, PMID 19717844, PMID 19753491, PMID 20801496, PMID 21059484, PMID 21147728, PMID 21170320, PMID 21200007, PMID 21315206, PMID 21368847, PMID 21412147, PMID 21470671, PMID 21576658, PMID 21632446, PMID 21699856, PMID 21872920, PMID 22000582, PMID 22038523, PMID 22054656, PMID 22083832, PMID 22084332, PMID 22172429, PMID 22174727, PMID 22215856, PMID 22236222, PMID 22318666, PMID 22374183, PMID 22390143, PMID 22449296, PMID 22514244, PMID 22686415, PMID 22686416, PMID 22698765, PMID 22700854
2019 (2), 2023 (2), 2005 (1), 2014 (1), R01HL146206 (1)