50 completed, 16 unknown, 6 withdrawn, 5 recruiting. 86 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 86 | Completed 50, Unknown 16, Withdrawn 6, Recruiting 5, Terminated 5, Active not recruiting 2, Not yet recruiting 2 |
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) Dopamine administration, Norepinephrine - Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN) | Phase 4 | Recruiting | University of California, Davis | 30 | 2026-10-30 | 2026-08-18 |
| Steroids for Rhinoplasty: Pain, Nausea, Edema and Ecchymosis Medrol 4 MG Oral Tablet Includes Medrol Dosepak - Edema, Bruising | Phase 4 | Withdrawn | Vanderbilt University Medical Center | 2026-01-01 | 2025-11-18 | |
| Early Sedation With Dexmedetomidine vs. Placebo in Older Ventilated Critically Ill Patients Dexmedetomidine, Placebo - Respiratory Insufficiency | Phase 4 | Not yet recruiting | St. Joseph's Healthcare Hamilton | 300 | 2025-09-07 | 2025-09-10 |
| Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments Remimazolam, Propofol - Postoperative Complications, Respiratory Depression | Phase 4 | Recruiting | Kaohsiung Veterans General Hospital. | 90 | 2025-02-12 | 2025-05-08 |
| Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression Propofol group, Remimazolam group - Respiratory Depression | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 96 | 2025-02-01 | 2025-02-10 |
| Oxymetazoline Bridge Therapy With Intranasal Corticosteroids in Pediatric Allergic Rhinitis Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 100 mcg, Oxymetazoline 0.05% nasal solution - Persistent Allergic Rhinitis | Phase 4 | Completed | Dr. Behcet Uz Children's Hospital | 76 | 2025-01-02 | 2026-05-18 |
| A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy Remimazolam besylate, Propofol - Colonic Polyp, Sedation Complication | Phase 4 | Recruiting | Clinical Hospital Centre Zagreb | 90 | 2025-01-01 | 2026-03-06 |
| Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support Enoxaparin Injectable Solution, Argatroban, 1 Mg/mL Intravenous Solution, Unfractionated heparin - Respiratory Insufficiency, Circulatory Failure | Phase 4 | Recruiting | Medical University of Vienna | 90 | 2024-07-30 | 2024-10-29 |
| Comparison of Gas Exchange Between Two Invasive Mechanical Ventilation Modes in Children Respiratory support a, Respiratory support b - Respiratory Failure | Phase 4 | Completed | University Children's Hospital, Zurich | 59 | 2024-01-15 | 2024-12-13 |
| The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate Caffeine citrate - Apnea of Prematurity, Premature Birth | Phase 4 | Recruiting | Semmelweis University | 226 | 2023-12-21 | 2024-05-06 |
| Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care Propofol, Remimazolam - Propofol, Remimazolam | Phase 4 | Completed | DongGuk University | 76 | 2023-08-24 | 2025-07-22 |
| Opioid-sparing Versus Sevoflurane Anesthesia on Early Postoperative Hypoventilation in Laparoscopic Bariatric Surgery Opioid-sparing based anesthesia, Sevoflurane-based anesthesia - Anesthesia, Hypoventilation | Phase 4 | Unknown | Tanta University | 72 | 2023-08-10 | 2023-07-27 |
| Oliceridine in Patients With Acute Burn Injuries Oliceridine, Historical opioid use - Acute Pain, Burns | Phase 4 | Completed | University of Tennessee | 31 | 2023-04-01 | 2023-10-26 |
| Effect of Esmolol on Perioperative Stress Reaction Esmolol, saline - Esmolol, Stress Reaction | Phase 4 | Unknown | Xiumei Song | 46 | 2023-02-01 | 2023-01-23 |
| Ciprofol Versus Propofol With Low-Dose Sufentanil for Painless Bronchoscopy Ciprofol, Propofol, Sufentanil - Bronchoscopy, Procedural Sedation | Phase 4 | Completed | Wenzhou Central Hospital | 100 | 2022-08-01 | 2026-08-04 |
| High-dose L-Carnitine and Diaphragmatic Function Assessed by Ultrasonography in Patients With Respiratory Failure. L Carnitine ( low dose), L-Carnitine ( high dose) - Respiratory Failure | Phase 4 | Completed | Ain Shams University | 60 | 2022-04-15 | 2022-10-17 |
| Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation Fentanyl, propofol, fentanyl and dexmedetomindine, Butorphanol and propofol - Respiratory Insufficiency | Phase 4 | Unknown | The Affiliated Hospital of Qingdao University | 300 | 2022-01-01 | 2021-08-27 |
| Influence of Δ9-tetrahydrocannabinol (THC) on Oxycodone Induced Ventilatory Depression in Healthy Volunteers Medicinal cannabis in combination with oxycodon, Medicinal cannabis in combination with placebo oxycodon - Respiratory Depression, Cannabis Use | Phase 4 | Unknown | Leiden University Medical Center | 20 | 2021-12-09 | 2022-02-11 |
| Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery Tranexamic Acid 1,000 Mg/10 mL (100 Mg/mL) INTRAVEN VIAL (ML) - Chronic Sinusitis, Nasal Obstruction | Phase 4 | Completed | Stanford University | 40 | 2021-06-17 | 2023-04-05 |
| Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk Spinal anesthesia with intraoperative dexmedetomidine sedation, Spinal anesthesia with intraoperative midazolam sedation, Dexmedetomidine - Anesthesia, Anesthesia Complication | Phase 4 | Completed | University Hospital of Split | 115 | 2021-04-01 | 2022-04-08 |
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Nasal Obstruction (17) · Pulmonary Disease, Chronic Obstructive (8) · Airway Obstruction (5) · Critical Illness (5) · Pain, Postoperative (4) · Respiratory Aspiration (4) · Agnosia (3) · COVID-19 (3) · Hypoxia (3) · Pain (3) · Postoperative Nausea and Vomiting (3) · Respiratory Distress Syndrome (3) · Rhinitis (3) · Acute Pain (2)
Respiration Disorders (86) · Respiratory Tract Diseases (86) · Pathological Conditions, Signs and Symptoms (41) · Pathologic Processes (27) · Signs and Symptoms (24) · Lung Diseases (21) · Otorhinolaryngologic Diseases (18) · Airway Obstruction (17) · Nose Diseases (17) · Infections (14) · Disease Attributes (13) · Neurologic Manifestations (13) · Signs and Symptoms, Respiratory (12) · Respiratory Tract Infections (10)
Propofol (7) · Dexmedetomidine (5) · Fentanyl (3) · Acetaminophen (2) · Acetazolamide (2) · Analgesics, Opioid (2) · Dexamethasone (2) · Midazolam (2) · Mometasone Furoate (2) · Neostigmine (2) · Oxygen (2) · Oxymetazoline (2) · Pseudoephedrine (2) · Rocuronium (2) · Standard of Care (2)
Leiden University Medical Center (3) · Aalborg University Hospital (2) · Hospital Clinic of Barcelona (2) · Mahidol University (2) · Stanford University (2) · UCB Pharma (2) · Ain Shams University (1) · Alper Tunga Dogan (1) · Althaia Xarxa Assistencial Universitària de Manresa (1) · Amsterdam UMC, location VUmc (1) · ArthroCare Corporation (1) · Ass.-Prof. PD Dr. Klaus Ulrich Klein (1) · Association pour la Recherche en Physiologie de l'Environnement (1) · B. Braun Medical SA (1) · Baylor Research Institute (1)
United States (14) · Spain (7) · Netherlands (6) · Norway (5) · China (4) · Switzerland (4) · Croatia (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Austria (2) · Belgium (2) · Denmark (2) · Egypt (2) · Finland (2) · France (2)
Bodil Steen Rasmussen, MD, PhD (2) · Albert Dahan, MD, PhD, Professor (1) · Alexander P Wilmer, MD Ph D (1) · Anders Perner, MD, PhD (1) · Andrew Goldberg, MD (1) · Anthony M Magit, MD (1) · Benjamin Benzon (1) · Bin Du, Dr (1) · Bozidar Duplancic (1) · Carlos Tajer, MD (1) · Cenk Kirakli, MD (1) · Chris Hargreaves (1)
PMID 38990335, PMID 40920961, PMID 10712328, PMID 11475180, PMID 16394778, PMID 18388356, PMID 18699897, PMID 18719057, PMID 19823201, PMID 20407252, PMID 21036778, PMID 21047406, PMID 21261975, PMID 21333087, PMID 21714640, PMID 22272061, PMID 22632574, PMID 22678319, PMID 23204255, PMID 23348400, PMID 23506003, PMID 23578004, PMID 23635608, PMID 24461665, PMID 24570244, PMID 24825371, PMID 24837977, PMID 24937564, PMID 25504992, PMID 25536092, PMID 25742308, PMID 26266842, PMID 26609095, PMID 26655725, PMID 27855722, PMID 28130688, PMID 28257388, PMID 28475354, PMID 28487139, PMID 28632682, PMID 28679605, PMID 28836546, PMID 28917549, PMID 29284510, PMID 29630212, PMID 29634491, PMID 29723512, PMID 30522856, PMID 31361307, PMID 31481633
2017 (2), 2009 (1), 2015 (1)