82 completed, 22 recruiting, 22 unknown, 12 terminated. 55 Phase 4, 45 Phase 2, 23 Not applicable, 20 Phase 1, 20 Phase 3.
Follow Acetazolamide: new trials by email Literature Review of Acetazolamide trials Research Report on Acetazolamide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ACetazolamide in Patients With Heart Failure, to Decrease Weight and relIEVE Symptoms. Acetazolamide, Furosemide - Heart Failure | Phase 3 | Not yet recruiting | University Hospital, Montpellier | 366 | 2026-10-01 | 2026-08-17 |
| DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea. IHL-42X: 2.5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 125 mg acetazolamide - Obstructive Sleep Apnea (OSA) | Phase 2 | Recruiting | Incannex Healthcare Ltd | 120 | 2026-07-21 | 2026-10-13 |
| TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart Failure Intravenous furosemide bolus injections, ACETAZOLAMIDE oral capsule, Hydrochlorothiazide (HCT) - Acute Heart Failure (AHF) | Phase 4 | Not yet recruiting | Lucrecia Maria Burgos | 60 | 2026-06-15 | 2026-05-18 |
| Idiopathic Intracranial Hypertension: Prognostic Factors and Multidisciplinary Management lumbo-peritoneal shunt, Conservative Management: Centered on lifestyle modifications for weight reduction, alongside targeted medical therapies including carbonic anhydrase inhibitors (e.g., acetazolamide) and/or topiramate. - Idiopathic Intracranial Hypertension | Not applicable | Active not recruiting | Sohag University | 30 | 2026-06-01 | 2026-07-21 |
| Add-on Diuretics in Acute Decompensated Heart Failure empagliflozin, Acetazolamide, metolazone - Acute Decompensated Heart Failure | Phase 2 | Recruiting | Tanta University | 66 | 2026-02-01 | 2026-02-04 |
| Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term Acetazolamide Acetazolamide, Stent (Tentos 4F or Precise ProRX) - Idiopathic Intracranial Hypertension (IIH) | Not applicable | Recruiting | University Hospital, Montpellier | 114 | 2026-01-05 | 2026-03-06 |
| Preoperative Acetazolamide Acetazolamide 500 MG Extended Release Oral Capsule, Placebo - Post Operative Pain, Laparoscopic Hysterectomy | Phase 4 | Recruiting | Prisma Health-Upstate | 100 | 2025-10-30 | 2026-10-06 |
| Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure Acetazolamide, Metolazone - Acute Decompensated Heart Failure, Heart Failure, Diastolic | Not applicable | Recruiting | University of Health Sciences Lahore | 320 | 2025-10-11 | 2025-10-03 |
| Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder Acetazolamide, Placebo - Central Sleep Apnea Comorbid With Opioid Use | Phase 2 | Recruiting | Sanjay R Patel | 40 | 2025-09-30 | 2026-06-25 |
| Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase Best medical care, Intervention (stenting) - Idiopathic Intracranial Hypertension (IIH) | Not applicable | Recruiting | University Hospital, Montpellier | 114 | 2025-09-19 | 2025-10-03 |
| The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude ACETAZOLAMIDE oral capsule, Placebo Arm - Hypoxemia, Acute Mountain Sickness (AMS) | Early Phase 1 | Active not recruiting | University of California, Riverside | 19 | 2025-09-17 | 2026-04-08 |
| Acetazolamide to Reduce Spinal Fluid Leaks After Spine Surgery. Acetazolamide, Standard Care (in control arm) - Cerebrospinal Fluid Leak, Dural Tear | Phase 4 | Completed | Ain Shams University | 26 | 2025-04-06 | 2026-10-15 |
| Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea Sivopixant, Placebo, Acetazolamide - Sleep Apnea | Phase 2 | Active not recruiting | Shionogi | 60 | 2025-04-02 | 2026-05-06 |
| A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning [O-15]Water, Acetazolamide - Validation of a New Noninvasive Method to Obtain the Arterial Input Function (AIF) Directly by PET Imaging | Early Phase 1 | Withdrawn | University of Alabama at Birmingham | 2025-02-01 | 2024-03-01 | |
| Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload Acetazolamide, Metolazone 2.5 MG, Double-placebo - Acute Heart Failure | Phase 4 | Recruiting | Johannes Grand | 939 | 2024-09-05 | 2026-08-14 |
| Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients Acetazolamide, Dapagliflozin 10mg - Acute Decompensated Heart Failure | Phase 3 | Unknown | Helwan University | 60 | 2024-08-24 | 2024-08-05 |
| Assessing the Clinical Outcomes of Dapagliflozin Versus Acetazolamide in Patients With Acute Heart Failure Dapagliflozin 10mg, Acetazolamide 500mg - Acute Heart Failure | Phase 2 / Phase 3 | Recruiting | Mansoura University | 100 | 2024-08-15 | 2025-01-20 |
| Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial Acetazolamide, Placebo - Type 1 Diabetes | Phase 2 | Recruiting | University of California, San Diego | 25 | 2024-08-14 | 2025-06-17 |
| HighCycle Study: Acetazolamide, High Altitude and Plasma Volume Acetazolamide, Placebo - High Altitude Effects, High Altitude Hypoxia | Phase 4 | Recruiting | Centre d'Expertise sur l'Altitude EXALT | 270 | 2024-07-15 | 2025-08-12 |
| HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men Acetazolamide, Placebo - Sleep-Disordered Breathing | Phase 4 | Completed | University of Zurich | 303 | 2024-07-15 | 2026-06-05 |
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Altitude Sickness (29) · Sleep Apnea, Obstructive (17) · Hypoxia (12) · Sleep Apnea Syndromes (12) · Pulmonary Disease, Chronic Obstructive (11) · Heart Failure (9) · Hypertension, Pulmonary (6) · Pseudotumor Cerebri (6) · Emphysema (5) · Cerebrospinal Fluid Leak (4) · Edema (4) · Sleep Apnea, Central (4) · Alkalosis (3) · Apnea (3) · Glaucoma (3)
University of Zurich (26) · University of California, San Diego (6) · VA Office of Research and Development (4) · Brigham and Women's Hospital (3) · Incannex Healthcare Ltd (3) · Stanford University (3) · Tehran University of Medical Sciences (3) · University Hospital, Antwerp (3) · University Hospital, Montpellier (3) · University of Miami (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Ain Shams University (2) · Centre d'Expertise sur l'Altitude EXALT (2) · Danish Headache Center (2) · Mayo Clinic (2)
United States (53) · Kyrgyzstan (22) · Egypt (7) · Belgium (6) · Canada (6) · France (6) · Iran (6) · Switzerland (6) · Israel (4) · Denmark (3) · Netherlands (3) · Peru (3) · Brazil (2) · Chile (2) · India (2)
Konrad E Bloch, MD (16) · Talant M Sooronbaev, MD (14) · Michael Furian, MSc (8) · Silvia Ulrich, MD (8) · Michael Furian, Prof. Dr. (3) · Talant Sooronbaev, Prof. Dr. (3) · Christopher Schmickl, MD, PhD (2) · Glen E Foster, Ph.D. (2) · Michael Wall, MD (2) · Olivier Vanderveken, MD, PhD (2) · Susmita Chowdhuri, MD MS (2) · Talant M Sooronbaev (2) · Talant M Sooronbaev,, MD (2) · Vishnumurthy S Hedna, MD (2)
PMID 38296630, PMID 10662747, PMID 11772581, PMID 11904109, PMID 11927799, PMID 12119802, PMID 12832331, PMID 14581110, PMID 15066944, PMID 15710782, PMID 15738343, PMID 15911704, PMID 15983467, PMID 16391986, PMID 17515447, PMID 17515448, PMID 18071739, PMID 18388356, PMID 18719057, PMID 19687359, PMID 20837887, PMID 21965050, PMID 22278334, PMID 22311903, PMID 22943271, PMID 22994519, PMID 23098412, PMID 23292683, PMID 23578004, PMID 24002370, PMID 24227635, PMID 24366914, PMID 24495468, PMID 24606242, PMID 24721800, PMID 24756302, PMID 24756514, PMID 24781936, PMID 24991933, PMID 25370510, PMID 25370513, PMID 26024112, PMID 26335066, PMID 26618282, PMID 26778344, PMID 26824595, PMID 26836730, PMID 26934136, PMID 27121942, PMID 27271310
2017 (9), 2025 (1), I01CX001944 (1), K23HL151880 (1), K23HL161336 (1), R01DA059465 (1), R01EY014957 (1), R01HL136484 (1), R01HL160993 (1), U10EY017281 (1), U10EY017387 (1), U10EY025990 (1), U54NS059065 (1), UL1TR000445 (1)