Nose Diseases: Clinical Trials

1326 completed, 229 unknown, 113 recruiting, 96 terminated. 502 Not applicable, 398 Phase 3, 342 Phase 2, 259 Phase 4, 158 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	502	Completed 279, Unknown 76, Recruiting 46, Terminated 34, Not yet recruiting 33, Withdrawn 16, Active not recruiting 13, Enrolling by invitation 4, Suspended 1
Phase 3	398	Completed 305, Unknown 34, Recruiting 18, Terminated 15, Withdrawn 15, Active not recruiting 5, Not yet recruiting 5, Enrolling by invitation 1
Phase 2	342	Completed 263, Unknown 21, Terminated 20, Recruiting 15, Active not recruiting 8, Not yet recruiting 7, Withdrawn 7, Suspended 1
Phase 4	259	Completed 189, Unknown 27, Terminated 15, Withdrawn 10, Recruiting 7, Active not recruiting 6, Not yet recruiting 5
Phase 1	158	Completed 120, Unknown 13, Terminated 11, Withdrawn 8, Recruiting 3, Not yet recruiting 2, Active not recruiting 1
Early Phase 1	18	Unknown 8, Completed 7, Terminated 2, Withdrawn 1

Follow Nose Diseases: new trials by email Literature Review of Nose Diseases trials Research Report on Nose Diseases

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Acoustic Resonance Therapy for Treating Empty Nose Syndrome Personalized ART, Non-personalized ART - Empty Nose Syndrome, Nasal Obstruction	Not applicable	Not yet recruiting	Stanford University	40	2028-07-01	2025-10-10
EFFECT OF AYURVEDA TREATMENT IN ALLERGIC RHINITIS AYURVEDA treatment protocol, Control(Citrizine 10mg) - Allergic Rhinitis (AR)	Not applicable	Not yet recruiting	Amrita Vishwa Vidyapeetham	104	2028-06-30	2026-06-04
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma	Phase 1 / Phase 2	Recruiting	National Cancer Institute (NCI)	120	2026-11-05	2026-11-02
Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers Quinton Medical Nasal Health Baby® - Nasal Congestion, Common Cold		Not yet recruiting	Laboratoires Quinton International S.L.	83	2026-11-01	2026-10-13
Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding	Phase 2	Not yet recruiting	Assiut University	78	2026-11-01	2026-10-08
Prevelance of Bronchial Asthma and Allergic Rhinitis Among Children With Nephrotic Syndrom at Sohag University Hospital Allergic Diseases in Nephrotic Children, Nephrotic Syndrom		Not yet recruiting	Sohag University	20	2026-11-01	2026-10-27
Oral Mucosal Grafting for Nasal Septal Perforation Repair Nasal Septal Perforation Repair With an Autologous Oral Mucosal Graft - Nasal Septal Perforation		Not yet recruiting	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz	46	2026-11-01	2026-10-29
Measuring Nasal Airway Changes After VivAer Treatment Using AI Analysis VivAer Stylus - Nasal Airway Obstruction	Not applicable	Recruiting	Aerin Medical	30	2026-11-01	2026-10-30
China CRSwNP Registry Study Routine Clinical Care for CRSwNP - Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)		Not yet recruiting	Beijing Tongren Hospital	1000	2026-10-31	2026-08-31
FESS With or Without Intranasal Desmopressin in Chronic Rhinosinusitis With Nasal Polyps Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray, Functional Endoscopic Sinus Surgery - Chronic Sinusitis, Nasal Polyposis	Not applicable	Not yet recruiting	Services Institute of Medical Sciences, Pakistan	174	2026-10-15	2026-10-23
Observational Study of RHINOSEDAL in Acute Nasal Obstruction RHINOSEDAL - Nasal Obstruction, Common Cold		Not yet recruiting	Laboratoires Elerte	126	2026-10-15	2026-06-02
Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube, Sham Nebulization - Postoperative Sore Throat, Nasal Obstruction	Not applicable	Not yet recruiting	Mansoura University	105	2026-10-15	2026-10-15
Validating Blinding Maintenance of a Sham-Sensitization Control Design for Sensitization Acupuncture Trials Sensitization Acupuncture, Traditional Acupuncture - Knee Osteoarthritis; Insomnia; Cervical Spondylosis; Chronic Low Back Pain; Allergic Rhinitis	Not applicable	Not yet recruiting	Jiangxi University of Traditional Chinese Medicine	30	2026-10-10	2026-10-09
Peppermint and Decongestant Technique on Chronic Sinusitis Sinus self-massage and inhalation of steated boiled peppermint - Sinus Disease	Not applicable	Not yet recruiting	Assiut University	108	2026-10-01	2026-10-08
Topical TOR-582 Treatment of Epistaxis in HHT Topical sirolimus ointment - Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis	Phase 1	Not yet recruiting	Columbia University	27	2026-10-01	2026-08-21
Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI) Respiratory Tract Infection, Smell Disorder		Recruiting	National Institute on Deafness and Other Communication Disorders (NIDCD)	80	2026-10-01	2026-10-09
Study of CM512 Injection in Patients With Perennial Allergic Rhinitis on Background Therapy CM512, Placebo - Perennial Allergic Rhinitis (PAR)	Phase 2	Not yet recruiting	Beijing Keymed Biosciences Co., Ltd.	200	2026-10-01	2026-10-22
Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis) Amoxicillin, Amoxi Clavulanate, Amoxicillin Placebo - ACUTE SINUSITIS, Sinusitis	Phase 4	Recruiting	Nader Shaikh	1100	2026-10-01	2026-10-20
Allergy, Asthma, and Atopic Eczema in Finland No intervention, No Intervention: Observational Cohort - Asthma, Asthma in Children		Enrolling by invitation	Tampere University	1600000	2026-10-01	2026-10-27
A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) GSK5784283, Placebo, Standard of Care - Nasal Polyps	Phase 3	Recruiting	GlaxoSmithKline	218	2026-09-28	2026-10-14

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Narrower conditions

Rhinitis, Allergic (682)  ·  Rhinitis, Allergic, Seasonal (384)  ·  Rhinitis (212)  ·  Asthma (196)  ·  Sinusitis (189)  ·  Rhinitis, Allergic, Perennial (178)  ·  Nasal Obstruction (170)  ·  Nasal Polyps (158)  ·  Hypersensitivity (148)  ·  Rhinosinusitis (90)  ·  Epistaxis (89)  ·  Dust Mite Allergy (45)  ·  Dermatitis, Atopic (39)  ·  Conjunctivitis, Allergic (34)  ·  Respiratory Tract Infections (32)

Broader conditions

Otorhinolaryngologic Diseases (1933)  ·  Respiratory Tract Diseases (1925)  ·  Immune System Diseases (1228)  ·  Hypersensitivity, Immediate (1192)  ·  Respiratory Hypersensitivity (1186)  ·  Rhinitis (1138)  ·  Hypersensitivity (1066)  ·  Infections (515)  ·  Respiratory Tract Infections (484)  ·  Rhinitis, Allergic (455)  ·  Pathological Conditions, Signs and Symptoms (398)  ·  Paranasal Sinus Diseases (299)  ·  Lung Diseases (245)  ·  Bronchial Diseases (230)

Interventions

Mometasone Furoate (77)  ·  Fluticasone (62)  ·  montelukast (43)  ·  azelastine (41)  ·  levocetirizine (37)  ·  Cetirizine (33)  ·  desloratadine (33)  ·  Loratadine (32)  ·  Sodium Chloride (31)  ·  Budesonide (30)  ·  Omalizumab (22)  ·  fexofenadine (22)  ·  Pseudoephedrine (21)  ·  Beclomethasone (19)  ·  Oxymetazoline (19)

Sponsors

GlaxoSmithKline (98)  ·  Organon and Co (77)  ·  ALK-Abelló A/S (30)  ·  AstraZeneca (28)  ·  Sanofi (21)  ·  Assiut University (20)  ·  University of Chicago (20)  ·  Beijing Tongren Hospital (19)  ·  Bayer (17)  ·  UCB Pharma (17)  ·  Inmunotek S.L. (15)  ·  Meda Pharmaceuticals (15)  ·  Fraunhofer-Institute of Toxicology and Experimental Medicine (14)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (14)  ·  Stallergenes Greer (14)

Countries

United States (551)  ·  Canada (146)  ·  China (134)  ·  Germany (130)  ·  France (101)  ·  Spain (72)  ·  United Kingdom (65)  ·  Poland (54)  ·  South Korea (51)  ·  Italy (50)  ·  Belgium (42)  ·  Egypt (41)  ·  Turkey (Türkiye) (37)  ·  Austria (36)  ·  Thailand (32)

Top investigators

Luo Zhang (15)  ·  Robert M Naclerio, MD (10)  ·  Anne K Ellis, MD (6)  ·  Lewis M Fredane, MD (6)  ·  Amin Javer, MD (5)  ·  Jacob Johnson, MD (5)

Results publications

PMID 33710614, PMID 19001265, PMID 32926419, PMID 24184147, PMID 18331513, PMID 21439168, PMID 22464647, PMID 23374268, PMID 24035151, PMID 24836393, PMID 25685162, PMID 28602936, PMID 29656145, PMID 33548517, PMID 37951571, PMID 38197558, PMID 39035788, PMID 11297958, PMID 15817806, PMID 17021840, PMID 18946234, PMID 19680119, PMID 20167147, PMID 20642206, PMID 20816182, PMID 20819318, PMID 21518040, PMID 22469599, PMID 22726593, PMID 22737708, PMID 23156847, PMID 25104279, PMID 25137523, PMID 25644617, PMID 25788949, PMID 26044169, PMID 26141263, PMID 26342289, PMID 26364765, PMID 26507708, PMID 26706294, PMID 28078544, PMID 28392807, PMID 29438602, PMID 29756407, PMID 30027002, PMID 31209698, PMID 31919742, PMID 32548677, PMID 32679209

NIH funding

2015 (8), 2009 (6), 2023 (6), 2005 (5), 2017 (5), 2018 (5), 2004 (4), 2008 (4), 2014 (4), 2016 (4), 2019 (4), 2025 (4), K08HL107142 (1), M01RR000069 (1), P01ES018176 (1)