Nasal Obstruction: Clinical Trials

106 completed, 17 unknown, 12 recruiting, 10 terminated. 85 Not applicable, 21 Phase 3, 17 Phase 4, 16 Phase 2, 7 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	85	Completed 50, Unknown 12, Not yet recruiting 6, Terminated 6, Active not recruiting 4, Recruiting 4, Withdrawn 2, Enrolling by invitation 1
Phase 3	21	Completed 15, Withdrawn 2, Enrolling by invitation 1, Recruiting 1, Terminated 1, Unknown 1
Phase 4	17	Completed 11, Withdrawn 3, Unknown 2, Terminated 1
Phase 2	16	Completed 11, Terminated 2, Not yet recruiting 1, Recruiting 1, Withdrawn 1
Phase 1	7	Completed 6, Terminated 1
Early Phase 1	1	Completed 1

Follow this condition Literature Review of Nasal Obstruction trials Research Report on Nasal Obstruction

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Acoustic Resonance Therapy for Treating Empty Nose Syndrome Personalized ART, Non-personalized ART - Empty Nose Syndrome, Nasal Obstruction	Not applicable	Not yet recruiting	Stanford University	40	2028-07-01	2025-10-10
Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers Quinton Medical Nasal Health Baby® - Nasal Congestion, Common Cold		Not yet recruiting	Laboratoires Quinton International S.L.	83	2026-11-01	2026-10-13
Observational Study of RHINOSEDAL in Acute Nasal Obstruction RHINOSEDAL - Nasal Obstruction, Common Cold		Not yet recruiting	Laboratoires Elerte	126	2026-10-15	2026-06-02
Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube, Sham Nebulization - Postoperative Sore Throat, Nasal Obstruction	Not applicable	Not yet recruiting	Mansoura University	105	2026-10-15	2026-10-15
Evaluation of the Outcome of Septoplasty With or Without Inferior Turbinate Reduction septoplasty, septoplasty with inferior turbinate reduction. - Deviated Nasal Septum, Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate Hypertrophy	Not applicable	Not yet recruiting	Sohag University	40	2026-09-01	2026-07-28
Active vs. Passive VR During Office-based ENT Procedures Passive virtual reality headset or goggles, Active virtual reality headset or goggles - Pain, Anxiety	Not applicable	Not yet recruiting	Cedars-Sinai Medical Center	132	2026-09-01	2026-08-17
Measuring Nasal Airway Changes After VivAer Treatment Using AI Analysis VivAer Stylus - Nasal Airway Obstruction	Not applicable	Not yet recruiting	Aerin Medical	30	2026-07-01	2026-05-14
Study to Investigate the Efficacy and Safety of Apomivir® Apomivir®, Placebo - Influenza	Phase 2	Not yet recruiting	Far East Bio-Tec Co., Ltd	196	2026-05-31	2025-05-14
Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg, Placebo - Common Cold/Flu, Nasal Congestion	Phase 3	Recruiting	Brainfarma Industria Química e Farmacêutica S/A	620	2026-05-08	2026-06-16
Efficacy and Safety of High-Concentration 35 kDa Hyaluronan Gel for Chronic Nasopharyngitis 13.6% High-Concentration 35 kDa Hyaluronan (HA35) Nasopharyngeal Care Gel - Chronic Rhinitis, Chronic Pharyngitis	Not applicable	Completed	Nakhia Impex LLC	30	2026-05-01	2026-09-23
A Study to Learn More About How Well Oxymetazoline HCl 0.05% Nasal Gel Works and How Safe It Is in Healthy Adults Oxymetazoline HCl 0.05% nasal gel, Placebo nasal gel - Nasal Congestion, Nasal Obstruction	Phase 2	Completed	Bayer	120	2026-04-20	2026-06-08
Patient-Reported Outcomes and Complications After Structural Rhinoplasty Using Septal Extension Grafts Nasal Deformity, Rhinoplasty		Recruiting	Cumhuriyet University Hospital	50	2026-04-01	2026-06-22
Traditional vs. Posterior Nasal Radiofrequency Ablation for Chronic Rhinitis Traditional Radiofrequency Ablation of Inferior Turbinates With Posterior Nasal Radiofrequency Ablation, Traditional Radiofrequency Ablation of Inferior Turbinates - Nasal Obstruction, Chronic Rhinitis	Not applicable	Active not recruiting	Chien Yu Huang	60	2026-03-01	2026-05-13
Evaluation of the Reliability of AAR as an Independent Tool for Surgical Indication in Nasal Obstruction preoperative rhinomanometry - Nasal Obstruction		Recruiting	Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer	200	2026-01-27	2026-07-07
Steroids for Rhinoplasty: Pain, Nausea, Edema and Ecchymosis Medrol 4 MG Oral Tablet Includes Medrol Dosepak - Edema, Bruising	Phase 4	Withdrawn	Vanderbilt University Medical Center		2026-01-01	2025-11-18
Steroid Treatment for Elimination of Rebound Obstruction From Intranasal Decongestants Oxymetazoline + Triamcinolone - Nasal Obstruction, Chronic Rhinitis	Phase 2	Terminated	Washington University School of Medicine	3	2025-11-10	2026-03-23
Vibroacoustic Therapy With Oscillating Positive Expiratory Pressure in the Treatment of Nasal Congestion VPAT (Vibratory Positive Pressure Therapeutic Apparatus）, basic medications (antihistamines, mometasone furoate nasal spray, ICS-LABA, OPEP（Oscillating Positive Expiratory Pressure device） - Atopic Rhinitis, Atopic Asthma	Not applicable	Not yet recruiting	Second Affiliated Hospital, Zhejiang University, School of Medicine	200	2025-08-01	2025-08-11
Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and Palate Mailing and completing CLEFT-Q and NOSE questionnaires - Cleft Lip and Cleft Palate		Recruiting	University Hospital, Montpellier	80	2025-07-09	2025-07-22
An Ambispective Registry Study Comparing Clinical Outcomes of Surgical Interventions for the Treatment of Nasal Airway Obstruction. Nasal Airway Obstruction		Completed	Aerin Medical	1110	2025-03-14	2025-12-26
A Prospective Study Comparing VivAer to Alternative Surgical Procedures to Treat Nasal Airway Obstruction in Patients With Nasal Valve Dysfunction. Nasal Airway Obstruction		Active not recruiting	Aerin Medical	400	2025-02-28	2026-03-23

Showing 20 of 170. Sign in to see all of them.

Narrower conditions

Rhinitis, Allergic (16)  ·  Sneezing (16)  ·  Common Cold (14)  ·  Rhinitis (11)  ·  Rhinorrhea (11)  ·  Sleep Apnea, Obstructive (10)  ·  Cough (9)  ·  Rhinitis, Allergic, Seasonal (9)  ·  Headache (8)  ·  Pharyngitis (8)  ·  Inflammation (7)  ·  Respiratory Tract Infections (7)  ·  Fever (6)  ·  Influenza, Human (6)

Broader conditions

Otorhinolaryngologic Diseases (170)  ·  Airway Obstruction (169)  ·  Nose Diseases (169)  ·  Respiration Disorders (169)  ·  Respiratory Insufficiency (169)  ·  Respiratory Tract Diseases (169)  ·  Pathological Conditions, Signs and Symptoms (52)  ·  Signs and Symptoms (42)  ·  Infections (34)  ·  Signs and Symptoms, Respiratory (33)  ·  Respiratory Tract Infections (27)  ·  Immune System Diseases (26)  ·  Hypersensitivity, Immediate (25)  ·  Respiratory Hypersensitivity (25)  ·  Hypersensitivity (23)

Interventions

Oxymetazoline (8)  ·  Acetaminophen (3)  ·  Mometasone Furoate (3)  ·  Nasal Lavage (3)  ·  Pseudoephedrine (3)  ·  Sodium Chloride (3)  ·  Standard of Care (3)  ·  Triamcinolone (3)  ·  bilastine (3)  ·  Budesonide (2)  ·  Chlorpheniramine (2)  ·  Culture Media (2)  ·  Diphenhydramine (2)  ·  Intubation, Intratracheal (2)  ·  Phenylephrine (2)

Sponsors

Aerin Medical (10)  ·  GlaxoSmithKline (6)  ·  Stanford University (5)  ·  Third Wave Therapeutics (4)  ·  Ache Laboratorios Farmaceuticos S.A. (3)  ·  Bayer (3)  ·  Church & Dwight Company, Inc. (3)  ·  Faes Farma, S.A. (3)  ·  McNeil AB (3)  ·  Norwegian University of Science and Technology (3)  ·  Spirox, Inc. (3)  ·  University Hospital Ostrava (3)  ·  University of Lausanne Hospitals (3)  ·  BioCryst Pharmaceuticals (2)  ·  Hospital de Clinicas de Porto Alegre (2)

Countries

United States (64)  ·  France (11)  ·  Brazil (10)  ·  Canada (7)  ·  Turkey (Türkiye) (7)  ·  Norway (6)  ·  Czechia (5)  ·  Israel (5)  ·  Italy (5)  ·  Australia (4)  ·  Belgium (4)  ·  Poland (4)  ·  Spain (4)  ·  Switzerland (4)  ·  United Kingdom (4)

Top investigators

Jacob Johnson, MD (3)  ·  Carol Epstein, MD (2)  ·  Douglas Sidle, MD (2)  ·  Grant Hamilton, MD (2)  ·  Melissa Israel, BS (2)  ·  Ofer Jacobowitz, MD, PhD (2)  ·  Sam P Most, MD (2)  ·  Scott Wolf, MD (2)  ·  Sung-won Kim, professor (2)  ·  Alan Greene, MD (1)

Results publications

PMID 29756407, PMID 31209698, PMID 33853139, PMID 35639525, PMID 15725047, PMID 16448254, PMID 19132976, PMID 19823201, PMID 20109318, PMID 20595158, PMID 22077106, PMID 22185733, PMID 23070968, PMID 23985625, PMID 24983742, PMID 25115871, PMID 25432641, PMID 25628001, PMID 27178892, PMID 27212955, PMID 27513397, PMID 27591949, PMID 29800001, PMID 30154874, PMID 31119695, PMID 31226238, PMID 31254279, PMID 32104962, PMID 32312677, PMID 32502854, PMID 34240571, PMID 35096167, PMID 36048465, PMID 36608352, PMID 36791622, PMID 36908245, PMID 37130297, PMID 37621275, PMID 38217847, PMID 39266682, PMID 39822054, PMID 39936254, PMID 40128836, PMID 40196218, PMID 40677297, PMID 41979070, PMID 42439048, PMID 42747526, PMID 42843159

NIH funding

2009 (2), 2005 (1), 2018 (1), R01DE028554 (1), R01HL084139 (1), R44AI082728 (1), R61HL151952 (1)