Airway Obstruction: Clinical Trials

192 completed, 44 unknown, 26 recruiting, 19 terminated. 159 Not applicable, 24 Phase 2, 24 Phase 3, 22 Phase 4, 10 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	159	Completed 94, Unknown 26, Terminated 13, Recruiting 11, Not yet recruiting 7, Active not recruiting 4, Withdrawn 3, Enrolling by invitation 1
Phase 2	24	Completed 14, Terminated 3, Unknown 3, Recruiting 2, Not yet recruiting 1, Withdrawn 1
Phase 3	24	Completed 16, Withdrawn 3, Unknown 2, Enrolling by invitation 1, Recruiting 1, Terminated 1
Phase 4	22	Completed 13, Withdrawn 4, Unknown 3, Terminated 2
Phase 1	10	Completed 9, Terminated 1
Early Phase 1	1	Completed 1

Follow Airway Obstruction: new trials by email Literature Review of Airway Obstruction trials Research Report on Airway Obstruction

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Acoustic Resonance Therapy for Treating Empty Nose Syndrome Personalized ART, Non-personalized ART - Empty Nose Syndrome, Nasal Obstruction	Not applicable	Not yet recruiting	Stanford University	40	2028-07-01	2025-10-10
Influence of Patient Positioning During Nasal Lavage Supine position nasal lavage, Semi-sitting position nasal lavage - Acute Upper Respiratory Tract Infections, Nasal Obstruction	Not applicable	Not yet recruiting	Hospital Universitario La Paz	145	2026-11-15	2026-11-06
Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers Quinton Medical Nasal Health Baby® - Nasal Congestion, Common Cold		Not yet recruiting	Laboratoires Quinton International S.L.	83	2026-11-01	2026-10-13
Measuring Nasal Airway Changes After VivAer Treatment Using AI Analysis VivAer Stylus - Nasal Airway Obstruction	Not applicable	Recruiting	Aerin Medical	30	2026-11-01	2026-10-30
Observational Study of RHINOSEDAL in Acute Nasal Obstruction RHINOSEDAL - Nasal Obstruction, Common Cold		Not yet recruiting	Laboratoires Elerte	126	2026-10-15	2026-06-02
Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube, Sham Nebulization - Postoperative Sore Throat, Nasal Obstruction	Not applicable	Recruiting	Mansoura University	105	2026-10-15	2026-11-03
Evaluation of the Outcome of Septoplasty With or Without Inferior Turbinate Reduction septoplasty, septoplasty with inferior turbinate reduction. - Deviated Nasal Septum, Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate Hypertrophy	Not applicable	Not yet recruiting	Sohag University	40	2026-09-01	2026-07-28
Active vs. Passive VR During Office-based ENT Procedures Passive virtual reality headset or goggles, Active virtual reality headset or goggles - Pain, Anxiety	Not applicable	Not yet recruiting	Cedars-Sinai Medical Center	132	2026-09-01	2026-08-17
A Study to Evaluate the Diagnostic Performance of Portable Oscillometry Across Chronic Respiratory Diseases COPD, Asthma (Diagnosis)		Not yet recruiting	The First Affiliated Hospital of Guangzhou Medical University	4000	2026-07-30	2026-06-08
Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring Standard General Anesthesia per Institutional Protocol - Cleft Palate, Cleft Lip		Not yet recruiting	Marmara University Pendik Training and Research Hospital	150	2026-06-27	2026-06-16
Study to Investigate the Efficacy and Safety of Apomivir® Apomivir®, Placebo - Influenza	Phase 2	Not yet recruiting	Far East Bio-Tec Co., Ltd	196	2026-05-31	2025-05-14
Supplemental Oxygen and Oxygen Desaturations in Colonoscopies Breath-synchronized oxygen, CPAP, Control - Oxygen Desaturation, Apnea (Central and Obstructive)	Not applicable	Not yet recruiting	University of Utah	280	2026-05-18	2026-04-07
Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg, Placebo - Common Cold/Flu, Nasal Congestion	Phase 3	Recruiting	Brainfarma Industria Química e Farmacêutica S/A	620	2026-05-08	2026-06-16
Efficacy and Safety of High-Concentration 35 kDa Hyaluronan Gel for Chronic Nasopharyngitis 13.6% High-Concentration 35 kDa Hyaluronan (HA35) Nasopharyngeal Care Gel - Chronic Rhinitis, Chronic Pharyngitis	Not applicable	Completed	Nakhia Impex LLC	30	2026-05-01	2026-09-23
Evaluation of Foreign Body Airway Obstruction Interventions Among Young Children: A Prospective Cohort Study Choking		Recruiting	University of Calgary	381	2026-05-01	2026-09-14
Evaluation of Foreign Body Airway Obstruction Interventions: A Prospective Cohort Study of Adults and Children Choking		Recruiting	University of Calgary	640	2026-05-01	2026-09-11
A Study to Learn More About How Well Oxymetazoline HCl 0.05% Nasal Gel Works and How Safe It Is in Healthy Adults Oxymetazoline HCl 0.05% nasal gel, Placebo nasal gel - Nasal Congestion, Nasal Obstruction	Phase 2	Completed	Bayer	120	2026-04-20	2026-06-08
Patient-Reported Outcomes and Complications After Structural Rhinoplasty Using Septal Extension Grafts Nasal Deformity, Rhinoplasty		Recruiting	Cumhuriyet University Hospital	50	2026-04-01	2026-06-22
Traditional vs. Posterior Nasal Radiofrequency Ablation for Chronic Rhinitis Traditional Radiofrequency Ablation of Inferior Turbinates With Posterior Nasal Radiofrequency Ablation, Traditional Radiofrequency Ablation of Inferior Turbinates - Nasal Obstruction, Chronic Rhinitis	Not applicable	Active not recruiting	Chien Yu Huang	60	2026-03-01	2026-05-13
Flow-Controlled Versus Volume-Controlled Ventilation During Balloon Dilatation Under Direct Laryngoscopy FCV Group, VCV Group - Airway Stenosis, Upper Airway Obstruction	Not applicable	Recruiting	Ankara Etlik City Hospital	40	2026-02-24	2026-02-25

Showing 20 of 313. Sign in to see all of them.

Narrower conditions

Nasal Obstruction (171)  ·  Sleep Apnea, Obstructive (17)  ·  Pulmonary Disease, Chronic Obstructive (16)  ·  Rhinitis, Allergic (16)  ·  Sneezing (16)  ·  Asthma (15)  ·  Common Cold (14)  ·  Cough (11)  ·  Rhinitis (11)  ·  Rhinorrhea (11)  ·  Inflammation (9)  ·  Pharyngitis (9)  ·  Respiratory Aspiration (9)  ·  Respiratory Tract Infections (9)

Broader conditions

Respiration Disorders (311)  ·  Respiratory Tract Diseases (311)  ·  Respiratory Insufficiency (308)  ·  Otorhinolaryngologic Diseases (181)  ·  Nose Diseases (173)  ·  Pathological Conditions, Signs and Symptoms (113)  ·  Signs and Symptoms (73)  ·  Signs and Symptoms, Respiratory (57)  ·  Pathologic Processes (54)  ·  Infections (45)  ·  Immune System Diseases (40)  ·  Hypersensitivity, Immediate (39)  ·  Nervous System Diseases (39)  ·  Hypersensitivity (37)

Interventions

Oxymetazoline (8)  ·  Acetaminophen (4)  ·  Sodium Chloride (4)  ·  Standard of Care (4)  ·  Albuterol (3)  ·  Dexamethasone (3)  ·  Heimlich Maneuver (3)  ·  Mometasone Furoate (3)  ·  Nasal Lavage (3)  ·  Pseudoephedrine (3)  ·  Triamcinolone (3)  ·  bilastine (3)  ·  Blood Specimen Collection (2)  ·  Budesonide (2)  ·  Cannula (2)

Sponsors

Aerin Medical (10)  ·  GlaxoSmithKline (7)  ·  Massachusetts General Hospital (5)  ·  Stanford University (5)  ·  University of Calgary (5)  ·  Third Wave Therapeutics (4)  ·  Ache Laboratorios Farmaceuticos S.A. (3)  ·  Assistance Publique - Hôpitaux de Paris (3)  ·  Bayer (3)  ·  Church & Dwight Company, Inc. (3)  ·  Faes Farma, S.A. (3)  ·  Mahidol University (3)  ·  McNeil AB (3)  ·  Norwegian University of Science and Technology (3)  ·  Spirox, Inc. (3)

Countries

United States (102)  ·  France (20)  ·  Turkey (Türkiye) (15)  ·  Canada (13)  ·  Brazil (12)  ·  Norway (11)  ·  China (10)  ·  Spain (10)  ·  Poland (9)  ·  United Kingdom (9)  ·  Italy (8)  ·  Taiwan (8)  ·  Czechia (7)  ·  Egypt (7)  ·  Germany (7)

Top investigators

Cody Dunne, MD (3)  ·  Jacob Johnson, MD (3)  ·  Yandong Jiang, MD, PhD (3)  ·  Carol Epstein, MD (2)  ·  Chao-Hsien Lee, MD (2)  ·  Dawid J Aleksandrowicz, PhD (2)  ·  Douglas Sidle, MD (2)  ·  Grant Hamilton, MD (2)  ·  Kai Kuck, PhD (2)  ·  Melissa Israel, BS (2)  ·  Ofer Jacobowitz, MD, PhD (2)  ·  Sam P Most, MD (2)

Results publications

PMID 29756407, PMID 31209698, PMID 32312677, PMID 33853139, PMID 35639525, PMID 10781266, PMID 15385385, PMID 15601274, PMID 15725047, PMID 16424722, PMID 16448254, PMID 16540947, PMID 17605780, PMID 18997526, PMID 19132976, PMID 19809328, PMID 19823201, PMID 19934141, PMID 20109318, PMID 20346568, PMID 20595158, PMID 20920189, PMID 21447488, PMID 21795876, PMID 22077106, PMID 22185733, PMID 22321104, PMID 22465313, PMID 2281232, PMID 23070968, PMID 23192066, PMID 23868428, PMID 23907810, PMID 23985625, PMID 24365207, PMID 24983742, PMID 25115871, PMID 25122497, PMID 25285269, PMID 25432641, PMID 25628001, PMID 25905714, PMID 26250700, PMID 26355460, PMID 26481391, PMID 26487748, PMID 27110692, PMID 27178892, PMID 27212955, PMID 27513397

NIH funding

2009 (2), 2005 (1), 2015 (1), 2018 (1), R01DE028554 (1), R01HL084139 (1), R01HL089761 (1), R33AT009991 (1), R44AI082728 (1), R61HL151952 (1)