44 completed, 2 unknown, 2 withdrawn, 1 recruiting. 15 Phase 1, 12 Phase 3, 9 Not applicable, 7 Phase 4, 5 Phase 2.
Follow Pseudoephedrine: new trials by email Literature Review of Pseudoephedrine trials Research Report on Pseudoephedrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Assess Safety and Efficacy of Fexofenadine Hydrochloride (HCL) + Pseudoephedrine HCL Fixed Dose Combination in Indian Male and Female Participants With Allergic Rhinitis (AR) Who Are 12 Years and Above Fexofenadine HCL and pseudoephedrine HCL - Rhinitis Allergic | Phase 4 | Completed | Sanofi | 203 | 2025-06-15 | 2026-02-17 |
| Barotrauma in Hyperbaric Oxygen Therapy Pseudoephedrine Pill, Placebo - Barotrauma | Not applicable | Recruiting | John Muir Health | 90 | 2023-01-31 | 2025-08-27 |
| A Study of Continuous Blood Pressure Monitoring in Healthy Participants Propranolol, Pseudoephedrine, ABPM and Wearable Novel Devices - Healthy | Not applicable | Completed | Eli Lilly and Company | 24 | 2023-01-31 | 2023-04-13 |
| Pseudoephedrine Prophylaxis for Prevention of Middle Ear Barotrauma in Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy, Pseudoephedrine 60 MG, Placebo oral tablet - Barotrauma;Ear | Phase 4 | Completed | University of Maryland, Baltimore | 105 | 2021-05-01 | 2025-01-08 |
| A Study of Continuous Heart Rate Monitoring in Healthy Participants Propranolol, Pseudoephedrine, Wearable Biosensor Patch Device - Healthy | Not applicable | Completed | Eli Lilly and Company | 21 | 2021-01-27 | 2021-04-19 |
| Drug-drug Interaction Study of Ozanimod With Pseudoephedrine to Evaluate the Effect on Blood Pressure and Heart Rate ozanimod, Pseudoephedrine, ozanimod placebo - Healthy Volunteers | Phase 1 | Completed | Celgene | 54 | 2018-07-11 | 2019-05-30 |
| Ibuprofen and Pseudoephedrine Comparative Pharmacokinetic Study Test Nurofen Cold and Flu®, Ibuprofen and pseudoephedrine liquid capsules, Comparator 1 Nurofen Cold and Flu®, ibuprofen and pseudoephedrine tablets, Comparator 2 Nurofen Immedia 200 mg Weichkapseln, ibuprofen liquid capsules - Healthy | Phase 1 | Completed | Reckitt Benckiser Healthcare (UK) Limited | 55 | 2016-08-10 | 2017-06-14 |
| Water and Sudafed in Autonomic Failure Pseudoephedrine + 480 ml water, Pseudoephedrine + 50 ml water, Placebo + 480 ml water (optional) - Shy-Drager Syndrome, Multiple System Atrophy | Early Phase 1 | Terminated | Vanderbilt University | 35 | 2014-10-01 | 2021-05-05 |
| Single-Dose Bioavailability Study of Two Formulations of Ibuprofen and Pseudoephedrine Hydrochloride Tablets Ibuprofen/Pseudoephedrine HCl 200/30 mg Film-Coated Tablets, RhinAdvil Rhume 200 mg/30 mg Film-Coated Tablets - Pain, Head, Pain, Acute | Phase 1 | Completed | Institut für Pharmakologie und Präventive Medizin | 66 | 2014-04-27 | 2018-02-12 |
| StahistRx Phase 2, Five-arm, Parallel Group, Active vs Active, Double-blind Study PSE 120 mg, CM 8 mg, Atr 0.36 mg, PSE 120 mg, CM 8 mg, Atr 0.24 mg, PSE 120 mg, CM 8 mg, Atr 0.12 mg - Rhinitis, Seasonal, Allergic | Phase 2 | Unknown | Magna Pharmaceuticals, Inc. | 125 | 2014-03-01 | 2014-05-30 |
| Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients Phenylephrine, Epinephrine, Albumin - Intracranial Aneurysm, Brain Edema | Not applicable | Completed | NYU Langone Health | 66 | 2014-03-01 | 2019-08-28 |
| TransMEM Gas Exchange -- Project 1, Aim 2 ragweed, histamine, pseudoephedrine - Middle Ear Disease, Nasal Allergy | Phase 1 | Completed | Cuneyt M. Alper | 84 | 2013-10-01 | 2020-02-07 |
| A Multicenter Study of Pseudoephedrine for the Temporary Relief of Nasal Congestion in Children With the Common Cold pseudoephedrine hydrochloride 30 mg tablets, Placebo tablets - Nasal Congestion Associated With the Common Cold | Phase 3 | Completed | Perrigo Company | 565 | 2012-11-01 | 2016-04-22 |
| Warming Sensation Intensity and Acceptability of the Flavour, Local Tolerability of Paracetamol 500 mg + Pseudoephedrine 30 mg Syrup in Patients Suffering a URTI IFF flavor 316 282, Paracetamol, Pseudoephedrine - Upper Respiratory Infections | Phase 3 | Completed | Novartis | 56 | 2012-05-01 | 2013-08-07 |
| Evaluation of Efficacy and Safety in Control Cough and the Relief of Nasal Symptoms in Children 2-12 Years Old,Suffering From Cough and Acute Rhinitis diphenhydramine + dropropizine + pseudoephedrine, Dropropizine and fixed dose combination of pseudoephedrine hydrochloride + brompheniramine maleate (Dimetapp® elixir). - Inflammation, Cough | Phase 3 | Withdrawn | Ache Laboratorios Farmaceuticos S.A. | 2011-10-01 | 2016-10-19 | |
| Effectiveness of Two Preparations of Loratadine + Pseudoephedrine in Patients With Perennial Allergic Rhinitis. Cloratadd-D, Allegra-D - Perennial Allergic Rhinitis | Phase 3 | Completed | Azidus Brasil | 156 | 2011-08-01 | 2016-04-11 |
| Efficacy/Safety of Pseudoephedrine Plus Levocetirizine Versus Placebo in Patients With Vasomotor Rhinitis Pseudoephedrine / Levocetirizine - Vasomotor Rhinitis | Phase 3 | Completed | Hanmi Pharmaceutical Company Limited | 137 | 2011-05-01 | 2013-05-23 |
| Fexofenadine HCL - Pseudoephedrine HCL Combination Versus Allegra in Patients With Seasonal Allergic Rhinitis fexofenadine HCL (M016455), pseudoephedrine, fexofenadine HCL matching placebo - Rhinitis Seasonal | Phase 3 | Completed | Sanofi | 520 | 2011-02-01 | 2013-10-16 |
| Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters Pseudoephedrine, Tamsulosin, Imipramine - Urethral Sphincter Activity | Not applicable | Completed | University of Alabama at Birmingham | 56 | 2010-04-01 | 2012-06-08 |
| Safety and Efficacy Study of Guaifenesin and Pseudoephedrine for Symptomatic Therapy to Treat Acute RTI Guaifenesin, Placebo - Acute Upper Respiratory Track Infection | Phase 4 | Completed | Reckitt Benckiser Inc. | 1179 | 2009-10-01 | 2020-12-30 |
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Rhinitis, Allergic, Seasonal (7) · Rhinitis (6) · Sinusitis (5) · Common Cold (4) · Nasal Obstruction (3) · Pure Autonomic Failure (3) · Rhinitis, Allergic, Perennial (3) · AIDS-Related Complex (2) · Acquired Immunodeficiency Syndrome (2) · HIV Infections (2) · Headache (2) · Hypersensitivity (2) · Respiratory Tract Infections (2) · Rhinitis, Allergic (2) · Rhinosinusitis (2)
Dr. Reddy's Laboratories Limited (8) · Vanderbilt University (3) · Bayer (2) · Boehringer Ingelheim (2) · Eli Lilly and Company (2) · Fraunhofer-Institute of Toxicology and Experimental Medicine (2) · Johnson & Johnson Consumer and Personal Products Worldwide (2) · Sanofi (2) · Ache Laboratorios Farmaceuticos S.A. (1) · Azidus Brasil (1) · Celgene (1) · Clinvest (1) · Cuneyt M. Alper (1) · GlaxoSmithKline (1) · Hanmi Pharmaceutical Company Limited (1)
United States (20) · India (8) · Canada (4) · Germany (2) · Singapore (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · Italy (1) · Japan (1) · Poland (1) · Slovakia (1) · South Korea (1)
Dr. Dharmesh Domadia (2) · Italo Biaggioni, MD (2) · Sandhya Ravi, MBBS, MS. (2) · Vijayanthi G, MBBS, MD (2) · Antonio R Pizarro, MD (1) · Cuneyt M Alper, MD (1) · Dr.Denis Audet, MD (1) · Elisabeth A Kruse, PhD (1) · Emily M Garland, PhD, MSCI (1) · Holly E Richter, PhD, MD (1) · J Zurlo (1)
PMID 10662747, PMID 11904109, PMID 11927799, PMID 12119802, PMID 12832331, PMID 15066944, PMID 15710782, PMID 15738343, PMID 17116758, PMID 17515447, PMID 17515448, PMID 19230461, PMID 20837887, PMID 21457883, PMID 21844413, PMID 22311903, PMID 22337680, PMID 22469621, PMID 27271310, PMID 28761581, PMID 32364251, PMID 33025342, PMID 39727053, PMID 9727818
2005 (1), 2009 (1), P01HL056693 (1), P50DC007667 (1), U01AI064655 (1), UL1TR000445 (1)