479 completed, 164 unknown, 97 recruiting, 80 terminated. 931 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 931 | Completed 479, Unknown 164, Recruiting 97, Terminated 80, Not yet recruiting 49, Withdrawn 30, Active not recruiting 22, Enrolling by invitation 7, Suspended 3 |
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acoustic Resonance Therapy for Treating Empty Nose Syndrome Personalized ART, Non-personalized ART - Empty Nose Syndrome, Nasal Obstruction | Not applicable | Not yet recruiting | Stanford University | 40 | 2028-07-01 | 2025-10-10 |
| Adiposity Distribution in Acute Respiratory Failure PEEP Titration Using Electrical Impedance Tomography (EIT), Body Positioning: Supine and Prone - Acute Hypoxemic Respiratory Failure, Obesity | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 80 | 2028-01-01 | 2025-06-13 |
| TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease TORCH Congenital Advanced Therapies Pathway (TORCH-CATP) - Congenital Heart Disease, Advanced Heart Failure | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical Ventilation Oxygen therapy - Weaning From Mechanical Ventilation, Tracheostomy Weaning | Not applicable | Recruiting | Henrik Endeman | 20 | 2026-12-31 | 2026-10-01 |
| Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea Sleep Inertia Questionnaire (SIQ) - Obstructive Sleep Apnea, Obesity (BMI>30) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 150 | 2026-11-01 | 2026-09-09 |
| Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning - Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy | Not applicable | Not yet recruiting | Rush University Medical Center | 2000 | 2026-11-01 | 2026-09-25 |
| Measuring Nasal Airway Changes After VivAer Treatment Using AI Analysis VivAer Stylus - Nasal Airway Obstruction | Not applicable | Recruiting | Aerin Medical | 30 | 2026-11-01 | 2026-10-30 |
| Bedside Spirometry for Acute Lung Injury Hand-held spirometer, NIV - Respiratory Insufficiency | Not applicable | Recruiting | Centre Hospitalier Departemental Vendee | 30 | 2026-10-16 | 2026-10-19 |
| Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube, Sham Nebulization - Postoperative Sore Throat, Nasal Obstruction | Not applicable | Not yet recruiting | Mansoura University | 105 | 2026-10-15 | 2026-10-15 |
| Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations Biphasic cuirass ventilator which is a type of negative pressure ventilator will be applied to patients on the intervention arm - Respiratory Failure, Extubation Failure | Not applicable | Not yet recruiting | University of Missouri-Columbia | 50 | 2026-10-01 | 2026-07-28 |
| Inhaled Nitric Oxide in Severe Obesity Nitric oxide - Obesity, Respiratory Insufficiency | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-10-01 | 2026-05-20 |
| Clinical Evaluation of an Alarm Activated Detection System to Enable Early Intervention of Emerging Respiratory Decline With the Linshom Medical Continuous Predictive Respiratory Sensor (CPRS) Linshom Continuous Predictive Respiratory Monitoring - Post Surgical Respiratory Failure, Respiratory Complication | Not applicable | Not yet recruiting | Linshom Medical, Inc. | 394 | 2026-10-01 | 2026-09-01 |
| Optimized Costoclavicular Block for Elderly Proximal Humeral Fracture Surgery Costoclavicular Brachial Plexus Block, Interscalene Brachial Plexus Block, Superficial Cervical Plexus Block - Proximal Humeral Fracture, Anesthesia, Regional | Not applicable | Withdrawn | Shanghai Tong Ren Hospital | 2026-10-01 | 2026-07-09 | |
| Trcheal High-flow for Weaning From Mechanical Ventilation Oxygen therapy - Tracheostomy, Mechanical Ventilation | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 500 | 2026-10-01 | 2026-07-20 |
| Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm Function Flow-Controlled Ventilation, Pressure-Controlled Ventilation (PCV) - Coronary Artery Disease, Postoperative Pulmonary Complications | Not applicable | Not yet recruiting | Koşuyolu Kartal Heart Training and Research Hospital | 154 | 2026-09-30 | 2026-09-02 |
| Evaluation of the FreeO2 System for Oxygen Weaning After Acute Hypoxemic Respiratory Failure FreeO2 automated oxygen titration system, Standard oxygen weaning - Acute Hypoxemic Respiratory Failure, Hypoxemia | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Besancon | 40 | 2026-09-15 | 2026-08-31 |
| AI-Guided Mechanical Ventilation in Children: A Randomized Controlled Trial AI-generated recommendations for ventilator parameters. - Acute Respiratory Distress Syndrome, Pneumonia in Children | Not applicable | Not yet recruiting | Wu Rongzhou | 200 | 2026-09-01 | 2026-07-27 |
| Mechanical Ventilator Adjustments and Patient Dyspnea Change to VC/AC, Change in Tidal Volume, Change in inspiratory flow - Respiratory Failure, Dyspnea During Mechanical Ventilation | Not applicable | Not yet recruiting | Beth Israel Deaconess Medical Center | 20 | 2026-09-01 | 2026-07-14 |
| Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation - Acute Exacerbation of Chronic Obstructive Pulmonary Disease | Not applicable | Not yet recruiting | Hospital del Mar Research Institute (IMIM) | 14 | 2026-09-01 | 2026-08-25 |
| Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure Spontaneous Ventilation Strategy, Controlled Ventilation Strategy - Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure | Not applicable | Recruiting | Oslo University Hospital | 80 | 2026-09-01 | 2026-10-15 |
Showing 20 of 931. Sign in to see all of them.
Nasal Obstruction (85) · Airway Obstruction (74) · Pulmonary Disease, Chronic Obstructive (62) · Hypoventilation (59) · Hypoxia (47) · Respiratory Distress Syndrome (43) · Obesity Hypoventilation Syndrome (41) · Respiratory Aspiration (40) · COVID-19 (34) · Critical Illness (31) · Pneumonia (23) · Dyspnea (21) · Sleep Apnea, Obstructive (21) · Hypercapnia (20)
Respiratory Tract Diseases (930) · Respiration Disorders (917) · Pathological Conditions, Signs and Symptoms (377) · Signs and Symptoms (247) · Lung Diseases (196) · Pathologic Processes (196) · Signs and Symptoms, Respiratory (164) · Nervous System Diseases (150) · Disease Attributes (102) · Otorhinolaryngologic Diseases (98) · Infections (96) · Nose Diseases (87) · Nutritional and Metabolic Diseases (86) · Airway Obstruction (84)
Noninvasive Ventilation (51) · Standard of Care (13) · Continuous Positive Airway Pressure (12) · Prone Position (8) · Fentanyl (6) · Interactive Ventilatory Support (6) · Propofol (6) · Oxygen (5) · Respiration, Artificial (5) · Saline Solution (5) · Cannula (4) · Albuterol (3) · Dexmedetomidine (3) · Educational Status (3) · Electric Stimulation (3)
Massachusetts General Hospital (16) · Assistance Publique - Hôpitaux de Paris (13) · Laval University (10) · Assiut University (9) · University of Sao Paulo General Hospital (9) · Fisher and Paykel Healthcare (8) · Aerin Medical (7) · Beth Israel Deaconess Medical Center (7) · Mayo Clinic (7) · Stanford University (7) · University Health Network, Toronto (7) · University Hospital, Bordeaux (7) · University of Utah (7) · Universitätsklinikum Hamburg-Eppendorf (7) · Beijing Chao Yang Hospital (6)
United States (231) · France (85) · Canada (55) · China (55) · Italy (55) · Turkey (Türkiye) (43) · Spain (40) · Germany (33) · Brazil (32) · United Kingdom (32) · Egypt (23) · Netherlands (18) · Taiwan (18) · Denmark (16) · Thailand (12)
Massimo Antonelli, MD (6) · Ewan Goligher, MD, PhD (5) · Laurent Brochard, MD (4) · Steven Mink, MD (4) · Jacob Johnson, MD (3) · Jennifer Beck, PhD (3) · John P Kress, MD (3) · Lorenzo Berra, MD (3) · Marcelo BP Amato, MD, PhD (3) · Yandong Jiang, MD, PhD (3) · Alexander Supady, Dr., MPH (2) · Alexandre B Cavalcanti, MD (2) · Anita Simonds, MD, FRCP (2) · Annemijn Jonkman, PhD (2)
PMID 25003980, PMID 25980660, PMID 27997805, PMID 28466461, PMID 22382596, PMID 23460154, PMID 25915102, PMID 25981908, PMID 26923627, PMID 27406165, PMID 28851800, PMID 28860265, PMID 29146865, PMID 29756407, PMID 30935737, PMID 32071135, PMID 33853139, PMID 10080847, PMID 10414409, PMID 10555090, PMID 10781266, PMID 10836341, PMID 10859037, PMID 11029353, PMID 11179136, PMID 11227314, PMID 11280630, PMID 11316667, PMID 11502631, PMID 11502632, PMID 11591566, PMID 11604980, PMID 1163544, PMID 11673215, PMID 11719318, PMID 11730446, PMID 11972163, PMID 11990923, PMID 12082446, PMID 12109234, PMID 12212984, PMID 12351998, PMID 12421743, PMID 12706763, PMID 12799407, PMID 12802491, PMID 12950321, PMID 14564379, PMID 14609453, PMID 14738245
2025 (3), K23HL088020 (2), 1SB1HL182474-01 (1), 2016 (1), 2017 (1), 2019 (1), 2023 (1), 5KL2TR001859-04 (1), K23AG066929 (1), K23DK127251 (1), K23HL138206 (1), K23HL145126 (1), K23HL155735 (1), K23HL175246 (1), K23HL181397 (1)