114 completed, 50 unknown, 22 recruiting, 19 terminated. 158 Not applicable, 10 Phase 4, 7 Phase 2, 5 Phase 3, 2 Phase 1.
Follow Noninvasive Ventilation: new trials by email Literature Review of Noninvasive Ventilation trials Research Report on Noninvasive Ventilation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Systematic and Sequential Leg Elevation on Cardiac Output in Healthy Volunteers Passive Leg Raising, Non-Invasive Ventilation - Healthy Adult, Cardiac Output | Not applicable | Not yet recruiting | Centre Hospitalier Régional d'Orléans | 20 | 2026-10-10 | 2026-10-08 |
| Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation - Acute Exacerbation of Chronic Obstructive Pulmonary Disease | Not applicable | Not yet recruiting | Hospital del Mar Research Institute (IMIM) | 14 | 2026-09-01 | 2026-08-25 |
| A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) Non-invasive ventilation - Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure | Phase 2 | Recruiting | University of Pennsylvania | 48 | 2026-06-11 | 2026-06-26 |
| Non-invasive Ventilation or CPAP in OSA-COPD Following Admission for an Acute Hypercapnic Respiratory Failure Non-invasive Ventilation (NIV), Continous Positive Airway Pressure (CPAP) - Chronic Obstructive Pulmonary Disease Exacerbation, Obstructive Sleep Apnea Exacerbation | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 386 | 2026-06-03 | 2026-06-09 |
| The Effect of Home and Hospital Mask Designs on Respiratory Variables in Healthy Volunteers Non-invasive ventilation (NIV) - Healthy Volunteers | Not applicable | Not yet recruiting | Fisher and Paykel Healthcare | 10 | 2026-03-01 | 2026-03-11 |
| High-Flow Nasal Cannula Versus Noninvasive Ventilation After Extubation in Patients With COPD and Mild Hypercapnic Respiratory Failure Non-Invasive Ventilation (NIV), High-Flow Nasal Cannula (HFNC) - COPD | Not applicable | Active not recruiting | Assiut University | 150 | 2026-01-01 | 2026-02-02 |
| Impact of Home Non Invasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease Discharged From Assiut University Hospital BiPAP device (non invasive ventilation), Optimal Medical Management ( long acting beta agonist , long acting muscarinic antagonist and inhaled corticosteroids) - COPD, COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Not yet recruiting | Assiut University | 40 | 2026-01-01 | 2025-09-30 |
| The Effects of Different Non-invasive Respiratory Support Continuous Positive Airway Pressure, Non-invasive ventilation, High-flow nasal oxygen - Acute Respiratory Failure (ARF) | Not applicable | Not yet recruiting | Southeast University, China | 60 | 2025-11-30 | 2025-11-25 |
| HFNC Versus NIV in Hypercapneic COPD Patients high flow nasal cannula, non invasive ventilation - COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Recruiting | Mohammed Shehta | 70 | 2025-11-03 | 2026-10-02 |
| Effect of Exercise Ventilatory Support Pressure on Endurance in Patients With Severe Chronic Obstructive Pulmonary Disease - AVE-BPCO non-invasive ventilation - Chronic Obstructive Pulmonary Disease (COPD) | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Saint Etienne | 30 | 2025-10-01 | 2025-08-15 |
| High-Flow Nasal Cannula Versus Non-Invasive Ventilation for Acute Respiratory Failure in Pulmonary Embolism. High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV) - Pulmonary Embolism | Not applicable | Active not recruiting | Assiut University | 100 | 2025-10-01 | 2026-02-02 |
| Asymmetrical High Flow Oxygen Versus Noninvasive Ventilation in Acute Hypercapnic Respiratory Failure asymmetrical high-flow nasal cannula, non-invasive ventilation with standard mask, non-invasive ventilation with a new mask - Acute Hypercapnic Respiratory Failure | Not applicable | Not yet recruiting | Unity Health Toronto | 24 | 2025-08-25 | 2025-09-05 |
| Noninvasive Support for Acute Respiratory Failure in Guillain-Barré Syndrome Non-Invasive Ventilation (NIV), High Velocity Nasal Insufflation - Guillain-Barre Syndrome | Not applicable | Recruiting | Assiut University | 80 | 2025-08-01 | 2026-09-22 |
| Value of Volume Oxygenation Index to Detect Early Failure of Non-invasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease non invasive ventilation - COPD, Non Invasive Ventilation (NIV) | Not yet recruiting | Assiut University | 190 | 2025-07-15 | 2025-07-20 | |
| Noninvasive Support Methods for Acute Respiratory Failure of Community-acquired Pneumonia Non-Invasive ventilation (NIV), High Velocity Nasal Insufflation - Community-acquired Pneumonia, Community-Acquired Infections | Not applicable | Recruiting | Assiut University | 100 | 2025-07-01 | 2026-09-22 |
| NIV With Airway Washout for Dual Limb Ventilation: Improvement in Minute Ventilation Non-invasive ventilation mask with airway washout, non-invasive ventilation - Respiratory Failure Requiring Non Invasive Ventilation | Not applicable | Not yet recruiting | Fisher and Paykel Healthcare | 20 | 2025-07-01 | 2025-05-22 |
| Oxygenation Procedure for Obese Patients During Intubation in the Operating Room NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen), NIV (Non Invasive Ventilation) - Anesthesia Induction | Not applicable | Completed | Clinique Pasteur | 124 | 2025-06-19 | 2026-06-15 |
| High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery High Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV) - Heart Defects, Congenital, Intensive Care Units, Pediatric | Not applicable | Recruiting | Universitas Indonesia | 114 | 2025-06-05 | 2025-07-11 |
| Effects of Non-invasive Ventilation Therapies on the Lung in Hypoxemic Chest Trauma Patients Non invasive ventilation (NIV), High flow oxygen therapy (HFO) - Lung Trauma, Lung Contusion | Not applicable | Recruiting | Hospices Civils de Lyon | 30 | 2025-04-22 | 2025-06-24 |
| Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV) - Type II Respiratory Failure, Hypercapnic Respiratory Failure | Not applicable | Completed | Benha University | 200 | 2025-04-15 | 2026-08-25 |
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Respiratory Insufficiency (57) · Pulmonary Disease, Chronic Obstructive (47) · Hypercapnia (11) · Heart Failure (8) · Hypoxia (8) · Obesity Hypoventilation Syndrome (8) · Amyotrophic Lateral Sclerosis (6) · Motor Activity (6) · COVID-19 (5) · Pulmonary Edema (5) · Sleep Apnea, Obstructive (5) · Cystic Fibrosis (4) · Dyspnea (4) · Hypoventilation (4) · Neuromuscular Diseases (4)
Assiut University (16) · Universidade Federal de Pernambuco (6) · Assistance Publique - Hôpitaux de Paris (4) · Fisher and Paykel Healthcare (4) · Poitiers University Hospital (4) · The First Affiliated Hospital of Guangzhou Medical University (4) · University Hospital, Clermont-Ferrand (4) · University Hospital, Montpellier (4) · University Hospital, Rouen (4) · Ospedale S. Giovanni Bosco (3) · ResMed (3) · Schön Klinik Berchtesgadener Land (3) · Spaulding Rehabilitation Hospital (3) · Unity Health Toronto (3) · University Hospital, Grenoble (3)
France (42) · Italy (19) · China (17) · Brazil (16) · Egypt (15) · Germany (15) · United States (15) · Spain (12) · United Kingdom (8) · Canada (6) · Netherlands (5) · Turkey (Türkiye) (4) · Belgium (3) · Sweden (3) · Argentina (2)
Giovanni Ferrari, MD (3) · Ahmad M. Shaddad, MD (2) · Aliae A. Hussien, MD (2) · Israel Maia, MD (2) · J. Andrew Taylor, PhD (2) · Klaus Kenn, MD (2) · Klaus Kenn, Prof. Dr. (2) · Leticia Kawano-Dourado, MD (2) · Mustapha Sebbane, MD, PhD (2) · Rongchang Chen (2) · Rongchang Chen, MD (2) · Shuliang Guo, MD (2) · Stefano Nava (2) · Stefano Nava, MD (2)
PMID 12684289, PMID 19484669, PMID 19682735, PMID 20952768, PMID 22781558, PMID 27706464, PMID 27997805, PMID 31577036, PMID 31738927, PMID 10836341, PMID 11179102, PMID 11809990, PMID 11866011, PMID 11867822, PMID 11972163, PMID 12351998, PMID 12840089, PMID 12907562, PMID 15189655, PMID 15459142, PMID 15857531, PMID 16354864, PMID 16387803, PMID 16627862, PMID 16696863, PMID 17015575, PMID 17133177, PMID 17433956, PMID 1758504, PMID 17675317, PMID 17848876, PMID 17908705, PMID 18079549, PMID 18416851, PMID 18679148, PMID 18957151, PMID 19183949, PMID 19240806, PMID 19242034, PMID 19253509, PMID 19393106, PMID 19416146, PMID 19749006, PMID 20100768, PMID 20375160, PMID 20448091, PMID 20606908, PMID 21287368, PMID 21602746, PMID 21680944
2023 (1), U01HL159882 (1)