36 completed, 5 withdrawn, 3 terminated, 3 unknown. 49 Phase 1, 16 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 49 | Completed 36, Withdrawn 5, Terminated 3, Unknown 3, Not yet recruiting 1, Suspended 1 |
| Phase 2 | 16 | Completed 13, Terminated 2, Withdrawn 1 |
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhaled Treatment for Bronchopulmonary Dysplasia GSNO - Bronchopulmonary Dysplasia | Phase 1 | Withdrawn | University Hospitals Cleveland Medical Center | 2025-08-01 | 2025-08-22 | |
| ENA-001 for Opioid Induced Respiratory Depression ENA-001, Placebo Comparator - Respiratory Depression | Phase 1 | Completed | Enalare Therapeutics Inc. | 62 | 2025-05-14 | 2026-09-16 |
| Effect of Different Proprioceptive Neuromuscular Facilitation Techniques Versus Flow Trigger Sensitivity on Weaning Off Mechanical Ventilation Flow trigger sensitivity group, Active proprioceptive facilitation technique ( active PNF) technique, Passive proprioceptive facilitation technique ( passive PNF) technique - Respiratory Failure | Phase 1 | Not yet recruiting | Beni-Suef University | 84 | 2025-02-20 | 2025-02-18 |
| Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery Rectus sheath block with bupivacaine - Coronary Artery Disease, Postoperative Pain | Phase 1 | Completed | Medical College of Wisconsin | 62 | 2023-06-19 | 2025-11-17 |
| Alirocumab in Patients with Sepsis Alirocumab, Placebo - Sepsis | Phase 1 | Completed | Jonathan Sevransky | 50 | 2023-01-04 | 2025-03-24 |
| Effect of Respiratory Muscle Training on Lung Function on Quarry Workers in Minia Government Egypt aerobic exercises with electrical treadmill for 30 min and inspiratory muscle training for 10 minutes., - Lung Function Decreased | Phase 1 | Completed | Deraya University | 40 | 2023-01-02 | 2023-11-07 |
| Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation Placebo and Oxycodone, Paroxetine and Oxycodone, Escitalopram and Oxycodone - Hypercapnia, Ventilatory Depression | Phase 1 | Completed | Food and Drug Administration (FDA) | 27 | 2022-09-01 | 2025-05-22 |
| Contrast Enhanced 3D Echocardiographic Quantification of Right Ventricular Volumes in Repaired CHD Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON] - Tetralogy of Fallot, Pulmonary Insufficiency | Phase 1 / Phase 2 | Completed | Nemours Children's Clinic | 25 | 2022-08-23 | 2026-04-27 |
| CONFOCAL-2 Interventional Pilot Study Autoregulation-based precision blood pressure management - Critical Illness, Respiratory Failure | Phase 1 / Phase 2 | Completed | Queen's University | 16 | 2022-07-29 | 2025-12-22 |
| Study of Epigallocatechin-3-gallate (EGCG) for Supportive and Symptomatic Management in Patients With Esophageal Cancer EGCG - Esophageal Obstruction | Phase 1 | Completed | Shandong Cancer Hospital and Institute | 18 | 2021-08-20 | 2024-04-03 |
| Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS Rapamycin, Placebo - Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Respiratory Failure | Phase 1 / Phase 2 | Withdrawn | The University of Texas Health Science Center at San Antonio | 2021-04-01 | 2021-06-01 | |
| Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease) Mesenchymal Stromal Cells, Supportive Care - Sars-CoV2, Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 28 | 2021-02-12 | 2026-10-21 |
| A Study of RLS-0071 in Patients With Acute Lung Injury Due to COVID-19 Pneumonia in Early Respiratory Failure RLS-0071 10 mg/kg, RLS-0071 40 mg/kg, Placebo - Acute Lung Injury, ALI | Phase 1 | Withdrawn | ReAlta Life Sciences, Inc. | 2021-01-01 | 2022-02-04 | |
| CLBS119 for Repair of COVID-19 Induced Pulmonary Damage CLBS119 - Covid-19 | Phase 1 | Withdrawn | Lisata Therapeutics, Inc. | 2020-10-05 | 2024-10-09 | |
| Use of Angiotensin-(1-7) in COVID-19 Angiotensin-(1-7), Placebo - Infection, Coronavirus, Respiratory Failure | Phase 1 / Phase 2 | Completed | Erasme University Hospital | 112 | 2020-08-05 | 2021-11-09 |
| Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation Oxycodone and Midazolam, Oxycodone, Paroxetine, and Quetiapine - Hypercapnia, Ventilatory Depression | Phase 1 | Completed | Food and Drug Administration (FDA) | 55 | 2020-06-15 | 2024-05-21 |
| Study of Open Label Losartan in COVID-19 Losartan - COVID-19 | Phase 1 | Completed | University of Kansas Medical Center | 34 | 2020-04-04 | 2024-08-02 |
| Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo. Belbuca 300 µg, Belbuca 600 µg, Belbuca 900 µg - Respiratory Depression | Phase 1 | Completed | BioDelivery Sciences International | 19 | 2019-07-23 | 2021-02-05 |
| Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression Continuous conversational interaction, Remifentanil infusion - Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain | Phase 1 | Completed | University of California, San Francisco | 20 | 2019-04-30 | 2020-03-10 |
| Use of Autologous Stem/Stromal Cells In Chronic Lung Disorders: Obstructive (COPD) & Restrictive (RLD) Lipoaspiration, AD-cSVF, Normal Saline IV - COPD, Respiratory Insufficiency | Phase 1 | Suspended | Healeon Medical Inc | 50 | 2019-04-10 | 2024-10-01 |
Showing 20 of 49. Sign in to see all of them.
Nasal Obstruction (7) · COVID-19 (5) · Respiratory Distress Syndrome (4) · Acute Lung Injury (3) · Airway Obstruction (3) · Lung Injury (3) · Pulmonary Disease, Chronic Obstructive (3) · Sneezing (3) · Apnea (2) · Coronavirus Infections (2) · Delirium (2) · Heart Failure (2) · Hypercapnia (2) · Hypoxia (2)
Respiration Disorders (49) · Respiratory Tract Diseases (48) · Pathological Conditions, Signs and Symptoms (23) · Signs and Symptoms (17) · Lung Diseases (12) · Infections (10) · Pathologic Processes (10) · Signs and Symptoms, Respiratory (10) · Airway Obstruction (7) · Neurologic Manifestations (7) · Nose Diseases (7) · Otorhinolaryngologic Diseases (7) · RNA Virus Infections (7) · Virus Diseases (7)
Dexmedetomidine (3) · Interactive Ventilatory Support (3) · Oxycodone (3) · Midazolam (2) · Noninvasive Ventilation (2) · Oxygen (2) · Paroxetine (2) · Saline Solution (2) · Acetaminophen (1) · Bupivacaine (1) · Buprenorphine (1) · Carbon Dioxide (1) · Diphenhydramine (1) · Endothelium-Dependent Relaxing Factors (1) · Escitalopram (1)
Food and Drug Administration (FDA) (2) · Insel Gruppe AG, University Hospital Bern (2) · University Hospitals Cleveland Medical Center (2) · 5i Sciences, Inc. (1) · Bayer (1) · Baylor College of Medicine (1) · Baylor Research Institute (1) · Beni-Suef University (1) · BioDelivery Sciences International (1) · Deraya University (1) · Drexel University (1) · Duke University (1) · Enalare Therapeutics Inc. (1) · Erasme University Hospital (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1)
United States (30) · Canada (3) · Egypt (2) · Germany (2) · Australia (1) · Brazil (1) · China (1) · France (1) · Honduras (1) · Ireland (1) · Portugal (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Lukas Brander, MD (2) · Ana Martins Valle (1) · Anatole D Martin, Ph D, PT (1) · Andrea Gabrielli, MD (1) · Anita K Simonds, MD (1) · Anne Castro (1) · Carlos Sanabria, MD (1) · Craig Weinert, MD (1) · David MacLeod, MB BS (1) · Dean L Kellogg, MD, PhD (1) · Douglas W Losordo, MD (1) · Edward S Schulman, MD (1) · Elisabeth Kruse, PhD (1) · Elosie Harman, MD (1)
PMID 16235359, PMID 16565429, PMID 16636091, PMID 16690673, PMID 17132052, PMID 17507545, PMID 18073405, PMID 19183804, PMID 21385346, PMID 21975749, PMID 22314182, PMID 22661448, PMID 22793939, PMID 22793945, PMID 23074435, PMID 23076942, PMID 23235687, PMID 23256721, PMID 23364286, PMID 2337756, PMID 23992090, PMID 24563632, PMID 24615270, PMID 25212533, PMID 25450456, PMID 26962013, PMID 27110692, PMID 30850876, PMID 32658300, PMID 32978722, PMID 33651243, PMID 34473343, PMID 35524938, PMID 36038890, PMID 36219407, PMID 37380156, PMID 39231898, PMID 39986981, PMID 41849255
2009 (2), R21NR012795 (1), R44DA057133 (1)