61 completed, 16 unknown, 14 terminated, 10 recruiting. 116 Phase 2, 19 Phase 3, 16 Phase 1.
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| ENA-001 for Post Operative Respiratory Depression (PORD) ENA-001 - Respiratory Depression | Phase 2 | Not yet recruiting | Enalare Therapeutics Inc. | 200 | 2026-12-15 | 2026-02-27 |
| A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) Non-invasive ventilation - Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure | Phase 2 | Recruiting | University of Pennsylvania | 48 | 2026-06-11 | 2026-06-26 |
| Study to Investigate the Efficacy and Safety of Apomivir® Apomivir®, Placebo - Influenza | Phase 2 | Not yet recruiting | Far East Bio-Tec Co., Ltd | 196 | 2026-05-31 | 2025-05-14 |
| A Clinical Trial to Evaluate agenT-797 Plus Standard of Care in Participants With Severe Pneumonia With Moderate to Severe Acute Hypoxemic Respiratory Failure agenT-797, Placebo, Standard of Care (SOC) - Pneumonia | Phase 2 | Recruiting | MiNK Therapeutics | 90 | 2026-05-26 | 2026-06-26 |
| A Study to Learn More About How Well Oxymetazoline HCl 0.05% Nasal Gel Works and How Safe It Is in Healthy Adults Oxymetazoline HCl 0.05% nasal gel, Placebo nasal gel - Nasal Congestion, Nasal Obstruction | Phase 2 | Completed | Bayer | 120 | 2026-04-20 | 2026-06-08 |
| Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients Esophageal pressure-guided PEEP titration, Standard care PEEP management - Respiratory Failure | Phase 2 | Recruiting | University of Alberta | 30 | 2026-02-05 | 2026-04-13 |
| Steroid Treatment for Elimination of Rebound Obstruction From Intranasal Decongestants Oxymetazoline + Triamcinolone - Nasal Obstruction, Chronic Rhinitis | Phase 2 | Terminated | Washington University School of Medicine | 3 | 2025-11-10 | 2026-03-23 |
| Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility Study Tocilizumab (Actemra®), Dexamethasone - Acute Hypoxemic Respiratory Failure | Phase 2 | Recruiting | Lorenzo delSorbo | 60 | 2025-10-20 | 2026-10-09 |
| COMBO Endoscopy Oropharyngeal Airway in Sedated Endoscopic Retrograde Cholangiopancreatography for Patients The COMBO Endoscopy Oropharyngeal Airway - Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice | Phase 2 | Recruiting | Zhejiang University | 50 | 2025-06-12 | 2025-06-24 |
| Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study Supraglottic Oxygen Delivery via an Endotracheal Tube - Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice | Phase 2 | Recruiting | Zhejiang University | 50 | 2025-06-12 | 2025-07-17 |
| A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma PF-07275315, Placebo - Asthma | Phase 2 | Recruiting | Pfizer | 252 | 2025-05-20 | 2026-11-06 |
| Sedation vs No Sedation in Mechanically Ventilated COPD Patients Midalozam - Chronic Obstructive Pulmonary Disease, Respiratory Failure | Phase 2 | Completed | Al-Azhar University | 100 | 2025-04-14 | 2026-06-02 |
| MRG-001 as an Immunoregulatory and Regenerative Therapy for ARDS Patients MRG-001 (Low-dose), MRG-001 (High-dose), Placebo - Acute Respiratory Distress Syndrome, Respiratory Failure | Phase 2 | Unknown | MedRegen LLC | 60 | 2024-12-01 | 2024-08-23 |
| Nasal Obstruction With Oxymetazoline and Corticosteroids Oxymetazoline Nasal Spray, Budesonide nasal spray - Nasal Obstruction | Phase 2 | Recruiting | Washington University School of Medicine | 80 | 2024-10-15 | 2025-09-11 |
| Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS) Rhu-pGSN, normal saline - Acute Respiratory Distress Syndrome, Infections | Phase 2 | Recruiting | BioAegis Therapeutics Inc. | 600 | 2024-10-03 | 2026-10-20 |
| Biological Effects of Quercetin in COPD Phase II Quercetin 1000 mg, Quercetin 500 MG, Placebo - Chronic Obstructive Pulmonary Disease, Emphysema | Phase 2 | Unknown | Temple University | 30 | 2023-11-01 | 2024-04-08 |
| The Evaluation of the Effectiveness and Safety of Nalbuphine Hydrochloride Injection for Analgesia in ICU Patients: A Multicenter, Randomized, Single-blinded, Parallel, Two-step Trial Nalbuphine hydrochloride injection, Hydromorphone hydrochloride injection - Respiratory Insufficiency | Phase 2 / Phase 3 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 204 | 2023-08-30 | 2025-01-21 |
| Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age Remifentanil Hydrochloride, Pupillometry measurement - Opioid Toxicity, Pupillary Miosis | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 10 | 2022-10-01 | 2025-05-02 |
| Contrast Enhanced 3D Echocardiographic Quantification of Right Ventricular Volumes in Repaired CHD Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON] - Tetralogy of Fallot, Pulmonary Insufficiency | Phase 1 / Phase 2 | Completed | Nemours Children's Clinic | 25 | 2022-08-23 | 2026-04-27 |
Showing 20 of 116. Sign in to see all of them.
COVID-19 (24) · Respiratory Distress Syndrome (18) · Nasal Obstruction (16) · Airway Obstruction (8) · Coronavirus Infections (7) · Critical Illness (7) · Acute Lung Injury (6) · Hypoxia (6) · Pneumonia (6) · Pulmonary Disease, Chronic Obstructive (6) · Dyspnea (5) · Pancreatitis (4) · Asthma (3) · Hypertension, Pulmonary (3)
Respiration Disorders (116) · Respiratory Tract Diseases (114) · Pathological Conditions, Signs and Symptoms (47) · Lung Diseases (46) · Infections (37) · Respiratory Tract Infections (29) · Virus Diseases (29) · RNA Virus Infections (28) · Signs and Symptoms (28) · Coronaviridae Infections (26) · Nidovirales Infections (26) · Pathologic Processes (25) · Pneumonia, Viral (22) · Pneumonia (20)
Standard of Care (6) · Saline Solution (5) · Dexamethasone (4) · Dexmedetomidine (3) · Oxymetazoline (3) · Sodium Chloride (3) · Aspirin (2) · Culture Media (2) · Glucose (2) · Morphine (2) · Nitric Oxide (2) · Noninvasive Ventilation (2) · Remifentanil (2) · angiotensin I (1-7) (2) · aviptadil (2)
GlaxoSmithKline (5) · NICHD Neonatal Research Network (3) · Novartis Pharmaceuticals (3) · Erasme University Hospital (2) · Johns Hopkins University (2) · KK Women's and Children's Hospital (2) · Mackay Memorial Hospital (2) · Patrick Murphy (2) · University of Turin, Italy (2) · Washington University School of Medicine (2) · Zhejiang University (2) · 5i Sciences, Inc. (1) · APR Applied Pharma Research s.a. (1) · AbbVie (1) · Abraham Edgar Gracia-Ramos (1)
United States (58) · Canada (8) · Italy (8) · United Kingdom (7) · Germany (6) · Brazil (5) · Taiwan (5) · China (4) · Spain (4) · Argentina (3) · Australia (3) · Belgium (3) · Denmark (3) · Hungary (3) · Netherlands (3)
Chao-Hsien Lee, MD (2) · Mouen Khashab, MD (2) · Abhik Das, PhD (1) · Abraham Edgar Gracia-Ramos, MD MSc (1) · Adrienne Randolph, MD (1) · Ajit Limaye, MD (1) · Amber U Luong, MD, PhD (1) · Ana Martins Valle (1) · Anders Perner, MD, PhD (1) · Atsushi Kawaguchi (1) · Ban L Sng, FANZCA (1) · Ban Leong Sng, MBBS, MMED (1)
PMID 25496504, PMID 31209698, PMID 34473343, PMID 15141377, PMID 15725047, PMID 16424722, PMID 16540947, PMID 17605780, PMID 19183804, PMID 20920189, PMID 20937093, PMID 22315264, PMID 22465313, PMID 22791092, PMID 23622977, PMID 23784924, PMID 23849147, PMID 23907810, PMID 23919993, PMID 24038922, PMID 26728475, PMID 27059469, PMID 27110692, PMID 27178892, PMID 27419080, PMID 28528348, PMID 28606907, PMID 28829877, PMID 29209510, PMID 29264361, PMID 29800001, PMID 29866165, PMID 29975735, PMID 30154874, PMID 30558653, PMID 30850876, PMID 30956804, PMID 31119695, PMID 31352795, PMID 31455384, PMID 31741746, PMID 31921715, PMID 31986264, PMID 32071149, PMID 32142651, PMID 32155444, PMID 32192578, PMID 32212240, PMID 32227760, PMID 32246450
U10HD036790 (3), U10HD021385 (2), U10HD027880 (2), U10HD034216 (2), U10HD040492 (2), U10HD040689 (2), U10HD053109 (2), 2009 (1), 2019 (1), R01HL084139 (1), R01HL130881 (1), R21NR012795 (1), R33AT009991 (1), U01HL102235 (1), U01HL102547 (1)