60 completed, 16 terminated, 13 unknown, 7 recruiting. 107 Phase 3, 19 Phase 2.
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg, Placebo - Common Cold/Flu, Nasal Congestion | Phase 3 | Recruiting | Brainfarma Industria Química e Farmacêutica S/A | 620 | 2026-05-08 | 2026-06-16 |
| Optimisation of High Flow Oxygen Therapy Settings During Hypoxaemic Respiratory Distress Based on Non-contact Measurement of Lung Volumes by Depth Camera high flow oxygen therapy rate adjusted of lung volumes measured - Hypoxemic Respiratory Failure | Phase 3 | Recruiting | University Hospital, Brest | 406 | 2026-04-08 | 2026-06-29 |
| The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients Phosphocreatine, Placebo - Hypotension, Consciousness, Level Altered | Phase 3 | Recruiting | Università Vita-Salute San Raffaele | 400 | 2024-10-08 | 2025-08-06 |
| Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose Nalmefene Injection, Naloxone Injection - Opioid Overdose, Opiate Overdose | Phase 3 | Withdrawn | University of New Mexico | 2024-08-26 | 2025-02-10 | |
| Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation Noradrenaline - Critical Illness, Respiratory Failure | Phase 3 | Recruiting | University of Turin, Italy | 420 | 2024-08-01 | 2025-03-28 |
| Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome Precision ventilation, Guided usual care ventilation - Acute Respiratory Distress Syndrome, Respiratory Failure | Phase 3 | Recruiting | Beth Israel Deaconess Medical Center | 1100 | 2024-06-24 | 2026-06-29 |
| The Evaluation of the Effectiveness and Safety of Nalbuphine Hydrochloride Injection for Analgesia in ICU Patients: A Multicenter, Randomized, Single-blinded, Parallel, Two-step Trial Nalbuphine hydrochloride injection, Hydromorphone hydrochloride injection - Respiratory Insufficiency | Phase 2 / Phase 3 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 204 | 2023-08-30 | 2025-01-21 |
| Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients Cuff Leak Test, Dexamethasone 4mg - Respiratory Failure | Phase 3 | Completed | St. Joseph's Healthcare Hamilton | 100 | 2023-04-05 | 2025-03-10 |
| Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age Remifentanil Hydrochloride, Pupillometry measurement - Opioid Toxicity, Pupillary Miosis | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 10 | 2022-10-01 | 2025-05-02 |
| Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure Norepinephrine, Lactated Ringers, Intravenous, normal saline - Respiratory Failure, Hypotension and Shock | Phase 3 | Completed | Wright State University | 42 | 2022-08-09 | 2024-07-15 |
| Non-invasive Ventilation and Dex in Critically Ill Adults Dexmedetomidine, Placebo - Respiratory Insufficiency | Phase 3 | Completed | St. Joseph's Healthcare Hamilton | 24 | 2022-03-07 | 2024-10-28 |
| the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial) Salbutamol, 0,9% Chloride Sodium - TTN, Respiratory Failure | Phase 3 | Active not recruiting | Medical University of Warsaw | 608 | 2021-12-31 | 2025-11-18 |
| Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial Angiotensin 1-7, Placebos - Coronavirus, Respiratory Failure | Phase 2 / Phase 3 | Unknown | Erasme University Hospital | 60 | 2021-12-30 | 2021-08-02 |
| Protective Effect of Sivelestat Sodium on ARDS in Patients With Sepsis Sivelestat sodium, Placebo - ARDS | Phase 3 | Unknown | Southeast University, China | 238 | 2021-10-11 | 2023-04-05 |
| Comparative Evaluation of the McGrath Videolaryngoscope and the Direct Laryngoscopy for Tracheal Intubation in the Prehospital Setting Videolaryngoscopy group, Direct laryngoscopy group - Indication of Orotracheal Intubation, Cardio Respiratory Arrest | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 150 | 2021-06-15 | 2021-06-18 |
| Furosemide as Supportive Therapy for COVID-19 Respiratory Failure Nebulized Furosemide, Nebulized Saline - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Terminated | Dr. John Muscedere | 40 | 2021-04-16 | 2023-12-11 |
| Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain VPIA pump, Morphine - Pain, Respiratory Depression | Phase 2 / Phase 3 | Active not recruiting | KK Women's and Children's Hospital | 40 | 2021-03-31 | 2026-08-07 |
| Randomized Open Investigation Determining Steroid Dose Weight-based dexamethasone dose - Covid19 | Phase 3 | Completed | Northwell Health | 142 | 2021-03-19 | 2023-07-20 |
| VA CoronavirUs Research and Efficacy Studies-1 Convalescent Plasma, Masked Saline Placebo - COVID-19 | Phase 3 | Terminated | VA Office of Research and Development | 75 | 2020-11-16 | 2022-09-23 |
| Nebulised Heparin in Patients With Severe COVID-19 Nebulised unfractionated heparin (UFH) - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Completed | Australian National University | 57 | 2020-11-01 | 2025-11-05 |
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Nasal Obstruction (21) · Respiratory Distress Syndrome (13) · COVID-19 (12) · Common Cold (6) · Critical Illness (6) · Heart Failure (6) · Pulmonary Disease, Chronic Obstructive (6) · Coronavirus Infections (5) · Cough (5) · Influenza, Human (5) · Pharyngitis (5) · Respiratory Aspiration (5) · Sneezing (5) · Headache (4)
Respiration Disorders (107) · Respiratory Tract Diseases (106) · Pathological Conditions, Signs and Symptoms (48) · Infections (36) · Lung Diseases (35) · Pathologic Processes (31) · Respiratory Tract Infections (27) · RNA Virus Infections (24) · Virus Diseases (24) · Signs and Symptoms (23) · Otorhinolaryngologic Diseases (22) · Airway Obstruction (21) · Nose Diseases (21) · Pneumonia (17)
Dexamethasone (4) · Dexmedetomidine (4) · Azithromycin (3) · Acetaminophen (2) · Blood Specimen Collection (2) · Chlorpheniramine (2) · Enoxaparin (2) · Fentanyl (2) · Heparin (2) · Hydroxychloroquine (2) · Noninvasive Ventilation (2) · Norepinephrine (2) · Saline Solution (2) · Standard of Care (2) · bilastine (2)
Assistance Publique - Hôpitaux de Paris (6) · NICHD Neonatal Research Network (5) · Ache Laboratorios Farmaceuticos S.A. (3) · UPECLIN HC FM Botucatu Unesp (3) · University of Turin, Italy (3) · BioCryst Pharmaceuticals (2) · Faes Farma, S.A. (2) · MDVI, LLC (2) · McMaster University (2) · Patrick Murphy (2) · St. Joseph's Healthcare Hamilton (2) · Stanford University (2) · United Christian Hospital (2) · AO GENERIUM (1) · APR Applied Pharma Research s.a. (1)
United States (36) · Canada (15) · France (14) · United Kingdom (13) · Brazil (12) · Italy (10) · Belgium (8) · Netherlands (7) · Australia (6) · Germany (6) · Russia (6) · Spain (6) · Argentina (5) · Czechia (5) · Poland (5)
Avroy A. Fanaroff, MD (5) · Edward F. Donovan, MD (5) · Lu-Ann Papile, MD (5) · Richard A. Ehrenkranz, MD (5) · Seetha Shankaran, MD (5) · Sheldon B. Korones, MD (5) · Barbara J. Stoll, MD (4) · Charles R. Bauer, MD (4) · David K. Stevenson, MD (4) · William Oh, MD (4) · James A. Lemons, MD (3) · Jon E. Tyson, MD MPH (3) · Waldemar A. Carlo, MD (3) · Carol Epstein, MD (2)
PMID 35639525, PMID 10400143, PMID 10545589, PMID 10802492, PMID 11150359, PMID 11416871, PMID 12219057, PMID 14510322, PMID 14993550, PMID 16651303, PMID 17307536, PMID 17764785, PMID 18245420, PMID 18714060, PMID 18989547, PMID 19132976, PMID 20302428, PMID 20407057, PMID 20562702, PMID 21403073, PMID 21983627, PMID 22077106, PMID 22580593, PMID 22997204, PMID 23644995, PMID 23944299, PMID 23985625, PMID 24652410, PMID 24973289, PMID 24983742, PMID 25115871, PMID 26158245, PMID 26162889, PMID 26730752, PMID 27751553, PMID 28118549, PMID 28286047, PMID 28528348, PMID 28606907, PMID 29275926, PMID 29866165, PMID 30145946, PMID 30523161, PMID 31012225, PMID 31120585, PMID 31352795, PMID 31529354, PMID 31577692, PMID 31585796, PMID 31910992
M01RR000070 (5), M01RR000750 (5), M01RR000997 (5), M01RR006022 (5), M01RR008084 (5), U10HD021385 (5), U10HD021397 (5), U10HD021415 (5), U10HD027853 (5), U10HD027871 (5), U10HD027880 (5), U10HD027881 (5), U10HD027904 (5), M01RR001032 (4), U10HD021364 (4)