86 completed, 26 unknown, 15 terminated, 13 recruiting. 98 Not applicable, 5 Phase 3, 3 Phase 2, 2 Phase 4, 1 Early Phase 1.
Follow Hypoventilation: new trials by email Literature Review of Hypoventilation trials Research Report on Hypoventilation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea Sleep Inertia Questionnaire (SIQ) - Obstructive Sleep Apnea, Obesity (BMI>30) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 150 | 2026-11-01 | 2026-09-09 |
| Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy Infrared Pupillometry - Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary) | Recruiting | NeurOptics Inc | 300 | 2026-05-04 | 2026-05-08 | |
| Assessing the Acute Effects of Virtual Reality Interventions on Stress VR (VR-Breathing+Mystical), VR (VR-Mystical), Computer (Non-VR-Breathing) - Slow Breathing | Not applicable | Recruiting | Prof. Dominique de Quervain, MD | 120 | 2026-03-05 | 2026-04-28 |
| Effects of Controlled Breathing on Cardiorespiratory Variables in Multiple Myeloma Controlled breathing exercise protocol + therapeutic exercise + initial education session, Therapeutic exercise + initial education session - Multiple Myeloma (MM), Breathing Techniques | Not applicable | Recruiting | Universidad Complutense de Madrid | 26 | 2026-02-11 | 2026-10-01 |
| Slow Breathing and Resistance Exercise in Fibromyalgia Slow Breathing with Visual Pacer, Slow Breathing without Visual Pacer, Spontaneous Breathing (Active Control) - Fibromyalgia, Fibromyalgia Syndrome | Not applicable | Enrolling by invitation | University of Malaga | 159 | 2026-02-01 | 2026-02-11 |
| Effects of Controlled Breathing Added to Therapeutic Exercise in Multiple Myeloma Controlled breathing exercise protocol + therapeutic exercise + initial education session, Therapeutic exercise + initial education session - Multiple Myeloma, Breathing Techniques | Not applicable | Recruiting | Universidad Complutense de Madrid | 32 | 2026-01-26 | 2026-10-01 |
| To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure). Use of NIV during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure, Use of HFNC during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure - Respiratory Failure With Hypercapnia, Therapeutic Bronchofiberoscopy | Not applicable | Not yet recruiting | Medical University of Silesia | 315 | 2025-10-01 | 2025-05-14 |
| Virtual Reality Relaxation for Insomnia Virtual reality relaxation intervention - Insomnia Disorder | Not applicable | Recruiting | Laval University | 30 | 2025-09-01 | 2026-06-05 |
| The Effect of Sarcopenic Obesity on Sleep in Individuals With Obesity Hypoventilation Syndrome Assessment-OHS, Assessment-Sarcopenic Obesity With OHS - Obesity Hypoventilation Syndrome (OHS), Obesity | Unknown | Istanbul University | 64 | 2025-07-10 | 2024-08-13 | |
| The Effect of Mask Design on Ventilation Parameters in COPD and OHS Patients on Long-term Home Non-invasive Ventilation. An Experimental Study. Investigational Mask, Conventional mask - COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS) | Not applicable | Not yet recruiting | Fisher and Paykel Healthcare | 20 | 2025-05-01 | 2025-05-15 |
| The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease Bronchial Asthma, Bronchiectasis | Recruiting | University College, London | 120 | 2025-04-30 | 2025-07-11 | |
| Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV) - Type II Respiratory Failure, Hypercapnic Respiratory Failure | Not applicable | Completed | Benha University | 200 | 2025-04-15 | 2026-08-25 |
| Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor IscAlert sensor - Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive | Completed | The Hospital of Vestfold | 21 | 2025-01-30 | 2026-06-11 | |
| PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study Ventilatory Failure, Hypoxemic Respiratory Failure | Recruiting | Unity Health Toronto | 80 | 2025-01-27 | 2025-05-20 | |
| Assessment of Breathing Pattern During NIV NIV mask A, NIV mask B - COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS) | Not applicable | Recruiting | Fisher and Paykel Healthcare | 40 | 2025-01-24 | 2025-05-11 |
| Risk Indicators and IPI Performance in Sedation-Related Respiratory Deterioration in COPD Sedation Analgesia and Respiratory Monitoring (Integrated Pulmonary Index - IPI) - COPD (Chronic Obstructive Pulmonary Disease), Endoscopy, Gastrointestinal | Completed | Umran Karaca | 100 | 2025-01-20 | 2025-12-04 | |
| Functional Capacity, Sleep Quality, and Cognitive Function in Obesity Hypoventilation Syndrome Obesity Hypoventilation Syndrome (OHS) | Completed | Bezmialem Vakif University | 36 | 2025-01-01 | 2026-07-10 | |
| Evaluation of Upper Extremity Functions in Obesity Hypoventilation Syndrome Patients Assessment - Obesity Hypoventilation Syndrome (OHS) | Not yet recruiting | Istanbul University - Cerrahpasa | 31 | 2025-01-01 | 2025-01-09 | |
| Non-invasive Monitoring of Mixed Venous Oxygen Saturation Using the Capnodynamic Method in Adults Ventilatory Failure, Cardiac Failure | Not yet recruiting | Fundación de Investigación Biomédica - Hospital Universitario de La Princesa | 25 | 2024-12-01 | 2024-10-10 | |
| Effects of End-inspiratory Pause on Ventilation mechanical ventilation setting - Acute Respiratory Distress Syndrome | Not applicable | Not yet recruiting | Clinica las Condes, Chile | 20 | 2024-11-20 | 2024-11-18 |
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Obesity Hypoventilation Syndrome (72) · Pulmonary Disease, Chronic Obstructive (30) · Respiratory Insufficiency (30) · Neuromuscular Diseases (18) · Sleep Apnea, Obstructive (14) · Hypoxia (12) · Obesity (11) · Sleep Apnea Syndromes (10) · Respiratory Aspiration (8) · Hypercapnia (7) · Respiratory Distress Syndrome (6) · COVID-19 (4) · Amyotrophic Lateral Sclerosis (3) · Respiration Disorders (3)
Respiratory Tract Diseases (162) · Respiration Disorders (159) · Respiratory Insufficiency (132) · Pathological Conditions, Signs and Symptoms (128) · Signs and Symptoms (107) · Signs and Symptoms, Respiratory (96) · Nervous System Diseases (93) · Dyssomnias (80) · Sleep Disorders, Intrinsic (80) · Apnea (78) · Nutritional and Metabolic Diseases (77) · Sleep Wake Disorders (77) · Nutrition Disorders (74) · Overnutrition (74) · Overweight (73)
Noninvasive Ventilation (12) · Acetazolamide (2) · Blood Gas Analysis (2) · Continuous Positive Airway Pressure (2) · Exercise Therapy (2) · Mindfulness (2) · Polysomnography (2) · Restraint, Physical (2) · Analgesics, Opioid (1) · Bariatric Surgery (1) · Calorimetry, Indirect (1) · Capnography (1) · Critical Pathways (1) · Diagnostic Tests, Routine (1) · Diet (1)
Guy's and St Thomas' NHS Foundation Trust (6) · Fisher and Paykel Healthcare (5) · ResMed (5) · Istanbul University (4) · Assiut University (3) · Beth Israel Deaconess Medical Center (3) · National Taiwan University Hospital (3) · Sociedad Española de Neumología y Cirugía Torácica (3) · University Hospital, Geneva (3) · University Hospital, Grenoble (3) · Wissenschaftliches Institut Bethanien e.V (3) · AGIR à Dom (2) · Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil (2) · Chang Gung Memorial Hospital (2) · Faculdade de Motricidade Humana (2)
United States (35) · France (18) · United Kingdom (15) · Spain (12) · Turkey (Türkiye) (11) · Egypt (6) · Germany (6) · Taiwan (5) · Canada (4) · New Zealand (4) · Portugal (4) · Singapore (4) · Switzerland (4) · Italy (3) · Netherlands (3)
Winfried J Randerath, Prof. Dr. (3) · Anita Simonds, MD, FRCP (2) · Gustavo Plaza-Manzano, PhD (2) · Joerg Steier, PhD (2) · Stephen McNulty, DO (2) · William Good, Medical degree (2) · Ahmed Mostafa Abdelhamid, Professor of Anesthesia (1) · Alain Kalmar, MD PhD (1) · Alexandre Demoule, MD, PHD (1) · Amartya Mukhopadhyay, MBBS (1) · Ana Fernandez-Bustamante, MD, PhD (1) · Anand R Rose, MD,FRACP (1)
PMID 25915102, PMID 26923627, PMID 27406165, PMID 29146865, PMID 30935737, PMID 31368798, PMID 10080847, PMID 10414409, PMID 10555090, PMID 11029353, PMID 11316667, PMID 11502631, PMID 11502632, PMID 11591566, PMID 1163544, PMID 12082446, PMID 12950321, PMID 14609453, PMID 15030692, PMID 15190137, PMID 15781100, PMID 16164877, PMID 16335330, PMID 17353076, PMID 17391112, PMID 18388356, PMID 18538199, PMID 18719057, PMID 18801962, PMID 19104167, PMID 1935291, PMID 19701463, PMID 20348200, PMID 20875161, PMID 20957853, PMID 21199816, PMID 21885724, PMID 22382596, PMID 22390777, PMID 22476448, PMID 22569877, PMID 23103736, PMID 23341888, PMID 23540885, PMID 23714281, PMID 23765764, PMID 24028180, PMID 24247410, PMID 24649370, PMID 25080050
2017 (1), 2025 (1), K23AG066929 (1), K99AT010158 (1), R00AT010158 (1), R41DA047779 (1), R44DA055407 (1), R61AT009340 (1)