37 completed, 14 unknown, 9 terminated, 6 withdrawn. 41 Not applicable, 3 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 41 | Completed 21, Terminated 6, Unknown 6, Withdrawn 5, Not yet recruiting 2, Recruiting 1 |
| Phase 2 | 3 | Completed 2, Not yet recruiting 1 |
| Phase 3 | 2 | Completed 2 |
| Phase 1 | 1 | Unknown 1 |
Follow Obesity Hypoventilation Syndrome: new trials by email Literature Review of Obesity Hypoventilation Syndrome trials Research Report on Obesity Hypoventilation Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea Sleep Inertia Questionnaire (SIQ) - Obstructive Sleep Apnea, Obesity (BMI>30) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 150 | 2026-11-01 | 2026-09-09 |
| The Effect of Sarcopenic Obesity on Sleep in Individuals With Obesity Hypoventilation Syndrome Assessment-OHS, Assessment-Sarcopenic Obesity With OHS - Obesity Hypoventilation Syndrome (OHS), Obesity | Unknown | Istanbul University | 64 | 2025-07-10 | 2024-08-13 | |
| The Effect of Mask Design on Ventilation Parameters in COPD and OHS Patients on Long-term Home Non-invasive Ventilation. An Experimental Study. Investigational Mask, Conventional mask - COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS) | Not applicable | Not yet recruiting | Fisher and Paykel Healthcare | 20 | 2025-05-01 | 2025-05-15 |
| The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease Bronchial Asthma, Bronchiectasis | Recruiting | University College, London | 120 | 2025-04-30 | 2025-07-11 | |
| Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor IscAlert sensor - Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive | Completed | The Hospital of Vestfold | 21 | 2025-01-30 | 2026-06-11 | |
| Assessment of Breathing Pattern During NIV NIV mask A, NIV mask B - COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS) | Not applicable | Recruiting | Fisher and Paykel Healthcare | 40 | 2025-01-24 | 2025-05-11 |
| Functional Capacity, Sleep Quality, and Cognitive Function in Obesity Hypoventilation Syndrome Obesity Hypoventilation Syndrome (OHS) | Completed | Bezmialem Vakif University | 36 | 2025-01-01 | 2026-07-10 | |
| Evaluation of Upper Extremity Functions in Obesity Hypoventilation Syndrome Patients Assessment - Obesity Hypoventilation Syndrome (OHS) | Not yet recruiting | Istanbul University - Cerrahpasa | 31 | 2025-01-01 | 2025-01-09 | |
| Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation Non-Invasive Ventilation - Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS) | Not applicable | Completed | Breas Medical, Inc. | 23 | 2024-10-03 | 2026-01-28 |
| The Effect of Obesity Hypoventilation Syndrome on Exercise Capacity, Peripheral Muscle Strength, and Quality of Life in Obese Individuals Assessment - Obesity Hypoventilation Syndrome, Obesity | Completed | Istanbul University | 64 | 2024-04-10 | 2025-10-02 | |
| Comfort of Patients Under Non Invasive Ventilation According to the Mask mask - COPD Exacerbation, Hypercapnia | Unknown | Assistance Publique - Hôpitaux de Paris | 80 | 2024-01-01 | 2024-01-18 | |
| HVNI Versus NIV In Management Of Acute Hypercapnic Respiratory Failure In OHS High-Velocity Nasal Insufflation Therapy, Non-Invasive Ventilation - Obesity Hypoventilation Syndrome (OHS) | Not applicable | Unknown | Assiut University | 56 | 2023-05-01 | 2023-04-07 |
| Evaluation of High Velocity Nasal Insufflation in Management of Respiratory Failure in Patients With Overlap Syndrome High Velocity Nasal Insufflation, Non-invasive mechanical ventilation - Overlap Syndrome, Obesity Hypoventilation Syndrome | Not applicable | Unknown | Assiut University | 50 | 2023-03-01 | 2022-07-20 |
| Telemedical Assistance in Automatic Titration of Oxygen for Intensive Care Patients PHASE 1 Lowenstein medical BiLevel Prisma 25ST device: withount oxygen support., PHASE 2. Continous/Bilevel positive airway presure with additional oxygen support by Devilbiss 525 KS oxygen concentrator - Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Lung Disease | Not applicable | Unknown | Pauls Stradins Clinical University Hospital | 30 | 2023-03-01 | 2023-10-19 |
| "Post-acute Pickwick Study" (Postacute-Pick-2020) "Lifestyle modifications" group (Control), Automatic NIV, CPAP treatment group - Acute on Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome (OHS) | Not applicable | Withdrawn | Juan F. Masa | 2023-01-01 | 2023-05-11 | |
| Transdisciplinary Intervention for Obesity Hypoventilation Syndrome CABS - Obesity Hypoventilation Syndrome (OHS), Obstructive Sleep Apnea (OSA) | Completed | Chang Gung Memorial Hospital | 36 | 2022-09-01 | 2025-06-13 | |
| Study of AD981 Versus Placebo in Obesity Hypoventilation Syndrome AD981, Placebo - Obesity Hypoventilation Syndrome (OHS) | Phase 2 | Completed | Istituto Auxologico Italiano | 15 | 2022-06-21 | 2025-02-27 |
| Effects of Exercise Training on Exercise Capacity and Sleep Quality in Patients With Obesity Hypoventilation Syndrome Exercises and Diet, Diet - Obesity Hypoventilation Syndrome (OHS), Hypoventilation | Not applicable | Completed | Istanbul University | 40 | 2022-06-15 | 2025-08-29 |
| Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom Nasal High Flow - Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease | Not applicable | Unknown | Royal Free Hospital NHS Foundation Trust | 54 | 2022-03-28 | 2023-12-14 |
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Pulmonary Disease, Chronic Obstructive (22) · Neuromuscular Diseases (14) · Obesity (12) · Sleep Apnea, Obstructive (12) · Respiratory Insufficiency (11) · Sleep Apnea Syndromes (6) · Hypoventilation (4) · Hypercapnia (3) · Respiration Disorders (3) · Sleep Wake Disorders (3) · Lung Diseases, Interstitial (2) · Overweight (2) · Respiratory Aspiration (2) · Acid-Base Imbalance (1)
Apnea (73) · Dyssomnias (73) · Nervous System Diseases (73) · Nutrition Disorders (73) · Nutritional and Metabolic Diseases (73) · Overnutrition (73) · Respiratory Tract Diseases (73) · Sleep Disorders, Intrinsic (73) · Overweight (71) · Respiration Disorders (70) · Sleep Wake Disorders (70) · Hypoventilation (69) · Sleep Apnea Syndromes (67) · Respiratory Insufficiency (62) · Obesity (61)
Noninvasive Ventilation (8) · Polysomnography (2) · Restraint, Physical (2) · Acetazolamide (1) · Bariatric Surgery (1) · Blood Gas Analysis (1) · Calorimetry, Indirect (1) · Capnography (1) · Continuous Positive Airway Pressure (1) · Critical Pathways (1) · Diagnostic Tests, Routine (1) · Diet (1) · Diet, Ketogenic (1) · Exercise (1) · Exercise Test (1)
Fisher and Paykel Healthcare (5) · Guy's and St Thomas' NHS Foundation Trust (5) · Istanbul University (4) · ResMed (4) · Assiut University (3) · Wissenschaftliches Institut Bethanien e.V (3) · AGIR à Dom (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · Philips Respironics (2) · Sociedad Española de Neumología y Cirugía Torácica (2) · University Hospital, Geneva (2) · Air Liquide Santé International (1) · Albert Einstein Healthcare Network (1) · Assistance Publique - Hôpitaux de Paris (1) · Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche (1)
France (15) · United Kingdom (11) · United States (8) · Turkey (Türkiye) (7) · Spain (6) · Germany (5) · New Zealand (4) · Egypt (3) · Switzerland (2) · Taiwan (2) · Australia (1) · China (1) · Italy (1) · Latvia (1) · Norway (1)
Winfried J Randerath, Prof. Dr. (3) · Joerg Steier, PhD (2) · William Good, Medical degree (2) · Alexandre Demoule, MD, PHD (1) · Anita Simonds (1) · Anita Simonds, MD, FRCP (1) · Anita Simonds, Pr (1) · Anne-Marie Gabrielsen, MD, PhD (1) · Ashraf Z El-Abdeen Mohammed, Professor (1) · Babak Mokhlesi, MD (1) · Babak Mokhlesi, MD, Prof (1)
PMID 25915102, PMID 26923627, PMID 27406165, PMID 29146865, PMID 30935737, PMID 31368798, PMID 10080847, PMID 10414409, PMID 10555090, PMID 11029353, PMID 11502631, PMID 11502632, PMID 11591566, PMID 1163544, PMID 12082446, PMID 15781100, PMID 16164877, PMID 16335330, PMID 17391112, PMID 18538199, PMID 1935291, PMID 19701463, PMID 20348200, PMID 20875161, PMID 20957853, PMID 21199816, PMID 21885724, PMID 22382596, PMID 22569877, PMID 23103736, PMID 23341888, PMID 23714281, PMID 24028180, PMID 24649370, PMID 25080050, PMID 25188896, PMID 25671545, PMID 25771402, PMID 26680503, PMID 26918192, PMID 27335651, PMID 27568890, PMID 27766147, PMID 27852952, PMID 27983582, PMID 28286047, PMID 28760549, PMID 28790808, PMID 28824451, PMID 28958052
UG3DA062506-02 (1)