98 completed, 75 unknown, 29 recruiting, 17 not yet recruiting. 92 Not applicable, 14 Phase 2, 10 Phase 3, 6 Phase 4, 1 Early Phase 1.
Follow Anastomotic Leak: new trials by email Literature Review of Anastomotic Leak trials Research Report on Anastomotic Leak
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Eso-SPONGE for Treating Leaks After Upper Gastrointestinal Surgery sponge-based Endoscopic Vacuum Therapy (EVT) using Eso-SPONGE - Anastomotic Leaks | Not applicable | Not yet recruiting | Boston Scientific Corporation | 74 | 2026-12-01 | 2026-10-19 |
| Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area Endo-SPONGE - Anastomotic Leaks, Hartmanns Stump Leakage | Not applicable | Recruiting | Boston Scientific Corporation | 66 | 2026-11-01 | 2026-10-19 |
| Surgical Intuition in Anastomotic Leakage After Colorectal Surgery Anastomotic Leaks | Recruiting | University Hospital, Basel, Switzerland | 4300 | 2026-10-01 | 2026-10-22 | |
| Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled Trial Betacyanin, Pelvic Drainage Fluid Betacyanin Assay - Rectum Cancer, Anastomotic Leak | Not applicable | Not yet recruiting | Southwest Hospital, China | 120 | 2026-08-20 | 2026-07-27 |
| COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green Laser Speckle Contrast Imaging - Leakage, Anastomotic, Colon Cancer | Not yet recruiting | Leiden University Medical Center | 30 | 2026-08-01 | 2026-07-22 | |
| VACStent Use for the Treatment of Anastomotic Leakage Following coloREctal Surgery VacStent GI Colon device - Colorectal Surgery, Anastomotic Leak Rectum | Not applicable | Not yet recruiting | Amsterdam UMC, location VUmc | 40 | 2026-07-01 | 2026-06-08 |
| The Value of Early Postoperative Colonoscopy in The Early Diagnosis of Anastomotic Leakage After Surgery for Low Colorectal Cancer electronic colonoscopy - Anastomotic Leakage | Not applicable | Recruiting | Nanchong Central Hospital | 140 | 2026-06-21 | 2026-06-25 |
| REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department Without a preventive stoma, With a preventive stoma - TME, Rectal Cancer Surgery | Not applicable | Recruiting | ANO Scientific and Practical Club for the Development of Modern Medical Technologies | 442 | 2026-05-05 | 2026-05-13 |
| The Transit Bipartition With the Use of a Metallic Anastomosis Clip and Circular Fundocorporeal Gastroplication Laparoscopic transit bipartition with Metallic Anastomotic Clip and Circular Fundocorporeal Gastroplication, Laparoscopic transit bipartition (gastroenteroanastomosis and entero-enteric anastomosis) use the Metallic Anastomotic Clip and with sleeve gastrectomy, laparoscopic duodenal transit bipartition using the Metallic Anastomotic Clip with circular fundocorporeal gastroplication without gastrectomy - Type 2 Diabetes Mellitus (T2DM), Obesity & Overweight | Not applicable | Recruiting | The Society of Bariatric and Metabolic Surgeons of Kazakhstan | 90 | 2026-04-30 | 2026-05-07 |
| Endoscopic COlorectal Mucosal Evaluation of Oxygen Tension A novel endoscopic imaging system that displays real-time oxygen saturation levels - Anastomotic Leak Rectum, Anastomotic Leak Large Intestine | Recruiting | Vanderbilt University Medical Center | 80 | 2026-03-16 | 2026-06-11 | |
| Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak Esophagectomy - Esophageal Malignant Neoplasm Primary, Anastomotic Leak | Recruiting | Memorial Sloan Kettering Cancer Center | 40 | 2026-02-25 | 2026-03-04 | |
| Perioperative Biomarkers in Colorectal and Gastric Cancer Surgery Perioperative Biomarker-Guided Monitoring - Colorectal (Colon or Rectal) Cancer, STOMACH NEOPLASM | Not applicable | Recruiting | Bucharest Emergency Hospital | 320 | 2026-02-25 | 2026-10-19 |
| Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery Percutaneous transluminal angiopasty and endovascular stenting of the superior mesenteric artery, Colon surgery, Mono antiplatelet therapy with Ascal 80mg daily - Mesenteric Vascular Disease, Colorectal Surgery | Not applicable | Recruiting | Medisch Spectrum Twente | 360 | 2026-02-01 | 2026-07-27 |
| Leakage Rate of Ileo-COlic Sutured Anastomosis After Right Hemicolectomy Monoplus Suture Material - Anastomotic Leak, Colon Cancer | Recruiting | Aesculap AG | 249 | 2026-01-26 | 2026-06-09 | |
| Single-Stapled Technique for Colorectal Anastomosis Single-stapled colorectal anastomosis, Double-stapled colorectal anastomosis - Colorectal Cancer, Colorectal Anastomosis | Recruiting | Umeå University | 500 | 2026-01-07 | 2026-02-18 | |
| Indocyanine Green-guided Omental Shield Anastomosis for Cervical Esophagogastric Anastomosis in Minimally Invasive McKeown Esophagectomy Indocyanine green-guided omental shield anastomosis for cervical esophagogastric anastomosis - Esophageal Squamous Cell Carcinoma (ESCC), Esophageal Cancer | Phase 2 | Not yet recruiting | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 73 | 2026-01-01 | 2026-01-29 |
| Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections Signia™ circular stapler with Tri-Staple™ Technology (Signia™ Circular Stapling system) - Colorectal Anastomosis, Left-sided Colon Resection | Not applicable | Recruiting | Medtronic - MITG | 137 | 2025-12-30 | 2026-09-01 |
| The SMART Trial: Modified Single-Stapled Anastomosis in Laparoscopic or Robotic Low Anterior Resection for Rectal Cancer Modified single-stapled anastomosis technique - Rectal Neoplasms, Rectal Neoplasms Malignant | Not applicable | Enrolling by invitation | Korea University Anam Hospital | 450 | 2025-12-20 | 2026-01-29 |
| Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate Pancreatic parenchymal injection of N-butyl-2- cyanoacrylate(Histoacryl®)Injection Group., Standard Pancreaticojejunostomy - Pancreaticoduodenectomy, Postoperative Pancreatic Fistula | Phase 2 | Recruiting | Minia University | 90 | 2025-12-01 | 2025-12-02 |
| Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior Resection Somatostatin, Clear Liquid Diet, Prophylactic Diverting Stoma - Rectal Cancer, Anastomotic Leakage | Not applicable | Recruiting | Tongji Hospital | 72 | 2025-11-17 | 2026-05-26 |
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Rectal Neoplasms (53) · Colorectal Neoplasms (39) · Esophageal Neoplasms (25) · Colonic Neoplasms (19) · Postoperative Complications (18) · Stomach Neoplasms (10) · Colitis, Ulcerative (6) · Crohn Disease (6) · Pancreatic Neoplasms (6) · Gastrointestinal Neoplasms (5) · Ileus (5) · Obesity, Morbid (5) · Surgical Wound Infection (5) · Diverticulitis (4)
Pathologic Processes (230) · Pathological Conditions, Signs and Symptoms (230) · Postoperative Complications (212) · Digestive System Diseases (147) · Gastrointestinal Diseases (142) · Neoplasms (131) · Neoplasms by Site (131) · Digestive System Neoplasms (128) · Gastrointestinal Neoplasms (120) · Intestinal Diseases (104) · Intestinal Neoplasms (92) · Rectal Diseases (82) · Colonic Diseases (56) · Colorectal Neoplasms (53) · Esophageal Diseases (28)
Indocyanine Green (4) · Metronidazole (3) · Proctectomy (3) · Surgical Procedures, Operative (3) · Anastomosis, Surgical (2) · Bioseal (2) · Blood Specimen Collection (2) · Colectomy (2) · Endoscopy (2) · Esophagectomy (2) · Fibrin Tissue Adhesive (2) · Ileostomy (2) · Neomycin (2) · Serum Albumin, Human (2) · Stents (2)
Amsterdam UMC, location VUmc (5) · Nanchong Central Hospital (5) · FluidAI Medical (4) · Odense University Hospital (4) · Alexandria University (3) · Charite University, Berlin, Germany (3) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (3) · Fudan University (3) · Hvidovre University Hospital (3) · Minia University (3) · Radboud University Medical Center (3) · Southwest Hospital, China (3) · Third Military Medical University (3) · University of Foggia (3) · Acibadem University (2)
China (45) · Italy (25) · United States (14) · Denmark (13) · Egypt (13) · Netherlands (13) · Spain (13) · France (12) · Germany (11) · Russia (8) · Switzerland (8) · Canada (7) · Belgium (6) · Turkey (Türkiye) (6) · Sweden (5)
Freek Daams, MD PhD (3) · Saleh K Saleh, MD (3) · Cheng-Le Zhuang, MD, PhD (2) · Niels Qvist, Professor (2) · Ziyu Li, MD PhD (2) · Adeline Germain, MD, PhD (1) · Ahmed Elshamy, MD (1) · Amber Jones, DO, MPH (1) · Anas Taha, Dr. med. (1) · Anass Majbar, MD (1) · Andrea Romboli, MD (1) · Annette Fritscher-Ravens, MD (1) · Antonino Agrusa, Professor (1) · Antonino Spinelli, M.D., Ph.D. (1) · Antonio Gil-Moreno, MD (1)
PMID 21394013, PMID 30527497, PMID 34613330, PMID 42548154, PMID 10789750, PMID 11379639, PMID 11496079, PMID 12168979, PMID 12194550, PMID 12791002, PMID 14578723, PMID 15051021, PMID 15273542, PMID 15555621, PMID 16259892, PMID 16607682, PMID 17072945, PMID 17390180, PMID 1742526, PMID 17506796, PMID 17708549, PMID 17917772, PMID 17981197, PMID 18193178, PMID 18358585, PMID 18483828, PMID 18564126, PMID 18585889, PMID 19016817, PMID 19228539, PMID 19258111, PMID 19841989, PMID 19879566, PMID 20004450, PMID 20100698, PMID 20332477, PMID 21037443, PMID 21107104, PMID 21107847, PMID 21149849, PMID 21541799, PMID 21557015, PMID 21769467, PMID 21909698, PMID 22411569, PMID 22646630, PMID 22748849, PMID 22986932, PMID 23011462, PMID 23014975
2019 (2), 2016 (1), 2023 (1)