182 completed, 74 unknown, 32 recruiting, 17 not yet recruiting. 120 Not applicable, 75 Phase 2, 35 Phase 4, 33 Phase 3, 29 Phase 1.
Follow Reperfusion Injury: new trials by email Literature Review of Reperfusion Injury trials Research Report on Reperfusion Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease | Early Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 30 | 2027-12-01 | 2026-03-17 |
| Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control) - Metabolic Syndrome, Vascular Injury | Early Phase 1 | Not yet recruiting | Gary Van Guilder | 68 | 2026-10-01 | 2025-02-13 |
| Safely Quenching Complement in Stroke Survivors Pegcetacoplan Injection [Empaveli] - Acute Ischemic Stroke, Cerebral Infarction | Phase 1 | Not yet recruiting | Columbia University | 20 | 2026-10-01 | 2026-04-29 |
| Spectroscopic Assessment of Myocardial Oxygenation Changes in Pediatric Heart Surgery Myocardial Ischemia, Heart Defects, Congenital | Recruiting | Spectrocor | 30 | 2026-09-17 | 2026-09-28 | |
| Timing of Empagliflozin in Primary PCI: Pre-Reperfusion Versus Post-Reperfusion Versus Placebo in South Asian STEMI Patients empagliflozin, Placebo - ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI) | Phase 2 | Not yet recruiting | Rehman Medical Institute - RMI | 480 | 2026-09-01 | 2026-08-06 |
| Breakthrough Platform Trial for PCAS Head Positioning, Temperature Control - Cardiac Arrest (CA), Post Cardiac Arrest Syndrome | Not applicable | Not yet recruiting | Kagawa University | 630 | 2026-09-01 | 2026-08-17 |
| The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal Transplantation Furosemide, Mannitol - Delayed Graft Function, Kidney Transplantation | Not applicable | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 160 | 2026-09-01 | 2026-09-18 |
| Combined Antioxidant Therapy for Acute Myocardial Infarction Combined antioxidant therapy, Placebo - Acute Myocardial Infarction (AMI), ST Elevation (STEMI) Myocardial Infarction | Phase 2 | Not yet recruiting | University of Chile | 46 | 2026-09-01 | 2026-08-20 |
| Inflammatory Markers and Prognosis After Cerebral Thrombectomy in Large Vessel Occlusion Prospective Mechanical Thrombectomy Cohort - Acute Ischemic Stroke, Large Vessel Occlusion | Not yet recruiting | Zhongshan Hospital Xiamen University | 50 | 2026-08-01 | 2026-08-10 | |
| Light Utilization COX-Inhibitory Device Therapy for Infant Cardiac Arrest (LUTICA Study). The LUCID Device is Used in the Treatment of Ischemic Brain Reperfusion Injury Caused by Cardiac Arrest in Pediatric Patients. LUTICIA - Light Utilization COX-Inhibitory Device) - Reperfusion Injury, Post Cardiac Arrest Brain Injury | Not applicable | Not yet recruiting | Mitovation, Inc | 30 | 2026-07-15 | 2026-04-29 |
| Avoiding Recooling After Normothermic Machine Perfusion in Liver Transplantation No Recooling Before Liver Implantation, Traditional Recooling Before Liver Implantation - Liver Transplantation (LT), Ischemia-Reperfusion Injury | Not applicable | Recruiting | The Mediterranean Institute for Transplantation and Advanced Specialized Therapies | 170 | 2026-07-07 | 2026-07-14 |
| Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial Infarction Xolatryp, Placebo - Myocardial Infarction, Reperfusion Injury | Phase 2 | Recruiting | Nyrada Pty Ltd | 300 | 2026-07-02 | 2026-10-06 |
| Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation Reperfusion Blood Discard, Standard Liver Transplantation - Liver Transplantation, Ischaemia Reperfusion Injury | Not applicable | Not yet recruiting | University of Sao Paulo General Hospital | 132 | 2026-07-01 | 2026-06-08 |
| New Biomarkers for Organ Viability Assessment During Hypothermic Machine Perfusion in Liver Transplantation: the Role of Extemporaneous Histological Examination. Hypothermic Oxygenated Machine Perfusion (HOPE/D-HOPE) - Liver Transplantation (LT), Early Allograft Dysfunction | Not applicable | Not yet recruiting | The Mediterranean Institute for Transplantation and Advanced Specialized Therapies | 150 | 2026-07-01 | 2026-06-29 |
| Perioperative Ursodeoxycholic Acid for Renal Protection in Adults Undergoing Partial Nephrectomy for Renal Tumors UDCA (Ursodeoxycholic acid), Placebo - Kidney Cancer | Phase 2 | Recruiting | Jinling Hospital, China | 162 | 2026-06-01 | 2026-10-15 |
| Hypothermic Machine Perfusion for Liver Graft Preservation Hypothermic Machine Perfusion, Static Cold Storage - Liver Transplant, Liver Failure | Not applicable | Not yet recruiting | University of Sao Paulo General Hospital | 40 | 2026-05-07 | 2026-05-19 |
| Prospective Reduction Of Transplant Complications Through Enhanced Preservation Therapy to Prevent Primary Graft Dysfunction Xo Port Organ Preservation System, Standard of Care - Ice packs - Primary Graft Dysfunction | Not applicable | Recruiting | University Health Network, Toronto | 50 | 2026-04-17 | 2026-07-13 |
| Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b) Non-invasive convective head cooling, Standard of Care (SOC) - Stroke, Acute Ischemic Stroke | Not applicable | Not yet recruiting | Auckland City Hospital | 182 | 2026-04-10 | 2026-04-13 |
| Remote Ischemic Preconditioning for Aute Type A Aortic Dissection Surgery Remote ischemic preconditioning (RIPC) - Aortic Dissection Type A | Not applicable | Recruiting | Fujian Medical University | 1312 | 2026-03-29 | 2026-09-16 |
| Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest Xenon - Post-Cardiac Arrest Syndrome | Phase 3 | Not yet recruiting | Invero Pharma, Inc. | 1436 | 2026-03-01 | 2025-04-03 |
Showing 20 of 339. Sign in to see all of them.
Myocardial Reperfusion Injury (56) · Myocardial Infarction (32) · Post-Cardiac Arrest Syndrome (30) · Primary Graft Dysfunction (25) · ST Elevation Myocardial Infarction (25) · Heart Arrest (23) · Myocardial Ischemia (16) · Out-of-Hospital Cardiac Arrest (13) · Inflammation (12) · Ischemia (12) · Ischemic Stroke (12) · Cardiovascular Diseases (11) · Delayed Graft Function (8) · Heart Failure (8)
Pathological Conditions, Signs and Symptoms (339) · Vascular Diseases (339) · Pathologic Processes (338) · Postoperative Complications (336) · Cardiovascular Diseases (328) · Heart Diseases (140) · Myocardial Ischemia (77) · Cardiomyopathies (55) · Ischemia (53) · Nervous System Diseases (53) · Infarction (52) · Necrosis (51) · Central Nervous System Diseases (49) · Brain Diseases (48)
Sodium Chloride (18) · Saline Solution (14) · Ischemic Postconditioning (7) · Sevoflurane (7) · Ascorbic Acid (5) · Atorvastatin (5) · Dexmedetomidine (5) · Morphine (5) · Blood Specimen Collection (4) · Control Groups (4) · Cyclosporine (4) · Standard of Care (4) · salicylhydroxamic acid (4) · Acetylcysteine (3) · Adenosine (3)
Radboud University Medical Center (17) · Chinese PLA General Hospital (6) · Hospices Civils de Lyon (6) · Medical University of Vienna (5) · University College, London (5) · University of Aarhus (5) · Xijing Hospital (5) · Policlinico Hospital (4) · University of Pennsylvania (4) · Dompé Farmaceutici S.p.A (3) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (3) · Mansoura University (3) · National Taiwan University Hospital (3) · Region Skane (3) · Universitas Indonesia (3)
United States (55) · China (40) · Netherlands (23) · Italy (20) · United Kingdom (18) · Canada (14) · Denmark (14) · France (13) · Turkey (Türkiye) (12) · Austria (10) · South Korea (10) · Germany (9) · Belgium (8) · Spain (8) · Sweden (8)
Amr M Yassen, MD (3) · Gerard Rongen, MD PhD (3) · Gerard Rongen, MD, Phd (3) · Blair Smith, MD (2) · Changxi Wang, M.D., Ph.D (2) · Christoph Testori, MD (2) · Cristina Rabadan-Diehl, PharmD, PhD (2) · Dai Yun Chen, MD (2) · Domeinco Pagano, MD FRCS (2) · Gerard Rongen, MD, PhD (2) · Ingegerd Dalfelt (2) · Jason D. Christie, MD (2) · Matteo Ravaioli, PhD (2) · Min-Shan Tsai, MD, PhD (2)
PMID 28286967, PMID 10231466, PMID 10446825, PMID 11283527, PMID 11604419, PMID 12143206, PMID 12219027, PMID 12234307, PMID 12389082, PMID 12411407, PMID 12548508, PMID 1382099, PMID 14762851, PMID 14987462, PMID 15229201, PMID 15251365, PMID 15358759, PMID 15618244, PMID 15645611, PMID 15670785, PMID 15698835, PMID 15788779, PMID 16904537, PMID 17123867, PMID 17336333, PMID 17394957, PMID 18371465, PMID 18381567, PMID 18653494, PMID 18948032, PMID 18954363, PMID 18963350, PMID 19081089, PMID 19092335, PMID 19094562, PMID 19151200, PMID 19300227, PMID 19359665, PMID 19564319, PMID 1963650, PMID 19638737, PMID 19715808, PMID 19762739, PMID 19906454, PMID 19996767, PMID 20118150, PMID 20129356, PMID 20137393, PMID 20189026, PMID 20409520
2009 (4), 2014 (3), 2025 (2), R01HL112815 (2), 2017 (1), R01HL081619 (1), R01HL087115 (1), R01HL151732 (1), U44NS125160 (1)