87 completed, 47 unknown, 17 recruiting, 8 terminated. 66 Not applicable, 22 Phase 4, 7 Phase 2, 3 Phase 3, 2 Phase 1.
Follow Postoperative Cognitive Dysfunction: new trials by email Literature Review of Postoperative Cognitive Dysfunction trials Research Report on Postoperative Cognitive Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine BrainProtect System, Standard perioperative management - Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Scienceforbrain, UAB | 304 | 2026-09-30 | 2026-10-14 |
| Effect of Ciprofol Injection on Postoperative Cognitive Function Ciprofol group, Propofol group - Postoperative Cognitive Dysfunction | Phase 4 | Active not recruiting | The Second Affiliated Hospital of Chongqing Medical University | 298 | 2026-06-01 | 2026-06-29 |
| Palmitoylethanolamide/Luteolin Supplementation in Older Adults Undergoing Cardiac Surgery co-ultramicronized Palmitoylethanolamide + Luteolin (700 mg + 70 mg in 10 ml), Standard of Care - Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Fondazione IRCCS San Gerardo dei Tintori | 100 | 2026-06-01 | 2026-07-02 |
| POCD After Major Gynecologic Surgery Postoperative Cognitive Dysfunction, Perioperative Neurocognitive Disorder | Recruiting | Fatihhan Zeytun | 72 | 2026-05-06 | 2026-06-12 | |
| Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty Ketamine - Postoperative Delirium, Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Istinye University | 80 | 2026-05-05 | 2025-05-09 |
| Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients Cognitive and Delirium Assessment (MoCA and CAM) - Postoperative Delirium, Postoperative Cognitive Dysfunction | Recruiting | Muğla Sıtkı Koçman University | 150 | 2026-04-05 | 2026-07-22 | |
| Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone Postoperative Cognitive Dysfunction | Not yet recruiting | Minia University | 50 | 2026-02-01 | 2026-02-10 | |
| Evaluation of the Ketogenic Diet to Improve Post Operative Cognitive Decline in Cardiac Surgery Ketogenic diet, Control diet - Postoperative Cognitive Dysfunction | Not applicable | Withdrawn | University of Missouri-Columbia | 2026-01-15 | 2026-06-02 | |
| Minimal-flow Anesthesia and Cognitive Outcomes in Elderly Surgical Patients Mini-Mental State Examination - Postoperative Cognitive Dysfunction | Not applicable | Completed | Ankara Etlik City Hospital | 90 | 2025-10-03 | 2026-03-18 |
| Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO] - Postoperative Cognitive Dysfunction, Orthopedic Procedures | Phase 3 | Recruiting | Romanian Society for Enteral and Parenteral Nutrition | 120 | 2025-10-01 | 2025-10-01 |
| Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery Sevoflurane group, Propofol group - Postoperative Cognitive Dysfunction, Postoperative Delirium | Not applicable | Not yet recruiting | General Hospital of Ningxia Medical University | 200 | 2025-09-15 | 2025-09-25 |
| Optic Nerve Sheath Diameter and Cognitive Outcomes in Bentall Surgery Postoperative Cognitive Dysfunction | Recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 100 | 2025-08-30 | 2026-03-06 | |
| The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy Remimazolam, Propofol - Remimazolam Besylate, Thoracoscopic Lobectomy | Phase 1 / Phase 2 | Not yet recruiting | Jinqiao Qian | 150 | 2025-08-01 | 2025-07-25 |
| Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass Transcranial Doppler measurement of the middle cerebral artery - Postoperative Cognitive Dysfunction, Delirium, Postoperative | Completed | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 110 | 2025-04-17 | 2026-10-20 | |
| Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor Transcutaneous acupoint electrical stimulation - Postoperative Cognitive Dysfunction | Not applicable | Not yet recruiting | Subei People's Hospital of Jiangsu Province | 238 | 2025-01-01 | 2024-09-20 |
| Effect of Pericapsular Nerve Group Block on Postoperative Cognitive Function Pericapsular nerve group block, No Pericapsular nerve group block - Total Hip Replacement, Pericapsular Nerve Group Bloc | Not applicable | Completed | Ankara City Hospital Bilkent | 84 | 2024-12-19 | 2025-08-15 |
| GDFT and Postoperative Cognitive Function in Geriatric Cancer Surgery Masimo Root Hemodynamic Monitoring - Postoperative Cognitive Dysfunction, Geriatrics | Completed | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 180 | 2024-12-01 | 2026-04-30 | |
| Older People's Neurocognitive Recovery After Cardiac Surgery Elective or urgent cardiac surgery - Postoperative Cognitive Dysfunction, Postoperative Recovery | Recruiting | Karolinska Institutet | 220 | 2024-11-01 | 2024-11-07 | |
| Effects of Dexmedetomidine on Postoperative Neurocognitive Disorder mini mental state assessment test, mini-cog test - Neurocognitive Disorder, Dexmedetomidine Infusion | Active not recruiting | Haseki Training and Research Hospital | 80 | 2024-10-13 | 2024-11-14 |
Showing 20 of 175. Sign in to see all of them.
Postoperative Cognitive Complications (175) · Emergence Delirium (51) · Delirium (21) · Cognitive Dysfunction (18) · Pain, Postoperative (11) · Postoperative Complications (9) · Cognition Disorders (6) · Depression (5) · Neurocognitive Disorders (5) · Neuroinflammatory Diseases (5) · Coronary Artery Disease (4) · Alzheimer Disease (3) · Frailty (3) · Neurologic Manifestations (3) · Pain (3)
Mental Disorders (175) · Pathologic Processes (175) · Pathological Conditions, Signs and Symptoms (175) · Neurocognitive Disorders (170) · Cognition Disorders (169) · Postoperative Complications (166) · Cognitive Dysfunction (157) · Signs and Symptoms (81) · Nervous System Diseases (80) · Neurologic Manifestations (76) · Neurobehavioral Manifestations (67) · Confusion (66) · Delirium (45) · Brain Diseases (16) · Central Nervous System Diseases (16)
Dexmedetomidine (10) · Propofol (9) · Sevoflurane (9) · Mental Status and Dementia Tests (5) · Midazolam (5) · Saline Solution (5) · Blood Specimen Collection (4) · Ketamine (4) · Sodium Chloride (4) · Anesthesia, General (3) · Desflurane (3) · Dexamethasone (3) · Spectroscopy, Near-Infrared (3) · Amantadine (2) · Anesthesia, Spinal (2)
Icahn School of Medicine at Mount Sinai (5) · University Hospital, Basel, Switzerland (4) · Heart and Brain Research Group, Germany (3) · RenJi Hospital (3) · University of Michigan (3) · Xuzhou Medical University (3) · Ankara City Hospital Bilkent (2) · Beijing Chao Yang Hospital (2) · Beni-Suef University (2) · Beth Israel Deaconess Medical Center (2) · Charite University, Berlin, Germany (2) · Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital (2) · Dr. Stephen Choi (2) · Han Yuan (2) · Jessa Hospital (2)
China (41) · United States (27) · Turkey (Türkiye) (20) · Germany (7) · Canada (6) · Italy (5) · Switzerland (5) · United Kingdom (5) · Brazil (4) · Croatia (4) · Egypt (4) · Russia (4) · Belgium (3) · Netherlands (3) · Sweden (3)
Nicolai Goettel, MD (3) · Claudia Spies, MD, Prof. (2) · Jeff Silverstein, MD (2) · Luzius A Steiner, MD, PhD (2) · Marius Butz, Dipl.-Psych. (2) · Maura Marcucci, MD (2) · Miles Berger, MD, PhD (2) · Stephen Choi, MD,FRCPC,MSc (2) · Susana Vacas, M.D., Ph.D. (2) · Tibo Gerriets, Prof.Dr.med. (2) · Alain Vuylsteke, MD (1) · Alex Bekker, MD, PhD (1) · Alina Borkowska, Professor (1) · Amira F Elgaml (1)
PMID 9525362, PMID 18156878, PMID 28593326, PMID 10439740, PMID 10686270, PMID 10881154, PMID 11032280, PMID 11065205, PMID 11425500, PMID 11772567, PMID 12088953, PMID 12648190, PMID 12707126, PMID 12817919, PMID 12960545, PMID 13688369, PMID 15010086, PMID 15374380, PMID 15728054, PMID 15781453, PMID 16571963, PMID 16616662, PMID 16901646, PMID 16934234, PMID 17297830, PMID 1742815, PMID 17934180, PMID 18345523, PMID 18662642, PMID 18820789, PMID 19128879, PMID 19224088, PMID 19379886, PMID 19422355, PMID 19573267, PMID 19820242, PMID 20042477, PMID 20585847, PMID 20938352, PMID 20948768, PMID 21194015, PMID 21222188, PMID 21233500, PMID 21490501, PMID 21945231, PMID 21945705, PMID 22014763, PMID 22037126, PMID 22245975, PMID 22321085
2016 (1), 2023 (1), K23AG048332 (1), K23GM152933 (1), P30AG028716 (1), R01AG029656 (1), R01AG046634 (1), R01AG075005 (1), R21HD098754 (1)