250 completed, 63 unknown, 28 recruiting, 25 terminated. 403 Phase 2, 96 Phase 3, 39 Phase 1.
Follow Pain, Postoperative: new trials by email Literature Review of Pain, Postoperative trials Research Report on Pain, Postoperative
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety of F14 Following Total Knee Replacement F14 (sustained release celecoxib) - Analgesia | Phase 2 / Phase 3 | Suspended | Arthritis Innovation Corporation | 100 | 2027-01-01 | 2026-06-05 |
| Efficacy of Intravenous Oxytocin to Speed Recovery After THA intravenous administration of oxytocin, Placebo - Total Hip Arthroplasty | Phase 2 | Enrolling by invitation | Wake Forest University Health Sciences | 80 | 2026-12-01 | 2026-10-23 |
| Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric Adenotonsillectomy Celecoxib, Acetaminophen, Dexamethasone - Adenotonsillectomy, Postoperative Pain | Phase 1 / Phase 2 | Not yet recruiting | NYU Langone Health | 500 | 2026-11-01 | 2026-10-13 |
| Reducing Opioid Use and Misuse After Wisdom Molar Extractions Twin block, iPill dispenser - Pain, Postoperative | Phase 2 | Suspended | Rutgers, The State University of New Jersey | 133 | 2026-11-01 | 2026-06-22 |
| The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration - Post Operative Pain, Acute, Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 40 | 2026-10-01 | 2026-09-21 |
| Dexmedetomidine as an Adjuvant to Greater Auricular Nerve Block in Middle Ear Surgeries Bupivacaine, Dexmedetomidine, Normal saline - Postoperative Pain, Middle Ear Surgery | Phase 2 | Recruiting | Minia University | 40 | 2026-09-25 | 2026-10-16 |
| A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction CYT-1010, Placebo - Acute Postoperative Pain, Dental Pain | Phase 1 / Phase 2 | Recruiting | Cytogel Pharma, LLC | 32 | 2026-09-25 | 2026-10-29 |
| Long-acting Local Vaginal Cuff Anesthesia Following Hysterectomy Combined Bupivacaine and Exparel, Normal Saline (NS) - Pain, Postoperative | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center, Houston | 104 | 2026-09-17 | 2026-09-25 |
| Jaw Muscle Pain Post Wisdom Molar Surgery Temporo-masseteric Nerve Block Injection, Oral Pain Medications only - Post Operative Pain, Impacted Third Molar Tooth | Phase 2 | Not yet recruiting | Rutgers, The State University of New Jersey | 80 | 2026-09-01 | 2026-06-18 |
| REctus Sheath Trial 1.0% lidocaine with epinephrine (1:100,000) - Acute Pain, Postoperative Pain, Acute | Phase 2 | Not yet recruiting | Duke University | 25 | 2026-09-01 | 2026-06-17 |
| Effect of Opioid-Sparing Anesthesia on Postoperative Opioid Consumption and Pain in Elderly Patients Undergoing Spine Surgery Opioid-Sparing Protocol, Routine anesthesia protocol - Opoid Managment, Pain Management | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-09-01 | 2026-09-08 |
| Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia Standard Bupivacaine, Liposomal Bupivacaine - Pain, Postoperative | Phase 2 | Recruiting | Washington University School of Medicine | 45 | 2026-08-01 | 2026-08-18 |
| Impact of RADA16 Use on Outcomes Following Tonsillectomy in Children RADA16 hydrogel - Postoperative Pain | Phase 2 | Recruiting | Rutgers, The State University of New Jersey | 134 | 2026-07-09 | 2026-07-22 |
| Phase II, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Omega-3 Fatty Acids as an Adjunct to Morphine in Acute Postoperative Pain Omega-3 fatty acids + Morphine group, Placebo+ Morphine group - Pain Postoperative, Analgesia | Phase 2 | Not yet recruiting | National University of La Rioja | 40 | 2026-06-15 | 2026-06-18 |
| Intraperitoneal Irrigation of Ondansteron in Combination With Lidocaine in Acute Postoperative Pain ondansteron - Acue Postoperative Pain | Phase 1 / Phase 2 | Recruiting | Assiut University | 20 | 2026-06-01 | 2026-07-15 |
| Evaluation of Postoperative Pain and Bacterial Load After Hyalone or Calcium Hydroxide Medication in Mandibular First Molars Hyalone, Calcium Hydroxide (Ca(OH)2) Intracanal Medication - Bacterial Load Reduction, Postoperative Pain | Phase 2 | Active not recruiting | Future University in Egypt | 28 | 2026-06-01 | 2026-08-20 |
| Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Abdominal Surgery HL-1186, HL-1186 placebo, Oxycodone-Acetaminophen - Postoperative Pain | Phase 2 / Phase 3 | Recruiting | Shanghai Huilun Pharmaceutical Co., Ltd. | 330 | 2026-05-11 | 2026-07-16 |
| Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Orthopedic Surgery HL-1186, HL-1186 placebo, Oxycodone-Acetaminophen - Postoperative Pain | Phase 2 / Phase 3 | Recruiting | Shanghai Huilun Pharmaceutical Co., Ltd. | 330 | 2026-05-09 | 2026-07-13 |
| The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis. anti-inflammatory ketorolac tromethamine - Postoperative Pain | Phase 2 | Not yet recruiting | Ain Shams University | 60 | 2026-04-11 | 2026-04-15 |
| MAG-PAIN - MAGnesium for Postoperative Analgesia In the Newly Delivered Magnesium group, Placebo - Postoperative Pain, Quality of Recovery (QoR-15) | Phase 2 | Not yet recruiting | Region Halland | 150 | 2026-04-02 | 2026-04-17 |
Showing 20 of 403. Sign in to see all of them.
Pain (55) · Agnosia (52) · Acute Pain (16) · Postoperative Nausea and Vomiting (12) · Chronic Pain (10) · Hernia, Inguinal (8) · Bunion (7) · Phantom Limb (6) · Neuralgia (5) · Postoperative Complications (5) · Toothache (5) · Hernia (4) · Obesity (4) · Breast Neoplasms (3)
Neurologic Manifestations (403) · Pathologic Processes (403) · Pathological Conditions, Signs and Symptoms (403) · Signs and Symptoms (402) · Postoperative Complications (398) · Pain (348) · Nervous System Diseases (73) · Neurobehavioral Manifestations (60) · Perceptual Disorders (57) · Pathological Conditions, Anatomical (18) · Musculoskeletal Diseases (17) · Signs and Symptoms, Digestive (15) · Neoplasms (13) · Neoplasms by Site (13) · Nausea (12)
Bupivacaine (70) · Saline Solution (30) · Acetaminophen (23) · Sodium Chloride (23) · Morphine (22) · Dexmedetomidine (21) · Ketamine (16) · Dexamethasone (15) · Epinephrine (15) · Ibuprofen (14) · Ropivacaine (14) · Ketorolac (13) · Lidocaine (12) · Pregabalin (10) · Injections (9)
Assiut University (34) · Heron Therapeutics (11) · Pacira Pharmaceuticals, Inc (8) · Cairo University (6) · Innocoll (6) · Vivozon, Inc. (6) · Adynxx, Inc. (5) · Ain Shams University (5) · Concentric Analgesics (5) · Sahiwal medical college sahiwal (5) · Sohag University (5) · Durect (4) · Grünenthal GmbH (4) · Qazvin University Of Medical Sciences (4) · Rutgers, The State University of New Jersey (4)
United States (156) · Egypt (58) · Canada (19) · China (14) · France (13) · Pakistan (11) · Germany (8) · Australia (7) · Denmark (7) · Brazil (6) · Greece (6) · United Kingdom (6) · Iran (5) · Italy (5) · South Korea (5)
David Prior (6) · Hala S Abdel-Ghaffar, MD (5) · Adeel Riaz, MD (4) · Seham M Moeen, MD (4) · Daneshvari Solanki, MD (3) · Donald C Manning, MD, PhD (3) · Gregory Bell, MD (3) · Kay Warnott, RN, ACNP (3) · Neil Singla, MD (3) · Seonjun Bae, MD, PhD (3) · David H Chi, MD (2) · Dmitri Lissin, MD (2) · Erol Onel, MD (2) · Fouad I Soliman, MD (2)
PMID 22900785, PMID 22510183, PMID 22792007, PMID 10613619, PMID 11323325, PMID 12145072, PMID 12148679, PMID 12807853, PMID 12873949, PMID 12907905, PMID 14665993, PMID 1517644, PMID 15230906, PMID 15616047, PMID 15680647, PMID 15919269, PMID 16400513, PMID 16436839, PMID 16698416, PMID 17312203, PMID 17341537, PMID 17437870, PMID 17678782, PMID 18042413, PMID 18498882, PMID 18648238, PMID 18844269, PMID 19092351, PMID 20052461, PMID 20418538, PMID 20632263, PMID 21368651, PMID 21470608, PMID 21851346, PMID 22013534, PMID 22066560, PMID 22227789, PMID 22286518, PMID 22337568, PMID 22546966, PMID 23041302, PMID 23049275, PMID 23063945, PMID 23152696, PMID 23241361, PMID 23271030, PMID 23370085, PMID 23390367, PMID 23545428, PMID 23719070
2019 (4), 2009 (2), 2014 (2), 1UG3DA048375-01 (1), 2016 (1), 2025 (1), P01NS119159 (1), R01HD037007 (1), R37GM048085 (1)