38 completed, 13 unknown, 12 terminated, 8 recruiting. 38 Not applicable, 11 Phase 3, 9 Phase 2, 7 Phase 4, 5 Phase 1.
Follow Pain, Intractable: new trials by email Literature Review of Pain, Intractable trials Research Report on Pain, Intractable
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain Resiniferatoxin - Intractable Pain, Palliative Care | Phase 1 / Phase 2 | Not yet recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 30 | 2026-11-27 | 2026-10-05 |
| Lidocaine Infusions for Pain in Patients With Malignant Bowel Obstruction Lidocaine - Malignant Bowel Obstruction, Cancer Pain | Not yet recruiting | Fundación Santa Fe de Bogota | 50 | 2026-11-01 | 2026-10-02 | |
| Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients ZenctuaryVR+ Interactive Virtual Reality - Palliative Care, Refractory Pain | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 20 | 2026-09-01 | 2026-04-22 |
| Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy Commercially available Inceptiv™ neurostimulation systems - Chronic Pain, Intractable Pain | Recruiting | Medtronic | 970 | 2026-04-17 | 2026-09-03 | |
| MRI Evaluation of Spinal Cord Edema After CT-Guided Percutaneous Cordotomy in Cancer Pain Patients CT-guided Percutaneous Cervical Cordotomy - Cancer Pain, Intractable Pain | Not yet recruiting | Mersin University | 15 | 2026-03-01 | 2026-02-10 | |
| Sensory Spinal Cord Stimulation Spinal cord stimulation (SCS) - Pain Management, Pain, Intractable | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 10 | 2026-01-06 | 2026-02-04 |
| Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control Boston Scientific WaveWriter Alpha™ SCS Systems - Chronic Pain, Intractable Pain | Not applicable | Recruiting | Boston Scientific Corporation | 70 | 2025-11-07 | 2026-10-13 |
| Study to Assess Epidural Resiniferatoxin for the Treatment of Intractable Pain Associated With Advanced Cancer Resiniferatoxin, Placebo - Pain, Intractable, Pain Cancer | Phase 2 | Suspended | Sorrento Therapeutics, Inc. | 120 | 2025-09-01 | 2024-03-18 |
| A Study of the Safety and Tolerability of GA in the Treatment of Patients With Refractory Neuropathic Pain GA+clozapine - Pain, Intractable | Early Phase 1 | Recruiting | Beijing Tiantan Hospital | 6 | 2024-09-11 | 2026-07-31 |
| Use of Ketamine in Severe Pain Syndromes Pain, Intractable, Pain, Chronic | Completed | Erasme University Hospital | 89 | 2024-08-01 | 2025-02-25 | |
| Radiosurgery for Severe Refractory Cancer Pain: A Sham-Controlled Pilot Trial Triple-target stereotactic radiosurgery, Sham radiosurgery - Cancer Pain, Refractory Pain | Not applicable | Terminated | Centro Internacional del Cáncer | 10 | 2024-04-01 | 2026-10-13 |
| Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofrequency for Refractory Trigeminal Neuralgia Bipolar pulsed radiofrequency, Mopolar pulsed radiofrequency - Trigeminal Neuralgia, Refractory Pain | Not applicable | Recruiting | Alexandria University | 20 | 2024-01-01 | 2025-01-17 |
| Effectiveness and Safety of Implantable Intrathecal Systems for Refractory Pain in Spain (INTRATHECAL-RENASED) Refractory Pain | Unknown | Sociedad Espanola del Dolor | 504 | 2023-08-01 | 2024-05-22 | |
| Study to Evaluate Neuromodulation Subject Experience With Contemporary Spinal Cord Stimulation (SCS) Modalities for Chronic Pain Commercially available neurostimulation systems - Pain, Intractable, Pain, Chronic | Terminated | MedtronicNeuro | 91 | 2023-04-25 | 2026-01-14 | |
| Medullary Stimulation for the Treatment of Refractory Neck Pain (S2M) Implantation of the WAVEWRITER ALPHA ™ device - Pain, Intractable | Not applicable | Recruiting | Nantes University Hospital | 12 | 2022-11-23 | 2024-11-18 |
| APP-based Precise Management System of Chronic Intractable Pain Precise management - Pain, Chronic, Pain, Intractable | Not applicable | Unknown | Beijing Tsinghua Chang Gung Hospital | 120 | 2022-09-26 | 2023-03-09 |
| Impact of DuoTherm Compared to TENS on Pain and Disability With Acute and Chronic Low Back Pain Duotherm VibraCool Back Device, TENS 8-channel unit - Acute Low-back Pain, Chronic Low-back Pain | Not applicable | Completed | MMJ Labs LLC | 160 | 2022-06-23 | 2025-07-18 |
| Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2022 and 2025 Ozone therapy - Radiation Toxicity, Chemotherapeutic Toxicity | Active not recruiting | Bernardino Clavo, MD, PhD | 105 | 2022-06-15 | 2026-09-25 | |
| Observational Study of Ketamine Infusions for the Treatment of Chronic Pain Ketamine - Chronic Pain | Enrolling by invitation | Theresa Lii | 100 | 2022-06-01 | 2025-12-19 |
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Chronic Pain (27) · Pain (16) · Neuralgia (13) · Back Pain (12) · Cancer Pain (12) · Agnosia (10) · Neoplasms (10) · Failed Back Surgery Syndrome (4) · Low Back Pain (4) · Somatoform Disorders (4) · Acute Pain (2) · Anxiety Disorders (2) · Complex Regional Pain Syndromes (2) · Depression (2)
Neurologic Manifestations (86) · Pathological Conditions, Signs and Symptoms (86) · Signs and Symptoms (86) · Pain (70) · Nervous System Diseases (27) · Neuromuscular Diseases (15) · Peripheral Nervous System Diseases (15) · Neurobehavioral Manifestations (11) · Mental Disorders (10) · Perceptual Disorders (10) · Pathologic Processes (9) · Back Pain (5) · Musculoskeletal Diseases (5) · Postoperative Complications (5) · Muscular Diseases (4)
Spinal Cord Stimulation (8) · Ketamine (6) · Fentanyl (3) · Morphine (3) · resiniferatoxin (3) · Analgesics, Opioid (2) · Cognitive Behavioral Therapy (2) · Dexmedetomidine (2) · Hydromorphone (2) · Lidocaine (2) · Methadone (2) · Propofol (2) · ziconotide (2) · Acetaminophen (1) · Acupuncture Therapy (1)
Boston Scientific Corporation (4) · MedtronicNeuro (4) · Abbott Medical Devices (3) · Assistance Publique - Hôpitaux de Paris (3) · Flowonix Medical (3) · Centre Hospitalier Universitaire de Nice (2) · Chulalongkorn University (2) · Institut Cancerologie de l'Ouest (2) · Janssen Pharmaceutical K.K. (2) · National Cancer Institute, Naples (2) · Rush University Medical Center (2) · Sorrento Therapeutics, Inc. (2) · University of Texas Southwestern Medical Center (2) · Vanderbilt University Medical Center (2) · Alexandria University (1)
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PMID 34854473, PMID 15992242, PMID 19470987, PMID 20959867, PMID 21587327, PMID 21683527, PMID 22105041, PMID 22200521, PMID 22248793, PMID 23102757, PMID 23215625, PMID 25135035, PMID 25751701, PMID 26357522, PMID 26814257, PMID 27187854, PMID 27730704, PMID 28431428, PMID 30271455, PMID 31992344, PMID 32379556, PMID 33738491, PMID 34812195, PMID 35263346, PMID 37310492, PMID 37642628, PMID 37691092, PMID 40423401, PMID 40901560, PMID 42189020
2008 (1), 7DP2NS136872-02 (1), R44DA049631 (1)