23 completed, 7 unknown, 2 not yet recruiting, 2 terminated. 37 Phase 2, 10 Phase 3, 8 Phase 1.
Follow Oxidative Stress: new trials by email Literature Review of Oxidative Stress trials Research Report on Oxidative Stress
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Relaxin Therapy for Atrial Fibrillation Relaxin, Placebo - Atrial Fibrillation (AF), Arrhythmia | Phase 1 / Phase 2 | Not yet recruiting | Deeptankar DeMazumder | 208 | 2027-01-01 | 2026-01-22 |
| Impact of Chromium Supplementation on Glucido-lipidic Metabolism, Oxidative Stress and Inflammatory State in Patients with Gestational Diabetes Oral chromium supplementation during gestational diabetes mellitus through the administration of chromium picolinate tablets (200 µg/d), Dietary Supplement: Oral chromium supplementation during gestational diabetes mellitus through the administration of chromium picolinate tablets (400 µg/d) - Gestational Diabetes Mellitus (GDM), Oxidative Stress | Phase 1 / Phase 2 | Not yet recruiting | University of Kasdi Merbah | 200 | 2025-05-01 | 2025-03-05 |
| NAC for Attenuation of COVID-19 Symptomatology N-acetylcysteine, Placebo - Covid19, COVID-19 Pneumonia | Phase 2 | Unknown | Cambridge Health Alliance | 200 | 2024-03-31 | 2023-08-07 |
| Effect of Supplementation With Anthocyanins on Iron Metabolism in Female Swimmers Black chokeberry extract in capsules with 18% standardization of the anthocyanins content, Chokeberry fiber in capsules - Iron Deficiencies, Inflammation | Phase 1 / Phase 2 | Completed | Poznan University of Physical Education | 22 | 2023-03-01 | 2024-07-03 |
| Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep, Placebo and Normoxia Sleep - Obstructive Sleep Apnea of Adult, Hypoxia, Brain | Phase 1 / Phase 2 | Recruiting | University of Calgary | 12 | 2023-01-01 | 2026-05-01 |
| Effect of Combined Antioxidant Therapy on Oxidative Stress Markers and Inflammatory Cytokines in Patients With Tinnitus Drusen Mega®, Sertraline, Placebo - Tinnitus, Subjective, Tinnitus, Bilateral | Phase 2 | Unknown | University of Guadalajara | 58 | 2022-12-01 | 2023-04-07 |
| Vitamin D, Oxidative Stress and Inflammation in Hemodialysis Cholecalciferol - Oxidative Stress, Inflammation | Phase 2 / Phase 3 | Completed | Ain Shams University | 25 | 2022-05-15 | 2023-02-06 |
| Oxytocin for Oxidative Stress and Inflammation Oxytocin nasal spray, Placebo nasal spray - Oxidative Stress, Inflammation | Phase 2 | Completed | Florida Institute for Human and Machine Cognition | 40 | 2022-02-01 | 2024-02-22 |
| The Effect of Enalapril, Losartan or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients Angiotensin converting enzyme inhibitor, Angiotensin Receptor Blockers - Oxidative Stress | Phase 2 | Completed | Unidad de Investigacion Medica en Enfermedades Renales | 39 | 2022-01-01 | 2022-02-09 |
| Effect of Topical Antioxidants in Dry Eye Disease and Diabetic Retinopathy VisuXL®, Lagricel PF®, Humylub PF® - Dry Eye Syndromes, Diabetic Retinopathy | Phase 2 | Unknown | Adolfo Daniel Rodriguez-Carrizalez | 78 | 2021-11-01 | 2022-06-29 |
| Impact of Vitamin C on Biomarkers of Neurologic Injury in Survivors of Cardiac Arrest Vitamin C, Placebo - Heart Arrest, Out-Of-Hospital, Biomarkers | Phase 2 | Unknown | University Medical Centre Maribor | 150 | 2020-10-01 | 2020-09-24 |
| Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease N-acetylcysteine - COVID, Sars-CoV2 | Phase 2 | Completed | Cambridge Health Alliance | 165 | 2020-09-23 | 2021-05-28 |
| Enriched Oxygen Mixtures in Athletes L-HBO, HBO, 30% O2 - Oxidative Stress, Stem Cell Research | Phase 2 | Completed | University of Padova | 42 | 2020-09-15 | 2021-04-30 |
| Garcinia Mangostana L Rind and Solanum Lycopersicum Fructus Trial to Prevent Exercise-induced Oxidative Stress Garcinia-mangostana-L-rind and Solanum-Lycopersicum-Fructus mixture-extract, Placebo Control - Exertion; Excess, Oxidative Stress | Phase 2 / Phase 3 | Unknown | Universitas Negeri Semarang | 30 | 2020-07-15 | 2019-07-30 |
| Combined Antioxidant Therapy on Oxidative Stress in Aqueous and Vitreous Humor of Diabetic Retinopathy Patients Combined antioxidant therapy, Placebo - Diabetic Retinopathy, Oxidative Stress | Phase 2 | Completed | University of Guadalajara | 40 | 2020-03-25 | 2022-04-01 |
| Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD Nicotinamide riboside - Vascular Diseases, Kidney Disease | Phase 2 | Active not recruiting | University of Colorado, Denver | 118 | 2019-11-19 | 2026-10-02 |
| Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia Omega 3, Nigella Sativa Oil, Hydroxyurea - Iron Overload, Oxidative Stress | Phase 2 / Phase 3 | Completed | Beni-Suef University | 350 | 2019-11-01 | 2021-01-27 |
| Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics Pyridoxine, Cobalamin, Placebo Oral Tablet - Schizophrenia, Drug Induced Movement Disorder, Unspecified | Phase 2 / Phase 3 | Unknown | Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara | 45 | 2019-09-03 | 2019-12-18 |
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia Alpha-lipoic acid, Placebo Oral Tablet - Schizophrenia, Oxidative Stress | Phase 2 / Phase 3 | Completed | Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara | 48 | 2019-09-01 | 2022-08-29 |
| Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients Nitrogen Gas for Inhalation, Blood withdrawal, Nitric Oxide - Cardiovascular Diseases, Oxidative Stress | Phase 2 | Withdrawn | Massachusetts General Hospital | 2019-07-25 | 2025-12-02 |
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Inflammation (9) · Pain (3) · Alzheimer Disease (2) · COVID-19 (2) · Cardiovascular Diseases (2) · Dementia (2) · Diabetes, Gestational (2) · Diabetic Nephropathies (2) · Diabetic Retinopathy (2) · Hyperlipidemias (2) · Muscle Weakness (2) · Proteinuria (2) · Renal Insufficiency, Chronic (2) · Schizophrenia (2) · Stroke (2)
Pathological Conditions, Signs and Symptoms (17) · Nutritional and Metabolic Diseases (11) · Pathologic Processes (11) · Metabolic Diseases (9) · Nervous System Diseases (9) · Signs and Symptoms (9) · Endocrine System Diseases (8) · Cardiovascular Diseases (7) · Diabetes Mellitus (7) · Mental Disorders (7) · Brain Diseases (6) · Central Nervous System Diseases (6) · Diabetes Complications (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Neurologic Manifestations (5)
Acetylcysteine (4) · Docosahexaenoic Acids (3) · Magnesium Oxide (2) · Thioctic Acid (2) · secoisolariciresinol diglucoside (2) · Acetaminophen (1) · Angiotensin Receptor Antagonists (1) · Angiotensin-Converting Enzyme Inhibitors (1) · Ascorbic Acid (1) · Capsules (1) · Cerebrovascular Circulation (1) · Cholecalciferol (1) · Core Binding Factors (1) · Deferoxamine (1) · Enalapril (1)
Universidad de Granada (3) · University of Guadalajara (3) · Cambridge Health Alliance (2) · Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara (2) · University of Saskatchewan (2) · Adolfo Daniel Rodriguez-Carrizalez (1) · Ain Shams University (1) · Beni-Suef University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Deeptankar DeMazumder (1) · Florida Institute for Human and Machine Cognition (1) · Indiana University (1) · Massachusetts General Hospital (1) · Oregon Health and Science University (1) · Poznan University of Physical Education (1)
United States (12) · Mexico (5) · Canada (4) · Spain (3) · Brazil (2) · Egypt (2) · Algeria (1) · Denmark (1) · France (1) · Germany (1) · Indonesia (1) · Italy (1) · Poland (1) · Saudi Arabia (1) · Slovenia (1)
Julio J Ochoa, Ph.D. (2) · Lia LO Sanders, MD, PhD (2) · Adolfo D Rodriguez-Carrizalez, M.D/PhD (1) · Adolfo D Rodriguez-Carrizalez, PhD, MD (1) · Ahmed F Mahmoud Hussein, MS.c (1) · Alejandra G Miranda-Diaz, PhD,MD,FACS (1) · Andrej Markota, MD, PhD, Assist. Prof. (1) · Daniel M Riche, Pharm.D. (1) · Deeptankar DeMazumder, MD, PhD (1) · Geannyne Villegas-Rivera, PhD, MD (1) · Gerardo Bosco, MD, PhD (1) · Henrik Enghusen Poulsen, Professor MD (1)
PMID 28159728, PMID 22088584, PMID 23333585, PMID 23431291, PMID 23804455, PMID 23827090, PMID 23875878, PMID 24077434, PMID 25057276, PMID 25899538, PMID 25988553, PMID 26235932, PMID 26290682, PMID 26896310, PMID 28922068, PMID 30753761, PMID 31182351, PMID 31322567, PMID 31547752, PMID 33451627, PMID 34532852, PMID 36584248, PMID 37532985, PMID 37916745, PMID 41264372
R21AT004490 (2), I01CX000264 (1), K23AT004251 (1), M01RR000334 (1), R01DK121516 (1), R21AG023805 (1)