283 completed, 89 unknown, 43 recruiting, 34 not yet recruiting. 140 Phase 2, 114 Not applicable, 65 Phase 4, 55 Phase 3, 38 Phase 1.
Follow Diabetic Nephropathies: new trials by email Literature Review of Diabetic Nephropathies trials Research Report on Diabetic Nephropathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Naoxintong Capsule for Diabetic Nephropathy With Dampness Retention Pattern: A Multicenter, Randomized, Double-Blind, Placebo-Controlled TrialAcronymNXT-DKD Naoxintong Capsule, Placebo - Diabetic Nephropathy | Phase 4 | Not yet recruiting | Chen Xiangmei | 410 | 2027-03-01 | 2026-07-13 |
| dApagliflozin SC0062 and Prevention of Renal Injury; a Randomized Evaluation Dapagliflozin (Forxiga®), SC0062 strength 10mg, SC0062 and dapagliflozin - Type 1 Diabetes Mellitus With Diabetic Nephropathy | Phase 2 | Not yet recruiting | University Medical Center Groningen | 36 | 2027-01-01 | 2026-10-20 |
| Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy Cognitive Behavioral Therapy (CBT), Oral Medication, Topical Medication - Painful Diabetic Neuropathy (PDN), Diabetic Nephropathies | Phase 4 | Not yet recruiting | University of Michigan | 600 | 2026-11-01 | 2026-10-21 |
| Clinical Predictors and Therapeutic Gaps in CKM Syndrome Among Adults With Type 2 Diabetes clinical and laboratory CKM staging evaluation - Type 2 Diabetes Mellitus, Cardiovascular-Kidney-Metabolic Syndrome | Not yet recruiting | Assiut University | 231 | 2026-10-20 | 2026-10-02 | |
| Impact of AI-Based Breath Ammonia Kidney Function Results on Clinical Pharmacist Medication Recommendations Diabetes Mellitus, Type 2, Diabetic Nephropathies | Not yet recruiting | Shanghai Pudong Hospital | 380 | 2026-10-09 | 2026-10-22 | |
| A Multicenter Randomized Double-Blind Trial of Chrocare CDSS for Integrated Management of Type 2 Diabetes AI large language model-based clinical decision support system, Standard diabetes integrated management formulated by endocrinologists - Type 2 Diabetes (T2DM), Diabetic Nephropathies | Not applicable | Not yet recruiting | Shanghai Jiao Tong University School of Medicine | 1200 | 2026-10-08 | 2026-09-22 |
| The Non-high-density Lipoprotein Cholesterol (Non-HDL-C) to High-density Lipoprotein Cholesterol (HDL-C) Ratio (NHHR) and Its Association With Occurrence of Diabetic Nephropathy in Patients With Diabetes Mellitus Diabetic Nephropathy, Dyslipidemia | Not yet recruiting | Assiut University | 84 | 2026-10-01 | 2026-03-17 | |
| Role of Triglyceride-Glucose Index and Inflammatory Biomarkers as Prognostic Tools for Progression of Diabetic Nephropathy Diabetes Mellitus, Diabetic Nephropathy | Not yet recruiting | Assiut University | 105 | 2026-10-01 | 2026-09-10 | |
| Role of Finerenone in African American Veterans With Diabetic Kidney Disease Finerenone 10 MG, Empagliflozin 10 MG - Diabetic Kidney Disease | Phase 4 | Not yet recruiting | Washington D.C. Veterans Affairs Medical Center | 30 | 2026-10-01 | 2026-08-21 |
| DEL-1 and Thromboxane A2 in Diabetic Nephropathy Patients No intervention - Nephropathy, Diabetic | Not yet recruiting | Aswan University | 80 | 2026-09-01 | 2026-08-06 | |
| Systemic Immune-Inflammation Index and Platelet Parameters in Diabetic Kidney Disease Diabetic Kidney Disease, Diabetic Nephropathies | Not yet recruiting | Assiut University | 120 | 2026-09-01 | 2026-08-19 | |
| Goal-Directed Therapy to Reduce Kidney and Cardiovascular Risk in Diabetic Kidney Disease (GOLD-STANDARD) Early goal-directed Cardio-Kidney-Metabolic (CKM) care, Standard care (Comparison arm) - Diabetic Kidney Disease (DKD), Type 2 Diabetes Mellitus (T2DM) | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 100 | 2026-08-26 | 2026-09-04 |
| The Relationship Between Psychological Well-being, Social Support, and Disease Self-management in Patients With Diabetic Nephropathy Diabetic Kidney Disease (DKD), Type 2 Diabetes | Not yet recruiting | National Taiwan University Hospital | 161 | 2026-08-07 | 2026-07-24 | |
| Evaluating the Effectiveness of a Smart Screening and Tiered Management Tool for Diabetic Kidney Disease in Primary Care: A Cluster Randomized Trial Intervention Name Clinical decision support system for diabetic kidney disease (DKD-CDSS), Routine guideline-based diabetes management - Type 2 Diabetes Mellitus, Diabetic Kidney Disease | Not applicable | Not yet recruiting | First Affiliated Hospital of Chongqing Medical University | 3000 | 2026-07-30 | 2026-07-16 |
| Finerenone for the Treatment of Type 2 Diabetes-Related Kidney Disease: Efficacy Observation and Related Factor Analysis Finerenone - Type 2 Diabetes Mellitus, Diabetic Kidney Disease | Not yet recruiting | First Affiliated Hospital of Chongqing Medical University | 425 | 2026-07-30 | 2026-07-21 | |
| Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cell Therapy in Diabetic Nephropathy Patients: A Clinical Trial Umbilical Cord Mesenchymal Stem Cells - Diabetic Nephropathy Type 2 | Phase 1 / Phase 2 | Recruiting | PT. Prodia Stem Cell Indonesia | 10 | 2026-07-01 | 2026-02-09 |
| Effect of Chinese Herbal Medicine on Renal Function in Diabetic Kidney Disease Chinese herbal formula DKD-1 - Diabetic Kidney Disease | Not applicable | Not yet recruiting | China Medical University Hospital | 66 | 2026-06-11 | 2026-06-18 |
| Diabetic Nephropathy, Glycemic Control and Pseudophakic Macular Edema After Cataract Surgery Phacoemulsification with posterior-chamber IOL - Pseudophakic Macular Edema, Diabetic Nephropathies | Active not recruiting | Thammasat University Hospital | 428 | 2026-06-01 | 2026-08-31 | |
| Evaluation of MTX-439 in Healthy Adults and Adults With Diabetic Kidney Disease MTX-439, Placebo - Healthy Adult Participants, Diabetic Kidney Disease | Phase 1 | Recruiting | Mediar Therapeutics | 88 | 2026-05-19 | 2026-06-29 |
| "Dapagliflozin vs Dapagliflozin-Finerenone for Albuminuria in CKD With Type 2 Diabetes" Dapagliflozin +Finerenone arm, Dapagliflozin arm - Diabetic Nephropathy | Phase 3 | Not yet recruiting | Chittagong Medical College | 88 | 2026-05-01 | 2026-05-20 |
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Diabetes Mellitus, Type 2 (126) · Diabetes Mellitus (90) · Renal Insufficiency, Chronic (83) · Kidney Diseases (58) · Proteinuria (42) · Albuminuria (38) · Diabetes Mellitus, Type 1 (37) · Hypertension (32) · Diabetes Complications (22) · Glomerulonephritis, IGA (14) · Diabetic Retinopathy (13) · Kidney Failure, Chronic (13) · Obesity (13) · Renal Insufficiency (12)
Female Urogenital Diseases (516) · Female Urogenital Diseases and Pregnancy Complications (516) · Male Urogenital Diseases (516) · Urogenital Diseases (515) · Urologic Diseases (512) · Endocrine System Diseases (511) · Diabetes Complications (494) · Kidney Diseases (458) · Diabetes Mellitus (426) · Nutritional and Metabolic Diseases (238) · Metabolic Diseases (232) · Glucose Metabolism Disorders (225) · Pathological Conditions, Signs and Symptoms (175) · Pathologic Processes (105) · Disease Attributes (96)
Losartan (17) · empagliflozin (11) · dapagliflozin (10) · finerenone (10) · p-Aminohippuric Acid (8) · Atrasentan (7) · Iohexol (7) · Lisinopril (7) · Spironolactone (7) · Ramipril (6) · Valsartan (6) · Angiotensin-Converting Enzyme Inhibitors (5) · Enalapril (5) · Standard of Care (5) · Telmisartan (5)
Assiut University (20) · University of Colorado, Denver (11) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (10) · Bayer (8) · Steno Diabetes Center Copenhagen (8) · Tanabe Pharma Corporation (7) · Ain Shams University (6) · Boehringer Ingelheim (6) · Chinese PLA General Hospital (6) · Tanta University (6) · Amsterdam UMC, location VUmc (5) · AstraZeneca (5) · Peter Rossing (5) · Shanghai Jiao Tong University School of Medicine (5) · University of Washington (5)
United States (151) · China (67) · Denmark (39) · Canada (34) · Japan (30) · Australia (27) · Germany (25) · Netherlands (24) · South Korea (24) · Egypt (23) · France (23) · Italy (21) · Spain (21) · Taiwan (21) · United Kingdom (19)
Petter Bjornstad, MD (5) · Alessandro Doria, MD PhD MPH (3) · Jamshid Roozbeh, MD (3) · LaTonya J Hickson, MD (3) · Michael Mauer, MD (3) · Yipeng Liu (3) · Anna Solini, MD, PhD (2) · Blai Coll, MD (2)
PMID 33107592, PMID 38682786, PMID 37916745, PMID 39171639, PMID 41805697, PMID 38770818, PMID 39963952, PMID 28756065, PMID 33358451, PMID 35224730, PMID 37872654, PMID 40526444, PMID 23986513, PMID 30990260, PMID 31583611, PMID 32974732, PMID 33131308, PMID 33264825, PMID 33280027, PMID 33782940, PMID 34449181, PMID 36251465, PMID 36287567, PMID 36328655, PMID 36639130, PMID 36645291, PMID 36864892, PMID 36927680, PMID 37716952, PMID 37745646, PMID 38046911, PMID 38048573, PMID 38449081, PMID 38508632, PMID 38537621, PMID 39380152, PMID 40009460, PMID 40315020, PMID 40333016, PMID 40498549, PMID 40892478, PMID 41196655, PMID 41198855, PMID 41289823, PMID 41533467, PMID 41665872, PMID 41679125, PMID 41827014, PMID 42234437, PMID 11128341
2015 (5), 2014 (4), 2005 (2), 2016 (2), 2017 (2), 2018 (2), R21AT004490 (2), 1KL2RR025015-01 (1), 2004 (1), 2009 (1), 2019 (1), I01CX000264 (1), K23DK082638 (1), K23HL159292 (1), P30DK017047 (1)