360 completed, 127 unknown, 72 recruiting, 45 terminated. 183 Not applicable, 99 Phase 2, 70 Phase 3, 51 Phase 4, 48 Phase 1.
Follow Diabetic Retinopathy: new trials by email Literature Review of Diabetic Retinopathy trials Research Report on Diabetic Retinopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Eye Health Intervention Study in Upper Manhattan Intervention, Usual Care - Glaucoma, Suspect, Diabetic Retinopathy | Not applicable | Withdrawn | Columbia University | 2027-04-01 | 2026-05-29 | |
| Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-02) OLN324, Aflibercept - Diabetic Macular Edema (DME) | Phase 3 | Not yet recruiting | Ollin Biosciences, Inc. | 450 | 2026-10-15 | 2026-09-25 |
| Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-03) OLN324, Aflibercept - Diabetic Macular Edema (DME) | Phase 3 | Not yet recruiting | Ollin Biosciences, Inc. | 450 | 2026-10-15 | 2026-09-25 |
| A Multicenter Randomized Double-Blind Trial of Chrocare CDSS for Integrated Management of Type 2 Diabetes AI large language model-based clinical decision support system, Standard diabetes integrated management formulated by endocrinologists - Type 2 Diabetes (T2DM), Diabetic Nephropathies | Not applicable | Not yet recruiting | Shanghai Jiao Tong University School of Medicine | 1200 | 2026-10-08 | 2026-09-22 |
| Screening for Diabetic RETINopathy Using a Non-mydriatic Retinograph Funduscope in Occupational MEDicine Non-mydriatic retinography, Self-administered questionnaire - Diabetic Retinopathy | Not applicable | Not yet recruiting | University Hospital, Clermont-Ferrand | 400 | 2026-10-01 | 2026-09-18 |
| Leveraging Artificial Intelligence to Prevent Vision Loss From Diabetes AI-BRIDGE, Educational Materials - Diabetic Retinopathy, Diabetes Mellitus | Not applicable | Recruiting | University of Wisconsin, Madison | 6900 | 2026-10-01 | 2026-10-22 |
| Randomized, Controlled Study to Investigate the 12-month Efficacy and Safety of Resveratrol Vitamin Supplements in Patients With Non-proliferative Diabetic Retinopathy Without Center Involved Diabetic Macular Edema (REVOLUTION Study) Resveratrol-Containing Vitamin Supplement - Diabetic Retinopathy, Non Proliferative Diabetic Retinopathy | Phase 4 | Completed | University of Athens | 100 | 2026-09-30 | 2026-10-09 |
| A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005) MK-8748, Aflibercept - Diabetic Retinopathy, Macular Edema | Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 1104 | 2026-09-25 | 2026-10-20 |
| Video Intervention to Improve Understanding of Diabetic Retinopathy at Zuckerberg San Francisco General Hospital and Trauma Center Animated Videos - Diabetic Retinopathy (DR), Macular Edema (ME) | Not applicable | Not yet recruiting | University of California, San Francisco | 150 | 2026-09-01 | 2026-07-22 |
| Continuous Delivery of Ranibizumab Via the Port Delivery System for Proliferative Diabetic Retinopathy-related Vitreous Hemorrhage With Pars Plana Vitrectomy and Limited PRP. PDS Implant filled with 100 mg/mL Ranibizumab, Ranibizumab - Proliferative Diabetic Retinopathy, Diabetic Retinopathy | Phase 4 | Not yet recruiting | Southeast Retina Center, Georgia | 20 | 2026-09-01 | 2026-10-13 |
| Glycemic Velocity and Early Retinal Microvascular Change With GLP-1RA Versus SGLT2i Initiation in Type 2 Diabetes (GLIDE) GLP-1 Receptor Agonists, SGLT2 inhibitor - Type 2 Diabetes Mellitus, Diabetic Retinopathy (DR) | Not yet recruiting | Thammasat University Hospital | 126 | 2026-09-01 | 2026-08-31 | |
| Intranasal Delivery of Octreotide for Treatment of Diabetic Macular Edema Octreotide (drug), Placebo - Diabetic Macular Edema | Phase 1 | Withdrawn | University of Alabama at Birmingham | 2026-08-31 | 2026-10-13 | |
| A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004) MK-8748, Aflibercept - Diabetic Retinopathy, Macular Edema | Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 960 | 2026-08-27 | 2026-10-20 |
| Pivotal Trial for an Automated AI-based System for Detection of Diabetic Retinopathy SaMD intended for the detection of diabetic retinopathy in adults with diabetes., An AI/ML-based Software as a Medical Device (SaMD) for the automated detection of diabetic retinopathy in adults with diabetes. - Diabetic Retinopathy (DR) | Recruiting | Digital Diagnostics, Inc. | 800 | 2026-08-24 | 2026-09-28 | |
| A Randomized, Phase 2 Study of Oral BGE-102 in Participants With Center-Involved Diabetic Macular Edema Oral BGE-102, Oral Placebo Matching BGE-102, Anti-VEGF - Diabetic Macular Edema (DME) | Phase 2 | Recruiting | BioAge Labs, Inc. | 180 | 2026-08-21 | 2026-09-10 |
| Relation Between Glycemic Control and Retinal Microvascular Changes in Diabetic Patients Using OCTA Diabetic Retinopathy (DR), Retinal Microvascular Changes | Not yet recruiting | Sohag University | 50 | 2026-08-01 | 2026-07-24 | |
| Pediatric Artificial Intelligence for Retinopathy Screening in Children With Type 1 Diabetes Non-mydriatic fundus camera photography, Fundus ophtalmoscopy, Optic coherence tomography - Type 1 Diabetes Mellitus | Not applicable | Recruiting | University Hospital, Motol | 400 | 2026-07-01 | 2026-07-20 |
| A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy RO7663498 - Diabetic Retinopathy | Phase 1 | Recruiting | Hoffmann-La Roche | 30 | 2026-06-18 | 2026-10-13 |
| Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema Surabgene Lomparvovec, Sham, Topical Steroid - Diabetic Retinopathy | Phase 2 / Phase 3 | Recruiting | AbbVie | 576 | 2026-06-01 | 2026-10-16 |
| Community-Based Eye Screening With Structured Referral Tracking for Preventing Avoidable Blindness in Adults in Rawalpindi, Pakistan Structured Referral Tracking (SRT) - Cataract, Refractive Error | Not applicable | Not yet recruiting | Health Services Academy, Islamabad, Pakistan | 500 | 2026-06-01 | 2026-06-04 |
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Diabetes Mellitus (142) · Macular Degeneration (94) · Macular Edema (75) · Retinal Diseases (55) · Glaucoma (40) · Retinal Vein Occlusion (38) · Diabetes Mellitus, Type 2 (37) · Diabetes Mellitus, Type 1 (27) · Cataract (23) · Eye Diseases (23) · Vision Disorders (19) · Diabetes Complications (13) · Diabetic Nephropathies (13) · Vitreous Hemorrhage (12)
Endocrine System Diseases (682) · Vascular Diseases (679) · Cardiovascular Diseases (678) · Diabetic Angiopathies (678) · Diabetes Complications (669) · Eye Diseases (659) · Retinal Diseases (627) · Diabetes Mellitus (540) · Metabolic Diseases (184) · Nutritional and Metabolic Diseases (184) · Glucose Metabolism Disorders (183) · Retinal Degeneration (147) · Pathological Conditions, Signs and Symptoms (94) · Macular Degeneration (57) · Nervous System Diseases (56)
aflibercept (45) · Ranibizumab (38) · Bevacizumab (29) · Tomography, Optical Coherence (15) · Triamcinolone Acetonide (14) · salicylhydroxamic acid (14) · Calcium Dobesilate (7) · Dexamethasone (7) · Fenofibrate (7) · Lasers (7) · Mydriatics (7) · Blood Specimen Collection (6) · Vitrectomy (6) · Fluorescein Angiography (5) · Octreotide (5)
National Eye Institute (NEI) (25) · Association for Innovation and Biomedical Research on Light and Image (16) · University of Sao Paulo (13) · Novartis Pharmaceuticals (11) · Jaeb Center for Health Research (9) · Zhongshan Ophthalmic Center, Sun Yat-sen University (9) · Sun Yat-sen University (7) · University of Alabama at Birmingham (7) · University of Wisconsin, Madison (7) · Assiut University (6) · Bayer (6) · Hospital Juarez de Mexico (6) · Medical University of Vienna (6) · National Taiwan University Hospital (6) · University of California, San Francisco (6)
United States (246) · China (60) · United Kingdom (36) · France (28) · Italy (27) · Spain (25) · Germany (22) · Mexico (22) · Portugal (22) · Brazil (21) · Egypt (21) · Canada (20) · Denmark (19) · Australia (17) · Puerto Rico (16)
Maria B Grant, MD (4) · Pablo Velazquez-Martin, MD (4) · Karl Beutner (3) · Sloan Rush (3) · Yao Liu, MD, MS (3) · Ahmed A Abdel-Kader, MD, PhD (2) · Ahmed A Mohalhal, MD, PhD (2) · Andrii MD Korol, PhD (2) · Ayman G Elnahry, MD, PhD (2)
PMID 26089210, PMID 21571677, PMID 25439614, PMID 37260074, PMID 18441312, PMID 20008710, PMID 20427088, PMID 20580421, PMID 22999634, PMID 24680929, PMID 26802783, PMID 27388251, PMID 28785768, PMID 31139483, PMID 31304320, PMID 32411431, PMID 32427087, PMID 33206392, PMID 39966603, PMID 10360304, PMID 10724830, PMID 10758220, PMID 10857967, PMID 10990036, PMID 11351356, PMID 11522720, PMID 12145239, PMID 13129861, PMID 13729802, PMID 14706060, PMID 15078674, PMID 15534124, PMID 15671304, PMID 16021194, PMID 16490489, PMID 16505050, PMID 16508446, PMID 16513455, PMID 16681561, PMID 16723443, PMID 17208303, PMID 17275910, PMID 17342504, PMID 17353400, PMID 17420374, PMID 17460251, PMID 17585001, PMID 17601545, PMID 17621193, PMID 17698196
U10EY014231 (6), U10EY014229 (5), U10EY018817 (5), 2019 (4), 2016 (3), 2015 (2), 2017 (2), 9SB1EY027241 (2), R44EY026864 (2), 1UG1EY032446 (1), 1UG1EY032446-01 (1), 2009 (1), 2014 (1), 2018 (1), 2023 (1)