Oxidative Stress: Clinical Trials

309 completed, 64 unknown, 32 recruiting, 16 not yet recruiting. 277 Not applicable, 37 Phase 2, 27 Phase 1, 24 Phase 3, 18 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	277	Completed 198, Unknown 25, Recruiting 23, Not yet recruiting 11, Active not recruiting 10, Terminated 5, Enrolling by invitation 3, Suspended 1, Withdrawn 1
Phase 2	37	Completed 23, Unknown 7, Not yet recruiting 2, Terminated 2, Active not recruiting 1, Recruiting 1, Withdrawn 1
Phase 1	27	Completed 19, Withdrawn 3, Not yet recruiting 2, Recruiting 1, Terminated 1, Unknown 1
Phase 3	24	Completed 13, Unknown 9, Terminated 2
Phase 4	18	Completed 10, Unknown 7, Terminated 1
Early Phase 1	8	Completed 5, Active not recruiting 1, Enrolling by invitation 1, Unknown 1

Follow Oxidative Stress: new trials by email Literature Review of Oxidative Stress trials Research Report on Oxidative Stress

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Relaxin Therapy for Atrial Fibrillation Relaxin, Placebo - Atrial Fibrillation (AF), Arrhythmia	Phase 1 / Phase 2	Not yet recruiting	Deeptankar DeMazumder	208	2027-01-01	2026-01-22
Effects of Manual Acupuncture on Malondialdehyde Levels and State Anxiety Inventory Scores in Active Smokers The manual acupuncture therapy, The sham manual acupuncture therapy - Oxidative Stress	Not applicable	Not yet recruiting	Universitas Indonesia	44	2026-11-01	2026-11-09
Impact of Electronic Cigarette Temperature and Solvent on Biomarkers High temperature wattage setting on electronic cigarette, Low temperature wattage setting on electronic cigarette, High concentration of Propylene Glycol - Oxidative Stress, Tobacco Use	Not applicable	Not yet recruiting	Milton S. Hershey Medical Center	50	2026-10-15	2026-09-15
Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy Natural Non-Alkalized Cocoa, Polyphenol-Rich Dietary Counseling - Pregnancy, Gestational Diabetes Mellitus (GDM)	Not applicable	Not yet recruiting	University of Salamanca	60	2026-09-01	2026-06-18
Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention - Air Pollution Exposure, Oxidative Stress	Not applicable	Not yet recruiting	Georgia Southern University	20	2026-09-01	2026-09-01
NVTIA® Ergothioneine for Healthy Aging and Skin Health NVTIA® Ergothioneine, Placebo - Healthy Aging, Skin Aging	Not applicable	Recruiting	EUROPEAN LIFE SCIENCE RESEARCH ASSOCIATION	50	2026-08-15	2026-08-06
Black Forest Cocoa Flavanol Supplementation and Health Trial Cocoa Flavanol Supplement, Low-Flavanol Control Powder - Endothelial Function, Oxidative Stress	Not applicable	Not yet recruiting	The Black Forest LLC	90	2026-08-15	2026-08-05
Vitamin D Status and Asthma Control, Pulmonary Function, and Oxidative Stress in Adults With Bronchial Asthma Bronchial Asthma, Vitamin D Deficiency		Not yet recruiting	Sinai University	134	2026-07-26	2026-07-29
Pumpkin Seed Oil as a Nutraceutical for Hemodialysis Patients Pumpkin Seed Oil 1000 mg, Standard hemodialysis care - End Stage Renal Disease, Chronic Kidney Disease Requiring Chronic Dialysis	Not applicable	Recruiting	Al-Mustansiriyah University	100	2026-07-20	2026-07-17
Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers Scaling and Root Planing, Hyaluronic Acid (HYADENT BG) - Hyaluronic Acid, Periodontal Therapy	Not applicable	Recruiting	Marmara University	23	2026-07-13	2026-08-18
Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers. supplementation, food - Prediabetes, Obesity & Overweight	Not applicable	Not yet recruiting	National and Kapodistrian University of Athens	60	2026-07-01	2026-06-22
Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling Post-exercise Recovery - Athletic Performance, Hyperbaric Oxygenation	Not applicable	Recruiting	Université Catholique de Louvain	48	2026-07-01	2026-11-06
OpioidRedoxStudyII Oxidative Stress, Opioid Use		Not yet recruiting	EPC Education s.r.o.	120	2026-06-30	2026-01-13
Evaluation of the Effect of Hyperuricemia on Alveolar Bone Loss Collection of gingival crevicular fluid (GCF) and serum samples, Measurement of periodontal clinical parameters - Periodontal Diseases, Hyperuricemia		Recruiting	Recep Tayyip Erdogan University Training and Research Hospital	80	2026-06-10	2026-06-26
Effect of Cordyceps Supplementation Timing on Physiological Responses and Aerobic Adaptation in Athletes Pre-Exercise Cordyceps Sinensis, Post-Exercise Cordyceps Sinensis, Placebo - Exercise Recovery, Exercise-induced Muscle Damage	Not applicable	Completed	Surabaya State University	30	2026-06-09	2026-08-25
Effects of Magnesium and Spinning Training on Echocardiographic, Inflammatory, and Aerobic Outcomes Spinning Training, Magnesium Supplementation - Oxidative Stress, Inflammation	Not applicable	Enrolling by invitation	Karamanoğlu Mehmetbey University	48	2026-06-01	2026-06-23
Ginger in the Modulation of Inflammatory Cytokines and Oxidative Stress in Patients With Coronary Artery Disease Ginger, Placebo - Coronary Artery Disease (CAD), Oxidative Stress	Not applicable	Not yet recruiting	Universidade Federal Fluminense	50	2026-05-18	2026-05-19
Effects of Royal Jelly and Propolis on Metabolomic Signatures, Inflammation, and Cardiovascular Risk in Patients With Coronary Artery Disease. Propolis + Royal Jelly, Placebo - Coronary Artery Disease (CAD), Oxidative Stress	Not applicable	Not yet recruiting	Universidade Federal Fluminense	50	2026-05-18	2026-05-19
Impact of Ganoderma Lucidum on NRF2 Levels and Antioxidant Status in Metabolic Asscociated Fatty Liver Disease (GL-MAFLD-NRF2 Study) Starch Placebo, Ganoderma lucidum - MAFLD, Fatty Liver	Not applicable	Enrolling by invitation	University of Agriculture, Peshawar	40	2026-04-28	2026-05-04
Mediterranean Diet and Oxidative Stress in Type 1 Diabetes (MEDOX-T1D) Mediterranean Diet Intervention - Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System	Not applicable	Not yet recruiting	Istanbul University	54	2026-04-01	2026-04-29

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Narrower conditions

Inflammation (106)  ·  Insulin Resistance (17)  ·  Cardiovascular Diseases (16)  ·  Diabetes Mellitus, Type 2 (13)  ·  Motor Activity (12)  ·  Metabolic Syndrome (10)  ·  Obesity (10)  ·  Atherosclerosis (9)  ·  Diabetes Mellitus (9)  ·  Dyslipidemias (9)  ·  Renal Insufficiency, Chronic (9)  ·  Coronary Artery Disease (8)  ·  Hypertension (8)  ·  Diabetes, Gestational (6)  ·  Hyperlipidemias (6)

Broader conditions

Pathological Conditions, Signs and Symptoms (181)  ·  Pathologic Processes (142)  ·  Nutritional and Metabolic Diseases (103)  ·  Metabolic Diseases (79)  ·  Signs and Symptoms (59)  ·  Glucose Metabolism Disorders (52)  ·  Nervous System Diseases (48)  ·  Urogenital Diseases (45)  ·  Cardiovascular Diseases (43)  ·  Vascular Diseases (43)  ·  Endocrine System Diseases (41)  ·  Female Urogenital Diseases and Pregnancy Complications (40)  ·  Behavior (36)  ·  Hyperinsulinism (27)  ·  Diabetes Mellitus (26)

Interventions

Acetylcysteine (14)  ·  Ascorbic Acid (12)  ·  Exercise (7)  ·  Melatonin (7)  ·  Resistance Training (7)  ·  Thioctic Acid (6)  ·  Dexmedetomidine (5)  ·  Vitamin E (5)  ·  maltodextrin (5)  ·  Antioxidants (4)  ·  Control Groups (4)  ·  Docosahexaenoic Acids (4)  ·  Acetaminophen (3)  ·  Blood Specimen Collection (3)  ·  Cholecalciferol (3)

Sponsors

Universidade Federal Fluminense (8)  ·  University of Thessaly (8)  ·  Universitas Indonesia (7)  ·  Ain Shams University (4)  ·  Applied Science & Performance Institute (4)  ·  Milton S. Hershey Medical Center (4)  ·  Palacky University (4)  ·  University of Guadalajara (4)  ·  Chang Gung Memorial Hospital (3)  ·  Fudan University (3)  ·  Green Beat (3)  ·  Harokopio University (3)  ·  Istanbul University (3)  ·  Loughborough University (3)  ·  Mardin Artuklu University (3)

Countries

United States (95)  ·  Turkey (Türkiye) (58)  ·  Brazil (21)  ·  Spain (21)  ·  Italy (20)  ·  Greece (17)  ·  Indonesia (15)  ·  Canada (14)  ·  China (11)  ·  Mexico (11)  ·  Taiwan (10)  ·  United Kingdom (10)  ·  Egypt (9)  ·  Poland (9)  ·  France (8)

Top investigators

Athanasios Z Jamurtas, PhD (3)  ·  Jonathan Himmelfarb, MD (3)  ·  A V Rao, PhD (2)  ·  Athanasios Z Jamurtas, Dr (2)  ·  Athanasios Z. Jamurtas, Professor (2)  ·  Chad M Kerksick, PhD (2)  ·  David Stensel (2)  ·  Julio J Ochoa, Ph.D. (2)  ·  Kyung-Jin Yeum, Ph.D. (2)  ·  Lia LO Sanders, MD, PhD (2)  ·  Manfred Lamprecht, PhD PhD (2)  ·  Rafaela G Feresin, PhD (2)  ·  Reto Auer, Prof.Dr.med (2)

Results publications

PMID 37916745, PMID 28159728, PMID 10488881, PMID 10799367, PMID 10890625, PMID 10924859, PMID 11089981, PMID 11090571, PMID 11160074, PMID 11283527, PMID 11325214, PMID 11359957, PMID 11574369, PMID 11883375, PMID 12163793, PMID 12235470, PMID 12396892, PMID 12570108, PMID 12626396, PMID 14568884, PMID 14605526, PMID 15068787, PMID 15209994, PMID 15229201, PMID 15564614, PMID 15579058, PMID 15919682, PMID 15981230, PMID 16040783, PMID 16195010, PMID 16213850, PMID 16506966, PMID 16937951, PMID 16953900, PMID 17172986, PMID 17182613, PMID 17298965, PMID 17376663, PMID 17486089, PMID 17509462, PMID 17671825, PMID 18005455, PMID 18006683, PMID 18030938, PMID 18166260, PMID 18191218, PMID 18555988, PMID 18993042, PMID 19081089, PMID 19381778

NIH funding

2017 (2), R21AT004265 (2), R21AT004490 (2), U54DA058271 (2), UL1TR001082 (2), 2005 (1), I01CX000264 (1), K23AT004251 (1), K23HD083511 (1), K23HL079114 (1), M01RR000334 (1), P20GM109040 (1), P50DA036107 (1), R01AG039396 (1), R01CA173465 (1)