67 completed, 20 unknown, 8 recruiting, 7 terminated. 36 Phase 4, 31 Phase 3, 20 Phase 2, 14 Not applicable, 8 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) Finerenone, Semaglutide, Lotensin - Chronic Kidney Disease, Type 2 Diabetes | Phase 4 | Enrolling by invitation | Baylor Research Institute | 64 | 2026-04-08 | 2026-10-13 |
| Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes Testosterone Enanthate, Testosterone Cypionate, Testosterone Propionate - Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes | Not applicable | Enrolling by invitation | Enhanced Emirates Limited | 60 | 2026-03-12 | 2026-05-06 |
| Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study Nifedipine and Enalapril, Nifedipine and Labetalol - Hypertension, Postpartum Preeclampsia | Not applicable | Recruiting | The Cleveland Clinic | 200 | 2026-03-10 | 2026-08-03 |
| Cardiovascular Protection After Preeclampsia With Enalapril Enalapril, Standard treatment - Preeclampsia, Hypertensive Disorder of Pregnancy | Phase 3 | Recruiting | Women and Infants Hospital of Rhode Island | 60 | 2026-01-01 | 2026-08-06 |
| Postpartum Evaluation of Nifedipine and Enalapril for Hypertension Enalapril 10mg QD, Nifedipine 30mg XL BID - Hypertension in Pregnancy | Phase 4 | Recruiting | Nebraska Methodist Health System | 850 | 2025-07-11 | 2025-10-22 |
| A Study of Enalapril in Treatment of Venous Malformations Enalapril - Venous Malformation, Pain | Phase 2 | Recruiting | Oslo University Hospital | 12 | 2025-02-01 | 2025-04-02 |
| Treatment of Patients With Diabetic Kidney Disease lisinopril, enalapril, dapagliflozin, empagliflozin - Diabetic Kidney Disease | Not applicable | Unknown | Assiut University | 70 | 2024-01-01 | 2024-01-02 |
| Comparison Between the Efficacy of SGLT2 Inhibitor Therapy Versus ACE Inhibitor in the Treatment of Diabetic Kidney Disease Empagliflozin 25 MG, Enalapril Maleate 20 mg - Diabetic Nephropathy Type 2 | Phase 2 / Phase 3 | Unknown | Omar Tarek Elfarargi | 212 | 2023-03-01 | 2022-05-13 |
| Medicine-induced Cardiac Hemodialysis on COVID-19 Nifedipine 30 MG, Kangzhu BPCB0A-3A, Low Mobility - Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis | Phase 4 | Completed | Yang I. Pachankis | 1 | 2023-01-02 | 2023-02-03 |
| Pulmonary REsistance Modification Under Treatment With Sacubitril/valsartaN in paTients With Heart Failure With Reduced Ejection Fraction Sacubitril-valsartan, Enalapril, placebo - Heart Failure | Phase 4 | Unknown | Clinical Hospital Heliodor Swiecicki of the Medical University of Karol Marcinkowski in Poznań | 260 | 2022-12-13 | 2023-06-18 |
| The Effect of Enalapril, Losartan or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients Angiotensin converting enzyme inhibitor, Angiotensin Receptor Blockers - Oxidative Stress | Phase 2 | Completed | Unidad de Investigacion Medica en Enfermedades Renales | 39 | 2022-01-01 | 2022-02-09 |
| The Effects of Sacubitril-Valsartan vs Enalapril on Left Ventricular Remodeling in ST-elevation Myocardial Infarction Sacubitril-Valsartan, Enalapril, Valsartan - STEMI | Phase 3 | Unknown | West China Hospital | 376 | 2021-11-01 | 2021-09-29 |
| Continuing or Discontinuing ACE/ARBs in Patients With Chronic Kidney Disease Undergoing Coronary Angiography Continue ACEI or ARBs ( Enalapril , Ramipril , Valsartan , Candesartan, Losartan ), Hold ACEI or ARBs - Contrast-induced Nephropathy, Chronic Kidney Diseases | Not applicable | Unknown | An-Najah National University | 600 | 2021-06-01 | 2023-06-06 |
| Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF. Sacubitril / Valsartan Oral Tablet [Entresto], Enalapril - Chagas Cardiomyopathy | Phase 3 | Unknown | University of Sao Paulo General Hospital | 200 | 2021-05-06 | 2024-04-04 |
| Blood Pressure Management in Stroke Following Endovascular Treatment Labetalol, Hydralazine, Enalapril - Stroke, Acute, Vessels; Occlusion | Phase 2 | Completed | Hamilton Health Sciences Corporation | 30 | 2020-10-23 | 2023-11-07 |
| Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy Aliskiren, Enalapril - C3 Glomerulopathy, Membranoproliferative Glomerulonephritis | Phase 2 | Recruiting | Region Skane | 30 | 2020-10-01 | 2025-06-22 |
| Coronavirus (COVID-19) ACEi/ARB Investigation Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor - Hypertension, COVID-19 | Phase 4 | Suspended | National University of Ireland, Galway, Ireland | 2414 | 2020-04-30 | 2020-06-30 |
| Angiotensin Converting Enzyme Inhibitors in Treatment of Covid 19 ACEIs, Conventional treatment - COVID | Phase 3 | Not yet recruiting | Tanta University | 60 | 2020-04-15 | 2020-04-14 |
| Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period NIFEdipine ER, Enalapril - Hypertension in Pregnancy, Preeclampsia Severe | Phase 4 | Completed | Brigham and Women's Hospital | 94 | 2020-01-24 | 2022-11-30 |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 |
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Hypertension (29) · Heart Failure (21) · Cardiovascular Diseases (10) · Renal Insufficiency, Chronic (6) · Diabetes Mellitus, Type 2 (5) · Diabetic Nephropathies (5) · Essential Hypertension (5) · Heart Diseases (4) · Heart Failure, Systolic (4) · Kidney Diseases (4) · Proteinuria (4) · Coronary Disease (3) · Diabetes Mellitus (3) · Hypertension, Pregnancy-Induced (3) · Motor Activity (3)
Novartis Pharmaceuticals (15) · Boehringer Ingelheim (3) · Chulalongkorn University (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Shenzhen Ausa Pharmed Co.,Ltd (3) · University of Vigo (3) · Brigham and Women's Hospital (2) · European Institute of Oncology (2) · Merck Sharp & Dohme LLC (2) · National Center for Research Resources (NCRR) (2) · University of Sao Paulo General Hospital (2) · University of Utah (2) · An-Najah National University (1) · Anhui Medical University (1) · Assistance Publique - Hôpitaux de Paris (1)
United States (31) · Spain (12) · United Kingdom (11) · Canada (10) · China (10) · France (10) · Germany (10) · Italy (10) · Belgium (8) · Brazil (8) · Denmark (8) · Poland (8) · Sweden (8) · Hungary (7) · India (7)
LuAnn Minich, MD (2) · Ramon C Hermida, PhD (2) · Talerngsak Kanjanabuch, Assist. Prf. (2) · Adam P Bress, PharmD, MS (1) · Alberto Zanchetti, MD (1) · Alisse Hauspurg, MD (1) · Amol Malshe, M.D. (1) · Anders F Edebo, MD PhD (1) · Anne H. Blaes, MD (1) · Antonio P Barretto, PhD (1) · Aristeidis H Katsanos, MD (1) · Bjorn Eriksson, MD (1)
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