Diabetes Complications: Clinical Trials

1592 completed, 530 unknown, 292 recruiting, 216 terminated. 1136 Not applicable, 518 Phase 2, 289 Phase 3, 231 Phase 4, 207 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	1136	Completed 588, Unknown 202, Recruiting 131, Terminated 74, Not yet recruiting 61, Withdrawn 36, Active not recruiting 33, Enrolling by invitation 9, Suspended 2
Phase 2	518	Completed 312, Unknown 68, Terminated 54, Recruiting 38, Withdrawn 19, Active not recruiting 13, Not yet recruiting 13, Suspended 1
Phase 3	289	Completed 164, Terminated 50, Unknown 40, Withdrawn 13, Recruiting 11, Not yet recruiting 7, Active not recruiting 4
Phase 4	231	Completed 142, Unknown 38, Terminated 17, Recruiting 12, Not yet recruiting 10, Withdrawn 7, Active not recruiting 3, Enrolling by invitation 2
Phase 1	207	Completed 111, Unknown 39, Recruiting 21, Terminated 15, Active not recruiting 8, Not yet recruiting 6, Withdrawn 5, Enrolling by invitation 1, Suspended 1
Early Phase 1	25	Unknown 11, Completed 8, Not yet recruiting 2, Recruiting 2, Enrolling by invitation 1, Withdrawn 1

Follow Diabetes Complications: new trials by email Literature Review of Diabetes Complications trials Research Report on Diabetes Complications

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
On the Move: Center and Home-Based Exercise to Enhance Mobility in Diabetic Foot Ulcer Recovery 12-week exercise regimen, 12-week standard of care - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	University of Maryland, Baltimore	60	2027-06-01	2026-10-07
Eye Health Intervention Study in Upper Manhattan Intervention, Usual Care - Glaucoma, Suspect, Diabetic Retinopathy	Not applicable	Withdrawn	Columbia University		2027-04-01	2026-05-29
Placental Cells for Diabetic Foot Ulcers Placenta Stem Cells - Diabetic Foot Ulcer	Phase 1	Not yet recruiting	Wake Forest University Health Sciences	12	2027-03-01	2026-10-23
Naoxintong Capsule for Diabetic Nephropathy With Dampness Retention Pattern: A Multicenter, Randomized, Double-Blind, Placebo-Controlled TrialAcronymNXT-DKD Naoxintong Capsule, Placebo - Diabetic Nephropathy	Phase 4	Not yet recruiting	Chen Xiangmei	410	2027-03-01	2026-07-13
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring. Sotagliflozin initiation - Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)	Phase 2	Not yet recruiting	HealthPartners Institute	80	2027-01-01	2026-10-23
dApagliflozin SC0062 and Prevention of Renal Injury; a Randomized Evaluation Dapagliflozin (Forxiga®), SC0062 strength 10mg, SC0062 and dapagliflozin - Type 1 Diabetes Mellitus With Diabetic Nephropathy	Phase 2	Not yet recruiting	University Medical Center Groningen	36	2027-01-01	2026-10-20
Relationship Between Insulin Dose and Complications in Type 1 Diabetes Routine/prescribed exogenous insulin dose - Diabetes Mellitus, Type 1 Diabetes, Cardiovascular Diseases (CVD)		Not yet recruiting	Rachel Miller	80	2027-01-01	2026-11-02
Subcutaneous Dexpanthenol Administration and Wound Epithelialization Dexpanthenol, Standard Wound Care - Chronic Wounds, Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Dilara CANBAY OZDEMIR	40	2026-12-02	2026-10-22
The BRIGHT Study (Device Name: HALO System) The HALO System - Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2	Not applicable	Not yet recruiting	Indigo Diabetes NV	12	2026-12-01	2026-08-04
Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy Topical Lidocaine 2% Gel, Duloxetine (60 MG) - Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies	Phase 4	Not yet recruiting	Wah Medical college , POF hospital	80	2026-12-01	2026-09-02
Clinical Efficacy of Modified Simiao Yongan Decoction and Endovascular Therapy for Diabetic Foot Ulcers Modified Simiao Yongan Decoction, Endovascular Therapy and Standard Care - Diabetic Foot Ulcer, Damp-Heat Toxins Accumulation Syndrome	Not applicable	Not yet recruiting	Chengdu University of Traditional Chinese Medicine	120	2026-12-01	2026-09-08
Measuring Plantar Pressures in Diabetic Patients With Lateral Forefoot Amputation Amputation, Diabetes Complications		Recruiting	Nanyang Technological University	70	2026-11-27	2026-10-08
Beta-2-Trace Protein in Diabetic Nephropathy Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus		Not yet recruiting	Assiut University	80	2026-11-10	2026-11-05
18F-FDG PET/CT for Diagnosis of Diabetic Foot Osteomyelitis 18F-FDG PET/CT - Diabetic Foot Infections		Not yet recruiting	Jewish General Hospital	150	2026-11-01	2026-09-18
Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy Cognitive Behavioral Therapy (CBT), Oral Medication, Topical Medication - Painful Diabetic Neuropathy (PDN), Diabetic Nephropathies	Phase 4	Not yet recruiting	University of Michigan	600	2026-11-01	2026-10-21
Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy Botulinum Toxin Type A, Duloxetine, Oral Placebo Tablet - Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy	Phase 2	Not yet recruiting	Assiut University	56	2026-11-01	2026-10-20
Comparison of Negative Pressure Wound Therapy Versus Moist Wound Dressing in Diabetic Foot Ulcer Patients Negative Pressure Wound Therapy, Moist Wound Dressing - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Abbas Institute of Medical Sciences	60	2026-11-01	2026-10-28
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes PAL-119, Placebo - Healthy Volunteers and Diabetes Participants	Phase 1 / Phase 2	Not yet recruiting	Paulex Bio Inc.	147	2026-11-01	2026-10-28
Comparative Effects of tDCS and tACS on Pain, Dexterity, and Strength in Diabetic Peripheral Neuropathy Transcranial Direct Current Stimulation (tDCS), Transcranial Alternating Current Stimulation (tACS) - Diabetic Peripheral Neuropathy (DPN)	Not applicable	Active not recruiting	University of Management and Technology Lahore	46	2026-10-22	2026-11-03
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery Diabetic Foot Ulcer, Wound Healing		Recruiting	Universidade Sao Francisco	40	2026-10-21	2026-10-22

Showing 20 of 2998. Sign in to see all of them.

Narrower conditions

Diabetic Foot (1032)  ·  Diabetic Retinopathy (684)  ·  Diabetes Mellitus (617)  ·  Diabetic Neuropathies (524)  ·  Diabetic Nephropathies (517)  ·  Diabetes Mellitus, Type 2 (333)  ·  Diabetes Mellitus, Type 1 (134)  ·  Foot Ulcer (111)  ·  Macular Degeneration (97)  ·  Renal Insufficiency, Chronic (93)  ·  Macular Edema (75)  ·  Pain (75)  ·  Varicose Ulcer (74)  ·  Diabetic Ketoacidosis (73)

Broader conditions

Endocrine System Diseases (2988)  ·  Diabetes Mellitus (2381)  ·  Cardiovascular Diseases (1819)  ·  Vascular Diseases (1785)  ·  Diabetic Angiopathies (1699)  ·  Nutritional and Metabolic Diseases (1047)  ·  Skin and Connective Tissue Diseases (1044)  ·  Skin Diseases (1033)  ·  Metabolic Diseases (1031)  ·  Skin Ulcer (1015)  ·  Leg Ulcer (992)  ·  Diabetic Neuropathies (983)  ·  Glucose Metabolism Disorders (978)  ·  Foot Ulcer (922)

Interventions

Standard of Care (103)  ·  aflibercept (45)  ·  Ranibizumab (39)  ·  Bevacizumab (30)  ·  Pregabalin (24)  ·  Sodium Chloride (23)  ·  Losartan (18)  ·  salicylhydroxamic acid (18)  ·  Exercise (17)  ·  Saline Solution (17)  ·  dapagliflozin (17)  ·  Control Groups (16)  ·  Duloxetine Hydrochloride (16)  ·  Insulin (16)  ·  finerenone (16)

Sponsors

Assiut University (46)  ·  Riphah International University (27)  ·  National Eye Institute (NEI) (25)  ·  Cairo University (22)  ·  University of Texas Southwestern Medical Center (20)  ·  Ain Shams University (19)  ·  University of Colorado, Denver (19)  ·  Bayer (17)  ·  Association for Innovation and Biomedical Research on Light and Image (16)  ·  Novartis Pharmaceuticals (16)  ·  Pfizer (16)  ·  University of Sao Paulo (16)  ·  Eli Lilly and Company (15)  ·  Steno Diabetes Center Copenhagen (15)  ·  Universidad Complutense de Madrid (14)

Countries

United States (983)  ·  China (204)  ·  United Kingdom (154)  ·  France (133)  ·  Germany (127)  ·  Denmark (124)  ·  Canada (116)  ·  Egypt (115)  ·  Italy (100)  ·  Turkey (Türkiye) (97)  ·  Spain (95)  ·  Pakistan (78)  ·  Brazil (69)  ·  South Korea (65)  ·  Taiwan (64)

Top investigators

Herbert B Slade, MD (7)  ·  Betty Tuller, PhD (6)  ·  David Armstrong, DPM, MD, PhD (6)

Results publications

PMID 33107592, PMID 38682786, PMID 39171639, PMID 41805697, PMID 37916745, PMID 38770818, PMID 39963952, PMID 20876709, PMID 24767584, PMID 26089210, PMID 27611736, PMID 28614678, PMID 30084288, PMID 30206821, PMID 30521533, PMID 31802967, PMID 16291066, PMID 21571677, PMID 22717465, PMID 23958264, PMID 25439614, PMID 26738255, PMID 27269974, PMID 28326159, PMID 28756065, PMID 31876991, PMID 33358451, PMID 34187716, PMID 35224730, PMID 35534614, PMID 35587172, PMID 37260074, PMID 37872654, PMID 40526444, PMID 10693087, PMID 10720604, PMID 11319655, PMID 11926784, PMID 12589096, PMID 15353531, PMID 15793206, PMID 16291063, PMID 16389125, PMID 16758177, PMID 17277315, PMID 18441312, PMID 18612117, PMID 18619874, PMID 18990064, PMID 19383872

NIH funding

2015 (10), 2019 (10), 2016 (9), 2018 (8), 2014 (6), U10EY014231 (6), 2005 (5), 2023 (5), U10EY014229 (5), U10EY018817 (5), 2009 (4), 2017 (4), 2004 (3), 2008 (3), U24DK122927 (3)