90 completed, 20 unknown, 11 recruiting, 10 not yet recruiting. 47 Not applicable, 45 Phase 2, 27 Phase 3, 24 Phase 1, 18 Phase 4.
Follow Thioctic Acid: new trials by email Literature Review of Thioctic Acid trials Research Report on Thioctic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Lipoic Acid on Chronic Ischemic Heart Failure Patients Alpha-Lipoic Acid (ALA), placebo - Heart Failure Due to Coronary Artery Disease | Phase 3 | Not yet recruiting | Shanghai Zhongshan Hospital | 1526 | 2026-11-01 | 2026-08-05 |
| Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity Alpha-lipoic acid, Mirabegron, Placebo - Insulin Resistance, Obesity | Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 60 | 2026-10-28 | 2026-10-23 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Efficacy and Safety of Low-Dose Duloxetine Plus Alpha-Lipoic Acid Versus Standard-Dose Duloxetine in Painful Diabetic Peripheral Neuropathy Duloxetine, Alpha-Lipoic Acid - Painful Diabetic Peripheral Neuropathy | Not applicable | Not yet recruiting | Bangladesh Medical University | 170 | 2026-08-25 | 2026-08-26 |
| Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in Gingivitis Placebo Administration, Alpha-Lipoic Acid 200 mg, Alpha-Lipoic Acid 600 mg - Gingivitis and Periodontal Diseases | Not applicable | Recruiting | Biruni University | 80 | 2026-08-05 | 2026-10-20 |
| Protective Role of Alpha-Lipoic Acid in Chemotherapy-Induced Mucositis alpha lipoic acid 600 mg twice daily, Placebo Tablet - Colorectal Cancer | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 50 | 2026-07-27 | 2026-07-30 |
| Colistin Nephrotoxicity and Role of Alpha Lipoic Acid alpha lipoic acid drug (thioctic acid acid) - Nephrotoxicity | Phase 3 | Not yet recruiting | Helwan University | 88 | 2026-06-30 | 2026-06-25 |
| Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age Alpha-Lipoic Acid (ALA) - Female Infertility Due to Diminished Ovarian Reserve | Not applicable | Recruiting | Kaohsiung Veterans General Hospital. | 60 | 2026-06-11 | 2026-07-07 |
| Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLC Alpha Lipoic Acid 600mg - Advanced Non Small Cell Lung Cancer (NSCLC) | Phase 2 | Not yet recruiting | Ain Shams University | 60 | 2026-04-20 | 2026-05-08 |
| Alpha-Lipoic Acid in Mitigating Cisplatin-Induced Nephrotoxicity Alpha-Lipoic Acid (ALA) - Cisplatin Nephrotoxicity, Nephrotoxicity | Phase 2 | Recruiting | Minia University | 50 | 2026-03-10 | 2026-05-04 |
| Efficacy of Alpha Lipoic Acid Combined With Myo-Inositol in Non-Diabetic PCOS Patients Myo-inositol, Folic Acid, Alpha Lipoic Acid - Poly Cystic Ovary Syndrome | Phase 3 | Recruiting | Beni-Suef University | 180 | 2026-03-10 | 2026-06-05 |
| Effect of Low-Dose Versus High-Dose Alpha-Lipoic Acid on Oxidative Stress, Inflammation, and Clinical Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease Alpha Lipoic Acid 600 MG Oral Tablets, Alpha Lipoic Acid, Placebo - Acute Exacerbation Chronic Obstructive Pulmonary Disease | Phase 3 | Not yet recruiting | Ain Shams University | 75 | 2026-02-28 | 2026-03-30 |
| Effects of Lower Body Positive Pressure Therapy Versus Alpha Lipoic Acid and Omega-3 Fatty Acids on Knee Osteoarthritis Alpha-Lipoic Acid (ALA)+PT, Omega-3 cap+ PT, Lower body positive pressure therapy (LBPP)+PT - Knee Osteoarthritis | Phase 3 | Not yet recruiting | Badr University | 160 | 2026-02-15 | 2026-02-10 |
| Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot Study Tai Chi/Qi Gong, α- Lipoic acid, Acupuncture - Peripheral Neuropathy | Not applicable | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 60 | 2026-01-20 | 2026-04-14 |
| Comparing N-Acetylcysteine (NAC) Versus Alpha-Lipoic Acid (ALA) as Adjuncts for Postoperative Pain Management After Laparoscopic Appendectomy N Acetyl Cysteine, Alpha-Lipoic Acid (ALA), Placebo - Laparoscopic Appendectomy, Pain Management | Not applicable | Not yet recruiting | Ain Shams University | 180 | 2025-12-28 | 2026-01-22 |
| A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome Alpha-Lipoic Acid, Vitamin E, and Vitamin B Complex, Combination Vitamin B1,B6,B12 - Carpal Tunnel Syndrome | Not applicable | Recruiting | Hospital Universiti Sains Malaysia | 84 | 2025-12-08 | 2026-04-23 |
| Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycystic Ovary Syndrome Quercetin, Alpha Lipoic Acid 600 MG Oral Tablet, MetFORMIN 500 Mg Oral Tablet - PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries | Phase 2 | Recruiting | Al-Mustansiriyah University | 150 | 2025-09-20 | 2025-09-19 |
| Evaluating the Effect of N-Acetyl Cysteine and Alpha Lipoic Acid in Patients With Beta Thalassemia Iron chelating intervention, N Acetyl cysteine 600mg, Alpha Lipoic Acid 600 MG Oral Tablets - Beta Thalassemia | Phase 3 | Not yet recruiting | Tanta University | 66 | 2025-08-30 | 2025-09-05 |
| Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12 - Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy | Not applicable | Recruiting | BREGO Life Sciences | 100 | 2025-07-22 | 2026-10-16 |
| The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19 NAC (N-acetyl cysteine), Alpha lipoic acid (ALA), liposomal glutathione (GSH) - COVID-19 | Early Phase 1 | Withdrawn | University of California, Irvine | 2025-06-01 | 2024-11-05 |
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Diabetes Mellitus, Type 2 (11) · Diabetic Neuropathies (9) · Inflammation (9) · Multiple Sclerosis (9) · Diabetes Mellitus (8) · Insulin Resistance (7) · Obesity (7) · Polycystic Ovary Syndrome (7) · Breast Neoplasms (4) · Multiple Sclerosis, Chronic Progressive (4) · Alzheimer Disease (3) · Burning Mouth Syndrome (3) · Cardiovascular Diseases (3) · Hypertension (3) · Peripheral Nervous System Diseases (3)
Ain Shams University (16) · Oregon Health and Science University (7) · Augusta University (4) · National Center for Complementary and Integrative Health (NCCIH) (4) · Tanta University (4) · Damanhour University (3) · University of California, San Francisco (3) · VA Office of Research and Development (3) · Catholic University of the Sacred Heart (2) · Lo.Li.Pharma s.r.l (2) · Lu Jiang (2) · MEDA Pharma GmbH & Co. KG (2) · Oregon State University (2) · University of British Columbia (2) · University of Thessaly (2)
United States (53) · Egypt (28) · China (9) · Italy (6) · South Korea (4) · Canada (3) · Mexico (3) · Spain (3) · Brazil (2) · France (2) · Greece (2) · India (2) · Malaysia (2) · Netherlands (2) · Turkey (Türkiye) (2)
Lynne Shinto, ND, MPH (3) · Alp Ikizler, MD (2) · Athanasios Z Jamurtas, PhD (2) · Gerd Bobe, PhD (2) · Jonathan Himmelfarb, MD (2) · Umesh Masharani, MD (2) · A Yoshida, MD, PhD (1) · Aaron M Cypess, M.D. (1) · Abdelrady S Ibrahim, M.D. (1) · Abha Kumar, MD (1) · Ahmed Mostafa Abd-Elaziz (1) · Aldo Torre Delgadillo, M.D., M. Sc. (1) · Alfred Slonim, MD (1) · Amal Kamal Hussein (1)
PMID 21775755, PMID 35596774, PMID 10856474, PMID 12457622, PMID 15135924, PMID 17065669, PMID 17131349, PMID 18663426, PMID 19499849, PMID 19786984, PMID 20307398, PMID 21073761, PMID 21187189, PMID 21304145, PMID 21600374, PMID 21615001, PMID 22431837, PMID 22619725, PMID 23471087, PMID 23562296, PMID 24077434, PMID 24563654, PMID 24675228, PMID 24777126, PMID 24898524, PMID 25095826, PMID 25104975, PMID 25410210, PMID 25511715, PMID 25575710, PMID 26345602, PMID 26431839, PMID 26962183, PMID 28606823, PMID 28676917, PMID 28680916, PMID 29143287, PMID 29291932, PMID 29743087, PMID 30241687, PMID 30264707, PMID 30477834, PMID 30721699, PMID 31077039, PMID 31285784, PMID 31333648, PMID 31651976, PMID 32418846, PMID 32554133, PMID 32692358
P01AT002034 (2), 2005 (1), K23DK070715 (1), M01RR000334 (1), P01HL069999 (1), P20DK100863 (1), P30AG044271 (1), P50AT000066 (1), R21AG023805 (1), R21AT004493 (1), U10CA045809 (1), UL1RR025008 (1)