5 completed, 3 recruiting, 2 terminated, 1 unknown. 12 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 5, Recruiting 3, Terminated 2, Unknown 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Withdrawn 1 |
Follow Multiple Trauma: new trials by email Literature Review of Multiple Trauma trials Research Report on Multiple Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Whole Blood in Trauma Patients With Hemorrhagic Shock Transfusion of blood products - Trauma, Trauma Injury | Phase 3 | Recruiting | Fundacion Clinica Valle del Lili | 220 | 2023-01-14 | 2025-02-27 |
| Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen Ibuprofen 800 mg, Morphine Sulfate, Ibuprofen 400 mg plus Acetaminophen 1000 mg - Multiple Trauma, Acute Pain Due to Trauma | Phase 3 | Completed | Isfahan University of Medical Sciences | 150 | 2022-03-15 | 2023-09-07 |
| ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9% - Trauma, Traumatic Injury | Phase 3 | Recruiting | Australian and New Zealand Intensive Care Research Centre | 2500 | 2020-11-09 | 2025-07-16 |
| Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma Dornase Alfa Inhalant Solution [Pulmozyme], Placebos - Multiple Trauma, Respiratory Distress Syndrome, Adult | Phase 3 | Recruiting | University Hospital, Strasbourg, France | 500 | 2019-03-04 | 2026-08-20 |
| Intranasal Ketamine Versus Intranasal Fentanyl Placebo, Ketamine, Fentanyl - Multiple Trauma, Pain, Acute | Phase 3 | Completed | Isfahan University of Medical Sciences | 125 | 2017-04-01 | 2020-06-04 |
| Pre-Hospital Use of Plasma for Traumatic Hemorrhage Plasma, Normal saline - Shock, Hemorrhagic | Phase 2 / Phase 3 | Withdrawn | Virginia Commonwealth University | 2014-11-01 | 2016-02-23 | |
| Ketamine Patient-Controlled Analgesia for Acute Pain Ketamine, Hydromorphone - Acute Pain, Multiple Trauma | Phase 3 | Terminated | University of Cincinnati | 20 | 2014-04-01 | 2017-09-21 |
| The Clinical Role of Intravenous Glutamine in Trauma Patients Receiving Enteral Nutrition Dipeptiven, normal saline - Multiple Trauma, Critically Ill | Phase 3 | Unknown | Royal Brisbane and Women's Hospital | 88 | 2011-03-01 | 2012-05-24 |
| Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Placebo, Hydrocortisone Fludrocortisone - Traumatic Brain Injury, Trauma | Phase 3 | Completed | Nantes University Hospital | 336 | 2010-08-01 | 2017-09-14 |
| Antioxidant Supplementation in Trauma Patients powdered antioxidant, powdered cornstarch placebo - Multiple Trauma | Phase 3 | Terminated | Boston Medical Center | 18 | 2007-11-01 | 2016-01-26 |
| Treatment of Polytraumatisms With Corticoids hydrocortisone, NaCl - Polytraumatism | Phase 2 / Phase 3 | Completed | Nantes University Hospital | 150 | 2006-11-01 | 2026-09-14 |
| Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients Crystalloids, Colloids - Critical Illness | Phase 3 | Completed | University of Versailles | 2857 | 2003-02-01 | 2014-07-01 |
Wounds and Injuries (8) · Shock (3) · Acute Pain (2) · Brain Injuries, Traumatic (2) · Critical Illness (2) · Hemorrhage (2) · Accidental Injuries (1) · Adrenal Insufficiency (1) · Craniocerebral Trauma (1) · Fractures, Bone (1) · Pain (1) · Pneumonia (1) · Respiratory Distress Syndrome (1) · Sepsis (1)
Pathological Conditions, Signs and Symptoms (7) · Pathologic Processes (5) · Wounds and Injuries (4) · Brain Diseases (2) · Brain Injuries (2) · Central Nervous System Diseases (2) · Disease Attributes (2) · Infections (2) · Lung Diseases (2) · Nervous System Diseases (2) · Neurologic Manifestations (2) · Respiratory Tract Diseases (2) · Signs and Symptoms (2) · Trauma, Nervous System (2) · Adrenal Gland Diseases (1)
Ketamine (2) · Saline Solution (2) · Acetaminophen (1) · Blood Transfusion (1) · Colloids (1) · Crystalloid Solutions (1) · Epoetin Alfa (1) · Fentanyl (1) · Hydrocortisone (1) · Hydromorphone (1) · Ibuprofen (1) · Morphine (1) · Sodium Chloride (1) · alanylglutamine (1) · dornase alfa (1)
Isfahan University of Medical Sciences (2) · Nantes University Hospital (2) · Australian and New Zealand Intensive Care Research Centre (1) · Boston Medical Center (1) · Fundacion Clinica Valle del Lili (1) · Royal Brisbane and Women's Hospital (1) · University Hospital, Strasbourg, France (1) · University of Cincinnati (1) · University of Versailles (1) · Virginia Commonwealth University (1)
France (4) · Australia (2) · Belgium (2) · Iran (2) · United States (2) · Canada (1) · Colombia (1) · Finland (1) · Germany (1) · Ireland (1) · New Zealand (1) · Saudi Arabia (1) · Slovenia (1) · Switzerland (1) · Tunisia (1)
Alberto F Garcia, MD MSc (1) · Associate Professor Craig French (1) · Bruce D Spiess, MD, FAHA (1) · Djillali Annane, MD, PhD (1) · Eric W Mueller, Pharm.D. (1) · Jeffrey Lipman, MBBCh, MD (1) · Mahe Joachim, MD (1) · Marc Leonne (1) · Olivier Langeron (1) · Peter Burke, MD (1) · Pierre Albaladejo (1)
PMID 21427372, PMID 22102646, PMID 22777514, PMID 23450051, PMID 24108515, PMID 25066331, PMID 26220293, PMID 26452709, PMID 28183347, PMID 28988172, PMID 29605036, PMID 32183886, PMID 38273252, PMID 40087111