18 completed, 5 unknown, 4 terminated, 2 withdrawn. 11 Phase 3, 9 Phase 4, 6 Phase 2, 5 Not applicable, 2 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Supplementation With Immunonutrition and Its Impact on Surgical Outcome and Pain in Oral Cavity or Mandibular Tumours Standard feeding, Omega 3 and dipeptiven - Immunonutrition, Surgical Outcome | Not applicable | Completed | Cairo University | 176 | 2023-02-01 | 2024-04-02 |
| Effect of IV Alanyl Glutamine on Healing of Pressure Ulcers in Critically Ill Patients alanyl-glutamine - Pressure Ulcer | Not applicable | Unknown | Air Force Specialized Hospital, Cairo, Egypt | 200 | 2022-04-01 | 2022-10-19 |
| Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT) Alanyl-glutamine - Clostridioides Difficile Infection, Clostridium Difficile Infection | Phase 2 | Recruiting | University of Virginia | 260 | 2021-06-01 | 2024-10-26 |
| Glutamine Supplementation and Short-term Mortality in Covid-19 Standard enteral nutrition, Glutamine - Covid19 | Phase 3 | Completed | Assiut University | 60 | 2021-05-30 | 2021-11-05 |
| Role of Glutamine as Myocardial Protector in Elective On-Pump CABG Surgery With Low EF L-alanyl-L-glutamine dipeptide, Placebo - Coronary Artery Bypass, Cardiopulmonary Bypass | Phase 3 | Completed | National Cardiovascular Center Harapan Kita Hospital Indonesia | 60 | 2021-01-01 | 2023-11-13 |
| Glutamine Effects in Burn Patients Dipeptiven, normal Saline - Drug Effect | Phase 2 / Phase 3 | Unknown | Menoufia University | 60 | 2020-06-01 | 2021-12-01 |
| Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients N2-L-Alanyl-L-Glutamine (Substance) - Enteral Nutrition, Intensive Care Unit | Not applicable | Completed | Centre Hospitalier Universitaire de Besancon | 73 | 2019-11-28 | 2025-01-16 |
| Reduction of Occurence of Acute Kidney Injury (AKI) Through Administration of Glutamine L-Alanyl/L-Glutamine, Placebo - Cardiac Surgery, Acute Kidney Injury | Phase 3 | Completed | University Hospital Muenster | 64 | 2019-07-18 | 2020-05-21 |
| Alanyl-glutamine Supplementation of Standard Treatment for C. Difficile Infection Alanyl-glutamine - Clostridium Difficile Infection | Phase 2 | Terminated | University of Virginia | 7 | 2015-04-01 | 2022-06-07 |
| A Clinical Study of Alanyl-Glutamine for Reduction of Post-Myomectomy Adhesions L-Alanyl/L-Glutamine, Physiologic saline - Pelvic Adhesions | Phase 1 / Phase 2 | Completed | Temple Therapeutics BV | 47 | 2015-02-15 | 2021-05-07 |
| Randomized, Prospective, Multicenter Study to Compare Enteral Nutrition to Parenteral Nutrition as Feeding Support in Patients Presenting Malignant Hemopathy Who Underwent an Allogeneic Hematopoietic Stem Cell Transplantation. Enteral nutrition alanyl-glutamin, Dipeptiven - Myeloablative Allo-SCT | Phase 3 | Unknown | University Hospital, Clermont-Ferrand | 240 | 2013-11-01 | 2016-07-29 |
| Intervention and Mechanisms of Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy Alanyl-Glutamine - Malnutrition, Environmental Enteropathy | Phase 3 | Completed | Children's Hospital Medical Center, Cincinnati | 112 | 2013-10-01 | 2016-08-01 |
| Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery Glutamine, Ringer's solution - Rheumatic Heart Disease, Coronary Heart Disease | Phase 2 | Completed | Yuejiang Liu | 33 | 2013-01-01 | 2014-05-28 |
| Effects of Glutamine in Ischemic Heart Disease Patients Following Cardiopulmonary Bypass N(2)-L-Alanine L-Glutamine dipeptide, Placebo - Coronary Artery Disease | Phase 3 | Completed | Meshalkin Research Institute of Pathology of Circulation | 24 | 2012-01-01 | 2013-11-01 |
| Safety and Efficacy of the Addition of Alanyl-Glutamine-Dipeptide to Dialysis Solution in Peritoneal Dialysis Dipeptiven (Alanyl-glutamine-dipeptide) - End Stage Renal Disease | Phase 1 / Phase 2 | Terminated | Christoph Aufricht | 25 | 2011-04-01 | 2015-09-11 |
| The Clinical Role of Intravenous Glutamine in Trauma Patients Receiving Enteral Nutrition Dipeptiven, normal saline - Multiple Trauma, Critically Ill | Phase 3 | Unknown | Royal Brisbane and Women's Hospital | 88 | 2011-03-01 | 2012-05-24 |
| Modulation of Systemic Inflammatory Response in Critically Ill Children After Glutamine Supplementation solution of amino acids supplemented with glutamine, amino acids not supplemented with glutamine - Inflammatory Response, Multi-organ Failure | Phase 4 | Completed | Hospital Sant Joan de Deu | 101 | 2010-04-01 | 2013-09-06 |
| Microbial Invasion During Parenteral Nutrition in Surgical Infants Receiving Glutamine Isonitrogenous Vaminolact, Dipeptiven (L-glutamine- Lalanine) - Surgical Infants Requiring Total Parenteral Nutrition | Phase 4 | Completed | Institute of Child Health | 60 | 2009-07-01 | 2022-01-25 |
| Perioperative Immunonutrition, Phagocytic and Bactericidal Activity of Blood Platelets in Gastric Cancer Patients Early postoperative enteral nutrition, based on standard elementary diet (Peptisorb), glutamine, oral diet enriched with arginine (Cubitan) - Gastric Cancer | Not applicable | Unknown | Medical University of Bialystok | 240 | 2007-03-01 | 2020-03-17 |
| Nutrition for Colorectal Cancer Patients and Neutrophil Functions Standard (Kabiven), Standard-Glutamine, Standard-Omega 3 fatty acid - Malnutrition, Colorectal Cancer | Phase 4 | Completed | Kocaeli University | 36 | 2007-01-01 | 2013-04-15 |
Showing 20 of 30. Sign in to see all of them.
Critical Illness (5) · Malnutrition (5) · Diarrhea (4) · Hyperphagia (3) · Clostridium Infections (2) · Coronary Artery Disease (2) · Multiple Organ Failure (2) · Stomach Neoplasms (2) · Acute Kidney Injury (1) · Brain Injuries, Traumatic (1) · COVID-19 (1) · Colorectal Neoplasms (1) · Coma (1) · Coronary Disease (1) · Enterocolitis, Pseudomembranous (1)
University of Virginia (4) · Jagiellonian University (2) · Air Force Specialized Hospital, Cairo, Egypt (1) · Assiut University (1) · Cairo University (1) · Centre Hospitalier Universitaire de Besancon (1) · Children's Hospital Medical Center, Cincinnati (1) · Christoph Aufricht (1) · Daren K. Heyland (1) · Emory University (1) · Hospital Sant Joan de Deu (1) · Institute of Child Health (1) · Kocaeli University (1) · Medical University of Bialystok (1) · Menoufia University (1)
Egypt (4) · United States (4) · France (3) · Poland (3) · Germany (2) · Switzerland (2) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Canada (1) · China (1) · Indonesia (1) · Russia (1) · Slovenia (1)
Aldo Lima, MD, PhD (1) · Alexander Zarbock, MD, PhD (1) · Anne Mercier, MD (1) · Christoph Aufricht, Univ.Prof.Dr. (1) · Cirle A. Warren, M.D. (1) · Daren Heyland, MD (1) · Donna Chizen, MD, FRCSC (1) · Enas Mogawer, Professor (1) · I Made Adi Parmana (1) · Iolanda Jordan, PhMD (1) · Jan Wernerman, MD, PhD (1) · Jasna Uranjek, MD (1) · Jeffrey Lipman, MBBCh, MD (1)
PMID 18650630, PMID 21820770, PMID 22102646, PMID 23594003, PMID 24363760, PMID 24803474, PMID 24992948, PMID 25872934, PMID 26501700, PMID 31502272, PMID 32826717, PMID 36730070, PMID 37474181
2018 (1), U01DK069322 (1)