28 completed, 7 terminated, 7 unknown, 4 recruiting. 17 Phase 2, 11 Phase 3, 11 Phase 4, 9 Phase 1, 4 Not applicable.
Follow dornase alfa: new trials by email Literature Review of dornase alfa trials Research Report on dornase alfa
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD) Dornase Alfa, Isotonic Saline Solution - Ischemic Stroke, Inflammatory Response | Phase 2 | Recruiting | Ludwig-Maximilians - University of Munich | 36 | 2026-10-01 | 2026-09-11 |
| Efficacy and Safety of Intrapleural Fibrinolytic Therapy in Tuberculous Pleural Effusion Versus Non-Tuberculous Pleural Infection Intrapleural Fibrinolytic Therapy (IPFT) - Tuberculous Pleural Effusion | Not yet recruiting | National University of Malaysia | 160 | 2026-09-20 | 2026-09-16 | |
| Investigator Initiated Study to Assess the Safety of Combination of CLS-015 With Anti-CD-19 CAR-T Cells in Patients With Stable/Progressive Large B Cell Lymphoma at Lymphodepletion. rhDNase I - Large B-Cell Lymphoma (LBCL) | Phase 1 | Recruiting | Tel-Aviv Sourasky Medical Center | 12 | 2026-05-01 | 2026-05-01 |
| Flush, Lyse, Operate Intrapleural Saline with possible escalation to intraplerual alteplase and dornase. - Complicated Parapneumonic Effusion, Empyema, Pleural | Phase 4 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 30 | 2026-04-01 | 2026-05-18 |
| Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic Intrapleural fibrinolytic with alteplase 5mg and pulmozyme 5 mg, Saline irrigation with 250 mls normal saline (over 1 hour) - Pleural Infection | Not applicable | Completed | National University of Malaysia | 40 | 2023-07-10 | 2026-02-24 |
| Effectiveness of CFTR Modulators According to Co-therapy Discontinuation of respiratory co-therapy (azithromycin, RhDNase, or inhaled antibiotics) - Cystic Fibrosis | Unknown | Hospices Civils de Lyon | 1990 | 2023-03-01 | 2022-12-23 | |
| Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase) Dornase Alfa - Ischemic Stroke | Phase 2 | Completed | University of Melbourne | 330 | 2022-02-18 | 2026-05-06 |
| Usefulness of DORNASE in COVID-19 on HFNO Dornase Alfa, Saline - COVID-19 Pneumonia | Phase 4 | Terminated | University Medical Centre Ljubljana | 10 | 2021-12-01 | 2023-02-23 |
| DISmantling COvid iNduced Neutrophil ExtraCellular Traps (DISCONNECT-1) rhDNase I - COVID-19 Infection | Phase 1 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 15 | 2020-12-25 | 2023-03-17 |
| I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients Remdesivir, Imatinib Mesylate, Dexamethasone - COVID-19 | Phase 2 | Active not recruiting | QuantumLeap Healthcare Collaborative | 1500 | 2020-07-31 | 2026-03-16 |
| Pulmozyme to Improve COVID-19 ARDS Outcomes Pulmozyme, Placebo - COVID | Phase 2 | Unknown | Boston Children's Hospital | 60 | 2020-07-05 | 2021-12-17 |
| Dornase Alfa for ARDS in Patients With Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Dornase Alfa Inhalation Solution - SARS-CoV 2, ARDS | Phase 3 | Completed | University of Missouri-Columbia | 30 | 2020-06-19 | 2021-04-14 |
| Nebulised Dornase Alfa for Treatment of COVID-19 (Coronavirus Disease 2019) Dornase Alfa Inhalation Solution [Pulmozyme] - COVID-19 (Coronavirus Disease 2019), Hypoxia | Phase 2 | Completed | University College, London | 41 | 2020-06-16 | 2025-01-13 |
| Tigerase® Efficacy and Safety as Part of Complex Therapy in Patients With COVID-19 Tigerase® and best available care, Best available care - COVID-19, Coronavirus Disease 2019 | Phase 3 | Completed | AO GENERIUM | 100 | 2020-06-01 | 2020-10-14 |
| Dornase Alpha for the Treatment of COVID-19 Pulmozyme - COVID-19 | Phase 2 | Unknown | Acibadem University | 60 | 2020-05-25 | 2020-06-16 |
| Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure Pulmozyme/ Recombinant human deoxyribonuclease (rh-DNase), 0.9%sodium chloride - Covid19 | Phase 2 | Recruiting | Jon Simmons | 44 | 2020-04-28 | 2021-05-28 |
| Efficacy and Safety of aerosolizedDornase Alfa Administration in Patients With COVID19 Induced ARDS (COVIDORNASE) Dornase Alfa Inhalation Solution [Pulmozyme], standard procedure - COVID-19, Acute Respiratory Distress Syndrome | Phase 3 | Terminated | Fondation Ophtalmologique Adolphe de Rothschild | 77 | 2020-04-21 | 2022-01-11 |
| Dornase Alfa Administered to Patients With COVID-19 (DACOVID) Dornase Alfa - COVID-19, Mechanical Ventilation | Completed | Feinstein Institute for Medical Research | 5 | 2020-03-31 | 2020-11-13 | |
| Use of DNAse in Neutrophilic Asthma RhDNAse Inhalation Solution - Neutrophilic Asthma | Phase 1 / Phase 2 | Completed | National Jewish Health | 19 | 2020-02-12 | 2026-04-20 |
| Short Duration High Intensity Intrapleural Alteplase With Pulmozyme in Pleural Infection Management Intra-pleural Alteplase 16mg with Pulmozyme (DNase) 5mg - Loculated Empyema | Not applicable | Completed | National University of Malaysia | 30 | 2019-12-30 | 2021-06-07 |
Showing 20 of 51. Sign in to see all of them.
Cystic Fibrosis (13) · COVID-19 (8) · Respiratory Distress Syndrome (4) · Coronavirus Infections (3) · Empyema, Pleural (3) · Pulmonary Atelectasis (3) · Dry Eye Syndromes (2) · Ischemic Stroke (2) · Lung Diseases (2) · Pneumonia (2) · Respiratory Insufficiency (2) · Respiratory Tract Diseases (2) · Sinusitis (2) · Acute Disease (1) · Acute Lung Injury (1)
Genentech, Inc. (3) · National University of Malaysia (3) · AO GENERIUM (2) · The Hospital for Sick Children (2) · University of Illinois at Chicago (2) · University of Jena (2) · Acibadem University (1) · Azienda Ospedaliera di Padova (1) · Boston Children's Hospital (1) · Dartmouth-Hitchcock Medical Center (1) · Duke University (1) · Eastern Regional Medical Center (1) · Feinstein Institute for Medical Research (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Georgetown University (1)
United States (23) · Germany (4) · Australia (3) · Canada (3) · France (3) · Malaysia (3) · Russia (2) · United Kingdom (2) · Israel (1) · Italy (1) · Netherlands (1) · Slovenia (1) · Turkey (Türkiye) (1)
Michelle Freemer, M.D. (2) · Oksana A. Markova, MD (2) · Sandeep Jain, MD (2) · Adam Schrum, PhD (1) · Andrew Bush, FRCPCH (1) · Aron Chakera, DPhil (1) · Arthur Liesz, Prof. Dr. (1) · Benjamin J Tarrant, B.Physio (1) · Betsy J Barnes (1) · Bharat B. Mittal, MD (1) · Bruce CV Campbell, MBBS PhD (1) · Colin Wallis, FRCPCH (1) · Derek W Russell, MD (1)
PMID 33735508, PMID 39869712, PMID 17337677, PMID 18972410, PMID 19996349, PMID 20693248, PMID 21830966, PMID 22413805, PMID 22580235, PMID 23169882, PMID 24255046, PMID 24594542, PMID 25921451, PMID 26150913, PMID 27499981, PMID 28646887, PMID 30073253, PMID 31097519, PMID 32011642, PMID 32183886, PMID 32421353, PMID 32560746, PMID 33425359, PMID 34473343, PMID 34536698, PMID 34640410, PMID 34745093, PMID 34941914, PMID 35581627, PMID 36111237, PMID 36419155, PMID 36449818, PMID 36883141, PMID 38125799, PMID 38407974, PMID 39009040, PMID 39592213, PMID 39748171, PMID 40462830, PMID 40705350, PMID 41125713, PMID 41566445, PMID 41988261, PMID 42799508
R01EY024966 (1)