4 unknown, 3 completed, 1 enrolling by invitation, 1 suspended. 11 Phase 2, 4 Phase 1, 2 Phase 3.
Follow Multiple Trauma: new trials by email Literature Review of Multiple Trauma trials Research Report on Multiple Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Norepinephrine in Trauma Patients With Hemorrhagic Shock Norepinephrine, Placebo - Trauma, Multiple | Phase 1 / Phase 2 | Enrolling by invitation | Visarat Palitnonkiat | 40 | 2025-05-20 | 2025-05-18 |
| Role of Active Deresuscitation After Resuscitation: Furosemide Injection, Metolazone Tablets - Fluid Overload, Critical Illness | Phase 2 | Unknown | Unity Health Toronto | 120 | 2024-05-01 | 2024-03-22 |
| Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Intensive Rehabilitation Placebo, Oxycodone, Essential Oil - Spinal Cord Injuries, Polytrauma | Phase 2 | Completed | Spaulding Rehabilitation Hospital | 20 | 2019-02-20 | 2026-08-04 |
| Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage at Pre-hospital Phase of Care. Fibrinogen Concentrate (Human) 1 MG [RiaSTAP], Red blood cells concentrate, Tranexamic Acid - Polytrauma, Traumatic Hemorrhage | Phase 1 / Phase 2 | Completed | Banc de Sang i Teixits | 79 | 2018-11-21 | 2024-01-25 |
| Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients Ergocalciferol 8000 IU/ML Oral Liquid [DRISDOL], Propylene Glycol - Vitamin D Deficiency, Polytrauma | Phase 1 / Phase 2 | Suspended | New York City Health and Hospitals Corporation | 60 | 2017-07-01 | 2019-04-04 |
| Pre-Hospital Use of Plasma for Traumatic Hemorrhage Plasma, Normal saline - Shock, Hemorrhagic | Phase 2 / Phase 3 | Withdrawn | Virginia Commonwealth University | 2014-11-01 | 2016-02-23 | |
| Effects of Omega-3 Fatty Acid Supplementation on Inflammatory Response in Multisystem Trauma Patients Omega-3, Placebo - Multiple Trauma | Phase 1 / Phase 2 | Terminated | University of Cincinnati | 12 | 2011-06-01 | 2013-02-25 |
| Relationship Between Erythropoietin Administration and Stress Responses in Trauma Patients erythropoietin, placebo - Multiple Trauma | Phase 2 | Unknown | Tehran University of Medical Sciences | 20 | 2007-07-01 | 2010-11-18 |
| Treatment of Polytraumatisms With Corticoids hydrocortisone, NaCl - Polytraumatism | Phase 2 / Phase 3 | Completed | Nantes University Hospital | 150 | 2006-11-01 | 2026-09-14 |
| Use of Beta Blockers in Elderly Trauma Patients Esmolol, Metoprolol - Multiple Trauma, Cardiovascular Diseases | Phase 2 | Unknown | University of Texas Southwestern Medical Center | 148 | 2005-12-01 | 2007-05-10 |
| A Single Site Safety and Tolerability Study of HBOC-201 in Trauma Subjects Hemoglobin-based oxygen carrier-201 (HBOC 201), Standard of Care - Wounds and Injuries | Phase 2 | Unknown | Biopure Corporation | 53 | 2004-07-01 | 2008-03-06 |
Wounds and Injuries (5) · Agnosia (1) · Burns (1) · Cardiovascular Diseases (1) · Critical Illness (1) · Edema (1) · Hemorrhage (1) · Musculoskeletal Diseases (1) · Respiratory Distress Syndrome (1) · Sepsis (1) · Shock (1) · Shock, Hemorrhagic (1) · Spinal Cord Injuries (1) · Vitamin D Deficiency (1)
Wounds and Injuries (6) · Pathological Conditions, Signs and Symptoms (3) · Pathologic Processes (2) · Signs and Symptoms (2) · Avitaminosis (1) · Central Nervous System Diseases (1) · Deficiency Diseases (1) · Disease Attributes (1) · Infections (1) · Inflammation (1) · Lung Diseases (1) · Malnutrition (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Neurologic Manifestations (1)
Docosahexaenoic Acids (1) · Epoetin Alfa (1) · Ergocalciferols (1) · Erythropoietin (1) · Fibrinogen (1) · Fluid Therapy (1) · Furosemide (1) · HBOC 201 (1) · Hydrocortisone (1) · Metolazone (1) · Metoprolol (1) · Norepinephrine (1) · Oils, Volatile (1) · Oxycodone (1) · Propylene Glycol (1)
Banc de Sang i Teixits (1) · Biopure Corporation (1) · Nantes University Hospital (1) · New York City Health and Hospitals Corporation (1) · Spaulding Rehabilitation Hospital (1) · Tehran University of Medical Sciences (1) · Unity Health Toronto (1) · University of Cincinnati (1) · University of Texas Southwestern Medical Center (1) · Virginia Commonwealth University (1) · Visarat Palitnonkiat (1)
United States (5) · Canada (1) · France (1) · Iran (1) · South Africa (1) · Spain (1) · Thailand (1)
A. Gerson Greenburg, MD, PhD (1) · Bruce D Spiess, MD, FAHA (1) · John C Marshall, MD (1) · Krishna Athota, MD (1) · Mahe Joachim, MD (1) · Milan Sen, MD (1) · Professor Ken D Boffard, MD (1) · Randall Friese, MD (1) · Richard Branson, MSc (1) · Ross D Zafonte, DO (1)
PMID 18404076, PMID 21427372, PMID 22777514, PMID 23450051, PMID 26220293, PMID 28183347