66 completed, 16 unknown, 14 terminated, 3 recruiting. 31 Phase 3, 27 Phase 2, 18 Phase 1, 18 Phase 4, 8 Not applicable.
Follow Bosentan: new trials by email Literature Review of Bosentan trials Research Report on Bosentan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study in Healthy Men to Test How Bosentan Influences the Amount of Zongertinib in the Blood Zongertinib, Bosentan - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 16 | 2026-06-22 | 2026-09-04 |
| Bosentan in the Treatment of Giant Cell Arteritis Bosentan, Glucocorticoids - Giant Cell Arteritis (GCA) | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 40 | 2026-06-01 | 2026-05-06 |
| A Study in Healthy Men to Test How Bosentan Influences the Amount of Nerandomilast in the Blood Nerandomilast, Bosentan - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 16 | 2025-08-26 | 2025-10-14 |
| Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV) Bosentan and dapagliflozin - Large Vessel Vasculitis, Giant Cell Arteritis (GCA) | Phase 2 | Recruiting | University of Edinburgh | 60 | 2025-03-21 | 2026-01-14 |
| Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm Endothelin Receptor Antagonist, Placebo control - Coronary Spasm | Phase 2 / Phase 3 | Enrolling by invitation | Radboud University Medical Center | 100 | 2024-11-11 | 2024-11-18 |
| Bioequivalence Study to Compare Bosentan 32 mg Dispersible Tablets Versus Tracleer® 32 mg Tablets Bosentan Dispersible Tablets, Tracleer Tablet for Oral Suspension - Pulmonary Arterial Hypertension | Phase 1 | Completed | Humanis Saglık Anonim Sirketi | 32 | 2024-04-21 | 2024-07-03 |
| A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014) Embibatinib, Rabeprazole, Midazolam - Healthy | Phase 1 | Completed | Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 196 | 2023-12-21 | 2026-10-22 |
| A Study in Healthy Men to Test Whether Bosentan Influences the Amount of BI 425809 in the Blood BI 425809, Bosentan - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 14 | 2023-03-06 | 2026-03-30 |
| Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension Mono-Therapy with Sildenafil, Duo-Therapy with Sildenafil + Bosentan - Pediatric Pulmonary Hypertension | Phase 3 | Completed | Johns Hopkins University | 28 | 2022-08-01 | 2026-02-18 |
| Endothelin-1 Receptor Blockade in Resistant Hypertension Bosentan, Placebo - Resistant Hypertension | Phase 2 | Recruiting | University Hospital, Rouen | 24 | 2021-10-20 | 2026-02-17 |
| Gemcitabine, Nab-Paclitaxel, and Bosentan for the Treatment of Unresectable Pancreatic Cancer Bosentan, Gemcitabine, Nab-paclitaxel - Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8 | Phase 1 | Suspended | City of Hope Medical Center | 21 | 2021-09-01 | 2026-06-15 |
| Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1 Dietary Nitrates 400 mg, L-citrulline 3 g, Sildenafil 100 mg - Vascular Function, Racial Disparity | Early Phase 1 | Terminated | University of Mississippi Medical Center | 8 | 2021-05-27 | 2023-10-31 |
| Study to Evaluate the Effect of Bosentan on the Pharmacokinetics of Lurbinectedin in Patients With Advanced Solid Tumors Lurbinectedin, Bosentan - Advanced Solid Tumor | Phase 1 | Completed | PharmaMar | 11 | 2021-01-14 | 2025-09-16 |
| Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN Bosentan Tablets, Sildenafil Tablet, Tadalafil Tablets - Persistent Pulmonary Hypertension of the Newborn | Unknown | Shandong University | 500 | 2020-04-26 | 2020-05-07 | |
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: - Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension | Recruiting | Duke University | 5000 | 2020-03-05 | 2026-08-21 | |
| Safety of Bosentan in Type II Diabetic Patients Bosentan, Placebo - Diabetes Mellitus | Phase 1 | Completed | Retinset SL | 22 | 2019-09-07 | 2023-02-16 |
| Bioequivalence Study of Bosentan 125 mg Tablets Immediate Release (IR) Versus Tracleer® 125 mg Tablets IR In Healthy Subjects Bosentan 125 mg, Tracleer 125Mg Tablet - Bioequivalence | Phase 1 | Completed | Geropharm | 64 | 2018-05-24 | 2019-09-24 |
| Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of Bosentan BIA 5-1058, bosentan - Pulmonary Arterial Hypertension | Phase 1 | Completed | Bial - Portela C S.A. | 44 | 2018-02-06 | 2021-08-05 |
| the Effect of Tracleer on Tourniquet-associated Hypertension Tracleer 125Mg Tablet, Placebo - Tourniquets, Hypertension | Phase 4 | Unknown | Xuzhou Medical University | 80 | 2017-08-01 | 2017-07-25 |
| Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences Hypoxic exposure, modified Oxford test, Oral Bosentan 62.5 mg - Sleep Apnea, Healthy | Early Phase 1 | Completed | University of Missouri-Columbia | 54 | 2016-12-20 | 2021-12-06 |
Showing 20 of 105. Sign in to see all of them.
Pulmonary Arterial Hypertension (29) · Hypertension, Pulmonary (19) · Scleroderma, Systemic (10) · Hypertension (7) · Scleroderma, Diffuse (6) · Heart Defects, Congenital (5) · Idiopathic Pulmonary Fibrosis (5) · Lung Diseases, Interstitial (5) · Diabetes Mellitus, Type 2 (4) · Anemia, Sickle Cell (3) · Heart Failure (3) · Inflammation (3) · digital ulcers (3) · Aneurysm (2) · Arrhythmias, Cardiac (2)
Actelion (28) · Boehringer Ingelheim (4) · Assistance Publique - Hôpitaux de Paris (3) · Radboud University Medical Center (3) · Air Force Military Medical University, China (2) · Copenhagen University Hospital, Rigshospitalet (2) · Hospital Universitario Getafe (2) · Medical University of Vienna (2) · University Hospital, Grenoble (2) · University of Edinburgh (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · All India Institute of Medical Sciences (1) · Amsterdam UMC, location VUmc (1) · Augusta University (1) · Berto J Bouma (1)
United States (24) · Germany (14) · France (12) · Netherlands (10) · United Kingdom (10) · Australia (7) · Austria (7) · Canada (7) · China (7) · Italy (7) · Spain (7) · Belgium (4) · Israel (4) · Czechia (3) · India (3)
Andjela Kusic-Pajic, MD (3) · Isabelle Leconte (2) · Shengqing Li, MD, PhD (2) · Anders H Hebert, MD (1) · Andrea Lauer, Ph.D. (1) · Andries J Smit, MDPhD (1) · Annegret Kuhn, MD (1) · Anton Vonk Noordegraaf, MD, PhD (1) · Antonio Augusto Lopes, M.D. (1) · Athol U Wells, MD FRCP FRCR (1) · B.J. Bouma, MD, PhD (1)
PMID 20175775, PMID 33765691, PMID 10732898, PMID 10851208, PMID 11927799, PMID 12119802, PMID 12923400, PMID 15738343, PMID 16391172, PMID 16533484, PMID 17901413, PMID 18426998, PMID 18572079, PMID 19047577, PMID 19095129, PMID 19679600, PMID 19738158, PMID 20002090, PMID 20202971, PMID 20350333, PMID 20506355, PMID 20805294, PMID 21474646, PMID 22127844, PMID 22200728, PMID 22333218, PMID 22801444, PMID 23266540, PMID 23663658, PMID 24177203, PMID 24342407, PMID 24614374, PMID 24928953, PMID 24937643, PMID 24949994, PMID 25172889, PMID 25217217, PMID 25446057, PMID 26039810, PMID 26113687, PMID 26386921, PMID 26643404, PMID 26651453, PMID 26926644, PMID 27502103, PMID 27522443, PMID 27683610, PMID 28119496, PMID 28137820, PMID 28290120
2005 (2), 2015 (2), 2025 (2), 2004 (1), 2014 (1), K99HL130339 (1), P01HL069999 (1), R00HL130339 (1), U24TR001609 (1), U24TR004440 (1), UG3HL151458 (1), UH3HL151458 (1)