7 completed, 5 recruiting, 5 unknown, 3 not yet recruiting. 22 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Completed 7, Recruiting 5, Unknown 5, Not yet recruiting 3, Active not recruiting 2 |
Follow Mitral Valve Stenosis: new trials by email Literature Review of Mitral Valve Stenosis trials Research Report on Mitral Valve Stenosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral SAPIEN X4 THV - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Edwards Lifesciences | 125 | 2027-01-01 | 2025-12-22 |
| The Feasibility Study of Polymer Artificial Heart Valve for the Treatment the Mitral Valve Disease. mitral valve replacement - Severe Mitral Valve Regurgitation, Severe Mitral Valve Stenosis | Not applicable | Recruiting | Shanghai HeartEpoch Medical Technology Co., Ltd | 10 | 2025-11-19 | 2026-07-06 |
| Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve Polymer Prosthetic Heart Valve - AORTIC VALVE DISEASES, Mitral Valve Disease | Not applicable | Recruiting | Mitrassist Lifesciences Limited Co., Ltd. | 10 | 2025-06-27 | 2025-07-31 |
| Cephea South America Feasibility Study Cephea Mitral Valve System - Mitral Regurgitation, Mitral Stenosis | Not applicable | Active not recruiting | Abbott Medical Devices | 20 | 2025-06-17 | 2026-09-11 |
| Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVE SmartWave Lithotripsy balloon - Mitral Annulus Calcification, Rheumatic Heart Disease | Not applicable | Recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 10 | 2025-03-08 | 2026-09-16 |
| Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery Acute normovolemic hemodilution (ANH), hydroxyethyl starch (HES 130/0.6) - Mitral Regurgitation, Mitral Stenosis | Not applicable | Not yet recruiting | Konkuk University Medical Center | 70 | 2024-10-28 | 2024-10-31 |
| Impact of Percutaneous Transvenous Mitral Commissurotomy on The Left Atrial Appendage Function in Patients With Mitral Stenosis. Transesophageal echocardiography - Mitral Stenosis | Not applicable | Not yet recruiting | Assiut University | 25 | 2024-07-01 | 2024-04-02 |
| Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients Ultrasound examination of the lungs - Ischemic Heart Disease, Aortic Stenosis, Severe | Not applicable | Recruiting | Saint Petersburg State University, Russia | 186 | 2024-05-15 | 2024-12-09 |
| The China Mviv Registry Transseptal Transcatheter Mitral valve-in-valve Replacement - Bioprosthesis Failure, Mitral Stenosis With Insufficiency | Not applicable | Unknown | Xiamen Cardiovascular Hospital, Xiamen University | 50 | 2023-07-11 | 2023-06-29 |
| Rate Control Efficacy in Atrial Fibrillation With Rheumatic Mitral Stenosis: Lenient vs Strict Rate Control Strategies Rate control - Atrial Fibrillation, Rheumatic Mitral Stenosis | Not applicable | Unknown | University of Brawijaya | 100 | 2023-03-01 | 2024-05-10 |
| Clinical Investigation for the Foldax Tria Mitral Valve- India Mitral Valve Replacement - Mitral Valve Disease, Mitral Regurgitation | Not applicable | Unknown | Foldax, Inc | 70 | 2023-03-01 | 2024-01-05 |
| The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves). Transseptal ViMAC - Mitral Annular Calcification, Mitral Stenosis | Not applicable | Recruiting | Mayra Guerrero | 210 | 2021-03-08 | 2026-01-13 |
| Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement Foldax TRIA Mitral Valve - Mitral Valve Disease, Mitral Valve Stenosis | Not applicable | Unknown | Foldax, Inc | 15 | 2021-02-01 | 2023-09-13 |
| SLOW-Slower Progress of caLcificatiOn With Vitamin K2 Vitamin K2, Placebo - Aortic Valve Stenosis, Aortic Valve Calcification | Not applicable | Unknown | National and Kapodistrian University of Athens | 200 | 2019-09-23 | 2021-09-01 |
| NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation Edwards SAPIEN 3 transcatheter heart valve, ASHI INTECC Astato XS 20 - Mitral Valve Failure | Not applicable | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 32 | 2017-06-20 | 2023-08-15 |
| Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study Mitral Valve Replacement (MVR) with Sapien3 - Mitral Annular Calcification | Not applicable | Completed | Baylor Research Institute | 25 | 2016-11-04 | 2025-02-24 |
| Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery Acute normovolemic hemodilution (ANH), hydroxyethyl starch (HES 130/0.6) - Mitral Regurgitation, Mitral Stenosis | Not applicable | Completed | Konkuk University Medical Center | 70 | 2016-01-01 | 2020-01-30 |
| Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study Ambulation orderly - Coronary Artery Disease, Mitral Valve Insufficiency | Not applicable | Completed | Baystate Medical Center | 36 | 2015-03-01 | 2017-11-06 |
| ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE) Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M - Aortic Stenosis, Mitral Stenosis | Not applicable | Completed | Edwards Lifesciences | 777 | 2012-12-11 | 2026-05-07 |
| Teledi@Log - Tele-rehabilitation of Heart Patients Telerehabilitation programme - Heart Failure, Myocardial Infarction | Not applicable | Completed | Aalborg University | 151 | 2012-12-01 | 2015-12-30 |
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Mitral Valve Insufficiency (15) · Aortic Valve Stenosis (6) · Aortic Valve Insufficiency (5) · Heart Failure (3) · Tricuspid Valve Insufficiency (3) · Rheumatic Heart Disease (2) · Aneurysm, Ascending Aorta (1) · Angina Pectoris (1) · Aortic Valve Disease (1) · Aortic Valve, Calcification of (1) · Arrhythmias, Cardiac (1) · Atrial Fibrillation (1) · Bites and Stings (1) · Coronary Artery Disease (1)
Cardiovascular Diseases (22) · Heart Diseases (22) · Heart Valve Diseases (22) · Ventricular Outflow Obstruction (6) · Aortic Valve Disease (5) · Vascular Diseases (4) · Bacterial Infections (2) · Bacterial Infections and Mycoses (2) · Coronary Disease (2) · Gram-Positive Bacterial Infections (2) · Infections (2) · Myocardial Ischemia (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Rheumatic Fever (2)
Hydroxyethyl Starch Derivatives (2) · Blood Pressure Monitors (1) · Echocardiography, Transesophageal (1) · Heart Rate (1) · Vitamin K 2 (1)
Abbott Medical Devices (2) · Edwards Lifesciences (2) · Foldax, Inc (2) · Konkuk University Medical Center (2) · Aalborg University (1) · Asan Medical Center (1) · Assiut University (1) · Baylor Research Institute (1) · Baystate Medical Center (1) · Mayra Guerrero (1) · Mitrassist Lifesciences Limited Co., Ltd. (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · National and Kapodistrian University of Athens (1) · Prince of Wales Hospital, Shatin, Hong Kong (1) · Saint Petersburg State University, Russia (1)
United States (7) · China (3) · South Korea (3) · Brazil (1) · Canada (1) · Chile (1) · Denmark (1) · Greece (1) · Hong Kong (1) · India (1) · Indonesia (1) · Mexico (1) · Poland (1) · Russia (1)
Amar Krishnaswamy, MD (1) · Ardian Rizal, MD, FIHA (1) · Barathi Sethuraman (1) · Birthe Dinesen, PhD (1) · Duk-Hyun Kang, MD, PhD (1) · Frank Shannon, MD (1) · James McCabe, MD (1) · John Puskas, MD (1) · Kent So, MbChB (1) · Mayra Guerrero, MD (1) · Peter Lindenauer, MD, MSc (1) · Robert J Lederman, M.D. (1) · Robert Smith, MD (1) · Tae-Yop Kim, MD, PhD (1) · Urban Lonn, MD, PhD (1)
PMID 26579590, PMID 26713491, PMID 27044310, PMID 28605428, PMID 29699609, PMID 30455168, PMID 30687584, PMID 31118146, PMID 32340804, PMID 34191132, PMID 34526318, PMID 35065065, PMID 37778503, PMID 37808026, PMID 38135262, PMID 39243268, PMID 39780838, PMID 40589299, PMID 40748697, PMID 41960126