769 completed, 309 unknown, 150 recruiting, 83 terminated. 411 Not applicable, 226 Phase 4, 126 Phase 3, 87 Phase 2, 41 Phase 1.
Follow Acute Coronary Syndrome: new trials by email Literature Review of Acute Coronary Syndrome trials Research Report on Acute Coronary Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Spontaneous Coronary Artery Dissection - AntipLatelet Therapy Intensity in Guided coNservative Management (SCAD-ALIGN) Trial Acetylsalicylic acid ASA, ASA plus Clopidogrel - SCAD, ACS (Acute Coronary Syndrome) | Phase 4 | Not yet recruiting | Universitätsklinikum Hamburg-Eppendorf | 3518 | 2027-03-01 | 2026-10-16 |
| IVUS-Guided Sirolimus-Coated Balloon Versus Sirolimus-Eluting Stent for De Novo Large Vessel Lesions in ACS IVUS-Guided Sirolimus-Coated Balloon, IVUS-Guided Sirolimus-Eluting Stent - Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI) | Not applicable | Not yet recruiting | China National Center for Cardiovascular Diseases | 150 | 2026-12-01 | 2026-10-15 |
| Effect of Guided Imagery on Sleep Quality, State Anxiety, and Comfort in Patients With Acute Coronary Syndrome Guided Imagery - Acute Coronary Syndromes (ACS) | Not applicable | Not yet recruiting | Afyonkarahisar Health Sciences University | 64 | 2026-11-15 | 2026-08-31 |
| AI-ECG Detection of Occlusion Myocardial Infarction at Emergency Department Triage (TRIACS) Acute Coronary Syndromes, Chest Pain | Not yet recruiting | University Medical Centre Maribor | 1000 | 2026-10-19 | 2026-10-20 | |
| Real-World Outcomes of Drug-Coated Balloon Angioplasty in Coronary Artery Disease Coronary Drug-Coated Balloon - Coronary Artery Disease | Recruiting | Kristian Rivera | 2000 | 2026-10-16 | 2026-10-20 | |
| Noninferiority Trial Of Sirolimus With Ascorbic Acid Versus Everolimus in All-comers Sirolimus-Ascorbic Acid Eluting Stent, Everolimus-Eluting Stent - Coronary Artery Disease | Not applicable | Recruiting | Jung-min Ahn | 2034 | 2026-10-06 | 2026-10-07 |
| Common Femoral Vein-to-Artery Diameter Ratio for Detection of Elevated LVEDP Ultrasound Measurement of Common Femoral Vein-to-Artery Diameter Ratio - Acute Coronary Syndrome, Chronic Coronary Syndrome | Recruiting | Burapha University | 105 | 2026-10-01 | 2026-10-14 | |
| Echocardiographic Molecular Imaging for POC Detection of Ischemia Myocardial Contrast Echo (MCE) molecular imaging with Sonazoid - Acute Coronary Syndrome | Early Phase 1 | Not yet recruiting | University of Virginia | 80 | 2026-09-30 | 2026-08-20 |
| Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP) Intrahospital seasonal influenza vaccination offer, Standardized active influenza vaccination counseling, Standard of care discharge recommendation for ambulatory vaccination - Acute Coronary Syndrome, Heart Failure | Not applicable | Recruiting | Stephan Baldus | 482 | 2026-09-30 | 2026-10-13 |
| Smartphone AI Assistance for Prehospital ECG Interpretation Smartphone large language model assistance (GPT-4o, version-locked) - Acute Coronary Syndromes, ST Elevation Myocardial Infarction | Not applicable | Recruiting | École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care | 144 | 2026-09-02 | 2026-09-09 |
| Dual Antiplatelet Therapy Strategies After Acute Myocardial Infarction Undergoing PCI: Prasugrel vs Ticagrelor & 12 Months vs 1-3 Months Prasugrel, Ticagrelor - Myocardial Infarction (MI) | Phase 4 | Recruiting | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 8100 | 2026-09-02 | 2026-09-09 |
| "Discovery2" Study of Using MCG at Emergency Departments Magnetocardiography - Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD) | Not yet recruiting | SB Technology, Inc. | 200 | 2026-09-01 | 2026-09-16 | |
| Non-Invasive Follow-Up of Patients With Coronary Artery Disease Treated With Drug-Coated Balloon PCI Using CT-Derived Fractional Flow Reserve Coronary Arterial Disease (CAD), Acute Coronary Syndromes (ACS) | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 150 | 2026-09-01 | 2026-09-16 | |
| Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation 0/3-hour high-sensitivity cardiac troponin algorithm, 0/1-hour high-sensitivity cardiac troponin algorithm - Coronary Syndrome, Acute, Myocardial Infarction | Not applicable | Not yet recruiting | Herlev and Gentofte Hospital | 28000 | 2026-09-01 | 2026-08-06 |
| Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARL Pelacarsen, Placebo - Acute Coronary Syndrome (ACS) | Phase 3 | Withdrawn | Novartis Pharmaceuticals | 2026-09-01 | 2026-10-14 | |
| Music Medicine in Coronary Interventional Cardiology Procedures Music Medicine intervention - Acute Coronary Syndrome | Not applicable | Not yet recruiting | Azienda Ospedaliero Universitaria di Sassari | 208 | 2026-09-01 | 2026-08-26 |
| triPle Oral thERapy With Bempedoic Acid vs uSual Care in Early Lipid Management of Patients With acUte coronAry synDromE Triple oral lipid lowering treatment - Acute Coronary Syndromes, Secondary Prevention | Phase 3 | Not yet recruiting | Heart Care Foundation | 600 | 2026-09-01 | 2026-02-27 |
| Self-Management Support for Acute Coronary Syndrome Patients After Hospital Discharge COM-B and HAPA-based Self-management Support Program, Routine Health Education - Acute Coronary Syndrome (ACS) | Not applicable | Not yet recruiting | Nanfang Hospital, Southern Medical University | 80 | 2026-09-01 | 2026-09-04 |
| Early Intensive Lipid-Lowering With Inclisiran for Plaque Stabilization in Acute Coronary Syndrome Inclisiran, Atorvastatin or Rosuvastatin, Ezetimibe - Acute Coronary Syndromes (ACS) | Phase 4 | Not yet recruiting | Seoul National University Bundang Hospital | 294 | 2026-09-01 | 2026-09-02 |
| Left Atrial Strain for Predicting MACE in NSTEMI Non-ST Elevation Myocardial Infarction (NSTEMI), Acute Coronary Syndrome | Not yet recruiting | Assiut University | 150 | 2026-08-26 | 2026-09-01 |
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Myocardial Infarction (237) · Coronary Artery Disease (222) · Angina, Unstable (111) · ST Elevation Myocardial Infarction (108) · Chest Pain (93) · Cardiovascular Diseases (91) · Non-ST Elevated Myocardial Infarction (91) · Myocardial Ischemia (82) · Coronary Disease (59) · Heart Failure (49) · Atherosclerosis (48) · Angina Pectoris (40) · Angina, Stable (38) · Heart Diseases (37)
Vascular Diseases (1449) · Heart Diseases (1423) · Myocardial Ischemia (1378) · Cardiovascular Diseases (1369) · Pathological Conditions, Signs and Symptoms (597) · Pathologic Processes (473) · Necrosis (343) · Infarction (339) · Ischemia (339) · Signs and Symptoms (262) · Arteriosclerosis (254) · Arterial Occlusive Diseases (253) · Neurologic Manifestations (248) · Pain (237) · Coronary Disease (220)
Clopidogrel (102) · Ticagrelor (90) · Prasugrel Hydrochloride (51) · Aspirin (47) · Percutaneous Coronary Intervention (29) · Atorvastatin (28) · Rosuvastatin Calcium (23) · Rivaroxaban (18) · Colchicine (13) · Standard of Care (13) · Blood Specimen Collection (11) · Ezetimibe (11) · Heparin (10) · Tablets (10) · cangrelor (10)
AstraZeneca (33) · Assistance Publique - Hôpitaux de Paris (19) · Massachusetts General Hospital (19) · Assiut University (16) · Wake Forest University Health Sciences (13) · Yonsei University (13) · Shenyang Northern Hospital (12) · Columbia University (11) · Seoul National University Hospital (11) · Federico II University (10) · GlaxoSmithKline (10) · Ottawa Heart Institute Research Corporation (10) · Sohag University (10) · Assistance Publique Hopitaux De Marseille (9) · Beijing Anzhen Hospital (9)
United States (262) · China (176) · Italy (136) · France (125) · Canada (102) · South Korea (99) · United Kingdom (92) · Germany (91) · Spain (84) · Netherlands (82) · Poland (61) · Brazil (52) · Belgium (50) · Sweden (47) · Switzerland (42)
Fred S Apple, PhD (5) · Ron Waksman, MD (5) · Kit Yee Au-Yeung, PhD (4) · Anna Toso, MD (3) · Anthony P Sunjaya (3) · Antti Ylitalo, MD, PhD (3) · Furio Colivicchi, MD (3)
PMID 35224730, PMID 37131096, PMID 19717846, PMID 21670242, PMID 21873419, PMID 23996244, PMID 26089177, PMID 27902833, PMID 28382371, PMID 28988157, PMID 29632238, PMID 29910052, PMID 31242362, PMID 31535314, PMID 35196863, PMID 35641327, PMID 37619976, PMID 37745109, PMID 38551015, PMID 12241831, PMID 17982182, PMID 19106084, PMID 19915221, PMID 19915222, PMID 19923168, PMID 21470671, PMID 21570509, PMID 22253393, PMID 22305835, PMID 22496116, PMID 22858390, PMID 22922414, PMID 22995877, PMID 23314553, PMID 23375478, PMID 23473369, PMID 23491524, PMID 23991622, PMID 24076283, PMID 24291273, PMID 24345099, PMID 24473509, PMID 24768873, PMID 24884807, PMID 25773268, PMID 26198286, PMID 26320110, PMID 27160944, PMID 28183511, PMID 28385306
2014 (7), 2015 (5), 2009 (4), 2017 (4), 2016 (3), 2019 (3), P30AG064198 (3), R01HL113272 (3), 2025 (2), 1RC2HL101458-01 (1), 2008 (1), I01CX002045 (1), K23AT009715 (1), K23HL077597 (1), K24HL084034 (1)