11 completed, 3 unknown, 2 terminated, 2 withdrawn. 6 Phase 2, 3 Phase 1, 2 Phase 3, 2 Phase 4, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 4, Terminated 1, Unknown 1 |
| Phase 1 | 3 | Completed 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
| Phase 4 | 2 | Unknown 1, Withdrawn 1 |
| Not applicable | 1 | Completed 1 |
Follow Antithrombin III: new trials by email Literature Review of Antithrombin III trials Research Report on Antithrombin III
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of Antithrombin III, Protein C, Protein S and D-dimer in Acute Leukemia Antithrombin III, Protein C, Protein S - Acute Leukemia | Completed | Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy | 90 | 2023-06-01 | 2026-01-29 | |
| Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery Atenativ - Congenital Antithrombin Deficiency | Phase 3 | Recruiting | Octapharma | 38 | 2022-07-01 | 2026-09-28 |
| Antithrombin III in Infectious Disease Caused by COVID-19 Antithrombin III - Antithrombin III Deficiency, Covid19 | Phase 2 | Terminated | Enrique Ginzburg | 52 | 2021-07-06 | 2022-09-07 |
| Preventing de Novo Portal Vein Thrombosis With Antithrombin-III in Patients With Cirrhosis Antithrombin III, Placebo - Portal Vein Thrombosis, Cirrhosis, Liver | Phase 1 | Withdrawn | Jonathan Stine | 2021-01-01 | 2022-03-10 | |
| Observational, Retrospective Study to Evaluate Coagulation Changes and the Influence of Antithrombin III Treatment in Patients With Severe COVID-19 Infection Antithrombin III - Covid19 | Completed | Octapharma | 300 | 2020-10-19 | 2023-10-10 | |
| Antithrombin III Concentrate After Liver Transplantation Antithrombin III, continuous infusion, Antithrombin III, Intermittent infusion - Liver Transplant; Complications | Not applicable | Completed | Seoul National University Hospital | 130 | 2020-01-03 | 2022-07-01 |
| Prospective Investigation of Antithrombin III Deficiency in Adult Patients With ECMO Antithrombin III - Antithrombin III Deficiency, Extracorporeal Membrane Oxygenation Complication | Completed | Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital | 50 | 2020-01-01 | 2022-05-24 | |
| Haemostatic Imbalance in Patients With Chronic Liver Disease Laboratory investigations ( protein C, protein S , antithrombin III) - Haemostasis Imbalance in Chronic Liver Disease | Unknown | Assiut University | 100 | 2018-09-01 | 2018-07-18 | |
| Atenativ Effect on Uterine Blood Flow and Preeclampsia Atenativ - Antithrombin III Deficiency | Phase 4 | Withdrawn | Vastra Gotaland Region | 2016-01-01 | 2017-09-26 | |
| Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support Antithrombin III - Extracorporeal Membrane Oxygenation Complication, Cardiopulmonary Bypass | Phase 1 | Completed | Children's Hospital Medical Center, Cincinnati | 27 | 2015-06-01 | 2019-01-25 |
| Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL) Antithrombin-III, Infliximab, Apotransferrin - Reperfusion Injury | Phase 2 | Completed | Universitaire Ziekenhuizen KU Leuven | 143 | 2014-09-01 | 2024-08-23 |
| Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiopulmonary Bypass AT-III (Human), Placebo - Cardiac Surgery, Cardiopulmonary Bypass | Phase 2 | Completed | Grifols Therapeutics LLC | 425 | 2014-06-26 | 2019-03-15 |
| Anti-thrombin III (ATIII) vs Placebo in Children (<7mo) Undergoing Open Congenital Cardiac Surgery Anti-thrombin III, Placebo - ATIII Deficiency | Phase 2 | Completed | Duke University | 45 | 2014-06-01 | 2019-11-25 |
| Antithrombin-III for Patients With Hepatic Veno-occlusive Diseases Following Hematopoietic Stem Cell Transplantation Freeze-dried Concentrated Human Antithrombin Ⅲ 500 IU - Hepatic Veno-Occlusive Disease | Phase 2 | Unknown | Seoul National University Hospital | 32 | 2013-06-01 | 2021-03-30 |
| Antithrombin III in Infants With Cardiopulmonary Bypass (CPB) Antithrombin III, Placebo - Congenital Heart Disease | Phase 1 | Terminated | University of Rochester | 6 | 2012-07-01 | 2016-03-22 |
| Antithrombin Enhancement May Improve Anticoagulation Efficiency in Infants Undergoing Cardiopulmonary Bypass for Cardiac Surgery Antithrombin III, Saline Placebo - Cardiopulmonary Bypass | Phase 3 | Completed | The Hospital for Sick Children | 18 | 2011-11-01 | 2015-01-07 |
| Antithrombin III and Post-liver Transplantation Acute Kidney Injury Antithrombin III - Liver Transplantation and Antithrombin | Completed | Asan Medical Center | 2395 | 2010-01-04 | 2021-06-03 | |
| Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery antithrombin III - Aortic Valve Insufficiency, Aortic Valve Stenosis | Phase 4 | Unknown | University of Bari | 90 | 2009-09-01 | 2010-09-15 |
| Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass Antithrombin III - Acquired Antithrombin III Deficiency, Coronary Artery Bypass | Phase 2 | Completed | Instituto Grifols, S.A. | 200 | 2009-06-01 | 2016-09-20 |
Antithrombin III Deficiency (3) · COVID-19 (2) · Acute Coronary Syndrome (1) · Acute Kidney Injury (1) · Aortic Valve Insufficiency (1) · Aortic Valve Stenosis (1) · Heart Defects, Congenital (1) · Hepatic Veno-Occlusive Disease (1) · Liver Cirrhosis (1) · Mitral Valve Insufficiency (1) · Mitral Valve Stenosis (1) · Pre-Eclampsia (1) · Reperfusion Injury (1)
Octapharma (2) · Seoul National University Hospital (2) · Asan Medical Center (1) · Assiut University (1) · Children's Hospital Medical Center, Cincinnati (1) · Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital (1) · Duke University (1) · Enrique Ginzburg (1) · Grifols Therapeutics LLC (1) · Instituto Grifols, S.A. (1) · Jonathan Stine (1) · Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy (1) · The Hospital for Sick Children (1) · Universitaire Ziekenhuizen KU Leuven (1) · University of Bari (1)
United States (7) · Italy (3) · South Korea (3) · Austria (2) · France (2) · Germany (2) · Sweden (2) · Armenia (1) · Belgium (1) · Canada (1) · Czechia (1) · Egypt (1) · Georgia (1) · Hungary (1) · Israel (1)
Brian W McCrindle, MD (1) · David Cooper, MD (1) · Diethard Monbaliu, MD, PhD (1) · Domenico Paparella, Investigator (1) · Edmund Jooste, MD (1) · Enrique Ginzburg (1) · Ho Geol Ryu, MD, PhD (1) · Hyoung Jin Kang, MD, Ph.D (1) · Marco Ranucci, MD (1) · Margareta Hellgren, MD,PhD,prof (1) · Michael Eaton, MD (1)
PMID 11057854, PMID 14719181, PMID 15500369, PMID 17636190, PMID 18226126, PMID 23102903, PMID 2329037, PMID 26108065, PMID 28767184, PMID 35877927, PMID 36853611, PMID 39207911, PMID 39911044, PMID 6484893, PMID 6618278, PMID 6872275