8 completed, 4 unknown, 2 recruiting, 1 withdrawn. 15 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 15 | Completed 8, Unknown 4, Recruiting 2, Withdrawn 1 |
| Phase 2 | 3 | Completed 1, Unknown 1, Withdrawn 1 |
Follow Mechanical Ventilation: new trials by email Literature Review of Mechanical Ventilation trials Research Report on Mechanical Ventilation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Pain Treatment in Children On Mechanical Ventilation Acetaminophen, Ketorolac, Placebo - Mechanical Ventilation, Pediatric Acute Respiratory Failure | Phase 3 | Recruiting | Weill Medical College of Cornell University | 644 | 2025-12-29 | 2026-10-29 |
| Ketamine Sedation in the ICU (KANINE) RCT ketamine hydrochloride, Normal saline placebo - Mechanical Ventilation, Critically Ill Intensive Care Unit Patients | Phase 3 | Recruiting | McMaster University | 54 | 2025-11-20 | 2026-10-22 |
| Long-term Sedation With Remimazolam Besylate in Critically Ill Patients Remimazolam besylate, Propofol - Light Sedation, Mechanical Ventilation | Phase 3 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 728 | 2023-05-16 | 2023-05-26 |
| Step 2 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients Remimazolam besylate, Propofol, Remifentanil - Sedative, Mechanical Ventilation | Phase 3 | Completed | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 164 | 2023-02-28 | 2024-01-31 |
| Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study Nefopam, Standard of care in the ICU for assessment and management of pain, sedation, and delirium. - Analgesia, Critical Illness | Phase 3 | Completed | Cairo University | 60 | 2021-10-01 | 2025-12-19 |
| Propranolol as an Anxiolytic to Reduce the Use of Sedatives From Critically-ill Adults Receiving Mechanical Ventilation Propranolol Hydrochloride - Mechanical Ventilation, Sedation | Phase 3 | Completed | Ottawa Hospital Research Institute | 72 | 2021-01-08 | 2022-12-05 |
| Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients Ketamine - Critical Illness, Sedation | Phase 3 | Completed | King Faisal Specialist Hospital & Research Center | 84 | 2019-08-28 | 2021-05-07 |
| "NAVA-PAV" Study: a Cross-over Comparative Study of 2 Advanced Modes NAVA ventilatory mode, PAV+ ventilatory mode - Critical Illness, Mechanical Ventilation | Phase 3 | Completed | University Hospital, Montpellier | 13 | 2012-05-01 | 2014-12-03 |
| Speech Effects of a Speaking Valve Versus External Positive End-expiratory Pressure (PEEP) in Tracheostomized Ventilator-Dependent Neuromuscular Patients Passy Muir Valve, Positive end expiratory pressure - Tracheostomy, Mechanical Ventilation | Phase 2 / Phase 3 | Completed | University of Versailles | 10 | 2008-12-01 | 2009-09-17 |
| Intermittent Sedation Versus Daily Interruption of Sedation in Mechanically Ventilated Patients Intermittent sedation, Daily interruption of sedation - Mechanical Ventilation | Phase 3 | Completed | University of Sao Paulo General Hospital | 60 | 2008-09-01 | 2012-06-11 |
| Effect of the Homeopathic Remedy Kalium Bichromicum (Potassium Dichromate) on Viscosity and Amount of Sputum and Time to Extubation in Mechanically Ventilated ICU Patients. Potassium Dichromate (Homeopathy), Placebo homeopathic remedy - Mechanical Ventilation | Phase 3 | Unknown | Shaare Zedek Medical Center | 56 | 2008-07-01 | 2012-02-22 |
| Septic Shock em Steroids Hydrocortisone - Mechanical Ventilation, Mortality | Phase 2 / Phase 3 | Unknown | Unidade de Terapia Intensiva | 160 | 2008-05-01 | 2010-01-13 |
| Rapip Study: Clinical Trial on Remifentanyl for Analgesia and Sedation of Ventilated Neonates and Infants Remifentanyl, Fentanyl - Mechanical Ventilation | Phase 3 | Completed | University of Cologne | 24 | 2006-11-01 | 2010-06-25 |
| Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation High Frequency Percussive Ventilation - Respiratory Distress Syndrome, Adult, Pneumonia | Phase 2 / Phase 3 | Withdrawn | University of Texas Southwestern Medical Center | 2006-01-01 | 2019-01-17 | |
| Protective Ventilatory Strategy in Potential Organ Donors change ventilation - Mechanical Ventilation | Phase 3 | Unknown | University of Turin, Italy | 200 | 2004-09-01 | 2009-06-17 |
Critical Illness (5) · Agnosia (2) · Delirium (2) · Acute Lung Injury (1) · Adrenal Insufficiency (1) · Brain Death (1) · Pneumonia (1) · Pneumonia, Ventilator-Associated (1) · Respiratory Distress Syndrome (1) · Sepsis (1) · Shock (1)
Pathological Conditions, Signs and Symptoms (9) · Pathologic Processes (8) · Disease Attributes (6) · Nervous System Diseases (4) · Neurobehavioral Manifestations (4) · Neurologic Manifestations (4) · Signs and Symptoms (3) · Confusion (2) · Infections (2) · Mental Disorders (2) · Neurocognitive Disorders (2) · Perceptual Disorders (2) · Adrenal Gland Diseases (1) · Brain Diseases (1) · Central Nervous System Diseases (1)
Propofol (3) · Fentanyl (2) · Ketamine (2) · Remifentanil (2) · Acetaminophen (1) · Homeopathy (1) · Hydrocortisone (1) · Ketorolac (1) · Midazolam (1) · Nefopam (1) · Positive-Pressure Respiration (1) · Potassium Dichromate (1) · Propranolol (1) · Restraint, Physical (1) · Standard of Care (1)
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (2) · Cairo University (1) · King Faisal Specialist Hospital & Research Center (1) · McMaster University (1) · Ottawa Hospital Research Institute (1) · Shaare Zedek Medical Center (1) · Unidade de Terapia Intensiva (1) · University Hospital, Montpellier (1) · University of Cologne (1) · University of Sao Paulo General Hospital (1) · University of Texas Southwestern Medical Center (1) · University of Turin, Italy (1) · University of Versailles (1) · Weill Medical College of Cornell University (1)
Brazil (2) · Canada (2) · China (2) · France (2) · United States (2) · Egypt (1) · Germany (1) · Israel (1) · Italy (1) · Saudi Arabia (1)
Antonio Paulo Nassar Junior, MD (1) · Bernhard Roth, Prof. (1) · Chani Traube, MD (1) · Djillali Annane, MD, PhD (1) · James Downar, MDCM (1) · Marcelo Park, PhD (1) · Menachem Oberbaum, M.D. (1) · Mohammed Gamal Abdelraouf Amer, Pharm D (1) · Moshe Hersch, M.D. (1) · Randall Friese, MD (1)
PMID 21156950, PMID 22456770, PMID 24900938, PMID 32197636, PMID 34462007, PMID 37576823, PMID 38767196, PMID 39982178, PMID 40250620, PMID 40493335, PMID 41915173
U01HD116260 (1)