6 completed, 3 recruiting, 2 not yet recruiting, 2 unknown. 15 Phase 2, 3 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 6, Recruiting 3, Not yet recruiting 2, Unknown 2, Withdrawn 2 |
| Phase 3 | 3 | Completed 1, Unknown 1, Withdrawn 1 |
| Phase 1 | 2 | Not yet recruiting 1, Recruiting 1 |
Follow Mechanical Ventilation: new trials by email Literature Review of Mechanical Ventilation trials Research Report on Mechanical Ventilation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy Amino Acid infusion, Lactated ringers solution - Acute Kidney Injury, Mechanical Ventilation | Phase 2 | Recruiting | Dana Fuhrman | 30 | 2026-07-08 | 2026-07-24 |
| Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled Trial Microbiome-guided inhaled antibiotic prophylaxis, Placebo - Critical Illness, Mechanical Ventilation | Phase 2 | Not yet recruiting | University of Calgary | 70 | 2026-05-01 | 2026-03-11 |
| Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Recruiting | Charite University, Berlin, Germany | 80 | 2025-12-05 | 2026-10-15 |
| Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation fentanyl, Hydromorphone - Mechanical Ventilation, Sedation and Analgesia | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 319 | 2025-11-03 | 2026-07-14 |
| Improvement of Lung and Thoracic Compliance in ARDS Patients in Prone Position by Using Inflatable Air Bag prone position with airbags, prone position without airbags - ARDS, Prone Position | Phase 2 | Recruiting | Centre Hospitalier Universitaire, Amiens | 30 | 2022-08-23 | 2025-05-28 |
| CYCLE Pilot Randomized Trial In-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy - Intensive Care Unit Acquired Weakness, Critical Care | Phase 2 | Completed | McMaster University | 113 | 2015-03-01 | 2022-12-05 |
| Study of Muscle Effects of BYM338 in Mechanically Ventilated Patients BYM338, Placebo - Mechanical Ventilation | Phase 2 | Withdrawn | Novartis Pharmaceuticals | 2014-04-01 | 2015-01-07 | |
| Speech Effects of a Speaking Valve Versus External Positive End-expiratory Pressure (PEEP) in Tracheostomized Ventilator-Dependent Neuromuscular Patients Passy Muir Valve, Positive end expiratory pressure - Tracheostomy, Mechanical Ventilation | Phase 2 / Phase 3 | Completed | University of Versailles | 10 | 2008-12-01 | 2009-09-17 |
| Septic Shock em Steroids Hydrocortisone - Mechanical Ventilation, Mortality | Phase 2 / Phase 3 | Unknown | Unidade de Terapia Intensiva | 160 | 2008-05-01 | 2010-01-13 |
| Removal of Endotracheal Tube Secretions Comprehensively Until Extubation CAM (Complete Airway Management) Catheters - Mechanical Ventilation, Pneumonia | Phase 2 | Unknown | O. M. Neotech, Inc. | 30 | 2008-04-01 | 2008-05-29 |
| Investigating Modes of Progressive Mobility ETM protocol - Critical Care, Mechanical Ventilation | Phase 2 | Completed | Hill-Rom | 82 | 2007-11-01 | 2009-07-03 |
| Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation High Frequency Percussive Ventilation - Respiratory Distress Syndrome, Adult, Pneumonia | Phase 2 / Phase 3 | Withdrawn | University of Texas Southwestern Medical Center | 2006-01-01 | 2019-01-17 | |
| Family Preparation Study For Withdrawal of Mechanical Ventilation From Their Family Member family preparation for withdrawing life support - Mechanical Ventilation, Critically Ill | Phase 2 | Completed | University of Wisconsin, Madison | 20 | 2003-10-01 | 2015-10-05 |
| Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol Sedation management strategy - Critical Illness, Mechanical Ventilation | Phase 2 | Completed | Mount Sinai Hospital, Canada | 65 | 2001-02-01 | 2006-03-02 |
Critical Illness (3) · Pneumonia, Ventilator-Associated (3) · Heart Defects, Congenital (2) · Pneumonia (2) · Respiratory Insufficiency (2) · Acute Kidney Injury (1) · Acute Lung Injury (1) · Adrenal Insufficiency (1) · Agnosia (1) · Bites and Stings (1) · Cachexia (1) · Muscular Atrophy (1) · Respiratory Distress Syndrome (1) · Sepsis (1) · Shock (1)
Pathological Conditions, Signs and Symptoms (9) · Pathologic Processes (6) · Disease Attributes (5) · Respiratory Tract Diseases (5) · Infections (4) · Cross Infection (3) · Healthcare-Associated Pneumonia (3) · Iatrogenic Disease (3) · Lung Diseases (3) · Respiration Disorders (3) · Respiratory Tract Infections (3) · Signs and Symptoms (3) · Cardiovascular Abnormalities (2) · Cardiovascular Diseases (2) · Congenital Abnormalities (2)
Standard of Care (2) · Air Bags (1) · Catheters (1) · Complementary Therapies (1) · Fentanyl (1) · Hydrocortisone (1) · Hydromorphone (1) · Positive-Pressure Respiration (1) · Prone Position (1) · Ringer's Lactate (1) · bimagrumab (1)
Charite University, Berlin, Germany (2) · Beth Israel Deaconess Medical Center (1) · Centre Hospitalier Universitaire, Amiens (1) · Dana Fuhrman (1) · Hill-Rom (1) · McMaster University (1) · Mount Sinai Hospital, Canada (1) · Novartis Pharmaceuticals (1) · O. M. Neotech, Inc. (1) · Unidade de Terapia Intensiva (1) · University of Calgary (1) · University of Texas Southwestern Medical Center (1) · University of Versailles (1) · University of Wisconsin, Madison (1)
United States (6) · Canada (2) · France (2) · Germany (2) · Australia (1) · Brazil (1)
Chris Winkelman, PhD (1) · Djillali Annane, MD, PhD (1) · Elias N Baedorf-Kassis, MD (1) · Karin T Kirchhoff (1) · Michelle Kho, PT, PhD (1) · Orlando V. Morejon, MD (1) · Randall Friese, MD (1) · Sangeeta Mehta, MD (1) · Stuart Goldstein, MD (1)
PMID 18552687, PMID 27059469, PMID 30956804, PMID 31455384, PMID 31741746, PMID 33331622, PMID 37355270, PMID 38865147, PMID 39317833, PMID 39467285