30 completed, 6 unknown, 2 not yet recruiting, 2 recruiting. 17 Not applicable, 10 Phase 3, 7 Phase 2, 6 Phase 4, 3 Phase 1.
Follow Nefopam: new trials by email Literature Review of Nefopam trials Research Report on Nefopam
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2026-10-01 | 2026-09-18 |
| Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy Nefopam 120mg/day infusion, Lidocaine Infusion, Peridural - Pancreatoduodenectomy, Pain Management | Phase 4 | Recruiting | Iuliu Hatieganu University of Medicine and Pharmacy | 93 | 2026-03-01 | 2026-03-24 |
| Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries. Nefopam - Nefopam, Dexmeditomidine | Not applicable | Completed | Kasr El Aini Hospital | 240 | 2025-01-10 | 2025-07-10 |
| Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO) Nefopam, NaCl 0.9% - Total Hip Arthroplasty | Phase 3 | Not yet recruiting | University Hospital, Tours | 546 | 2024-04-01 | 2024-04-05 |
| The Analgesic Efficacy of Nefopam in Orthopedics Surgery Nefopam 20 MG/ML, Placebo - Pain Management, Orthopedic Procedure Pain | Early Phase 1 | Completed | King Abdullah University Hospital | 49 | 2023-06-01 | 2024-11-08 |
| Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty Fentanyl, ketorolac tromethamine with nefopam hydrochloride - Postoperative Pain, Acute | Not applicable | Completed | Chung-Ang University Gwangmyeong Hospital | 98 | 2023-02-07 | 2024-07-15 |
| Role of Nefopam in Rituximab Transfusion Reaction Nefopam ampule, diphenhydramine ampule - Nefopam | Phase 3 | Unknown | Ministry Of Health / Nineveh Health Directorate | 100 | 2022-12-20 | 2022-12-15 |
| Safety, Tolerability and Efficacy of Nefopam Cream in Burn Patients Nefopam, Placebo (Vehicle) - Burn; Multiple Body Regions, Max. Second Degree, Third-Degree Burn | Phase 2 | Completed | University of Alberta | 50 | 2022-07-10 | 2026-07-24 |
| Nefopam as a Multimodal Analgesia for Thoracic Surgery Nefopam - Lung Cancer | Not applicable | Completed | Kangbuk Samsung Hospital | 46 | 2021-12-08 | 2023-02-14 |
| Pharmacokinetic Study of a Fixed Dose Combination Nefopam Hydrochloride (30 mg) / Paracetamol (500 mg) nefopam hydrochloride 30mg X2, paracetamol 500 mg X2, Combination Product: nefopam hydrochloride 30mg / paracetamol 500mg X2 - Healthy Volunteers | Phase 1 | Completed | Unither Pharmaceuticals, France | 32 | 2021-11-29 | 2024-10-31 |
| Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study Nefopam, Standard of care in the ICU for assessment and management of pain, sedation, and delirium. - Analgesia, Critical Illness | Phase 3 | Completed | Cairo University | 60 | 2021-10-01 | 2025-12-19 |
| Post-operative Analgesic Effect of Oral Nefopam Oral nefopam, Placebo - Postoperative Pain After a Total Knee Arthroplasty | Phase 2 | Recruiting | Hospices Civils de Lyon | 50 | 2021-06-29 | 2026-05-14 |
| Nonopioid Analgesics and Cholecystectomy nefopam, ketoprofen, paracetamol, saline infusion, ketoprofen, paracetamol - Cholecystectomy, Pain, Postoperative | Phase 3 | Completed | American University of Beirut Medical Center | 90 | 2021-04-08 | 2023-05-06 |
| Nefopam for Post Video-Assisted Thoracoscopic Lobectomy Nefopam 20 MG/ML, Placebo - Pain, Postoperative | Phase 4 | Completed | Mahidol University | 72 | 2020-09-01 | 2024-11-20 |
| The Efficacy of Postoperative Analgesia of Gabapentin Plus Nefopam in the Spinal Surgery Gabapentin - Spinal Fusion | Not applicable | Completed | Gia Dinh People Hospital | 60 | 2020-08-01 | 2021-06-07 |
| Effects of Continuous Infusion of Intravenous Nefopam on Postoperative Pain and Opioid Consumption After VATS Nefopam 80mg/day, Normal saline - Postoperative Pain | Not applicable | Completed | Seoul National University Hospital | 90 | 2020-07-30 | 2022-05-06 |
| Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction nefopam hydrochloride 30mg / paracetamol 500mg X2, Paracetamol 500 Mg Oral Tablet X2, Nefopam HCl 30 MG Oral Tablet X2 - Acute Pain | Phase 3 | Completed | Unither Pharmaceuticals, France | 321 | 2020-02-22 | 2024-11-27 |
| Analgesic Effectiveness of Nefopam in Patients Undergoing Anterior Cervical Spine Surgery Nefopam 20 mg/ml, Normal saline - Cervical Spine Degeneration | Not applicable | Unknown | Mahidol University | 50 | 2019-05-15 | 2020-09-04 |
| Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering Nefopam, Tramadol, Metoclopramide - Post Anaesthetic Shivering | Phase 2 | Unknown | Lagos State Health Service Commission | 130 | 2018-10-12 | 2018-07-17 |
| Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery Tramadol, Nefopam 20 MG/ML, Morphine Sulfate - Tendon Injuries | Phase 4 | Completed | Centre Hospitalier Universitaire de Nīmes | 92 | 2017-09-01 | 2025-12-16 |
Showing 20 of 41. Sign in to see all of them.
Pain, Postoperative (9) · Agnosia (7) · Pain (5) · Hyperalgesia (2) · Lung Neoplasms (2) · Acute Pain (1) · Anemia, Sickle Cell (1) · Breast Neoplasms (1) · Burns (1) · Cholecystitis (1) · Chronic Disease (1) · Cicatrix, Hypertrophic (1) · Colonic Neoplasms (1) · Critical Illness (1) · Delirium (1)
Yonsei University (4) · Seoul National University Bundang Hospital (3) · Seoul National University Hospital (3) · Assistance Publique - Hôpitaux de Paris (2) · Centre Hospitalier Universitaire de Nīmes (2) · Mahidol University (2) · Unither Pharmaceuticals, France (2) · University Hospital, Clermont-Ferrand (2) · American University of Beirut Medical Center (1) · Cairo University (1) · Centre de Maternité de Monastir (1) · Chung-Ang University Gwangmyeong Hospital (1) · Galen Limited (1) · Gia Dinh People Hospital (1) · Hallym University Kangnam Sacred Heart Hospital (1)
South Korea (14) · France (10) · Egypt (2) · Thailand (2) · United Kingdom (2) · Belgium (1) · Canada (1) · Hungary (1) · India (1) · Jordan (1) · Lebanon (1) · Romania (1) · Russia (1) · Switzerland (1) · Tunisia (1)
Binh V. Huynh (1) · Capucine Morelot, MD, PhD (1) · Edward E Tredget, MD (1) · Eunsu Choi, pf (1) · Manee Raksakietisak, MD (1) · Maria Akintimoye (1) · Mohammed Gamal Abdelraouf Amer, Pharm D (1)
PMID 28192892, PMID 14690106, PMID 23063945, PMID 24748937, PMID 26725583, PMID 27358262, PMID 28039239, PMID 28554928, PMID 30915987, PMID 32950669, PMID 37259157, PMID 38983158, PMID 40250620, PMID 41346412
2014 (1), 2015 (1)