207 completed, 75 unknown, 67 recruiting, 47 not yet recruiting. 205 Not applicable, 23 Phase 4, 15 Phase 2, 15 Phase 3, 4 Phase 1.
Follow Mechanical Ventilation: new trials by email Literature Review of Mechanical Ventilation trials Research Report on Mechanical Ventilation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients Extubation Failure, Mechanical Ventilation | Not yet recruiting | Universidade Federal de Pernambuco | 800 | 2027-03-30 | 2026-06-22 | |
| Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm) - Congenital Heart Disease, Cardiopulmonary Bypass | Phase 1 / Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2027-01-01 | 2026-10-15 |
| HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport Advanced Respiratory Support During Patient Transport - Acute Respiratory Failure, Respiratory Insufficiency | Not yet recruiting | Medipol University | 565 | 2026-12-31 | 2026-09-04 | |
| Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment - Intra-Abdominal Hypertension, Respiratory Mechanics | Not yet recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 100 | 2026-12-01 | 2026-10-26 | |
| Flow-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After Thoracic Surgery Flow-Controlled Ventilation, Volume-Controlled Ventilation - Mechanical Ventilation, Postoperative Pulmonary Complications (PPCs) | Not applicable | Not yet recruiting | Cantonal Hospital of St. Gallen | 140 | 2026-12-01 | 2026-10-20 |
| The Hemodynamic Impact of High-frequency Oscillatory Ventilation and Periodic Sighs in Preterm Infants Superimposed sigh breaths, High frequency ventilation - Preterm, Respiratory Distress Syndrome in Premature Infant | Not applicable | Not yet recruiting | Alexandria University | 100 | 2026-11-15 | 2026-10-27 |
| Planned Operating-Room Extubation After Cardiac Surgery Planned Operating-Room Extubation, Standard Early ICU Extubation - Mechanical Ventilation, Cardiac Surgery | Not applicable | Not yet recruiting | Nova Scotia Health Authority | 336 | 2026-11-01 | 2026-10-15 |
| Effect of PEEP on Indirect Calorimetry in Critically Ill Patients Protocolized PEEP Adjustment - Indirect Calorimetry, Mechanical Ventilation | Not applicable | Not yet recruiting | Vastra Gotaland Region | 20 | 2026-11-01 | 2026-09-01 |
| Computed Inspiratory Muscle Pressure to Monitor Inspiratory Effort During Pressure-Targeted Assist/Control Ventilation Positive end-expiratory pressure 11, Positive end-expiratory pressure 9, Positive end-expiratory pressure 7 - Mechanical Ventilation, Critical Care | Not applicable | Not yet recruiting | Jian-Xin Zhou | 30 | 2026-11-01 | 2026-10-21 |
| Computed Inspiratory Muscle Pressure to Monitor Inspiratory Effort During Pressure Support Ventilation Pressure support 15, Pressure support 13, Pressure support 11 - Mechanical Ventilation, Critical Care | Not applicable | Not yet recruiting | Jian-Xin Zhou | 30 | 2026-11-01 | 2026-10-21 |
| Development and Prospective Validation of the AutoEIT Foundation Model for ARDS AutoEIT Model Training, AutoEIT Blinded Validation - ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure | Not yet recruiting | Ruijin Hospital | 1200 | 2026-11-01 | 2026-10-27 | |
| Dynamic POCUS of Diaphragm Function to Predict Respiratory Failure in Septic Shock Respiration Failure, Diaphragmatic Dysfunction | Not yet recruiting | Assiut University | 120 | 2026-10-01 | 2026-09-15 | |
| Use of Connected Glasses to Help the Communication of Non Temporarily Speaking Patients in Intensive Care Unit : a Pilot Study Mechanical Ventilation, Critical Care, Intensive Care | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2026-10-01 | 2026-08-20 | |
| Trcheal High-flow for Weaning From Mechanical Ventilation Oxygen therapy - Tracheostomy, Mechanical Ventilation | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 500 | 2026-10-01 | 2026-07-20 |
| BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury Adaptive Support Ventilation (ASV), Conventional Lung-Protective Mechanical Ventilation - Burn, Mechanical Ventilation | Not applicable | Not yet recruiting | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-09-23 | 2026-06-29 |
| ASV and Targeted Fluid Resuscitation in Severe Burns Burn, War-Related Injuries | Not yet recruiting | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-09-23 | 2026-07-08 | |
| VC-AF vs FCV in Obese Patients Undergoing Laparoscopic Surgery Anesthesia, Mechanical Ventilation | Recruiting | Kocaeli University | 78 | 2026-09-21 | 2026-10-15 | |
| Effort of Breathing and Dyssynchrony Burden During Assisted Ventilation in Paediatric Patients Pressure Control Mode, Pressure Support Mode - Mechanical Ventilation, Paediatric Intensive Care | Not applicable | Not yet recruiting | The Hospital for Sick Children | 25 | 2026-09-21 | 2026-09-01 |
| Titration of PS Guided by FI : A Pilot Study FI-guided ventilator support adjustment, Conventional PS titration - Mechanical Ventilation | Not applicable | Recruiting | Capital Medical University | 60 | 2026-09-01 | 2026-10-23 |
| Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients Structured Awakening Evaluation (SAE) - Critical Illness, Mechanical Ventilation | Not yet recruiting | Patricia Rodriguez Villamizar | 500 | 2026-09-01 | 2026-07-17 |
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Critical Illness (61) · Respiratory Insufficiency (39) · Respiratory Distress Syndrome (33) · Agnosia (14) · Pneumonia, Ventilator-Associated (13) · Respiratory Aspiration (12) · COVID-19 (10) · Delirium (9) · Pulmonary Atelectasis (9) · Acute Lung Injury (8) · Brain Injuries (7) · Sepsis (7) · Obesity (6) · Pneumonia (6) · Pain (5)
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Capital Medical University (13) · University Hospital, Clermont-Ferrand (12) · Assistance Publique - Hôpitaux de Paris (8) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (7) · Jian-Xin Zhou (7) · Assiut University (5) · Southeast University, China (5) · Cairo University (4) · McMaster University (4) · Shanghai Zhongshan Hospital (4) · Tanta University (4) · University Hospital, Montpellier (4) · Washington University School of Medicine (4) · Ankara Etlik City Hospital (3) · Beth Israel Deaconess Medical Center (3)
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5KL2TR002734-03 (1), K23GM068842 (1), K23HL141704 (1), K23HL175246 (1), K76AG054864 (1), R01HL162721 (1), R01HL168474 (1), R34HL150404 (1), U01HD116260 (1)