43 completed, 11 unknown, 7 terminated, 4 not yet recruiting. 22 Not applicable, 5 Phase 2, 5 Phase 3, 3 Phase 1, 3 Phase 4.
Follow Brain Death: new trials by email Literature Review of Brain Death trials Research Report on Brain Death
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Miniature In-line Respirator Hope inVent - Brain Death, Respiration, Artificial | Not applicable | Not yet recruiting | National Institutes of Health Clinical Center (CC) | 5 | 2026-10-26 | 2026-10-21 |
| Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP) Apnea test under HHFO followed by an apnea test under CPAP., Apnea test under CPAP followed by an apnea test under HHFO. - Death, Brain | Not applicable | Not yet recruiting | Centre Hospitalier Régional d'Orléans | 28 | 2026-09-15 | 2026-07-10 |
| Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence Terminal Illness, End-of-Life Care | Not yet recruiting | Noah Tech, Corp. | 20 | 2026-09-01 | 2026-03-17 | |
| CT-Angiography Versus Angiogram as Ancillary Tests in the Determination of Death by Neurologic Criteria Infarction, Brain | Recruiting | Region Stockholm | 50 | 2026-01-01 | 2026-03-17 | |
| ICU Management of Brain-Dead Donors Before Multi-Organ Procurement and Factors Associated With the Number of Organs Retrieved No interventtion - Death, Brain | Recruiting | Société Française d'Anesthésie et de Réanimation | 1000 | 2025-04-23 | 2025-05-16 | |
| Determining ICU Staffs Conceptions, Opinions, Views, Experiences and Reflection of Brain Death and Organ Donation Brain Death | Completed | University Hospital, Basel, Switzerland | 338 | 2024-10-14 | 2026-06-17 | |
| Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation Atorvastatin 20mg - Cerebrovascular Event, Stent Stenosis | Phase 4 | Recruiting | Duan Chuanzhi | 354 | 2024-07-30 | 2026-03-03 |
| Etiology and Hemodynamic Instability in Brain Death VIS, TIES - Brain Death | Completed | Antalya Training and Research Hospital | 216 | 2024-05-30 | 2025-02-07 | |
| Automated Screening for Clinically Ascertained Loss of Cerebral Functions DETECT, Conventional care - Irreversible Loss of Brain Function (ILBF) | Not applicable | Not yet recruiting | Technische Universität Dresden | 4800 | 2024-05-01 | 2024-03-05 |
| Implementation of Apnoea Test for Patients With Suspected Brain Death Brain Death | Unknown | Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged | 200 | 2024-05-01 | 2024-05-06 | |
| Pupillometric Evaluation in Patients Declared Brain Dead - a Prospective Quality Control Study non-invasive device-supported, automated pupillometry - Brain Death, Adults | Recruiting | University Hospital, Basel, Switzerland | 50 | 2023-12-18 | 2026-06-17 | |
| Validation of the Apnea Test Performed by High-flow Oxygen Therapy in Patients With Clinical Brain Death Apnea test under high-flow oxygenation - Brain Death | Not applicable | Completed | Centre Hospitalier Régional d'Orléans | 15 | 2023-07-10 | 2024-08-02 |
| ORI and ETCO₂ Relationship With Arterial Blood Gas During Apnea Test No intervention (observational monitoring only) - Brain Death | Completed | Bursa Yuksek Ihtisas Training and Research Hospital | 35 | 2023-07-01 | 2026-04-22 | |
| Prone vs Supine Position in Potential Organ Donors: Multicenter Clinical Trial Prone position - Prone Position, Donors | Not applicable | Completed | Hospital de Alta Complejidad del Bicentenario Esteban Echeverría | 254 | 2023-06-01 | 2025-11-26 |
| Research on the Brain Death Determination in China ancillary tests - Brain Death, Electroencephalogram | Completed | Xuanwu Hospital, Beijing | 1974 | 2023-02-01 | 2023-06-15 | |
| Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY) Tacrolimus, Placebo - Organ Transplant Failure or Rejection, Brain Death | Phase 2 | Active not recruiting | Université de Sherbrooke | 414 | 2022-07-11 | 2025-04-17 |
| Incidence of Complications of Brain Death Brain Death | Unknown | Brno University Hospital | 50 | 2022-04-01 | 2023-03-28 | |
| Methods of Confirmation of Brain Death Brain Death, Organ Donation | Unknown | Brno University Hospital | 60 | 2022-04-01 | 2023-03-28 | |
| Electrical Impedance Tomography Measurements During Apnea Test in Patients With Suspected Brain Death Apnea test, alveolar recruitment - Brain Death | Not applicable | Completed | Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged | 10 | 2021-04-01 | 2024-02-20 |
| Evaluation of CTA on the Assessment of Brain Death Combination Product, NO CTA examination - Brain Death | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 63 | 2021-02-01 | 2021-06-04 |
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Brain Injuries (4) · Brain Injuries, Traumatic (3) · Delayed Graft Function (3) · Rejection, Psychology (3) · Coma (2) · Critical Illness (2) · Death (2) · Heart Arrest (2) · Hypoxia (2) · Inflammation (2) · Renal Insufficiency (2) · Respiratory Aspiration (2) · Stroke (2) · Apnea (1)
Brain Diseases (71) · Central Nervous System Diseases (71) · Consciousness Disorders (71) · Nervous System Diseases (71) · Neurobehavioral Manifestations (71) · Neurologic Manifestations (71) · Pathologic Processes (71) · Pathological Conditions, Signs and Symptoms (71) · Unconsciousness (71) · Coma (69) · Death (69) · Cardiovascular Diseases (10) · Vascular Diseases (8) · Cerebrovascular Disorders (7) · Signs and Symptoms (7)
Sodium Chloride (4) · Thyroxine (4) · Ultrasonography, Doppler, Transcranial (3) · Cytidine Triphosphate (2) · Naloxone (2) · Acetylcysteine (1) · Albuterol (1) · Atorvastatin (1) · Computed Tomography Angiography (1) · Critical Care (1) · Cyclosporine (1) · Enteral Nutrition (1) · Flumazenil (1) · Hydrocortisone (1) · Hypothermia, Induced (1)
University Hospital, Basel, Switzerland (3) · Brno University Hospital (2) · Centre Hospitalier Régional d'Orléans (2) · Chinese Academy of Medical Sciences (2) · Institut d'Anesthesiologie des Alpes Maritimes (2) · Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged (2) · Nova Scotia Health Authority (2) · Vanderbilt University Medical Center (2) · Washington University School of Medicine (2) · Antalya Training and Research Hospital (1) · Aristotle University Of Thessaloniki (1) · Assistance Publique - Hôpitaux de Paris (1) · Bioquark Inc. (1) · Bursa Yuksek Ihtisas Training and Research Hospital (1) · Central Hospital, Nancy, France (1)
France (14) · United States (12) · Canada (5) · China (5) · Turkey (Türkiye) (5) · Brazil (3) · Switzerland (3) · Argentina (2) · Czechia (2) · Germany (2) · Italy (2) · Sweden (2) · Belgium (1) · Denmark (1) · Finland (1)
Rajat Dhar, MD (2) · Andrew J Mannes, M.D. (1) · Anna-Maija Antman, MD (1) · Anne Julie Frenette, M.Sc (1) · Arianeb Mehrabi, MD (1) · Aydin Cagac, MD (1) · Babuaro Koneru, MD (1) · Carole R Ichai, MD, PhD (1) · Caroline Boutin, MD (1) · Christophe Adrie, MD, PhD (1) · Chryssa Pourzitaki, MD, PhD (1) · Chuanzhi Duan, MD (1) · Cristiane Leitao, PhD (1)
PMID 21156950, PMID 10390410, PMID 10634801, PMID 10798503, PMID 11498461, PMID 12243491, PMID 12478412, PMID 15016135, PMID 16424709, PMID 16733422, PMID 16799075, PMID 17275466, PMID 17579950, PMID 17643226, PMID 18636057, PMID 19232208, PMID 19406767, PMID 19565357, PMID 19857731, PMID 20220416, PMID 20397343, PMID 21168593, PMID 21422364, PMID 21971739, PMID 22194439, PMID 22228421, PMID 22472556, PMID 22759403, PMID 22788547, PMID 22918218, PMID 22963221, PMID 23237700, PMID 23609279, PMID 23884915, PMID 23912380, PMID 24283226, PMID 24311403, PMID 24314951, PMID 24365763, PMID 24429157, PMID 24462073, PMID 24628890, PMID 25010954, PMID 25010965, PMID 25054379, PMID 25250647, PMID 25355814, PMID 26590269, PMID 27007078, PMID 27401581
2014 (1), 2019 (1)