34 completed, 22 unknown, 7 recruiting, 4 not yet recruiting. 44 Not applicable, 14 Phase 4, 7 Phase 3, 1 Phase 1.
Follow Lidocaine: new trials by email Literature Review of Lidocaine trials Research Report on Lidocaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Minimal Effective Volume 90% for Double-injection Costoclavicular Block Ultrasound-guided double-injection costoclavicular nerve block with same previous volume, Ultrasound-guided double-injection costoclavicular nerve block with lower volume - Brachial Plexus Blocks, Lidocaine | Phase 4 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 60 | 2026-06-16 | 2026-07-07 |
| Workflow Optimization During Pulse Field Ablation for Atrial Fibrillation lidocaine, Saline - Pulsed Field Ablation, Lidocaine | Phase 4 | Not yet recruiting | National Taiwan University Hospital | 60 | 2026-06-01 | 2026-04-20 |
| Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia Lidocaine + Dexmedetomidine, Lidocaine + Magnesium sulphate, Lidocaine - Hemodynamic Effect, Dexmedetomidine | Not applicable | Recruiting | Cairo University | 60 | 2026-05-16 | 2026-06-30 |
| Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Sleeve Gastrectomy intravenous lidocaine, intravenous dexmedetomidine - Bariatric Surgery, Lidocaine | Not applicable | Recruiting | Alexandria University | 40 | 2025-12-26 | 2026-01-08 |
| Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Fentanyl (IV), lidocaine - Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction | Not applicable | Completed | Cairo University | 48 | 2025-12-01 | 2026-08-07 |
| Intraperitoneal Lidocaine and Bupivacaine for Postoperative Pain After Laparoscopic Surgery Lidocaine, Placebo Normal Saline (NS), Bupivacaine - Abdominal Laparoscopic and/or Robotic Surgery, Local Anasthesia | Not applicable | Completed | Misr University for Science and Technology | 64 | 2025-08-06 | 2026-08-20 |
| Infusion of Dexmedetomidine Versus Lidocaine in Management of Acute Postoperative Pain After Modified Radical Mastectomy Dexmedetomidine, Lidocaine - Infusion, Dexmedetomidine | Not applicable | Completed | Cairo University | 40 | 2025-05-15 | 2025-09-03 |
| Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries Lidocaine group, Magnesium group, Control group - Enhanced Recovery, Functional Endoscopic Sinus Surgery | Phase 4 | Not yet recruiting | Cairo University | 156 | 2025-05-10 | 2025-05-11 |
| Intravenous Lidocaine Plus Intratracheal Dexmedetomidine on Postoperative Sore Throat Intracheal dexmedetomidine, Intravenous lidocaine, Intravenous lidocaine combined with intracheal dexmedetomidine - Dexmedetomidine, Lidocaine | Not applicable | Not yet recruiting | Anqing Municipal Hospital | 144 | 2025-04-25 | 2025-04-30 |
| Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries Lidocaine, Dexmedetomidine - Intraoperative Infusion, Lidocaine | Not applicable | Recruiting | Tanta University | 100 | 2025-04-17 | 2025-08-07 |
| Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy Dexmedetomidine, Lidocaine, Isotonic saline - Dexmedetomidine, Lidocaine | Not applicable | Recruiting | Cairo University | 90 | 2025-04-05 | 2025-04-08 |
| Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury IV Lidocaine, IV Saline - Pain Management, Burn Injury | Phase 4 | Not yet recruiting | University of Washington | 20 | 2025-04-01 | 2025-04-04 |
| Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery Lidocaine, Dexmedetomidine, Lidocaine and Dexmedetomidine - Lidocaine, Dexmedetomidine | Not applicable | Completed | Ain Shams University | 75 | 2025-02-20 | 2026-07-21 |
| Pharmacokinetic Profile of Lidocaine Given as a Weight-based Infusion for Postoperative Surgical Pain Control Blood samples to measure lidocaine levels - Acute Pain, Lidocaine | Terminated | University of Alberta | 7 | 2025-02-12 | 2026-02-09 | |
| Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy Propofol, Sevoflurane plus lidocaine infusion, Sevoflurane - Sevoflurane, Lidocaine | Not applicable | Recruiting | Tanta University | 90 | 2025-02-01 | 2025-07-14 |
| Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy Lidocaine, Fentanyl, Propofol - Post-induction Hypotension, Lidocaine | Phase 4 | Completed | Cairo University | 149 | 2025-02-01 | 2026-03-05 |
| Adding Dexamethasone to Lidocaine in Scalp Incision Infiltration for Craniotomy Xylocaine plus Dexamethasone, Xylocaine plus epinephrine - Dexamethasone, Lidocaine | Not applicable | Completed | Assiut University | 100 | 2024-12-01 | 2026-08-26 |
| Premixed vs Sequential Injections of Lidocaine and Bupivacaine for Supraclavicular Brachial Plexus Block in Patients Undergoing Arteriovenous Fistula Creation Lidocaine 2% then bupivacaine 0.5%, Lidocaine 2% and bupivacaine 0.5% - Premixed, Sequential | Not applicable | Completed | Tanta University | 100 | 2024-08-24 | 2025-04-08 |
| Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery Lidocaine, Dexmedetomidine - Lidocaine, Dexmedetomidine | Not applicable | Completed | Ain Shams University | 40 | 2024-07-01 | 2026-07-21 |
| Ultrasound-guided Infraclavicular Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures Ropivacaine 0.2% Injectable Solution, Lidocaine epinephrine, Ropivacaine 0.5% Injectable Solution - Distal Radius Fractures, Lidocaine | Phase 3 | Completed | Nordsjaellands Hospital | 67 | 2024-04-23 | 2025-06-26 |
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Pain, Postoperative (13) · Agnosia (9) · Chronic Pain (9) · Acute Pain (7) · Neuralgia (4) · Nociceptive Pain (4) · Cough (3) · Pain (3) · Pharyngitis (3) · Postoperative Nausea and Vomiting (2) · Wrist Fractures (2) · Angina, Unstable (1) · Arrhythmias, Cardiac (1) · Arteriovenous Fistula (1) · Blood Loss, Surgical (1)
Pathological Conditions, Signs and Symptoms (35) · Signs and Symptoms (30) · Neurologic Manifestations (24) · Pathologic Processes (20) · Pain (17) · Postoperative Complications (16) · Nervous System Diseases (13) · Neurobehavioral Manifestations (10) · Perceptual Disorders (9) · Respiratory Tract Diseases (6) · Cardiovascular Diseases (4) · Neuromuscular Diseases (4) · Peripheral Nervous System Diseases (4) · Respiration Disorders (4) · Vascular Diseases (4)
Lidocaine (35) · Dexmedetomidine (13) · Fentanyl (6) · Saline Solution (5) · Sodium Chloride (5) · Control Groups (3) · Dexamethasone (3) · Epinephrine (3) · Propofol (3) · Remifentanil (3) · Sevoflurane (3) · Acetaminophen (2) · Bupivacaine (2) · Gabapentin (2) · Ketamine (2)
Cairo University (6) · Aretaieion University Hospital (5) · Tanta University (5) · Anqing Municipal Hospital (3) · SciVision Biotech Inc. (3) · University of Saskatchewan (3) · Aalborg University (2) · Ain Shams University (2) · Alexandria University (2) · Assiut University (2) · Guangzhou First People's Hospital (2) · Affiliated Hospital of Nantong University (1) · Ajou University School of Medicine (1) · Beijing Tiantan Hospital (1) · Centre Hospitalier Universitaire, Amiens (1)
Egypt (22) · China (11) · Canada (8) · Greece (6) · Taiwan (5) · Denmark (3) · South Korea (2) · Thailand (2) · United States (2) · Argentina (1) · France (1) · Italy (1) · Lebanon (1) · Pakistan (1) · Turkey (Türkiye) (1)
Kassiani Theodoraki (3) · Jehan Elkholy, M.D. (2) · Kareem MA Nawwar, M.D. (2) · Xiangcai Ruan, PhD (2) · Dalia G Abdel Nasser, M.B.B.Ch. (1) · Dina M Mohamed, M.D. (1) · Dina Mohamed (1) · Eman F Ali,, M.D. (1) · Fang Luo, MD (1) · Ireana C Ng, MD (1) · James Green, MB BS (1) · Jillian A Macdonald, MD (1) · Jon Gamble, MD (1)
PMID 10319823, PMID 10522582, PMID 10636615, PMID 10673886, PMID 10935008, PMID 10964145, PMID 11004045, PMID 11578889, PMID 11860425, PMID 11867391, PMID 11907387, PMID 12145066, PMID 12401630, PMID 12651674, PMID 1389192, PMID 13983769, PMID 14988367, PMID 1514331, PMID 15385385, PMID 1547048, PMID 15635516, PMID 15815458, PMID 16126785, PMID 16450594, PMID 16874214, PMID 16914460, PMID 17052624, PMID 17660457, PMID 18200994, PMID 18420857, PMID 18420858, PMID 18825338, PMID 19145998, PMID 19411668, PMID 19478674, PMID 1967515, PMID 19864308, PMID 20303597, PMID 20460991, PMID 20542176, PMID 20870978, PMID 2113773, PMID 21205628, PMID 22001341, PMID 23866780, PMID 24428507, PMID 26603110, PMID 27075030, PMID 27189295, PMID 34348668