284 completed, 85 unknown, 54 recruiting, 28 terminated. 170 Not applicable, 70 Phase 2, 51 Phase 3, 50 Phase 4, 41 Phase 1.
Follow Cough: new trials by email Literature Review of Cough trials Research Report on Cough
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chronic COUGH Management in Interstitial Lung DisEase Non-pharmacological cough control therapy, Healthy lifestyle - Interstitial Lung Disease, Chronic Cough | Not applicable | Not yet recruiting | Aveiro University | 60 | 2027-12-20 | 2025-01-20 |
| Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment - Dysphagia, Critical Illness | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 120 | 2027-07-01 | 2026-10-14 |
| Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures Ultrasound for cough, Ultrasound for vocal fold atrophy or vocal fold paresis/paralysis, Ultrasound for dysphagia - Cough, Vocal Cord Atrophy | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 200 | 2027-01-01 | 2026-06-16 |
| Effect Of Intracuff Dexamethasone On Postoperative Sore Throat In Patients Undergoing Laparoscopic Cholecystectomy Dexamethasone (0.1 mg/kg), Normal Saline (0.9% NaCl) - Postoperative Sore Throat, Cough, Hoarseness | Not applicable | Not yet recruiting | B.P. Koirala Institute of Health Sciences | 40 | 2027-01-01 | 2026-08-24 |
| Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough Acceptance and Commitment Therapy (ACT) - Chronic Cough | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 30 | 2026-12-01 | 2026-11-02 |
| 90% Effective Infusion Time of Sufentanil to Prevent Induction Cough: A Biased Coin Sequential Study Sufentanil Citrate - Cough | Not applicable | Not yet recruiting | Shiyou Wei | 120 | 2026-11-01 | 2026-08-21 |
| Investigation of Injury Risk and Related Factors in Adolescent Male Soccer Players Physical evaluations in footballers - Injury;Sports, Athletic Injuries | Not yet recruiting | Izmir Democracy University | 44 | 2026-10-15 | 2026-09-28 | |
| Observational Study of SIROPSEDAL in Acute Cough Acute Cough, Upper Respiratory Tract Infection | Not yet recruiting | Laboratoires Elerte | 124 | 2026-10-15 | 2026-06-04 | |
| Gabapentin vs. Benzonatate vs. Standard of Care for Cough in ILD Gabapentin, Benzonatate 200 mg, Standard of care treatment for ILD - Interstitial Lung Disease | Phase 4 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 177 | 2026-10-07 | 2026-10-08 |
| Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After Thyroidectomy remifentanil, Lidocaine %2 ampoule - Tracheal Extubation, Cough | Phase 4 | Recruiting | Pamukkale University | 60 | 2026-10-01 | 2026-11-02 |
| A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin - Cough, Refractory Chronic Cough | Phase 4 | Not yet recruiting | McMaster University | 124 | 2026-09-30 | 2026-10-19 |
| Effects of Video LMA Cuff Pressure in Tympanoplasty. Oropharyngeal Leak Pressure, Airway Management | Not yet recruiting | Samsun University | 48 | 2026-09-25 | 2026-09-30 | |
| Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection - Postoperative Cough, Cough Hypersensitivity Syndrome | Not applicable | Not yet recruiting | Tongji Hospital | 248 | 2026-09-01 | 2026-05-07 |
| Physical Impairments in Premature Ventricular Complex Physical Evaluations of Patients with Premature Ventricular Complex, Physical Evaluations of Healthy Individuals - Premature Ventricular Complexes | Not yet recruiting | Izmir Democracy University | 52 | 2026-08-30 | 2026-07-07 | |
| Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic Cough BCS+inactive, BCS+active - Chronic Cough (CC), Refractory Chronic Cough | Phase 2 | Recruiting | University of Montana | 135 | 2026-08-13 | 2026-08-18 |
| Dose-Escalation Study of Artesunate Patients With IPF Artesuante, Placebo capsules - Idiopathic Pulmonary Fibrosis | Phase 1 | Recruiting | Joseph C. Wu | 15 | 2026-08-01 | 2026-08-11 |
| A Study to Investigate the Efficacy and Safety of SC0032, a Magnesium Salt Oral Spray, in Adults With Refractory or Unexplained Chronic Cough SC0032, Placebo - Refractory Chronic Cough and Unexplained Chronic Cough | Phase 2 | Recruiting | Sensory Cloud, Inc. | 60 | 2026-07-13 | 2026-10-14 |
| A Clinical Trial to Evaluate the Effects of Super Lungs Liquid Drops on Respiratory Comfort, Airway Soothing, and Overall Well-Being Super Lungs Liquid Drops - Coughing, Throat Irritation | Not applicable | Active not recruiting | SuperBonsai Inc. | 35 | 2026-07-02 | 2026-07-09 |
| A Study to Investigate the Difference In Blood Levels of Camlipixant Between Different Camlipixant Formulation Prototypes Camlipixant - Cough | Phase 1 | Withdrawn | GlaxoSmithKline | 2026-07-02 | 2026-08-31 | |
| Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy Pressure Transducer, Traditional Palpation Method - Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness | Not applicable | Recruiting | Ankara Etlik City Hospital | 60 | 2026-06-30 | 2026-07-07 |
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Chronic Cough (138) · Dyspnea (40) · Asthma (36) · Pulmonary Disease, Chronic Obstructive (36) · Gastroesophageal Reflux (24) · Pharyngitis (22) · Respiratory Tract Infections (22) · Fever (20) · Common Cold (17) · Respiratory Sounds (17) · COVID-19 (16) · Deglutition Disorders (15) · Hoarseness (15) · Fatigue (13)
Pathological Conditions, Signs and Symptoms (498) · Signs and Symptoms (496) · Respiratory Tract Diseases (491) · Signs and Symptoms, Respiratory (491) · Respiration Disorders (489) · Lung Diseases (133) · Infections (102) · Lung Diseases, Obstructive (80) · Pathologic Processes (79) · Respiratory Tract Infections (77) · Bronchial Diseases (65) · Nervous System Diseases (63) · Otorhinolaryngologic Diseases (61) · Neurologic Manifestations (58)
Gefapixant (15) · Sodium Chloride (14) · Lidocaine (11) · Saline Solution (11) · montelukast (10) · Remifentanil (9) · BLU-5937 (6) · Capsaicin (6) · Standard of Care (5) · Surveys and Questionnaires (5) · Azithromycin (4) · Bronchoscopy (4) · Dexmedetomidine (4) · Dextromethorphan (4) · Nalbuphine (4)
Hull University Teaching Hospitals NHS Trust (11) · McMaster University (11) · Bellus Health Inc. - a GSK company (10) · Merck Sharp & Dohme LLC (10) · Bayer (8) · Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (7) · GlaxoSmithKline (7) · Mayo Clinic (7) · University of Florida (6) · Centre hospitalier de l'Université de Montréal (CHUM) (5) · Izmir Democracy University (5) · University of Montana (5) · Medical University of Warsaw (4) · Pfizer (4) · Riphah International University (4)
United States (119) · United Kingdom (67) · Canada (48) · China (47) · South Korea (24) · Turkey (Türkiye) (24) · Spain (21) · Israel (18) · France (17) · Germany (17) · Poland (17) · Italy (16) · Netherlands (15) · Australia (14) · Brazil (11)
Anthony F. DiMarco, MD (3) · Gail Gauvreau, PhD (3) · Ian M Paul, MD, MSc (3) · Kewu Huang, M.D. (3) · Carlos Chaccour (2) · Carol Epstein, MD (2) · Herman A Cohen, Prof. (2)
PMID 15385385, PMID 16543552, PMID 19406289, PMID 19406290, PMID 26426314, PMID 28839984, PMID 35248186, PMID 35569802, PMID 35639525, PMID 37017634, PMID 10522582, PMID 10562778, PMID 10636615, PMID 10673886, PMID 10781266, PMID 10892855, PMID 10964145, PMID 11004045, PMID 11511368, PMID 11578889, PMID 11867391, PMID 11907387, PMID 12095178, PMID 12145066, PMID 12401630, PMID 12403874, PMID 12434607, PMID 12493340, PMID 12620368, PMID 12651674, PMID 1285737, PMID 12927665, PMID 13983769, PMID 14533659, PMID 14988367, PMID 1514331, PMID 15358710, PMID 1547048, PMID 15635516, PMID 15672845, PMID 15966463, PMID 16120227, PMID 16126785, PMID 16450594, PMID 16510137, PMID 16685003, PMID 16914460, PMID 17053496, PMID 17660457, PMID 17939003
2017 (5), 2015 (4), 2019 (4), 2018 (3), 2016 (2), 2023 (1), 2025 (1), K22CA163747 (1), K23DK066165 (1), K23HL169934 (1), R01DK139089 (1), R21CA184337 (1), R21DC014567 (1), R34HL132369 (1), R34HL174877 (1)