233 completed, 76 unknown, 49 terminated, 36 recruiting. 423 Phase 3, 79 Phase 2.
Follow Ischemia: new trials by email Literature Review of Ischemia trials Research Report on Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Recruiting | Yongjun Wang | 1440 | 2026-10-16 | 2026-10-22 |
| Cilostazol for Prevention of Recurrent Stroke Trial Cilostazol 100 mg Tablets, Placebo - Stroke Recurrence, Myocardial Infarction | Phase 3 | Not yet recruiting | Stanford University | 2000 | 2026-10-01 | 2026-10-26 |
| Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock istaroxime, placebo - Cardiogenic Shock | Phase 2 / Phase 3 | Recruiting | Seismic Pharmaceuticals Operations LLC | 600 | 2026-09-09 | 2026-09-23 |
| Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARL Pelacarsen, Placebo - Acute Coronary Syndrome (ACS) | Phase 3 | Withdrawn | Novartis Pharmaceuticals | 2026-09-01 | 2026-10-14 | |
| Comparative Evaluation of Sustained meChanical AsPiration Thrombectomy and no Thrombus Modification for Pre-stent Thrombus bUrden Reduction in Patients With Acute Myocardial Infarction Study: the CAPTURE AMI Study Sustained thrombectomy, Percutaneous Coronary Intervention - STEMI - ST Elevation Myocardial Infarction | Phase 2 / Phase 3 | Recruiting | Oxford University Hospitals NHS Trust | 60 | 2026-07-08 | 2026-07-10 |
| HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN) Tirofiban, dual antiplatelet therapy - Stroke, Acute, Stroke, Ischemic | Phase 3 | Recruiting | Weifang Medical University | 458 | 2026-06-22 | 2026-06-25 |
| Intravenous Thrombolysis With Tenecteplase Plus Thrombectomy Versus Thrombectomy Alone In Patients With A Large Ischemic Stroke: A Multicenter Randomized Controlled Trial (IVT-ALL-IN) Intravenous administration, MT alone - Stroke | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 486 | 2026-06-15 | 2026-05-22 |
| Colchicine in Chronic Limb-Threatening Ischemia Colchicine 0.5 MG Oral Tablet Once Daily, Placebo - Chronic Limb-Threatening Ischemia | Phase 3 | Recruiting | Shin Kong Wu Ho-Su Memorial Hospital | 200 | 2026-06-02 | 2026-07-14 |
| Evaluating Bu Yang Huanwu Decoction For Early Diabetic Vascular Disease Hua Yu Wan Capsule, Aspirin - Peripheral Arterial Disease, Diabetic Angiopathies | Phase 3 | Not yet recruiting | Xuanwu Hospital, Beijing | 300 | 2026-06-01 | 2026-06-22 |
| Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction Methoxyflurane, Morphine - STEMI - ST Elevation Myocardial Infarction | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 700 | 2026-06-01 | 2026-03-03 |
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 860 | 2026-05-21 | 2026-05-27 |
| An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) Pelacarsen (TQJ230) - Cardiovascular Disease and Lipoprotein(a) | Phase 3 | Active not recruiting | Novartis Pharmaceuticals | 5700 | 2026-05-11 | 2026-10-14 |
| Prehospital Pulse-dose Glucocorticoid in Patients With ST-segment Elevation Myocardial Infarction 2 - The PULSE-MI 2 Trial Methylprednisolone 250 mg, NaCl (0,9%) - STEMI - ST Elevation Myocardial Infarction | Phase 3 | Recruiting | Thomas Engstrom | 5204 | 2026-04-20 | 2026-04-23 |
| Ivabradine in the Acute Management of Cardiogenic Shock Ivabradine 5mg Tab, Placebo Oral Tablet - Cardiogenic Shock Post Myocardial Infarction | Phase 3 | Recruiting | National Institute of Cardiovascular Diseases, Pakistan | 200 | 2026-04-20 | 2026-07-20 |
| Normal Saline Infusion After Intravenous Thrombolysis in Stroke normal saline - Brain Infarction | Phase 3 | Not yet recruiting | Tianjin Medical University General Hospital | 752 | 2026-04-01 | 2026-04-23 |
| Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial 2mg Baricitinib, 4mg Baricitinib, Placebo - Acute Ichemic Stroke, Anterior Cerebral Artery Stroke | Phase 2 / Phase 3 | Not yet recruiting | The First Affiliated Hospital of University of Science and Technology of China | 750 | 2026-03-17 | 2026-03-04 |
| Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone Ticagrelor + placebo, Ticagrelor + aspirin - NSTEMI - Non-ST Segment Elevation MI, STEMI (ST Elevation MI) | Phase 3 | Recruiting | Montreal Heart Institute | 2570 | 2026-03-03 | 2026-03-10 |
| Aspirin Continuation or Interruption in Patients at Moderate Risk for Cardiovascular Events Undergoing Colonoscopy and/or Polypectomy Aspirin 80mg, Placebo Oral Tablet - Myocardial Infarction (MI), Cardiovascular Events | Phase 3 | Recruiting | Chinese University of Hong Kong | 2514 | 2026-02-10 | 2026-03-18 |
| Efficacy of Montelukast on STEMl Patients Montelukast, Placebo - Myocardial Infarction (MI) | Phase 3 | Recruiting | Shanghai Zhongshan Hospital | 512 | 2026-02-01 | 2026-01-13 |
| Inhibition of Late Sodium Current (INa) to Prevent Coronary MICROvascular Dysfunction in Patients Presenting With ST-Elevation Myocardial Infarction and Multivessel Disease: INaMICRON Study Ranolazine - STEMI (ST Elevation MI) | Phase 2 / Phase 3 | Recruiting | Federico II University | 100 | 2026-02-01 | 2026-03-11 |
Showing 20 of 423. Sign in to see all of them.
Myocardial Infarction (216) · ST Elevation Myocardial Infarction (94) · Stroke (69) · Cardiovascular Diseases (66) · Myocardial Ischemia (47) · Heart Diseases (46) · Acute Coronary Syndrome (42) · Heart Failure (33) · Coronary Artery Disease (31) · Coronary Disease (29) · Cerebral Infarction (28) · Chronic Limb-Threatening Ischemia (28) · Angina, Unstable (26) · Non-ST Elevated Myocardial Infarction (23)
Pathological Conditions, Signs and Symptoms (423) · Pathologic Processes (422) · Vascular Diseases (404) · Necrosis (357) · Infarction (352) · Cardiovascular Diseases (351) · Heart Diseases (279) · Myocardial Ischemia (275) · Nervous System Diseases (96) · Central Nervous System Diseases (93) · Myocardial Infarction (93) · Brain Diseases (88) · Cerebrovascular Disorders (81) · Arteriosclerosis (75)
Aspirin (27) · Clopidogrel (22) · Ticagrelor (16) · dapagliflozin (11) · Prasugrel Hydrochloride (9) · Tenecteplase (9) · Tissue Plasminogen Activator (9) · Colchicine (8) · Enoxaparin (8) · Standard of Care (8) · Heparin (7) · Rivaroxaban (7) · Saline Solution (7) · Sodium Chloride (6) · Warfarin (6)
National Heart, Lung, and Blood Institute (NHLBI) (20) · Assistance Publique - Hôpitaux de Paris (14) · Novartis Pharmaceuticals (8) · Boehringer Ingelheim (6) · AstraZeneca (5) · Sanofi (5) · The Medicines Company (5) · Collegium Medicum w Bydgoszczy (4) · GlaxoSmithKline (4) · Merck Sharp & Dohme LLC (4) · National Institute of Cardiovascular Diseases, Pakistan (4) · Pfizer (4) · Population Health Research Institute (4) · Brigham and Women's Hospital (3) · Capital Medical University (3)
United States (106) · France (71) · Canada (68) · Germany (64) · China (47) · Poland (47) · Spain (46) · United Kingdom (45) · Italy (44) · Netherlands (44) · Belgium (38) · Australia (37) · Czechia (37) · Hungary (36) · Brazil (35)
Ali Eskandari, MD (2) · Allan Barker (2) · Andreas M Zeiher, MD (2) · Brian Silver, MD (2) · David Richardson (2) · Deepak L. Bhatt, MD (2) · Eugene Braunwald (2) · Gary Wilner (2) · Gilbert Wagener, MD (2) · Hamid Gourabi, PhD (2) · Hossein Baharvand, PhD (2) · Hossein Vakili, M.D. (2)
PMID 35224730, PMID 34932836, PMID 41114449, PMID 19131498, PMID 20189026, PMID 22068990, PMID 23174632, PMID 24561145, PMID 25572507, PMID 26089177, PMID 26198286, PMID 27160944, PMID 27165710, PMID 27287251, PMID 28304242, PMID 29685591, PMID 29716940, PMID 29910052, PMID 31733140, PMID 35277540, PMID 36302586, PMID 10811917, PMID 11239408, PMID 11786451, PMID 12324494, PMID 12460865, PMID 12507972, PMID 14578255, PMID 14699020, PMID 15007111, PMID 15077099, PMID 15238590, PMID 15321804, PMID 15480537, PMID 15498829, PMID 15534844, PMID 15861319, PMID 15910853, PMID 15949912, PMID 16168297, PMID 16183441, PMID 16304073, PMID 16337036, PMID 16537663, PMID 16537665, PMID 16537725, PMID 16543037, PMID 16613998, PMID 16644654, PMID 16651474
2019 (5), 2025 (4), 2009 (3), 2005 (2), 2016 (2), 2017 (2), 2018 (2), 1RC2HL101458-01 (1), 1UG3NS133209-01A1 (1), 2014 (1), 2015 (1), 2023 (1), M01RR000048 (1), M01RR000645 (1), M01RR007122 (1)