133 completed, 45 recruiting, 45 unknown, 19 terminated. 85 Phase 2, 80 Phase 3, 58 Phase 4, 35 Phase 1, 23 Not applicable.
Follow Colchicine: new trials by email Literature Review of Colchicine trials Research Report on Colchicine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy Colchicine, Placebo - Head and Neck Cancer | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 250 | 2027-03-01 | 2026-10-05 |
| Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy. Colchicine, Amiodarone, Posterior pericardiotomy - Atrial Fibrillation (AF) | Phase 3 | Not yet recruiting | Elsan | 636 | 2027-01-01 | 2026-10-21 |
| Perioperative Colchicine for TKA Colchicine 1.8 mg (loading dose) + Dextrose Oral Placebo, Colchicine 1.8 mg + 0.6 mg, Dextrose Oral Placebo - Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Geisinger Clinic | 75 | 2026-12-01 | 2026-09-03 |
| Colchicine Effect on Amyotrophic Lateral Sclerosis Patients Colchicine 0.5 MG Oral Tablet, Placebo Oral Tablet - Amyotrophic Lateral Sclerosis | Phase 2 | Not yet recruiting | Azienda Ospedaliero-Universitaria di Modena | 87 | 2026-10-01 | 2026-09-10 |
| Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage Colchicine 0.5 MG, Placebo - Colchicine, ICH - Intracerebral Hemorrhage | Phase 3 | Not yet recruiting | Population Health Research Institute | 1125 | 2026-09-30 | 2026-09-01 |
| Low-dose Colchicine for CABG Graft Failure Prevention Colchicine Pill, Placebo - CAD - Coronary Artery Disease, CABG | Not applicable | Not yet recruiting | Beijing Anzhen Hospital | 622 | 2026-09-01 | 2026-05-06 |
| Colchicine to Reduce Your SympToms And Lower Levels of Inflammation, Zeroing in on Effective CPPD Disease Treatment Colchicine Pill, Placebo - CPPD - Calcium Pyrophosphate Deposition Disease | Phase 2 | Recruiting | Brigham and Women's Hospital | 150 | 2026-08-12 | 2026-09-21 |
| A Study of SSGJ-613 in Gout Participants Initiating Urate-Lowering Treatment SSGJ-613 100 mg Q12W, SSGJ-613 200 mg Q12W, SSGJ-613 100 mg Q4W - Gout Arthritis | Phase 2 | Not yet recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 200 | 2026-08-02 | 2026-07-20 |
| The Impact of Initiating Dotinurad Urate-Lowering Therapy at Different Time Windows on Gout Flare Resolution Time Dotinurad, colchicine, etoricoxib - Gout | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 142 | 2026-07-30 | 2026-06-22 |
| PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis Rosuvastatin 20 Mg Oral Tablet, Colchicine 0.5 MG Oral Tablet Once Daily, Placebo - Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression | Phase 3 | Recruiting | Duke University | 1500 | 2026-07-21 | 2026-10-07 |
| Colchicine for the Prevention of Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting: A Single-Center, Strategy-Stratified, Randomized, Double-Blind, Placebo-Controlled Trial Colchicine 0.5 MG oral tablet twice daily, Placebo Oral Tablet - Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG) | Phase 2 / Phase 3 | Enrolling by invitation | National Taiwan University Hospital | 400 | 2026-07-06 | 2026-07-10 |
| Anti-inflammatory and Anti-thrombotic Therapy With colcHicine and Low Dose Rivaroxaban for Major Adverse Cardiovascular Events Reduction in Ischemic Stroke Rivaroxaban 2.5 Mg Oral Tablet, Colchicine 0.5 MG, Placebo Rivaroxaban - Ischemic Stroke | Phase 4 | Not yet recruiting | Brazilian Clinical Research Institute | 4500 | 2026-07-01 | 2026-02-11 |
| Colchicine for Autoimmune and Subacute Thyroiditis colchicine, Prednisolone, NSAID - Hashimoto Thyroiditis, Subacute Thyroiditis | Phase 2 / Phase 3 | Recruiting | Mansoura University | 300 | 2026-06-15 | 2026-07-29 |
| Precision Colchicine Intervention to Suppress Atherosclerosis in TET2 Clonal Hematopoiesis Colchicine 0.5 mg orally once daily for 12 months., SoC therapy - Colchicine, Coronary Atherosclerosis Management | Phase 4 | Recruiting | Shenyang Northern Hospital | 120 | 2026-06-08 | 2026-10-01 |
| Colchicine in Chronic Limb-Threatening Ischemia Colchicine 0.5 MG Oral Tablet Once Daily, Placebo - Chronic Limb-Threatening Ischemia | Phase 3 | Recruiting | Shin Kong Wu Ho-Su Memorial Hospital | 200 | 2026-06-02 | 2026-07-14 |
| Colchicine to Reduce Coronary Artery Inflammation in People With HIV Colchicine 0.5 mg, Placebo - HIV Infection, Cardiovascular Diseases (CVD) | Phase 2 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 90 | 2026-06-01 | 2026-07-15 |
| Design and Rationale of the COLT Study Colchicine 0.5 MG Oral Tablet, Placebo - Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome | Phase 3 | Not yet recruiting | Azienda Sanitaria Locale ASL 6, Livorno | 940 | 2026-06-01 | 2026-02-25 |
| Efficacy and Safety of Thalidomide for Pediatric PFAPA Syndrome Thalidomide (50mg), Colchicine - Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome | Not applicable | Not yet recruiting | Wenjie Zheng | 106 | 2026-04-01 | 2026-03-17 |
| Proteomic and Inflammatory Omics Changes With Colchicine Therapy in Coronary Heart Disease colchicine - Coronary Heart Disease (CHD) | Phase 4 | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 176 | 2026-03-01 | 2026-03-19 |
| Low-dose Colchicine for Thromboprophylaxis After Transcatheter Aortic Valve Replacement Colchicine, Standard Care - Transcatheter Aortic Valve Replacement, Transcatheter Heart Valve Thrombosis | Not applicable | Not yet recruiting | China National Center for Cardiovascular Diseases | 116 | 2026-03-01 | 2026-03-12 |
Showing 20 of 278. Sign in to see all of them.
Inflammation (33) · COVID-19 (29) · Gout (27) · Coronary Artery Disease (22) · Atrial Fibrillation (18) · Atherosclerosis (15) · Acute Coronary Syndrome (13) · Cardiovascular Diseases (12) · Myocardial Infarction (10) · Coronavirus Infections (9) · Heart Failure (9) · Stroke (9) · Heart Diseases (7) · Pericarditis (7) · ST Elevation Myocardial Infarction (7)
Mutual Pharmaceutical Company, Inc. (19) · Population Health Research Institute (8) · Montreal Heart Institute (6) · Ain Shams University (5) · Assistance Publique - Hôpitaux de Paris (5) · Gilead Sciences (5) · NYU Langone Health (5) · Takeda (5) · Azienda Sanitaria Locale 3, Torino (4) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (4) · Brigham and Women's Hospital (3) · G.Gennimatas General Hospital (3) · Hamilton Health Sciences Corporation (3) · Shahid Beheshti University of Medical Sciences (3) · University of Sao Paulo General Hospital (3)
United States (80) · China (28) · Canada (26) · Egypt (17) · Italy (17) · France (11) · Spain (11) · Brazil (9) · Denmark (9) · Netherlands (9) · United Kingdom (8) · Greece (7) · Russia (7) · Switzerland (7) · Australia (6)
Anthony R Godfrey, Pharm.D. (7) · Binita Shah, MD (4) · Jean-Claude Tardif, MD (3) · Massimo Imazio, MD (3) · Anthony R Godfrey, PharmD (2) · Aristeidis Katsanos, MD (2) · Ashkan Shoamanesh, MD (2) · Darin B Brimhall, D.O. (2) · Hamid Ahmadieh, MD (2) · Hejian Zou (2) · Jack A Yanovski, M.D. (2) · Matthew Davis, M.D. (2) · Matthew Davis, MD (2)
PMID 34658014, PMID 21480191, PMID 25172965, PMID 31733140, PMID 32720823, PMID 32865380, PMID 16186437, PMID 22090167, PMID 22940371, PMID 23040570, PMID 24508207, PMID 26228647, PMID 31986264, PMID 32020029, PMID 32081221, PMID 32295417, PMID 32553209, PMID 32648087, PMID 33270311, PMID 34269908, PMID 34473343, PMID 37489818, PMID 38505729, PMID 15308692, PMID 15320751, PMID 16134130, PMID 16439323, PMID 19597921, PMID 20131255, PMID 20336760, PMID 20373128, PMID 20704622, PMID 20805112, PMID 21435708, PMID 21873705, PMID 21884871, PMID 22895665, PMID 22913907, PMID 23208422, PMID 23816016, PMID 23992557, PMID 24452746, PMID 24694983, PMID 24773578, PMID 25784519, PMID 25925674, PMID 26076938, PMID 26265659, PMID 26304941, PMID 26576054
2018 (2), 2023 (2), 2025 (2), R01HL146206 (2), 1UL1TR001114-01 (1), 2014 (1), 2015 (1), I01CX002358 (1), K23HL150311 (1), R01HL120905 (1), R01HL125059 (1), U01AR080985 (1), U10HL051823 (1), U10HL051831 (1), U10HL051834 (1)