157 completed, 84 unknown, 41 recruiting, 30 terminated. 114 Not applicable, 70 Phase 2, 49 Phase 1, 28 Phase 3, 20 Phase 4.
Follow Chronic Limb-Threatening Ischemia: new trials by email Literature Review of Chronic Limb-Threatening Ischemia trials Research Report on Chronic Limb-Threatening Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Spectroscopic Assessment of Tissue Oxygenation Changes During Vascular Surgery Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia | Not yet recruiting | Spectrocor | 30 | 2026-12-01 | 2026-08-26 | |
| DCB Outcomes After Non-Compliant Balloon Vessel Preparation With or Without Scoring in Patients With Femoropopliteal Arterial Disease Non-compliant Plain Balloon angioplasty (PBA), Non-compliant Scoring Balloon Angioplasty (SB) - Femoropopliteal Disease, Drug Coated Balloon | Not applicable | Not yet recruiting | Marc Sirvent | 142 | 2026-12-01 | 2026-10-07 |
| Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 180 | 2026-10-20 | 2026-09-18 |
| ORbital Atherectomy for Lesion Preparation in Patients With Chronic Limb-threatening ischEmia Stealth 360™ Peripheral Orbital Atherectomy System from Abbott - Chronic Limb Threatening Ischemia, Chronic Limb-Threatening Ischemia | Recruiting | Cardiovascular and Interventional Radiological Society of Europe | 250 | 2026-08-31 | 2026-09-23 | |
| REsorbable SCaffolds With everolimUs-Elution for the Treatment of Infrapopliteal Artery Disease in Patients With Chronic Limb-threatening Ischemia Esprit BTK™ Everolimus Eluting Resorbable Scaffold from Abbott - Chronic Limb Threatening Ischemia, Chronic Limb-Threatening Ischemia | Recruiting | Cardiovascular and Interventional Radiological Society of Europe | 400 | 2026-08-31 | 2026-09-23 | |
| IVUS Guidance in BTK Interventions Intravascular ultrasound-guided EVT, Angiography-guided EVT - Chronic Limb-Threatening Ischemia | Not applicable | Not yet recruiting | Shin Kong Wu Ho-Su Memorial Hospital | 212 | 2026-08-01 | 2026-07-28 |
| Drug Eluting Temporary Spur Stent System vs Percutaneous Balloon Angioplasty for the Treatment of Critical Limb Ischemia Drug Eluting Temporary Spur Stent System, Percutaneous Transluminal Balloon Angioplasty - Critical Limb Ischemia | Not applicable | Not yet recruiting | ReFlow Medical, Inc. | 518 | 2026-08-01 | 2026-01-07 |
| Vessel Recoil in Specific CLTI Populations Vessel recoil measurement 15 minutes post final treatment (angiographically) - Chronic Limb Threatening Ischemia | Recruiting | Medical University of Graz | 40 | 2026-07-01 | 2026-10-14 | |
| Home-based Exercise Therapy in Patients With Moderate to Severe Peripheral Artery Disease Home-Based Exercise Therapy Using Portable Pedal Exerciser - Peripheral Artery Disease | Not applicable | Recruiting | Laval University | 12 | 2026-06-23 | 2026-06-26 |
| Predictors of Major Adverse Limb Events After Endovascular Iliac Stenting: a Real-world Cohort Study Iliac stenting - Peripheral Arterial Disease, Aortoiliac Occlusive Disease | Recruiting | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 98 | 2026-06-16 | 2026-06-30 | |
| Colchicine in Chronic Limb-Threatening Ischemia Colchicine 0.5 MG Oral Tablet Once Daily, Placebo - Chronic Limb-Threatening Ischemia | Phase 3 | Recruiting | Shin Kong Wu Ho-Su Memorial Hospital | 200 | 2026-06-02 | 2026-07-14 |
| Expression of GLP1 Receptor on Peripheral Blood Mononuclear Cells in Advanced Peripheral Artery Disease: Paving the Way for GLP1R Agonists Treatment in Chronic Limb Threatening Ischemia Analysis of GLP-1 receptor expression - Peripheral Arterial Disease (PAD), Claudication, Intermittent | Not yet recruiting | University Hospital, Strasbourg, France | 50 | 2026-06-01 | 2026-01-14 | |
| Woundsome Revascularization in Chronic Limb-Threatening Ischemia Revascularization by Percutaneous Transluminal Angioplasty - Chronic Limb-Threatening Ischemia | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-04-01 | 2026-04-01 |
| Safety of Antithrombotic Heparin Proteoglycan Mimetic APAC in Peripheral Arterial Occlusive Disease and Chronic Limb-threatening Ischemia APAC - dose level 0.50 mg/kg,, Unfractionated heparin (UFH), APAC dose level 1: 0.25 mg/kg, - Peripheral Arterial Occlusive Disease, Chronic Limb-Threatening Ischemia | Phase 2 | Recruiting | Aplagon Oy | 42 | 2026-01-29 | 2026-04-09 |
| Transverse Tibial Transport for Chronic Limb-Threatening Ischemia (CLTI) Transverse Tibial Bone Transport, TrueLok Elevate - Chronic Limb Threatening Ischemia | Not applicable | Withdrawn | University Hospitals Cleveland Medical Center | 2026-01-05 | 2026-05-29 | |
| Evaluation of Safety, Tolerability and Preliminary Efficacy of Etrinabdione in Patients With Peripheral Arterial Disease Etribnabdione 25 mg BID, Etribnabdione 50 mg BID - Peripheral Arterial Disease | Phase 2 | Not yet recruiting | VivaCell Biotechnology España | 30 | 2026-01-01 | 2025-09-17 |
| Intravascular Ultrasound for Peripheral Artery Disease Revascularization IVUS-guided strategy - Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia | Not applicable | Recruiting | Hamilton Health Sciences Corporation | 772 | 2025-12-05 | 2026-09-18 |
| AcoArt Litos PCB Below-the-knee Global Trial PCB, PTA - Chronic Limb-Threatening Ischemia | Not applicable | Terminated | Acotec Scientific Co., Ltd | 75 | 2025-10-10 | 2026-08-26 |
| Pressure Wire Guidance for Infrapopliteal Artery Interventions Angiography-guided angioplasty, Pressure wire-guided angioplasty - Chronic Limb-Threatening Ischemia | Not applicable | Recruiting | Yonsei University | 100 | 2025-10-02 | 2025-12-02 |
| Oucomes of Endovascular Atherectomy in Femoropopliteal Arterial Disease Endovascular Atherectomy - Chronic Threatening Limb Ischemia | Active not recruiting | Assiut University | 60 | 2025-10-01 | 2025-11-20 |
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Peripheral Arterial Disease (136) · Peripheral Vascular Diseases (61) · Intermittent Claudication (34) · Diabetic Foot (20) · Arterial Occlusive Diseases (19) · Diabetes Mellitus (16) · Ischemia (16) · Vascular Diseases (14) · Peripheral Arterial Occlusive Disease 1 (12) · Thromboangiitis Obliterans (9) · Cardiovascular Diseases (8) · Leg Ulcer (7) · Ulcer (7) · Atherosclerosis (6)
Disease Attributes (353) · Pathologic Processes (353) · Pathological Conditions, Signs and Symptoms (353) · Chronic Disease (352) · Arteriosclerosis (350) · Atherosclerosis (347) · Cardiovascular Diseases (345) · Vascular Diseases (339) · Ischemia (337) · Arterial Occlusive Diseases (334) · Peripheral Vascular Diseases (292) · Peripheral Arterial Disease (217) · Signs and Symptoms (37) · Endocrine System Diseases (35) · Skin Diseases (28)
Angioplasty (8) · Saline Solution (6) · Standard of Care (6) · Aspirin (5) · Clopidogrel (5) · Angioplasty, Balloon (4) · Atherectomy (3) · Sodium Chloride (3) · Stents (3) · treprostinil (3) · Ankle Brachial Index (2) · BID protein, human (2) · Cell- and Tissue-Based Therapy (2) · Control Groups (2) · Injections (2)
AnGes USA, Inc. (6) · Assiut University (6) · Abbott Medical Devices (5) · Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud (5) · Flanders Medical Research Program (5) · Beijing Northland Biotech. Co., Ltd. (4) · LimFlow, Inc. (4) · Medtronic Endovascular (4) · Ospedale San Donato (4) · Pluristem Ltd. (4) · ReFlow Medical, Inc. (4) · Singapore General Hospital (4) · Yonsei University (4) · Cagent Vascular LLC (3) · Cardiovascular and Interventional Radiological Society of Europe (3)
United States (105) · Germany (32) · Italy (24) · China (23) · France (22) · United Kingdom (22) · Austria (17) · Canada (14) · Belgium (13) · Spain (12) · South Korea (11) · Hungary (10) · Netherlands (10) · Egypt (9) · Singapore (8)
Marc Bosiers, MD (5) · Jihad Mustapha, MD (4) · Marianne Brodmann, MD (4) · Dierk Scheinert, MD (3) · Leonardo Clavijo, MD, PhD (3) · Mehdi Shishehbor (3) · Richard Powell, MD (3) · Antonio Chacon, MD, PhD (2) · Carlos Mena-Hurtado, MD (2) · Daniel Clair, MD (2) · Diego Martinez, MD, PhD (2) · Donna SH Lin, MD (2) · Ezio Faglia, MD (2) · Gervasio Lamas, MD (2)
PMID 35802393, PMID 17223489, PMID 21146749, PMID 22169682, PMID 26062950, PMID 26861113, PMID 28411244, PMID 31159978, PMID 36342173, PMID 36988592, PMID 37740111, PMID 37844137, PMID 37888915, PMID 40927852, PMID 42126372, PMID 42573020, PMID 10591383, PMID 12270002, PMID 12765661, PMID 12893742, PMID 14970108, PMID 15234694, PMID 16163360, PMID 16325694, PMID 16380545, PMID 17251666, PMID 17683831, PMID 18195333, PMID 18372148, PMID 18559703, PMID 18612117, PMID 18687757, PMID 19301723, PMID 19700099, PMID 20007987, PMID 20117502, PMID 20354489, PMID 20393508, PMID 20529449, PMID 20573475, PMID 20668482, PMID 21205939, PMID 21372298, PMID 21586692, PMID 21594960, PMID 21621834, PMID 21622669, PMID 21636239, PMID 21684715, PMID 21696982
2009 (2), 2023 (2), 2005 (1), 2008 (1), 2014 (1), 2016 (1), 2025 (1), R01HL114978 (1), R01HL128816 (1), R01HL141213 (1), R21AG073769 (1), R38HL143615 (1), U01HL107407 (1)