177 completed, 70 unknown, 37 terminated, 22 recruiting. 92 Phase 4, 90 Phase 3, 68 Not applicable, 63 Phase 2, 27 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigation to Assess the Effects of Drug-COATED Balloons for Treatment of Plaques Erosions Causing Acute Coronary Syndromes PCI with size matched DCB, GP IIbIIIa inhibitor or heparin & dual antiplatelet therapy - Myocardial Infarction, Percutaneous Coronary Intervention (PCI) | Not applicable | Not yet recruiting | 3W-Research Collaboration Group | 62 | 2026-10-01 | 2026-08-25 |
| Study of 3 Monoclonal Antibodies (REGN9933, REGN7508, and REGN9533) in Adult Participants With End-Stage Kidney Disease on Hemodialysis REGN9933, REGN7508, REGN9533 - End-Stage Kidney Disease (ESKD) | Phase 1 | Recruiting | Regeneron Pharmaceuticals | 36 | 2026-09-17 | 2026-10-06 |
| Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial Tocilizumab, Baricitinib, Anakinra - Sepsis | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 2000 | 2026-07-09 | 2026-10-20 |
| Percutaneous Embolectomy, Low Dose Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism (STRATIFY II) Ultrasound assisted Thrombolysis, Percutaneous Embolectomy, Heparin - Pulmonary Embolism | Phase 3 | Recruiting | Jesper Kjaergaard | 210 | 2026-06-17 | 2026-07-02 |
| Comparison of Citrate and Heparin Anticoagulation During Postdilution Hemodiafiltration Regional citrate anticoagulation, Unfractionated heparin - End-Stage Kidney Disease, Hemodiafiltration | Not applicable | Not yet recruiting | University Medical Centre Ljubljana | 20 | 2026-06-05 | 2026-06-01 |
| STRATEGY-PE: Real-World Treatment Strategies for Intermediate-High Risk Pulmonary Embolism Anticoagulants, Thrombolytic Agents, Mechanical Thrombectomy Devices - Pulmonary Embolism, Venous Thromboembolism | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 1300 | 2026-06-01 | 2026-05-22 | |
| Heparin to Prevent Organ Failure in Acute Pancreatitis Unfractionated heparin, Standard supportive care - Acute Pancreatitis (AP) | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 100 | 2026-06-01 | 2026-08-03 |
| Safety of Antithrombotic Heparin Proteoglycan Mimetic APAC in Peripheral Arterial Occlusive Disease and Chronic Limb-threatening Ischemia APAC - dose level 0.50 mg/kg,, Unfractionated heparin (UFH), APAC dose level 1: 0.25 mg/kg, - Peripheral Arterial Occlusive Disease, Chronic Limb-Threatening Ischemia | Phase 2 | Recruiting | Aplagon Oy | 42 | 2026-01-29 | 2026-04-09 |
| Effect of Anticoagulant Therapy on Endometrial Receptivity and Pregnancy Outcomes in Infertility Routine Anticoagulant Therapy (Aspirin or Heparin Sodium) - Infertility | Recruiting | Tang-Du Hospital | 300 | 2025-09-01 | 2026-03-27 | |
| Open-Label Study to Assess Safety and Time to Catheter-related Bloodstream Infections (CRBSI) in Subjects From Birth to < 18 Years of Age (taurolidine and heparin) catheter lock solution, Standard of Care - Catheter-Related Infections | Phase 4 | Recruiting | CorMedix Therapeutics | 36 | 2025-07-08 | 2026-09-25 |
| Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults And Adolescent Participants Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC) (taurolidine and heparin) catheter lock solution, Heparin - Central Line Associated Blood Stream Infections (CLABSI) | Phase 3 | Recruiting | CorMedix Therapeutics | 200 | 2025-05-14 | 2026-09-25 |
| A Novel Strategy of ECMO Management Using Nafamostat for Regional Combined With Low Intensity Systematic Anticoagulation Nafamostat, Heparin - ECMO | Not applicable | Recruiting | Beijing Chao Yang Hospital | 140 | 2025-05-10 | 2026-09-09 |
| Bivalirudin with Prolonged Infusion During PCI Versus Heparin After Fibrinolytic Therapy Bivalirudin, Unfractionated heparin - ST-segment Elevation Myocardial Infarction (STEMI) | Not applicable | Not yet recruiting | First Affiliated Hospital Xi'an Jiaotong University | 2400 | 2025-05-01 | 2025-03-06 |
| Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System Cardiohelp device (VA-ECMO), Heparin, Bivalirudin - Heart Failure, Cardiogenic Shock | Phase 2 | Recruiting | Stanford University | 50 | 2025-04-15 | 2026-08-10 |
| Timing of Thromboprophylaxis After Postpartum Hemorrhage Pharmacologic Thromboprophylaxis - Postpartum Hemorrhage, Venous Thromboembolism | Completed | University Tunis El Manar | 236 | 2025-03-01 | 2026-07-08 | |
| Observation of the Effect and Mechanism of Multi Tunnel Minimally Invasive Treatment for Xanthelasma Palpebrarum Multi level and multi tunnel puncture treatment, Heparin Sodium Injection, Multi Level and Multi Tunnel Puncture Treatment + Heparin Sodium Injection - Xanthelasma Palpebrarum | Not applicable | Enrolling by invitation | Fuzhou First General Hospital Skin Disease Prevention and Control Hospital | 270 | 2025-02-01 | 2025-03-11 |
| Endovascular Treatment or Standard Medical Care for Cerebral Venous Sinus Thrombosis(ESCORT) Heparin, Endovascular treatment - Cerebral Venous Sinus Thrombosis | Not applicable | Active not recruiting | Beijing Tiantan Hospital | 224 | 2024-12-24 | 2026-08-21 |
| Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage Venous thromboembolism prophylaxis with unfractionated heparin or low molecular weight heparin starting within the first 2 days but not earlier than 12 hours after a hospital admission., Venous thromboembolism prophylaxis with unfractionated heparin or low molecular weight heparin starting on the 3rd day after a hospital admission. - Venous Thromboembolism, Pulmonary Embolism | Not applicable | Recruiting | Pirogov Russian National Research Medical University | 200 | 2024-10-21 | 2026-03-24 |
| Insulin and Insulin Pulses During Fasting Intralipid and heparin, Saline - PreDiabetes | Not applicable | Recruiting | Mayo Clinic | 60 | 2024-09-15 | 2026-10-07 |
| Safe and Fast Radial Hemostasis Using Synergistic Strategies: SAFE & FAST Trial Heparin, Terumo Radial Band, Vaosband - Cardiovascular Diseases, Bleeding | Not applicable | Completed | Regional Hospital of Scranton | 451 | 2024-08-15 | 2026-03-03 |
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Venous Thrombosis (25) · COVID-19 (23) · Thrombosis (21) · Pulmonary Embolism (20) · Hemorrhage (19) · Venous Thromboembolism (15) · Coronary Artery Disease (13) · ST Elevation Myocardial Infarction (13) · Acute Kidney Injury (11) · Kidney Failure, Chronic (11) · Myocardial Infarction (11) · Acute Coronary Syndrome (10) · Catheter-Related Infections (9) · Sepsis (9) · Cardiovascular Diseases (7)
The Medicines Company (6) · Azidus Brasil (5) · GlaxoSmithKline (5) · Mayo Clinic (5) · Sanofi (5) · CorMedix Therapeutics (4) · Daiichi Sankyo (4) · Medical University of Vienna (4) · University of Colorado, Denver (4) · University of Manitoba (4) · Ain Shams University (3) · Assistance Publique - Hôpitaux de Paris (3) · Bayer (3) · Beijing Chao Yang Hospital (3) · Boehringer Ingelheim (3)
United States (102) · China (43) · Canada (39) · France (30) · Germany (25) · Brazil (24) · Italy (23) · Netherlands (21) · Spain (16) · Austria (12) · India (12) · Czechia (11) · Denmark (11) · Belgium (10) · Poland (10)
Adnan Kastrati, MD (3) · Bing Sun, MD (2) · Julinda Mehilli, MD (2) · Olle Korsgren, MD (2) · Ryan Zarychanski, MD MSc (2) · Yaling Han, MD (2) · A Giachino (1)
PMID 35244208, PMID 33314078, PMID 33502773, PMID 32407672, PMID 25572507, PMID 25717286, PMID 25851062, PMID 25880826, PMID 27165710, PMID 27287251, PMID 30957581, PMID 33095849, PMID 36942550, PMID 38189593, PMID 10208997, PMID 10636365, PMID 10647756, PMID 10661066, PMID 10927736, PMID 11113041, PMID 11157643, PMID 12397189, PMID 12586125, PMID 12601337, PMID 12719198, PMID 14638511, PMID 14650471, PMID 14710061, PMID 15162899, PMID 15383479, PMID 15842354, PMID 16042729, PMID 16155063, PMID 16352794, PMID 16641463, PMID 17353249, PMID 17403700, PMID 17517855, PMID 17538551, PMID 17556722, PMID 17646239, PMID 17717539, PMID 17855670, PMID 18204981, PMID 18349379, PMID 18499566, PMID 18559747, PMID 18585496, PMID 18621928, PMID 18643743
2016 (4), 2017 (2), 2019 (2), UL1TR001082 (2), 1OT2HL156812-01 (1), 2008 (1), 2009 (1), 2014 (1), 2015 (1), 2023 (1), 2025 (1), P30CA016672 (1), P50HL054502 (1), R01DK126206 (1), R01HL042428 (1)